GO:0018105

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Name peptidyl-serine phosphorylation
Categary Process
Go Slim No
Go Link GO:0018105
Unique Molecular Interactions 2734
Total Molecular Interactions 3407
Total Single Events 25721
Pain Genes Associated 82

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for peptidyl-serine phosphorylation. They are ordered first by their pain relevance and then by number of times they were reported for peptidyl-serine phosphorylation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT132225 Negative_regulation of Binding of Akt1 and Sh2d6 1 0.10 3.92 7.2
2 INT130625 Prkcg Regulation of Prkaca 1 0.23 1.32 3.87
3 INT132231 Negative_regulation of Binding of Akt1 and Pik3cg 1 0.34 1.96 3.6
4 INT317522 Akt1 Positive_regulation of Phosphorylation of Nos1 1 0.43 0.4 3.13
5 INT118158 Binding of Prkca and Prkcz 1 0.07 1.14 2.98
6 INT298456 Prkaca Positive_regulation of Phosphorylation of Adarb1 1 0.00 1.86 2.85
7 INT168758 Hist1h1t Positive_regulation of Phosphorylation of Akt1 2 0.02 0.44 2.79
8 INT317551 Binding of Akt1 and Oprm1 1 0.19 0.21 2.74
9 INT167769 Prkca Positive_regulation of Positive_regulation of Sigmar1 1 0.38 0.86 2.63
10 INT223866 Ltp Positive_regulation of Positive_regulation of Mapk1 2 0.46 0.75 2.61
11 INT121746 Prkaca Positive_regulation of Ephb1 2 0.23 0.92 2.35
12 INT121726 Ngf Positive_regulation of Phosphorylation of Akt1 1 0.37 1.4 2.34
13 INT139723 PROC Positive_regulation of MAPK8 1 0.01 2.98 2.33
14 INT314205 Ngf Positive_regulation of Phosphorylation of Mapk14 1 0.43 1.24 2.3
15 INT114432 Oprl1 Positive_regulation of Akt1 1 0.18 0.08 2.2
16 INT135035 Binding of Hk1 and Tac1 1 0.35 0.18 2.14
17 INT196586 Negative_regulation of Mapk14 Negative_regulation of TNF 2 0.04 2.02 2.08
18 INT281084 Prkaca Positive_regulation of Mapk1 2 0.25 0 2.06
19 INT121216 Prkca Regulation of Positive_regulation of Oprd1 1 0.02 0.32 2.02
20 INT104855 Prkaca Regulation of TRPV1 3 0.06 1.52 1.92
21 INT112514 Binding of Prkaca and Trib3 1 0.03 1.18 1.9
22 INT186432 Prkaca Regulation of Creb1 1 0.14 0.45 1.9
23 INT112517 Binding of Ephb1 and Prkaca 3 0.18 0.58 1.85
24 INT314210 Ngf Regulation of Phosphorylation of Mapk14 1 0.34 0.85 1.84
25 INT121218 Arrb2 Regulation of Negative_regulation of Prkca 1 0.17 0.23 1.8
26 INT132229 Binding of Akt1 and Sh2d6 1 0.09 0.98 1.8
27 INT168715 Mapk8 Negative_regulation of Oprk1 1 0.18 0.26 1.75
28 INT332773 Positive_regulation of Prkaca Positive_regulation of Phosphorylation of Grin1 1 0.04 0.73 1.75
29 INT168716 Mapk8 Negative_regulation of Insrr 1 0.01 0.25 1.75
30 INT167765 Prkca Positive_regulation of Sigmar1 1 0.41 0.63 1.74
31 INT169464 Akt1 Positive_regulation of Egfr 1 0.28 1.63 1.7
32 INT167427 Mapk8 Regulation of Regulation of Tnf 1 0.26 2.83 1.7
33 INT139433 Binding of Prkaca and Prkca 1 0.37 0.13 1.67
34 INT322412 PPBP Negative_regulation of Phosphorylation of Akt1 1 0.01 0 1.65
35 INT122286 Prkaca Negative_regulation of Negative_regulation of Calca 1 0.12 0.54 1.63
36 INT21570 Binding of Cck and Mapk8 1 0.06 0 1.6
37 INT195930 OPRM1 Regulation of Prkaca 1 0.01 0 1.59
38 INT54601 Binding of Mtor and Ache 1 0.20 0.8 1.58
39 INT158774 Mapk14 Regulation of Il6 1 0.11 0.08 1.57
40 INT314214 Mapk14 Positive_regulation of Ngf 1 0.43 1.97 1.56
41 INT113337 EPO Positive_regulation of JAK2 1 0.76 2.8 1.55
42 INT249498 Src Positive_regulation of Phosphorylation of Grin2b 1 0.22 1.11 1.54
43 INT121741 Prkaca Negative_regulation of Positive_regulation of Creb1 1 0.10 0.2 1.49
44 INT136844 Binding of Prkca and Nrgn 1 0.33 0 1.47
