GO:0019001

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Name guanyl nucleotide binding
Categary Function
Go Slim No
Go Link GO:0019001
Unique Molecular Interactions 114
Total Molecular Interactions 191
Total Single Events 842
Pain Genes Associated 16

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for guanyl nucleotide binding. They are ordered first by their pain relevance and then by number of times they were reported for guanyl nucleotide binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT269444 Binding of RAB5A and HHIP 1 0.04 0 5.79
2 INT264929 Binding of Cnr1 and Gnaz 1 0.18 1.71 2.89
3 INT115985 Cpe Positive_regulation of Binding of Gnas 1 0.00 0.17 1.28
4 INT124874 Gnat3 Positive_regulation of Localization of Calca 2 0.08 0.75 1.2
5 INT264930 Gnaz Positive_regulation of Negative_regulation of Cnr1 1 0.20 0 1.14
6 INT130627 Gnas Regulation of Prkaca 1 0.00 0 1.13
7 INT264931 Binding of Gnaz and Hrh1 1 0.01 0.83 1.12
8 INT269443 Positive_regulation of Binding of RAB5A and HHIP 1 0.04 0 1.06
9 INT118859 GNA14 Positive_regulation of STAT3 1 0.01 0.38 1.03
10 INT264926 Binding of Gnaz and Pag1 1 0.08 0.19 0.94
11 INT54200 Gnai1 Negative_regulation of Pag1 1 0.05 0.18 0.9
12 INT54197 Binding of Gnai1 and Pag1 1 0.04 0.18 0.9
13 INT301079 Binding of GNAT1 and INPP5E 1 0.00 0.59 0.89
14 INT124878 Gnat3 Negative_regulation of Gene_expression of FOS 1 0.09 0.16 0.85
15 INT269455 Binding of RAB5A and GOPC 1 0.08 0 0.82
16 INT124877 Gnat3 Negative_regulation of FOS 1 0.09 0.15 0.82
17 INT124876 Gnat3 Negative_regulation of Positive_regulation of FOS 1 0.09 0.15 0.82
18 INT128180 Gna12 Regulation of Regulation of RHOA 1 0.00 0 0.78
19 INT81976 Binding of GNA15 and OPRL1 1 0.02 0 0.77
20 INT118854 GNA14 Positive_regulation of Positive_regulation of STAT3 1 0.02 0.31 0.76
21 INT148909 Binding of GNA13 and TP53INP2 1 0.06 0.31 0.73
22 INT262574 Gnaq Positive_regulation of Prkca 1 0.00 0.57 0.71
23 INT123869 Binding of GNAS and OPRK1 1 0.00 0.37 0.7
24 INT264927 Cnr1 Regulation of Gnaz 1 0.23 0.05 0.66
25 INT334594 Binding of GNAI1 and MRGPRD 1 0.01 0.19 0.63
26 INT59635 Binding of Adarb1 and Gnaz 1 0.01 0 0.55
27 INT164971 Binding of Rgs7 and Gnai2 1 0.01 0 0.54
28 INT269449 Positive_regulation of Binding of RAB5A and GOPC 1 0.11 0 0.53
29 INT164970 Binding of Rgs8 and Gnai2 1 0.01 0 0.53
30 INT72016 Positive_regulation of Binding of Gnai2 and Ptprg 1 0.02 0 0.44
31 INT251430 Gnat3 Positive_regulation of Gucy1b2 1 0.04 0.48 0.42
32 INT269448 HHIP Positive_regulation of Binding of RAB5A 1 0.04 0 0.42
33 INT80233 Positive_regulation of OPRM1 Positive_regulation of GNAI1 1 0.23 0 0.41
34 INT72018 Binding of Gnai2 and Ptprg 1 0.01 0 0.41
35 INT80232 OPRM1 Positive_regulation of GNAI1 1 0.23 0 0.41
36 INT269456 RAB5A Regulation of Binding of HHIP 1 0.04 0 0.38
37 INT173356 Gnaq Positive_regulation of CDK20 1 0.06 0 0.37
38 INT251426 Gnat3 Negative_regulation of Aldh2 1 0.22 0 0.35
39 INT141438 Gnai2 Positive_regulation of Localization of ADCY1 1 0.01 0.43 0.29
40 INT251420 Aldh3a1 Regulation of Gene_expression of Gnat3 1 0.09 0.08 0.28
