GO:0017166

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Name vinculin binding
Categary Function
Go Slim No
Go Link GO:0017166
Unique Molecular Interactions 38
Total Molecular Interactions 47
Total Single Events 240
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for vinculin binding. They are ordered first by their pain relevance and then by number of times they were reported for vinculin binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT189671 DAG1 Positive_regulation of PRKCA 3 0.12 0.71 0.82
2 INT263236 DAG1 Positive_regulation of Prkcg 2 0.01 0.31 0.7
3 INT52333 Fos Regulation of Gene_expression of Synm 1 0.02 0 0.33
4 INT143688 Binding of Dlc1 and Trpv1 1 0.01 0.45 0.3
5 INT343569 Negative_regulation of Synm Positive_regulation of Gpt 1 0.01 0.96 0.29
6 INT343571 Synm Positive_regulation of ALPP 1 0.01 1.28 0.28
7 INT343570 Synm Positive_regulation of Gpt 1 0.01 1.28 0.28
8 INT343573 Synm Positive_regulation of SLC17A5 1 0.17 1.28 0.28
9 INT44091 Binding of ACTN1 and CAMSAP2 1 0.08 0 0.28
10 INT345008 Binding of ACTN1 and CSF2 1 0.02 0.53 0.26
11 INT189670 CHKB Negative_regulation of Gene_expression of DAG1 1 0.11 0 0.24
12 INT274005 KCNK3 Positive_regulation of SYNM 1 0.06 0 0.23
13 INT335464 Binding of DAG1 and PRKCA 1 0.03 0 0.22
14 INT178074 EDN1 Positive_regulation of Phosphorylation of PXN 1 0.05 0.82 0.2
15 INT177980 CSF1R Regulation of PXN 1 0.07 0.48 0.11
16 INT352763 Sms Regulation of Gene_expression of DAG1 1 0.08 0.64 0.11
17 INT243996 Binding of Dag1 and Dmd 1 0.04 0.08 0.11
18 INT244027 Binding of Dag1 and Helt 1 0.00 0.05 0.08
19 INT159852 Gene_expression of IL2 Regulation of Gene_expression of ACTN1 1 0.03 0.16 0.07
20 INT283126 Dag1 Positive_regulation of Localization of Aqp4 1 0.47 0.2 0.07
21 INT352766 DAG1 Positive_regulation of Prkd1 1 0.15 0.38 0.07
22 INT333247 Gene_expression of Cxcl12 Negative_regulation of Pxn 1 0.09 1 0.07
23 INT352762 DAG1 Regulation of Sms 1 0.03 0.37 0.05
24 INT352764 DAG1 Positive_regulation of Sms 1 0.06 0.11 0.03
25 INT238212 Binding of STAT3 and Pxn 1 0.02 0 0.03
26 INT222140 Binding of Cdh2 and Synm 1 0.00 0 0
27 INT269585 MAPKAP1 Negative_regulation of Phosphorylation of ACTN1 1 0.00 0 0
28 INT276586 Binding of Wt1 and Actn1 1 0.34 0.41 0
29 INT355603 Binding of CTNNA1 and Ctnnb1 1 0.00 1.07 0
30 INT355588 Binding of CDH1 and CTNNA1 1 0.00 1.12 0
31 INT230762 Binding of DAG1 and Tbx15 1 0.00 0.21 0
32 INT343572 Negative_regulation of Synm Positive_regulation of SLC17A5 1 0.16 0.44 0
33 INT249192 Binding of ACTN1 and S100A9 1 0.01 0 0
34 INT283122 Binding of Dag1 and Sptbn1 1 0.00 0.07 0
35 INT222141 Binding of Serpina3f and Synm 1 0.03 0 0
36 INT276591 Binding of Actn1 and KTWS 1 0.02 0.41 0
37 INT352765 DAG1 Regulation of Localization of Prkd1 1 0.09 0.09 0
38 INT249186 Binding of ACTN1 and S100A8 1 0.01 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for vinculin binding. They are ordered first by their pain relevance and then by number of times they were reported in vinculin binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6758 Positive_regulation of Synm 12 0.43 2.57 6.83
2 INT316829 Negative_regulation of SYNM 4 0.54 3.31 3.32
3 INT45303 Binding of SYNM 4 0.40 2.14 3.07
4 INT274527 Regulation of SYNM 3 0.20 2.68 2.7
5 INT242107 Positive_regulation of SYNM 8 0.38 2.82 2.39
6 INT6759 Regulation of Positive_regulation of Synm 1 0.21 0 2.19
7 INT134673 Gene_expression of SYNM 16 0.75 2.72 1.62
8 INT173328 Positive_regulation of DAG1 6 0.31 1.74 1.36
9 INT274526 Localization of SYNM 1 0.33 1.36 1.34