45 INT156008 Bcl2 Regulation of Localization of Aifm1 1 0.17 1.92 1.47
46 INT158711 Cdk5 Positive_regulation of Phosphorylation of Trh 1 0.02 0 1.46
47 INT169800 Negative_regulation of Adrbk1 Positive_regulation of Positive_regulation of Mapk1 1 0.39 1.04 1.45
48 INT221242 Ros1 Positive_regulation of Prkca 1 0.02 0.39 1.44
49 INT214372 Ptprq Positive_regulation of Akt1 1 0.04 0.88 1.43
50 INT169801 Binding of Adrbk1 and Rapgef3 1 0.34 1.04 1.43
51 INT261831 Mapk1 Negative_regulation of Hspg2 1 0.00 1.26 1.42
52 INT148450 Gene_expression of Inhbe Positive_regulation of Mapk1 1 0.07 1.35 1.41
53 INT161670 H2-M3 Positive_regulation of Positive_regulation of Mapk1 1 0.14 0.73 1.41
54 INT214369 Pik3cb Positive_regulation of Akt1 1 0.56 0.87 1.41
55 INT78974 Binding of Prkcg and Prkaca 2 0.31 0.35 1.4
56 INT225019 PDGFB Positive_regulation of Gene_expression of Cxcl1 1 0.27 0.54 1.4
57 INT134679 FSCN1 Positive_regulation of MAPK8 1 0.01 0.56 1.39
58 INT262568 Prkaca Regulation of Trpv1 2 0.10 0.65 1.38
59 INT161511 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il1b 1 0.41 0.27 1.36
60 INT161513 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Tnf 1 0.33 0.27 1.35
61 INT145930 ecs Positive_regulation of Gene_expression of Bcl2 1 0.01 2.06 1.34
62 INT314213 Mapk14 Positive_regulation of Agtrap 1 0.04 1.15 1.34
63 INT300864 Ngf Positive_regulation of Mapk14 2 0.60 1.38 1.32
64 INT124926 Negative_regulation of Prkaca Negative_regulation of Localization of Pag1 1 0.00 0.61 1.3
65 INT195929 Binding of OPRM1 and Prkaca 1 0.02 0.33 1.27
66 INT314209 Ngf Positive_regulation of Binding of Mapk14 1 0.43 1.48 1.27
67 INT139724 PROC Positive_regulation of MAPK14 1 0.00 1.57 1.25
68 INT317569 Prkca Positive_regulation of Phosphorylation of Src 1 0.11 0 1.25
69 INT161508 Tlr4 Positive_regulation of Mapk14 2 0.19 0.46 1.24
70 INT314198 Mapk14 Positive_regulation of Gene_expression of Trpv1 1 0.48 1.09 1.24
71 INT314212 Mapk14 Positive_regulation of Gene_expression of Agtrap 1 0.06 1.09 1.24
72 INT141244 Fos Regulation of Prkaca 1 0.18 0.07 1.24
73 INT195926 Prkaca Positive_regulation of Trpv1 1 0.10 0.44 1.24
74 INT249487 Binding of Ephb1 and Src 1 0.17 0.74 1.23
75 INT75229 Prkaca Positive_regulation of Phosphorylation of Oprm1 1 0.44 0 1.22
76 INT76163 Prkaca Positive_regulation of Phosphorylation of Oprm1 1 0.02 0.08 1.22
77 INT328743 TNF Positive_regulation of Mapk14 1 0.04 1.4 1.21
78 INT166388 Binding of Gnb2l1 and Mapk1 1 0.49 0.49 1.21
79 INT328742 Il1 Positive_regulation of Mapk14 1 0.01 1.4 1.2
80 INT166301 Adrbk1 Positive_regulation of Localization of Trpv1 1 0.45 1.17 1.2
81 INT169802 Negative_regulation of Adrbk1 Positive_regulation of Positive_regulation of Rapgef3 1 0.44 0.75 1.19
82 INT330379 Gene_expression of IL10 Negative_regulation of Positive_regulation of MAPK14 1 0.00 1.95 1.18
83 INT141245 Prkaca Regulation of Gene_expression of Th 1 0.15 0.17 1.17
84 INT85780 Prkaca Regulation of Prkcg 1 0.29 0.47 1.17
85 INT169557 Cacna1h Positive_regulation of Mapk1 1 0.07 0.91 1.17
86 INT161509 Tlr4 Positive_regulation of Mapk8 1 0.15 0.3 1.16
87 INT161510 Tlr4 Positive_regulation of Mapk1 1 0.14 0.3 1.16
88 INT314206 Mapk14 Positive_regulation of Pax3 1 0.08 0.67 1.15
89 INT190771 Gene_expression of Il4 Negative_regulation of Gene_expression of Mapk14 1 0.15 1.14 1.13
90 INT130627 Gnas Regulation of Prkaca 1 0.00 0 1.13
91 INT190770 Il4 Negative_regulation of Gene_expression of Mapk14 1 0.20 1.14 1.13
92 INT249488 Positive_regulation of Binding of Ephb1 and Src 1 0.23 0.68 1.12