41 INT118852 Positive_regulation of GNA14 Positive_regulation of CAMK2G 1 0.01 0.09 0.27
42 INT118855 Binding of SRC and GNA14 1 0.01 0.13 0.27
43 INT118846 GNA14 Positive_regulation of CAMK2G 1 0.01 0.09 0.27
44 INT118848 GNA14 Positive_regulation of RAC1 1 0.01 0.14 0.26
45 INT118856 Positive_regulation of GNA14 Positive_regulation of STAT3 1 0.01 0.14 0.26
46 INT118849 GNA14 Positive_regulation of MAPK1 1 0.00 0.14 0.26
47 INT118851 GNA14 Positive_regulation of RAF1 1 0.00 0.14 0.26
48 INT118850 GNA14 Positive_regulation of Phosphorylation of SRC 1 0.02 0.15 0.23
49 INT173358 Gnaq Positive_regulation of SMPD1 1 0.01 0.13 0.23
50 INT173357 Gnaq Positive_regulation of PRKCA 1 0.01 0 0.22
51 INT72015 Binding of Adora2a and Gnai2 1 0.01 0 0.21
52 INT72019 Binding of Gnaq and Ptprg 1 0.01 0 0.21
53 INT199192 Gnat3 Positive_regulation of Hmox1 1 0.27 0.23 0.19
54 INT291788 ALDOA Positive_regulation of Gnat3 2 0.02 0.52 0.18
55 INT148563 Ngf Positive_regulation of GNAS 1 0.06 0.07 0.16
56 INT269450 Binding of RAB5A and ISM2 1 0.00 0 0.16
57 INT251435 Gnat3 Positive_regulation of NPR1 1 0.22 0.2 0.15
58 INT269451 Negative_regulation of Binding of RAB5A and HHIP 1 0.03 0 0.15
59 INT251424 Positive_regulation of Gnat3 Positive_regulation of Gucy1b2 1 0.02 0.2 0.15
60 INT269452 RAB5A Regulation of Localization of HHIP 1 0.04 0 0.15
61 INT199195 Gnat3 Regulation of Transcription of Hmox1 1 0.24 0.12 0.14
62 INT251431 Negative_regulation of Gnat3 Positive_regulation of Gucy1b2 1 0.02 0.1 0.14
63 INT269445 Localization of HHIP Regulation of Gene_expression of RAB5A 1 0.03 0 0.13
64 INT269457 RAB5A Regulation of Regulation of HHIP 1 0.02 0 0.13
65 INT347065 Binding of Gnat2 and Rho 1 0.14 0 0.12
66 INT269491 Racgap1 Negative_regulation of RAB5A 1 0.01 0 0.12
67 INT255811 Binding of GNAS and MAPT 1 0.00 0.67 0.11
68 INT327188 Gnat3 Regulation of PAEP 1 0.25 1.38 0.11
69 INT269458 HHIP Regulation of Gene_expression of RAB5A 1 0.04 0 0.1
70 INT17394 Adra2a Positive_regulation of GNAI1 1 0.02 0.37 0.1
71 INT113362 Gnat3 Positive_regulation of Serpina3c 1 0.17 0.25 0.09
72 INT255289 Snap25 Regulation of Gene_expression of Gnas 1 0.00 0 0.09
73 INT269460 ISM2 Positive_regulation of Binding of RAB5A 1 0.00 0 0.09
74 INT199193 Gnat3 Positive_regulation of Gene_expression of Ros1 1 0.08 0.18 0.08
75 INT284303 Mir155 Negative_regulation of Gnas 1 0.00 0.49 0.08
76 INT327189 Gnat3 Regulation of Positive_regulation of PAEP 1 0.25 0.72 0.07
77 INT227593 Gnaq Negative_regulation of GLUL 1 0.01 0 0.06
78 INT227562 GNAI1 Negative_regulation of GLUL 1 0.01 0 0.06
79 INT251427 Gnat3 Positive_regulation of Aldh2 1 0.26 0 0.05
80 INT291782 Binding of ALDH2 and Gnat3 1 0.12 0 0.04
81 INT251425 Aldh2 Negative_regulation of Negative_regulation of Gnat3 1 0.19 0 0.04
82 INT291781 Regulation of Binding of ALDH2 and Gnat3 1 0.11 0 0.04
83 INT291792 Regulation of Binding of ALDOA and Gnat3 1 0.02 0 0.04
84 INT291789 Binding of ALDOA and Gnat3 1 0.01 0 0.04
85 INT199196 Gnat3 Positive_regulation of Aldh2 2 0.26 1.06 0.03
86 INT269453 HHIP Positive_regulation of RAB5A 1 0.04 0 0.03
