GO:0018963

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Name phthalate metabolic process
Categary Process
Go Slim No
Go Link GO:0018963
Unique Molecular Interactions 72
Total Molecular Interactions 102
Total Single Events 2364
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for phthalate metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for phthalate metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT124547 Trib3 Regulation of Regulation of Th 1 0.02 0.79 2.64
2 INT63939 Vta1 Positive_regulation of Th 1 0.14 0 1.61
3 INT40887 Penk Regulation of Th 1 0.04 0 1.53
4 INT106070 Positive_regulation of Oprl1 Positive_regulation of TH 1 0.13 0.15 1.36
5 INT60989 Ngf Regulation of Th 1 0.17 0 1.34
6 INT98833 Th Regulation of Gene_expression of Drd2 1 0.19 0.64 1.27
7 INT98832 Th Regulation of Dbh 1 0.32 0.53 1.2
8 INT141245 Prkaca Regulation of Gene_expression of Th 1 0.15 0.17 1.17
9 INT141246 Trib3 Regulation of Gene_expression of Th 1 0.02 0.17 1.17
10 INT60990 Bdnf Negative_regulation of Th 1 0.15 0 1.17
11 INT106069 TH Positive_regulation of Th 1 0.07 0.16 1.14
12 INT88446 Uncx Positive_regulation of Th 1 0.13 0 1.1
13 INT31547 Binding of Th and Vip 1 0.31 0 1.08
14 INT41175 Adra2a Regulation of Th 1 0.59 0 1.04
15 INT31548 Binding of Th and Dbh 1 0.35 0 0.98
16 INT63940 Negative_regulation of Vta1 Positive_regulation of Th 1 0.13 0 0.81
17 INT7958 LOC686180 Positive_regulation of Gene_expression of Th 1 0.02 0 0.64
18 INT7957 Calca Positive_regulation of Gene_expression of Th 1 0.39 0 0.47
19 INT121837 Sct Positive_regulation of Th 1 0.23 0.06 0.43
20 INT139487 Oprm1 Positive_regulation of Th 1 0.26 0.1 0.42
21 INT7625 Man2a2 Regulation of Th 1 0.01 0.07 0.4
22 INT31794 Hps6 Positive_regulation of Th 1 0.03 0 0.38
23 INT187064 ARSD Negative_regulation of CYP19A1 1 0.22 0.7 0.35
24 INT173476 Th Regulation of Gene_expression of Bcar1 1 0.10 0 0.34
25 INT34855 Negative_regulation of Maoa Negative_regulation of Th 1 0.17 0 0.34
26 INT173478 Th Regulation of Localization of Ins1 1 0.13 0 0.34
27 INT175330 IL6 Positive_regulation of Gene_expression of CYP19A1 1 0.01 0.97 0.32
28 INT153019 nct Positive_regulation of Transcription of Th 1 0.19 0.61 0.32
29 INT153020 nct Positive_regulation of Gene_expression of Th 1 0.19 0.61 0.32
30 INT222299 Binding of CYP19A1 and AIS 2 0.25 1.65 0.31
31 INT55404 Binding of ENG and Th 1 0.02 0 0.3
32 INT314484 TH Positive_regulation of RLS 1 0.01 1.66 0.29
33 INT134927 CYP19A1 Positive_regulation of Gene_expression of MME 1 0.30 1.04 0.28
34 INT134930 MME Positive_regulation of Gene_expression of CYP19A1 1 0.30 1.04 0.28
35 INT78484 Binding of DBH and TH 1 0.09 0 0.28
36 INT118461 Bmp7 Positive_regulation of Th 1 0.31 0.06 0.25
37 INT199970 CYP19A1 Positive_regulation of Gene_expression of ESR1 1 0.06 0.72 0.25
38 INT329432 Binding of CCR6 and TH 1 0.00 0.47 0.23
39 INT329431 Binding of CCL20 and TH 1 0.00 0.47 0.23
40 INT145140 Negative_regulation of CPOX Negative_regulation of Gene_expression of CYP19A1 1 0.13 0.47 0.2