93 INT317548 Positive_regulation of Akt1 Positive_regulation of Prkca 1 0.15 0 1.11
94 INT317516 Binding of Oprm1 and Negative_regulation of Positive_regulation of Akt1 1 0.17 0.1 1.11
95 INT223154 Negative_regulation of Mapk14 Negative_regulation of Localization of Il6 1 0.19 1.13 1.11
96 INT139704 Tnf Positive_regulation of Mapk14 1 0.22 0.73 1.1
97 INT317512 Binding of Oprm1 and Prkca 1 0.07 0.13 1.1
98 INT323175 PRKCA Positive_regulation of Akt1 1 0.02 0 1.1
99 INT269200 Prkaca Positive_regulation of Phosphorylation of Ceacam3 1 0.03 0.65 1.09
100 INT167429 Negative_regulation of Mapk8 Negative_regulation of RYBP 1 0.01 1.11 1.09
101 INT151825 Tnf Positive_regulation of Mapk14 1 0.22 1.72 1.09
102 INT283934 Phax Negative_regulation of Positive_regulation of Mapk14 1 0.03 2.06 1.09
103 INT108547 AKT1 Regulation of MAPKAPK5 1 0.04 1.2 1.08
104 INT139703 Tnf Positive_regulation of Mapk8 1 0.32 0.73 1.08
105 INT352468 Calca Positive_regulation of Prkaca 1 0.11 0.8 1.08
106 INT96906 Plxna3 Regulation of Regulation of Prkaca 1 0.17 0.71 1.08
107 INT107938 POMC Positive_regulation of Gene_expression of TGFBR2 1 0.42 1.09 1.07
108 INT223875 Negative_regulation of Mapk8 Negative_regulation of Positive_regulation of Ltp 1 0.31 0 1.07
109 INT292531 Il10 Negative_regulation of Positive_regulation of Mapk14 1 0.15 1.13 1.06
110 INT269198 Prkaca Regulation of Phosphorylation of Grin2a 1 0.02 0.63 1.06
111 INT146496 Snta1 Positive_regulation of Gene_expression of Adrbk1 1 0.13 0.73 1.05
112 INT269199 Prkaca Positive_regulation of Phosphorylation of Grin1 1 0.03 0.56 1.05
113 INT154846 Negative_regulation of Mapk14 Negative_regulation of Positive_regulation of Trpv1 1 0.23 0.07 1.05
114 INT133650 Epo Negative_regulation of TNF 1 0.35 2.7 1.04
115 INT352456 Dusp1 Negative_regulation of Mapk14 1 0.03 1.31 1.03
116 INT151218 Negative_regulation of SIGMAR1 Negative_regulation of Positive_regulation of Akt1 1 0.00 0.26 1.03
117 INT75486 Binding of Tgfbr1 and Tgfbr2 1 0.10 1.94 1.02
118 INT121743 Negative_regulation of Src Negative_regulation of Ephb1 1 0.27 0 1.02
119 INT240453 Prkcg Positive_regulation of Positive_regulation of Prkaca 1 0.23 0.63 1.01
120 INT148327 Binding of Pkd1 and Trpv1 1 0.52 2.23 1.01
121 INT240455 Ephb1 Positive_regulation of Positive_regulation of Prkaca 1 0.22 0.63 1.01
122 INT186161 Prkaca Positive_regulation of Phosphorylation of Grin1 1 0.11 1.05 1.01
123 INT320021 Prkaca Regulation of Positive_regulation of Kcnma1 1 0.00 0.54 1
124 INT317554 Akt1 Regulation of Negative_regulation of Oprm1 1 0.21 0.07 1
125 INT317518 Src Regulation of Negative_regulation of Oprm1 1 0.16 0.07 1
126 INT317568 Prkca Regulation of Negative_regulation of Oprm1 1 0.10 0.07 1
127 INT142202 FL Positive_regulation of Bcl2 1 0.05 0.39 0.99
128 INT143915 Src Regulation of Rbm39 1 0.03 0.18 0.99
129 INT283932 Positive_regulation of Mapk14 Regulation of Gene_expression of Trpv1 1 0.14 1.28 0.99
130 INT276864 Positive_regulation of Gpr65 Positive_regulation of Prkaca 1 0.16 0.74 0.97
131 INT121744 Src Positive_regulation of Positive_regulation of Ephb1 1 0.35 0 0.96
132 INT211745 Gnptab Regulation of Positive_regulation of Prkca 1 0.00 0 0.96
133 INT122144 Binding of Trpv1 and Prkd1 1 0.02 0.39 0.96
134 INT317567 Binding of Akt1 and Nos1 1 0.22 0 0.96
135 INT133652 Epo Negative_regulation of Gene_expression of TNF 1 0.35 2.64 0.96
136 INT308169 Negative_regulation of Mapk14 Negative_regulation of Ltp 1 0.01 0.79 0.95
137 INT123051 Gpbar1 Regulation of Phosphorylation of Prkca 1 0.43 0 0.94
