GO:0018024

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Name histone-lysine N-methyltransferase activity
Categary Function
Go Slim No
Go Link GO:0018024
Unique Molecular Interactions 44
Total Molecular Interactions 59
Total Single Events 237
Pain Genes Associated 14

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for histone-lysine N-methyltransferase activity. They are ordered first by their pain relevance and then by number of times they were reported for histone-lysine N-methyltransferase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT84867 Ptger1 Negative_regulation of SETD2 1 0.00 1.09 0.11
2 INT130958 Binding of Eif4h and Ash1l 1 0.07 0.29 0.08
3 INT321399 Positive_regulation of SETD7 Positive_regulation of SETDB1 1 0.00 1.25 0.06
4 INT290727 Binding of Prdm6 and Arsi 1 0.01 0.17 0.04
5 INT332938 Suv39h1 Positive_regulation of Hist1h3f 1 0.06 0.12 0.03
6 INT321398 SETD7 Positive_regulation of SETDB1 1 0.00 0.62 0.03
7 INT197808 Binding of MEN1 and NME1 1 0.00 1.81 0
8 INT197809 Binding of MEN1 and VIM 1 0.04 0.52 0
9 INT301474 Binding of Helz and Smyd2 1 0.40 0.14 0
10 INT348584 EZH2 Regulation of Gene_expression of PPARG 1 0.30 0.43 0
11 INT250953 Binding of USO1 and SETDB1 1 0.00 0.09 0
12 INT197810 Binding of MEN1 and MUC1 1 0.06 0.47 0
13 INT339096 Ezh2 Regulation of Rcc1 1 0.02 1.1 0
14 INT197816 Binding of MEN1 and NFKB1 1 0.05 0.07 0
15 INT197813 Binding of AMBP and MEN1 1 0.00 0.51 0
16 INT348588 MECP2 Positive_regulation of Gene_expression of EZH2 1 0.28 0.42 0
17 INT301464 Binding of Smyd3 and Dhx8 1 0.05 0.08 0
18 INT348596 EZH2 Positive_regulation of Gene_expression of MECP2 1 0.28 0.42 0
19 INT301473 Binding of Dhx8 and Smyd2 1 0.06 0.14 0
20 INT197817 Binding of JUND and MEN1 1 0.18 0.14 0
21 INT301466 Smyd2 Negative_regulation of Binding of Trp53 1 0.20 0.3 0
22 INT348591 EZH2 Regulation of Negative_regulation of MECP2 1 0.15 0.73 0
23 INT301468 Smyd2 Negative_regulation of Trp53 1 0.20 0.31 0
24 INT301467 Binding of Smyd3 and Helz 1 0.30 0.08 0
25 INT301469 Negative_regulation of Binding of Sin3a and Smyd2 1 0.28 0.31 0
26 INT197844 Binding of MEN1 and Nfkb1 1 0.06 0.26 0
27 INT301475 Binding of Sin3a and Smyd2 1 0.32 0.31 0
28 INT250955 Binding of HLA-B and SETDB1 1 0.01 0.08 0
29 INT197815 Binding of MEN1 and TGFB1 1 0.16 0.13 0
30 INT225537 Binding of Paxip1 and Mll2 1 0.12 0 0
31 INT301472 Binding of Polr2a and Smyd3 1 0.06 0.08 0
32 INT301470 Binding of Smyd2 and Hdac1 1 0.35 0.31 0
33 INT348585 EZH2 Regulation of PPARG 1 0.41 0.73 0
34 INT301463 Negative_regulation of Smyd2 Positive_regulation of Gene_expression of Smyd1 1 0.54 0.1 0
35 INT342096 Binding of Polr2f and Ehmt1 1 0.00 0.73 0
36 INT197814 Binding of MEN1 and RELA 1 0.42 0.07 0
37 INT194925 Binding of CD22 and MLL2 1 0.08 0.18 0
38 INT301471 Binding of Smyd1 and Smyd2 1 0.40 0.2 0