41 INT61987 Th Regulation of Penk 1 0.46 0 0.2
42 INT88450 Uncx Regulation of Gene_expression of Th 1 0.06 0 0.17
43 INT261456 Sftpd Positive_regulation of Gene_expression of Th 1 0.10 0.77 0.13
44 INT220394 MRXS5 Positive_regulation of Gene_expression of CYP19A1 1 0.00 0.89 0.09
45 INT285070 CCL16 Positive_regulation of Gene_expression of CYP19A1 1 0.02 0.69 0.09
46 INT220412 Cpox Positive_regulation of Gene_expression of CYP19A1 1 0.01 0.9 0.09
47 INT261262 AIS Negative_regulation of Cyp19a1 1 0.01 0.2 0.08
48 INT213933 AR Negative_regulation of Cyp19a1 1 0.07 0.79 0.07
49 INT187732 Binding of CYP19A1 and Cyp11a1 1 0.01 0.68 0.04
50 INT213262 IL6 Positive_regulation of CYP19A1 1 0.11 1.63 0.03
51 INT187676 Binding of CYP19A1 and SHBG 1 0.01 0.63 0.03
52 INT133804 Binding of CYP2B6 and CYP19A1 3 0.09 2.26 0
53 INT176564 Binding of Cyp17a1 and Cyp19a1 1 0.03 0.33 0
54 INT292968 Fto Regulation of Gene_expression of Th 1 0.30 1.11 0
55 INT350120 FSHR Regulation of CYP19A1 1 0.01 3.02 0
56 INT259451 Binding of DHCR7 and Cyp11a1 1 0.01 0.3 0
57 INT292970 Fto Regulation of Th 1 0.18 0.48 0
58 INT127058 Vta1 Negative_regulation of Positive_regulation of Th 1 0.33 0 0
59 INT242176 AIS Negative_regulation of CYP19A1 1 0.07 0.69 0
60 INT187674 FSHR Positive_regulation of Gene_expression of CYP19A1 1 0.24 0 0
61 INT49943 Binding of Th and Pdx1 1 0.02 0.17 0
62 INT242178 CYP19A1 Regulation of Cyp11a1 1 0.01 0.35 0
63 INT163744 Binding of Th and Gfra4 1 0.09 0 0
64 INT176569 Binding of FSHR and Cyp19a1 1 0.04 0.06 0
65 INT242179 Cyp11a1 Regulation of CYP19A1 1 0.01 0.7 0
66 INT259452 Binding of STAR and Cyp11a1 1 0.25 0.06 0
67 INT187670 Gene_expression of FSHR Positive_regulation of Gene_expression of CYP19A1 1 0.16 0 0
68 INT277622 Esr1 Positive_regulation of Gene_expression of Cyp19a1 1 0.03 1.37 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for phthalate metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in phthalate metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT4740 Gene_expression of Th 298 0.78 61.27 154.03
2 INT218 Positive_regulation of Th 245 0.70 40.5 120.1
3 INT7327 Regulation of Th 164 0.62 29.67 110.14
4 INT217 Negative_regulation of Th 134 0.59 26.83 62.63
5 INT350 Localization of Th 79 0.80 10.26 41.17
6 INT7326 Transcription of Th 83 0.72 13.5 35.33
7 INT6558 Positive_regulation of Gene_expression of Th 56 0.70 9.64 30.89
8 INT7956 Regulation of Gene_expression of Th 44 0.61 8.26 29.31
9 INT4781 Gene_expression of TH 68 0.73 26.92 24.01
10 INT26719 Negative_regulation of Gene_expression of Th 38 0.58 11.87 22.78
11 INT71047 Gene_expression of CYP19A1 122 0.78 68.78 22.21
12 INT13643 Phosphorylation of Th 20 0.82 1.9 20.97
13 INT14724 Negative_regulation of CYP19A1 233 0.59 96.56 18.26
14 INT13716 Positive_regulation of TH 33 0.68 19.11 16
15 INT31368 Positive_regulation of Positive_regulation of Th 19 0.51 2.2 12.68
16 INT141 Binding of Th 21 0.48 3.53 11.04
17 INT48496 Regulation of Transcription of Th 16 0.54 2.29 10.02
18 INT10597 Gene_expression of Cyp19a1 27 0.78 7.48 9.11