138 INT123050 Prkca Regulation of Phosphorylation of Grk4 1 0.33 0 0.94
139 INT123048 Grk4 Regulation of Phosphorylation of Prkca 1 0.33 0 0.94
140 INT252877 Prkaca Positive_regulation of Regulation of Grip2 1 0.01 0.22 0.94
141 INT123053 Prkca Regulation of Phosphorylation of Gpbar1 1 0.43 0 0.94
142 INT252878 Prkaca Regulation of Regulation of Grip2 1 0.01 0.22 0.94
143 INT137923 VEGFA Positive_regulation of Phosphorylation of Akt1 1 0.05 0 0.93
144 INT223871 Ltp Positive_regulation of Gene_expression of Mapk1 1 0.33 0 0.93
145 INT145853 Casp1 Positive_regulation of Mapk14 1 0.02 0.68 0.93
146 INT114883 Akt1 Regulation of Pik3r1 2 0.16 0.65 0.92
147 INT318461 Nnat Positive_regulation of Mapk14 1 0.05 0.97 0.92
148 INT252880 Positive_regulation of Prkaca Positive_regulation of Gene_expression of Tacr1 1 0.02 0.29 0.92
149 INT122269 Src Negative_regulation of Positive_regulation of Grin2b 1 0.27 0.44 0.92
150 INT195927 Binding of Prkaca and Trpv1 1 0.07 0.28 0.92
151 INT352465 Dusp1 Negative_regulation of Gene_expression of Mapk14 1 0.03 1.09 0.92
152 INT302828 Mapkapk5 Positive_regulation of Mapk1 1 0.07 1.38 0.91
153 INT112765 Binding of Nfkb1 and Bcl2 1 0.00 1.37 0.91
154 INT352444 Dusp1 Negative_regulation of Phosphorylation of Mapk14 1 0.03 1.09 0.91
155 INT317541 Oprd1 Negative_regulation of Akt1 1 0.06 0 0.91
156 INT122266 Src Negative_regulation of Grin2b 1 0.27 0.43 0.91
157 INT249012 Binding of Akt1 and Gabrg1 1 0.01 0 0.9
158 INT167767 Prkcz Positive_regulation of Phosphorylation of Sigmar1 1 0.04 0.23 0.9
159 INT167766 Prkcz Positive_regulation of Positive_regulation of Sigmar1 1 0.04 0.23 0.9
160 INT132226 Binding of Akt1 and Pik3cg 1 0.30 0.49 0.9
161 INT252876 Positive_regulation of Prkaca Regulation of Gene_expression of Tacr1 1 0.01 0.28 0.89
162 INT167771 Prkca Positive_regulation of Phosphorylation of Sigmar1 1 0.38 0.23 0.89
163 INT314207 Ngf Negative_regulation of Phosphorylation of Mapk14 1 0.33 0.4 0.88
164 INT196834 Prkaca Positive_regulation of Phosphorylation of Ppp1r1b 2 0.15 0 0.87
165 INT209928 IL1B Positive_regulation of MAPK14 2 0.15 1.69 0.87
166 INT199109 Binding of Akt1 and Arhgdia 1 0.02 2.73 0.87
167 INT317515 Binding of Hint1 and Prkca 1 0.13 0.17 0.87
168 INT249491 Efnb2 Positive_regulation of Phosphorylation of Src 1 0.01 0.5 0.87
169 INT112914 Ppp1r1b Negative_regulation of Prkaca 3 0.22 0.13 0.86
170 INT166634 Binding of Bcl2 and Becn1 1 0.20 0.5 0.86
171 INT150864 RYBP Positive_regulation of Positive_regulation of Bcl2 1 0.01 0.66 0.86
172 INT146495 Snta1 Positive_regulation of Adrbk1 1 0.14 0.68 0.85
173 INT110236 Hk1 Regulation of CSAD 1 0.01 1.57 0.84
174 INT116106 VEGFA Positive_regulation of AKT1 1 0.12 0.3 0.83
175 INT317546 Oprm1 Regulation of Prkca 1 0.06 0.4 0.82
176 INT317513 Oprm1 Regulation of Positive_regulation of Src 1 0.09 0.4 0.82
177 INT288201 Mapk14 Positive_regulation of Cish 1 0.03 0.06 0.82
178 INT317570 Oprm1 Regulation of Src 1 0.04 0.4 0.82
179 INT128590 Mapk14 Regulation of Nav1 1 0.21 0.25 0.82
180 INT185937 NOS2 Regulation of Prkaca 1 0.03 1.08 0.82
181 INT317556 Phosphorylation of Gopc Positive_regulation of Akt1 1 0.10 0.08 0.82
182 INT78972 Prkaca Regulation of Ina 1 0.11 0.09 0.82
183 INT317514 Akt1 Regulation of Localization of Oprm1 1 0.21 0.07 0.82
184 INT262572 Ngf Positive_regulation of Mapk1 2 0.04 0.52 0.81
185 INT190869 Binding of Prkca and Ltp 1 0.03 0.86 0.81
186 INT107937 POMC Regulation of Gene_expression of TGFBR2 1 0.28 0.82 0.81
187 INT157915 Prkca Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
188 INT228255 Binding of Akt1 and Pten 2 0.43 1.78 0.8