39 INT301476 Binding of Polr2a and Smyd2 1 0.08 0.13 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for histone-lysine N-methyltransferase activity. They are ordered first by their pain relevance and then by number of times they were reported in histone-lysine N-methyltransferase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT79361 Negative_regulation of Prdm6 5 0.51 3.79 1.4
2 INT170813 Gene_expression of Prdm6 11 0.65 4.35 0.88
3 INT197832 Localization of MEN1 1 0.80 11.01 0.63
4 INT66991 Positive_regulation of Prdm6 2 0.16 0.86 0.44
5 INT61102 Gene_expression of MEN1 12 0.78 17.7 0.43
6 INT250961 Gene_expression of SETDB1 1 0.03 0.75 0.43
7 INT160666 Binding of Prdm6 2 0.31 0.73 0.35
8 INT301442 Gene_expression of Smyd2 1 0.77 2.97 0.17
9 INT130955 Binding of Ash1l 1 0.20 0.32 0.08
10 INT130957 Localization of Ash1l 1 0.41 0.29 0.08
11 INT130954 Positive_regulation of Ash1l 1 0.27 0.32 0.08
12 INT197836 Positive_regulation of Gene_expression of MEN1 1 0.50 3.16 0.07
13 INT197828 Negative_regulation of MEN1 1 0.43 5.06 0.06
14 INT175365 Localization of Prdm6 2 0.54 0.1 0.05
15 INT339094 Gene_expression of Ezh2 1 0.78 67.79 0.05
16 INT301438 Negative_regulation of Smyd2 1 0.58 0.73 0.05
17 INT237668 Regulation of Prdm6 3 0.20 1.49 0.03
18 INT321419 Positive_regulation of SETD7 1 0.02 0.61 0.03
19 INT332918 Localization of Suv39h1 1 0.73 0.11 0.03
20 INT348609 Negative_regulation of EZH2 1 0.29 1.33 0.03
21 INT348611 Localization of EZH2 1 0.50 0.35 0.03
22 INT342085 Positive_regulation of Ehmt1 1 0.01 0.4 0
23 INT339087 Binding of Ezh2 1 0.37 1.14 0
24 INT301448 Transcription of Smyd2 1 0.69 0.3 0
25 INT197841 Positive_regulation of MEN1 1 0.41 2.38 0
26 INT301436 Positive_regulation of Gene_expression of Smyd2 1 0.50 0 0
27 INT348622 Binding of EZH2 1 0.21 0.39 0
28 INT194935 Binding of MLL2 1 0.10 0.17 0
29 INT301450 Localization of Smyd2 1 0.75 1.04 0
30 INT197843 Regulation of Localization of MEN1 1 0.45 0.24 0
31 INT348618 Gene_expression of EZH2 1 0.51 2.32 0
32 INT197838 Transcription of MEN1 1 0.69 0.13 0
33 INT342075 Negative_regulation of Ehmt1 1 0.01 0.69 0
34 INT250971 Positive_regulation of Gene_expression of SETDB1 1 0.02 0.12 0
35 INT301455 Regulation of Smyd2 1 0.27 0.66 0
36 INT348612 Regulation of Gene_expression of EZH2 1 0.30 0.65 0
37 INT225430 Gene_expression of Mll2 1 0.33 0 0
38 INT301433 Binding of Smyd2 1 0.48 0.68 0
39 INT339090 Positive_regulation of Ezh2 1 0.47 0.82 0
40 INT348624 Positive_regulation of EZH2 1 0.31 0.42 0
41 INT197824 Positive_regulation of Transcription of MEN1 1 0.50 0.13 0
42 INT301445 Positive_regulation of Smyd2 1 0.50 0.79 0
43 INT301443 Gene_expression of Smyd3 1 0.57 0 0
44 INT339091 Positive_regulation of Gene_expression of Ezh2 1 0.70 11.65 0
45 INT339095 Negative_regulation of Gene_expression of Ezh2 1 0.59 4.48 0
46 INT339089 Regulation of Gene_expression of Ezh2 1 0.45 3.76 0
47 INT197834 Binding of MEN1 1 0.48 3.32 0
48 INT301432 Negative_regulation of Gene_expression of Smyd2 1 0.58 0.58 0
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