19 INT119904 Regulation of CYP19A1 25 0.62 9.36 8.34
20 INT26643 Negative_regulation of Positive_regulation of Th 12 0.59 1.26 7.74
21 INT7624 Positive_regulation of Regulation of Th 7 0.50 2.41 7
22 INT122896 Negative_regulation of TH 23 0.57 9.27 6.88
23 INT3506 Localization of TH 12 0.81 0.78 6.66
24 INT7569 Positive_regulation of Transcription of Th 19 0.70 2.6 6.17
25 INT135760 Regulation of Gene_expression of Cyp19a1 2 0.62 1.15 5.81
26 INT30317 Regulation of TH 14 0.43 7.27 5.38
27 INT23010 Positive_regulation of CYP19A1 28 0.58 24.18 5.37
28 INT7623 Regulation of Regulation of Th 11 0.44 1.31 5.16
29 INT40620 Regulation of Positive_regulation of Th 9 0.45 2.45 4.69
30 INT30165 Positive_regulation of Phosphorylation of Th 8 0.56 0.75 4.22
31 INT77823 Negative_regulation of Negative_regulation of Th 9 0.59 1.56 3.79
32 INT112340 Gene_expression of Cyp11a1 11 0.77 5.19 3.7
33 INT31580 Negative_regulation of Cyp11a1 14 0.57 3.48 3.61
34 INT10824 Negative_regulation of Cyp19a1 38 0.57 25.18 3.56
35 INT30166 Regulation of Phosphorylation of Th 4 0.50 0.52 3.33
36 INT116376 Transcription of Cyp19a1 2 0.40 0.74 3.04
37 INT64386 Binding of Cyp11a1 13 0.46 5.09 3.01
38 INT133809 Negative_regulation of Gene_expression of CYP19A1 9 0.43 7.67 2.99
39 INT113277 Positive_regulation of Gene_expression of CYP19A1 13 0.69 10.23 2.97
40 INT4782 Positive_regulation of Gene_expression of TH 12 0.47 7.36 2.95
41 INT106066 Negative_regulation of Positive_regulation of TH 1 0.18 0.22 2.6
42 INT106068 Positive_regulation of Positive_regulation of TH 1 0.21 0.22 2.59
43 INT4704 Positive_regulation of Negative_regulation of Th 4 0.50 0.06 2.56
44 INT13644 Negative_regulation of Phosphorylation of Th 2 0.43 0.06 2.51
45 INT15210 Negative_regulation of Transcription of Th 9 0.59 0.47 2.37
46 INT71048 Transcription of CYP19A1 11 0.72 8.74 2.24
47 INT15209 Negative_regulation of Regulation of Th 6 0.51 1.64 2.16
48 INT111113 Binding of CYP19A1 15 0.36 9.17 2.12
49 INT342803 Positive_regulation of Transcription of Cyp19a1 1 0.30 0.33 2.08
50 INT81347 Regulation of Cyp19a1 7 0.40 2.1 1.94
51 INT1834 Positive_regulation of Binding of Th 1 0.46 0 1.91
52 INT314510 Protein_catabolism of TH 1 0.10 3.28 1.86
53 INT3505 Binding of TH 5 0.39 2.6 1.8
54 INT112339 Localization of Cyp11a1 2 0.71 0.94 1.68
55 INT145545 Transcription of TH 3 0.67 1.48 1.64
56 INT10596 Positive_regulation of Cyp19a1 10 0.42 2.08 1.62
57 INT127889 Regulation of Gene_expression of CYP19A1 11 0.62 6.7 1.41
58 INT10570 Positive_regulation of Cyp11a1 9 0.47 2.67 1.4
59 INT26760 Negative_regulation of Localization of Th 2 0.40 0.09 1.14
60 INT89670 Negative_regulation of Binding of Th 2 0.43 0.28 1.12
61 INT208792 Negative_regulation of Gene_expression of TH 6 0.35 1.11 0.94
62 INT10578 Transcription of Cyp11a1 3 0.53 0.84 0.93
63 INT208789 Negative_regulation of Localization of TH 2 0.25 0 0.89
64 INT53309 Regulation of Localization of Th 1 0.39 0 0.84
65 INT79344 Binding of Cyp19a1 4 0.33 0.61 0.8
66 INT161339 Localization of Cyp19a1 1 0.73 1.32 0.71