189 INT282063 Ngf Positive_regulation of Positive_regulation of Prkca 1 0.09 0.18 0.8
190 INT40610 Binding of Prkaca and Oprl1 1 0.02 0.09 0.8
191 INT262579 Ngf Positive_regulation of Prkca 1 0.07 0.36 0.8
192 INT168648 Positive_regulation of Cx3cr1 Positive_regulation of Phosphorylation of Mapk14 1 0.35 1.51 0.8
193 INT222024 Mapk8 Regulation of Mapk14 2 0.17 0.83 0.79
194 INT168647 Cx3cr1 Positive_regulation of Phosphorylation of Mapk14 1 0.52 1.51 0.79
195 INT186439 Prkaca Regulation of Phosphorylation of Creb1 1 0.06 0.08 0.79
196 INT161520 H2-M3 Regulation of Positive_regulation of Mapk1 1 0.09 0.47 0.79
197 INT132977 Tac1 Positive_regulation of Mapk1 1 0.06 0.17 0.79
198 INT117909 Mastl Positive_regulation of Mapk1 1 0.04 0 0.79
199 INT240454 Ephb1 Regulation of Prkaca 1 0.14 0.51 0.79
200 INT261834 Itpr3 Positive_regulation of Prkca 2 0.01 0.33 0.78

Single Events

The table below shows the top 100 pain related interactions that have been reported for peptidyl-serine phosphorylation. They are ordered first by their pain relevance and then by number of times they were reported in peptidyl-serine phosphorylation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94
2 INT94952 Positive_regulation of Mapk14 305 0.70 197.83 186.61
3 INT64161 Positive_regulation of Prkca 213 0.70 85.06 129.91
4 INT97701 Phosphorylation of Mapk14 191 0.82 115.33 100.46
5 INT52651 Positive_regulation of Prkaca 136 0.67 40.82 99.16
6 INT94953 Negative_regulation of Mapk14 156 0.59 104.77 91.51
7 INT96917 Positive_regulation of Mapk14 261 0.70 173.29 88.79
8 INT64158 Negative_regulation of Prkca 121 0.59 29.8 88.66
9 INT15898 Positive_regulation of Prkaca 199 0.70 50.89 87.54
10 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46
11 INT99070 Gene_expression of Mapk14 147 0.78 103.99 79.59
12 INT49111 Negative_regulation of Prkaca 102 0.59 27.44 71.77
13 INT53964 Negative_regulation of Prkaca 131 0.58 38.76 69.52
14 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34
15 INT64159 Gene_expression of Prkca 90 0.78 34.65 55.97
16 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03
17 INT117713 Phosphorylation of Akt1 275 0.82 95.82 54.34
18 INT96914 Phosphorylation of Mapk14 168 0.82 108.46 53.32
19 INT40777 Positive_regulation of Akt1 163 0.69 59.41 49.43
20 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82
21 INT110023 Negative_regulation of Mapk14 127 0.59 84.27 45.42
22 INT66383 Phosphorylation of Prkaca 143 0.80 30.85 43.38
23 INT57442 Phosphorylation of Prkca 98 0.70 31.58 41.04
24 INT92437 Positive_regulation of Phosphorylation of Mapk1 113 0.70 32.19 40.29
25 INT114751 Gene_expression of Mapk1 137 0.76 60.14 39.98
26 INT102611 Negative_regulation of Positive_regulation of Mapk1 74 0.58 35.57 39.37
27 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38
28 INT97702 Positive_regulation of Phosphorylation of Mapk14 69 0.69 49.21 36.81
29 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75
30 INT84260 Positive_regulation of Mapk8 124 0.69 72.84 35.98
31 INT95734 Phosphorylation of Mapk8 108 0.82 49.92 33.52
32 INT89055 Phosphorylation of Prkaca 60 0.61 13.41 32.49
33 INT96913 Positive_regulation of Mapk8 179 0.69 130.44 32.2
34 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81
35 INT117112 Negative_regulation of Mapk1 87 0.56 40.34 31.18
36 INT64164 Regulation of Prkca 34 0.62 10.44 30.99
37 INT110020 Gene_expression of Mapk14 142 0.77 72.33 30.08
38 INT66381 Regulation of Prkaca 40 0.62 13.38 27.96
39 INT112707 Negative_regulation of Akt1 89 0.59 28.85 27.76