10 INT202817 Gene_expression of Dag1 16 0.75 7.82 1.3
11 INT189771 Gene_expression of DAG1 5 0.27 4.14 1.12
12 INT211095 Negative_regulation of Dag1 14 0.57 7.18 1.07
13 INT52330 Gene_expression of Synm 4 0.45 0.72 1
14 INT71917 Gene_expression of ACTN1 4 0.24 2.27 0.96
15 INT64044 Localization of DAG1 3 0.59 0.27 0.87
16 INT103944 Negative_regulation of Synm 3 0.41 2.17 0.83
17 INT52332 Binding of Synm 2 0.30 0.59 0.75
18 INT283119 Regulation of Dag1 4 0.44 1.98 0.65
19 INT44092 Binding of ACTN1 7 0.20 1.52 0.62
20 INT283110 Localization of Dag1 5 0.73 3.14 0.61
21 INT163857 Gene_expression of Dlc1 1 0.03 0.17 0.6
22 INT111601 Negative_regulation of Gene_expression of CTNNA1 1 0.24 0.58 0.58
23 INT111609 Gene_expression of CTNNA1 3 0.46 3.2 0.57
24 INT155214 Negative_regulation of ACTN1 1 0.28 0.16 0.51
25 INT111606 Positive_regulation of CTNNA1 1 0.12 0.47 0.47
26 INT103945 Regulation of Synm 1 0.37 0.59 0.39
27 INT283120 Regulation of Gene_expression of Dag1 4 0.52 1.32 0.38
28 INT155215 Regulation of ACTN1 1 0.30 0.17 0.37
29 INT284325 Positive_regulation of Gene_expression of DAG1 3 0.13 1.08 0.36
30 INT143687 Positive_regulation of Dlc1 1 0.01 0.46 0.34
31 INT178106 Phosphorylation of PXN 2 0.12 1.14 0.25
32 INT286203 Protein_catabolism of Dag1 2 0.26 1.56 0.22
33 INT321550 Gene_expression of Pxn 5 0.18 2.08 0.21
34 INT316917 Negative_regulation of Protein_catabolism of Dag1 1 0.12 0.44 0.21
35 INT283102 Positive_regulation of Dag1 1 0.49 1.31 0.21
36 INT274007 Positive_regulation of Gene_expression of SYNM 2 0.27 0.12 0.2
37 INT243937 Binding of Dag1 1 0.05 0.13 0.19
38 INT343567 Localization of Synm 1 0.25 1.04 0.18
39 INT269610 Phosphorylation of ACTN1 1 0.03 0.19 0.18
40 INT283105 Positive_regulation of Gene_expression of Dag1 1 0.67 1.19 0.17
41 INT44093 Positive_regulation of ACTN1 3 0.24 0 0.14
42 INT242106 Positive_regulation of Positive_regulation of SYNM 1 0.24 0.54 0.12
43 INT321546 Negative_regulation of Pxn 3 0.10 0.72 0.11
44 INT333240 Negative_regulation of Gene_expression of Pxn 1 0.08 0.27 0.11
45 INT177991 Regulation of PXN 2 0.04 0.56 0.1
46 INT283103 Regulation of Localization of Dag1 1 0.44 0.32 0.09
47 INT181030 Regulation of Pxn 1 0.09 1.11 0.08
48 INT159857 Positive_regulation of Binding of ACTN1 1 0.08 0.16 0.08
49 INT159859 Regulation of Binding of ACTN1 1 0.04 0.16 0.07
50 INT333229 Negative_regulation of Phosphorylation of Pxn 1 0.08 0.96 0.06
51 INT333237 Phosphorylation of Pxn 1 0.12 0.95 0.06
52 INT225726 Positive_regulation of PXN 1 0.05 0.34 0.06
53 INT341884 Positive_regulation of Localization of DAG1 1 0.03 0.21 0.06
54 INT352747 Regulation of DAG1 1 0.16 0.99 0.05
55 INT352009 Positive_regulation of Gene_expression of Pxn 1 0.07 0.1 0.04
56 INT269625 Positive_regulation of Phosphorylation of ACTN1 1 0.02 0.08 0.04
57 INT286551 Binding of Pxn 1 0.08 0.94 0
58 INT352742 Regulation of Gene_expression of DAG1 1 0.12 0.14 0
59 INT276555 Gene_expression of Actn1 1 0.59 0.76 0
60 INT230759 Binding of DAG1 1 0.03 0.21 0
61 INT283107 Transcription of Dag1 1 0.61 0.44 0
62 INT134675 Negative_regulation of Gene_expression of SYNM 1 0.42 0.22 0
63 INT355598 Negative_regulation of CTNNA1 1 0.04 1.06 0
64 INT283101 Negative_regulation of Gene_expression of Dag1 1 0.57 0.96 0
65 INT283113 Regulation of Transcription of Dag1 1 0.52 0.44 0
66 INT269658 Negative_regulation of Phosphorylation of ACTN1 1 0.02 0.11 0
67 INT352733 Negative_regulation of Localization of DAG1 1 0.11 0.06 0
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