67 INT122934 Negative_regulation of Regulation of TH 1 0.03 0.56 0.63
68 INT171105 Positive_regulation of Positive_regulation of CYP19A1 5 0.39 4.02 0.58
69 INT13929 Protein_catabolism of Th 3 1.00 0 0.58
70 INT314505 Positive_regulation of Protein_catabolism of TH 1 0.05 1.07 0.56
71 INT353896 Negative_regulation of Phosphorylation of Cyp19a1 1 0.22 0.47 0.55
72 INT353893 Phosphorylation of Cyp19a1 1 0.31 0.46 0.55
73 INT314499 Negative_regulation of Protein_catabolism of TH 1 0.04 1.06 0.54
74 INT71046 Localization of CYP19A1 2 0.78 1.38 0.48
75 INT187717 Regulation of Negative_regulation of CYP19A1 11 0.42 2.85 0.45
76 INT127890 Positive_regulation of Negative_regulation of CYP19A1 6 0.50 1.41 0.45
77 INT68725 Regulation of Cyp11a1 6 0.19 2.62 0.44
78 INT111304 Regulation of Gene_expression of TH 2 0.17 0.57 0.44
79 INT121113 Protein_catabolism of Cyp11a1 2 0.65 0.37 0.44
80 INT84915 Negative_regulation of Gene_expression of Cyp19a1 2 0.15 1.29 0.42
81 INT314511 Positive_regulation of Binding of TH 1 0.04 0.68 0.38
82 INT181122 Positive_regulation of Gene_expression of Cyp19a1 1 0.02 0.68 0.36
83 INT209323 Positive_regulation of Transcription of CYP19A1 5 0.32 4.22 0.33
84 INT40588 Regulation of Negative_regulation of Th 1 0.16 0.26 0.26
85 INT117760 Regulation of Gene_expression of Cyp11a1 2 0.42 0.36 0.25
86 INT343976 Negative_regulation of Negative_regulation of TH 1 0.23 0.19 0.23
87 INT237448 Negative_regulation of Binding of TH 1 0.30 0.29 0.22
88 INT175360 Regulation of Transcription of CYP19A1 1 0.04 1 0.19
89 INT140716 Negative_regulation of Protein_catabolism of Th 1 0.59 0 0.19
90 INT140717 Positive_regulation of Protein_catabolism of Th 1 0.47 0 0.19
91 INT187614 Phosphorylation of Cyp17a1 1 0.25 0.06 0.17
92 INT187609 Negative_regulation of Phosphorylation of Cyp17a1 1 0.13 0.06 0.17
93 INT10575 Positive_regulation of Transcription of Cyp11a1 1 0.05 0 0.17
94 INT187610 Positive_regulation of Cyp17a1 1 0.14 0.06 0.17
95 INT10572 Positive_regulation of Positive_regulation of Cyp11a1 1 0.05 0 0.16
96 INT314508 Regulation of Positive_regulation of TH 1 0.04 0.92 0.08
97 INT187718 Negative_regulation of Positive_regulation of CYP19A1 1 0.33 0.61 0.05
98 INT140315 Regulation of Positive_regulation of Cyp11a1 1 0.19 0.07 0.05
99 INT176561 Gene_expression of Cyp17a1 3 0.25 1.38 0.04
100 INT187720 Negative_regulation of Negative_regulation of CYP19A1 5 0.34 0.99 0
101 INT187725 Positive_regulation of Localization of CYP19A1 1 0.39 0.23 0
102 INT213932 Negative_regulation of Negative_regulation of Cyp19a1 1 0.31 0.7 0
103 INT194353 Negative_regulation of Binding of Cyp19a1 1 0.15 0 0
104 INT145141 Negative_regulation of Transcription of CYP19A1 1 0.59 0.3 0
105 INT187719 Negative_regulation of Localization of CYP19A1 1 0.33 0.78 0
106 INT222306 Negative_regulation of Binding of CYP19A1 1 0.20 1.04 0
107 INT259446 Positive_regulation of Gene_expression of Cyp11a1 1 0.28 0 0
108 INT176563 Binding of Cyp17a1 1 0.13 0.32 0
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