40 INT95788 Positive_regulation of Positive_regulation of Mapk1 83 0.69 24.75 25.84
41 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53
42 INT106272 Positive_regulation of Positive_regulation of Mapk14 39 0.70 32.08 24.71
43 INT96904 Regulation of Prkaca 33 0.44 10.86 24.51
44 INT40776 Gene_expression of Akt1 99 0.77 34.91 24.39
45 INT117718 Positive_regulation of Phosphorylation of Akt1 112 0.69 39.26 24.09
46 INT86534 Positive_regulation of MAPK14 81 0.62 57.81 23.62
47 INT99069 Positive_regulation of Gene_expression of Mapk14 42 0.53 29.84 23.16
48 INT69322 Negative_regulation of MAPK14 70 0.54 42.92 22.71
49 INT171924 Gene_expression of MAPK14 60 0.65 54.38 21.68
50 INT99068 Gene_expression of Mapk8 62 0.78 33.57 21.25
51 INT117527 Binding of Prkca 25 0.48 6.43 21.05
52 INT89805 Gene_expression of Prkaca 45 0.77 11.03 20.77
53 INT50778 Gene_expression of Adrbk1 24 0.77 11.61 20.73
54 INT54708 Gene_expression of Adrbk1 22 0.75 1.06 20.62
55 INT112930 Negative_regulation of Adrbk1 17 0.58 15.04 20.41
56 INT125411 Negative_regulation of Phosphorylation of Mapk14 31 0.57 18.55 19.98
57 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61
58 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44
59 INT93734 Positive_regulation of Gene_expression of Bcl2 76 0.70 61.95 18.46
60 INT111531 Negative_regulation of Phosphorylation of Mapk14 37 0.50 20 17.68
61 INT116950 Negative_regulation of MAPK8 103 0.57 44.48 17.53
62 INT86673 Positive_regulation of Bcl2 77 0.70 57.74 17.37
63 INT109316 Negative_regulation of Mapk8 72 0.59 50.59 17.24
64 INT104493 Negative_regulation of Mapk8 56 0.53 27.76 16.86
65 INT109929 Phosphorylation of MAPK8 102 0.81 39.98 16.54
66 INT95790 Regulation of Mapk1 55 0.61 21.17 16.31
67 INT79458 Localization of Prkca 30 0.81 11.13 15.78
68 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59
69 INT111462 Negative_regulation of Phosphorylation of Mapk1 45 0.57 19.49 15.59
70 INT124371 Negative_regulation of Gsk3b 170 0.55 87.92 15.51
71 INT96911 Positive_regulation of Phosphorylation of Mapk14 46 0.70 43.03 15.15
72 INT2843 Gene_expression of Epo 100 0.78 62.01 14.66
73 INT124372 Gene_expression of Gsk3b 164 0.75 95.64 14.35
74 INT77619 Gene_expression of Prkaca 43 0.75 8.55 14.13
75 INT95738 Positive_regulation of Phosphorylation of Mapk8 40 0.70 23.46 13.88
76 INT18012 Gene_expression of EPO 169 0.78 108.36 13.75
77 INT109304 Positive_regulation of Phosphorylation of Akt1 113 0.69 40.92 13.49
78 INT80685 Gene_expression of MAPK8 90 0.72 51.91 13.36
79 INT76469 Positive_regulation of Gene_expression of Prkca 18 0.46 7.9 13.36
80 INT104954 Negative_regulation of Positive_regulation of Mapk14 29 0.58 17.71 13.31
81 INT80222 Negative_regulation of Bcl2 82 0.58 69.16 13.18
82 INT89842 Phosphorylation of Src 34 0.69 9.57 13.08
83 INT109223 Negative_regulation of Cdk5 14 0.59 3.27 12.73
84 INT110025 Positive_regulation of Positive_regulation of Mapk14 39 0.63 20.67 12.71
85 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54
86 INT150676 Positive_regulation of Gene_expression of Mapk1 30 0.45 10.06 12.37
87 INT119396 Regulation of Positive_regulation of Mapk1 22 0.61 7.88 12.25
88 INT117113 Regulation of Mapk14 28 0.45 16.71 11.99
89 INT26534 Regulation of Akt1 34 0.61 14.47 11.86
90 INT109315 Gene_expression of Mapk8 70 0.78 45.46 11.65
91 INT81640 Positive_regulation of Gene_expression of Bcl2 106 0.69 84.58 11.63
92 INT118906 Regulation of Mapk14 21 0.44 17.95 11.63
93 INT78970 Positive_regulation of Positive_regulation of Prkaca 14 0.47 3.06 11.49
94 INT96915 Phosphorylation of Mapk8 73 0.81 40.69 11.44
95 INT143098 Negative_regulation of Gene_expression of Adrbk1 9 0.58 8.51 11.37
96 INT15305 Positive_regulation of Mtor 51 0.67 8.28 11
97 INT54706 Regulation of Adrbk1 11 0.62 0.89 10.69
98 INT103923 Negative_regulation of Positive_regulation of Mapk14 23 0.53 13.95 10.64
99 INT110178 Phosphorylation of MAPK14 40 0.68 19.38 10.37
100 INT20166 Negative_regulation of Mtor 32 0.56 10.64 10.25
101 INT112940 Negative_regulation of Positive_regulation of Prkca 12 0.45 5.85 10
102 INT102865 Positive_regulation of Positive_regulation of Prkca 25 0.69 8.34 9.9
103 INT145695 Regulation of Mapk8 26 0.62 14.67 9.83
104 INT113667 Positive_regulation of Mapk7 15 0.70 12.24 9.72
105 INT75137 Regulation of Akt1 74 0.48 37.89 9.7
106 INT66382 Positive_regulation of Phosphorylation of Prkaca 33 0.49 7.05 9.69
107 INT54707 Positive_regulation of Adrbk1 14 0.67 0.51 9.51
108 INT15307 Regulation of Mtor 27 0.48 4.7 9.34
109 INT135372 Positive_regulation of Gsk3b 72 0.70 50.03 9.28
110 INT40609 Binding of Prkaca 23 0.36 3.42 9.19
111 INT89845 Positive_regulation of Src 19 0.44 7.5 9.01
112 INT120967 Negative_regulation of Phosphorylation of Akt1 47 0.57 23.67 8.98
113 INT111998 Positive_regulation of Positive_regulation of Mapk8 23 0.69 9.33 8.97
114 INT101602 Positive_regulation of Cdk5 15 0.70 4.1 8.96
115 INT71478 Positive_regulation of Positive_regulation of Prkaca 21 0.37 5.14 8.85
116 INT104396 Positive_regulation of Positive_regulation of Akt1 44 0.55 14.78 8.69
117 INT127555 Negative_regulation of Cdk5 59 0.59 50.2 8.45
118 INT104481 Regulation of Mapk8 21 0.50 13.87 8.41
119 INT70896 Gene_expression of PDGFB 48 0.65 33.55 8.39
120 INT86672 Negative_regulation of Bcl2 50 0.53 34.16 8.37
121 INT157580 Phosphorylation of Cdk5 4 0.77 0.73 8.33
122 INT96912 Positive_regulation of Phosphorylation of Mapk8 29 0.69 18.33 8.14
123 INT142526 Positive_regulation of Gene_expression of Prkaca 12 0.46 2.48 8.05
124 INT81345 Gene_expression of ADRBK1 21 0.70 2.89 7.9
125 INT80220 Positive_regulation of Bcl2 71 0.58 57.73 7.86
126 INT106522 Negative_regulation of Phosphorylation of Akt1 65 0.58 34.44 7.83
127 INT159750 Negative_regulation of Gene_expression of Mapk14 15 0.40 10.88 7.81
128 INT77306 Negative_regulation of Gene_expression of Bcl2 46 0.58 38.05 7.71
129 INT80686 Positive_regulation of Positive_regulation of MAPK8 42 0.68 26.95 7.63
130 INT99071 Positive_regulation of Gene_expression of Mapk8 16 0.55 9.87 7.58
131 INT91445 Regulation of Bcl2 50 0.56 38.8 7.41
132 INT103925 Negative_regulation of Positive_regulation of Akt1 32 0.58 15.19 7.39
133 INT98856 Negative_regulation of Gene_expression of Adrbk1 5 0.56 0.43 7.29
134 INT50779 Positive_regulation of Gene_expression of Adrbk1 9 0.56 2.79 7.23
135 INT128695 Regulation of Gene_expression of Mapk14 14 0.44 11.49 7.14
136 INT126748 Positive_regulation of Positive_regulation of Akt1 26 0.55 11.15 7.08
137 INT89052 Positive_regulation of Phosphorylation of Prkaca 13 0.37 2.92 7.05
138 INT3098 Positive_regulation of Epo 46 0.70 28.27 7
139 INT68466 Negative_regulation of Positive_regulation of Prkaca 6 0.57 2.29 6.83
140 INT93101 Regulation of Gene_expression of Bcl2 26 0.62 18.45 6.71
141 INT15872 Positive_regulation of EPO 74 0.70 45.35 6.67
142 INT118151 Positive_regulation of Prkcz 5 0.12 2.35 6.41
143 INT3738 Regulation of Epo 25 0.61 13.73 6.18
144 INT161352 Gene_expression of Map3k12 3 0.24 0.59 6.16
145 INT128587 Localization of Mapk14 15 0.81 8.41 6.1
146 INT117721 Positive_regulation of Gene_expression of Akt1 22 0.69 6.26 6.08
147 INT114882 Positive_regulation of Gene_expression of Akt1 45 0.69 21.29 6.06
148 INT127556 Positive_regulation of Cdk5 35 0.70 19.6 5.95
149 INT123045 Negative_regulation of Phosphorylation of Prkca 9 0.46 5.73 5.77
150 INT85777 Regulation of Negative_regulation of Prkaca 7 0.46 1.85 5.76
151 INT100422 Negative_regulation of Gene_expression of Bcl2 46 0.58 28.86 5.7
152 INT71477 Negative_regulation of Positive_regulation of Prkaca 10 0.37 1.69 5.57
153 INT101604 Regulation of Cdk5 10 0.61 2.2 5.53
154 INT124370 Positive_regulation of Gene_expression of Gsk3b 47 0.67 24.56 5.4
155 INT100222 Binding of Src 9 0.26 5.41 5.37
156 INT128922 Negative_regulation of Gene_expression of Mapk8 6 0.34 3.93 5.36
157 INT92571 Regulation of Mapk7 8 0.54 4.8 5.25
158 INT109928 Negative_regulation of Positive_regulation of MAPK8 19 0.42 10.42 5.23
159 INT176524 Binding of Mapk14 19 0.43 12.54 5.21
160 INT134468 Gene_expression of Cdk5r1 26 0.48 27.09 5.2
161 INT24080 Negative_regulation of Mtor 64 0.37 41.56 5.19
162 INT135291 Positive_regulation of Positive_regulation of Mapk8 24 0.64 19.37 5.16
163 INT126047 Regulation of Phosphorylation of Mapk14 7 0.60 5.05 5.03
164 INT23611 Gene_expression of Mtor 23 0.66 3.57 5.02
165 INT131717 Positive_regulation of Gene_expression of Mapk8 18 0.55 14.25 5.02
166 INT71244 Binding of Prkaca 8 0.30 2.64 4.96
167 INT89844 Positive_regulation of Phosphorylation of Src 10 0.43 4.71 4.95
168 INT100220 Negative_regulation of Src 13 0.41 6.37 4.93
169 INT105336 Regulation of AKT1 52 0.56 32.53 4.89
170 INT57441 Positive_regulation of Phosphorylation of Prkca 9 0.40 2.72 4.89
171 INT83205 Negative_regulation of Negative_regulation of Prkca 6 0.43 1.14 4.87
172 INT171472 Binding of Mapk14 10 0.36 6.79 4.83
173 INT92572 Gene_expression of Mapk7 17 0.78 3.71 4.76
174 INT135374 Binding of Gsk3b 46 0.48 24.36 4.75
175 INT204971 Gene_expression of Pink1 42 0.77 23.95 4.75
176 INT64160 Negative_regulation of Gene_expression of Prkca 8 0.43 3.01 4.72
177 INT79460 Positive_regulation of Localization of Prkca 11 0.70 2.72 4.71
178 INT134657 Localization of Akt1 37 0.68 11.58 4.62
179 INT98453 Positive_regulation of Src 19 0.47 7.84 4.62
180 INT54895 Binding of Epo 24 0.48 11.38 4.48
181 INT122569 Negative_regulation of Gene_expression of Akt1 34 0.54 17.15 4.44
182 INT26404 Positive_regulation of ATM 15 0.49 10.94 4.39
183 INT74531 Regulation of PDGFB 14 0.26 7.57 4.38
184 INT108354 Negative_regulation of Phosphorylation of Prkaca 18 0.41 6.24 4.37
185 INT168151 Gene_expression of Sgk1 10 0.76 5.58 4.35
186 INT92570 Negative_regulation of Mapk7 6 0.53 2.53 4.34
187 INT117920 Regulation of MAPK14 14 0.38 8.75 4.31
188 INT101957 Transcription of Bcl2 30 0.69 16.57 4.3
189 INT75523 Regulation of MAPK8 21 0.33 11.18 4.28
190 INT66366 Positive_regulation of Gsk3b 15 0.68 6.56 4.27
191 INT109219 Negative_regulation of Cdk5r1 5 0.43 1.22 4.25
192 INT167284 Phosphorylation of Gsk3b 88 0.82 36.03 4.21
193 INT109450 Positive_regulation of Phosphorylation of AKT1 62 0.64 25.18 4.21
194 INT110024 Negative_regulation of Gene_expression of Mapk14 19 0.42 7.83 4.21
195 INT109935 Positive_regulation of Phosphorylation of MAPK8 35 0.68 13.13 4.18
196 INT158416 Localization of Mapk1 19 0.67 5.32 4.18
197 INT117921 Positive_regulation of Positive_regulation of MAPK14 9 0.44 9.93 4.18
198 INT75136 Binding of Akt1 27 0.27 8.81 4.15
199 INT13190 Gene_expression of Pbk 10 0.31 1.97 4.14
200 INT110181 Negative_regulation of Phosphorylation of MAPK8 20 0.57 9.43 4.06
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