87 INT291786 GOPC Negative_regulation of Gene_expression of Gnat3 1 0.01 0 0.03
88 INT251419 Positive_regulation of Aldh2 Positive_regulation of Gnat3 1 0.20 0 0
89 INT291783 ALDOA Regulation of Gnat3 1 0.01 0 0
90 INT249538 Binding of BDNF and GNAS 1 0.08 0 0
91 INT284304 Binding of Adrb3 and Gnas 1 0.00 0.23 0
92 INT291787 Gnat3 Negative_regulation of ALDH2 1 0.11 0 0
93 INT251423 Gnat3 Regulation of Binding of Aldh3a1 1 0.09 0 0
94 INT179302 Gene_expression of GNAS Negative_regulation of CA2 1 0.01 0 0
95 INT330428 Gnat3 Negative_regulation of Aldh2 1 0.11 0.44 0
96 INT284302 Mir155 Regulation of Gnas 1 0.00 0.64 0
97 INT251418 Gnat3 Regulation of Aldh2 1 0.12 0 0
98 INT251429 Aldh2 Positive_regulation of Gnat3 1 0.20 0 0
99 INT272011 Binding of RAB5A and Tsc2 1 0.02 0.16 0
100 INT336989 Binding of GNAI1 and CALCRL 1 0.00 0 0
101 INT291791 ALDH2 Negative_regulation of Gnat3 1 0.15 0.06 0
102 INT159977 Binding of Mgst1 and Gnat3 1 0.03 0 0
103 INT231169 Gnas Positive_regulation of Gene_expression of Dmd 1 0.00 0.19 0
104 INT283201 Gm4658 Regulation of Gnas 1 0.00 0.56 0
105 INT65902 GSTK1 Regulation of Positive_regulation of Gnat3 1 0.02 0 0
106 INT251421 Binding of Gnat3 and Positive_regulation of Gene_expression of Aldh2 1 0.20 0 0
107 INT291784 Binding of SERPINE2 and Gnat3 1 0.00 0.3 0
108 INT251428 Aldh2 Negative_regulation of Gnat3 1 0.19 0 0
109 INT257984 GNAI1 Negative_regulation of RTCA 1 0.00 0.32 0
110 INT251422 Binding of Aldh2 and Gnat3 1 0.19 0 0
111 INT325836 Binding of Dnm2 and Gnas 1 0.00 0.22 0
112 INT325839 Binding of Dnm1 and Gnas 1 0.00 0.11 0
113 INT291785 ALDH2 Regulation of Localization of Gnat3 1 0.11 0 0
114 INT291790 Negative_regulation of Binding of ALDH2 and Gnat3 1 0.11 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for guanyl nucleotide binding. They are ordered first by their pain relevance and then by number of times they were reported in guanyl nucleotide binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT62919 Regulation of Gnas 22 0.43 5.61 9.55
2 INT264910 Positive_regulation of Gnaz 1 0.30 0 7.82
3 INT234813 Gene_expression of RAB5A 58 0.66 3.67 6.48
4 INT11258 Gene_expression of Gnas 58 0.58 21.6 6.33
5 INT67635 Negative_regulation of Gnas 29 0.04 11.4 6.32
6 INT20899 Negative_regulation of GNAI1 12 0.57 4.24 6.07
7 INT34742 Gene_expression of Gnat3 44 0.67 6.83 5.65
8 INT72000 Gene_expression of Gnaq 17 0.75 3.12 5.48
9 INT62920 Regulation of Gnai1 3 0.52 0.08 4.78
10 INT255981 Localization of RAB5A 3 0.68 0.88 4.76
11 INT269476 Binding of RAB5A 1 0.41 0 4.76
12 INT17391 Gene_expression of GNAI1 11 0.75 5.26 4.7
13 INT17393 Positive_regulation of GNAI1 17 0.49 2.42 4.66
14 INT98357 Binding of Gnas 11 0.41 1.87 4.35
15 INT34829 Positive_regulation of Gnat3 27 0.46 5.24 4.14
16 INT32933 Gene_expression of GNAS 57 0.32 10.58 4.03
17 INT25136 Localization of Gnat3 23 0.75 5.01 3.65
18 INT301081 Positive_regulation of GNAT1 1 0.12 4.16 3
19 INT234825 Positive_regulation of Gene_expression of RAB5A 16 0.59 1.15 2.71
20 INT11196 Negative_regulation of Gnat3 26 0.37 3.14 2.69
21 INT264915 Positive_regulation of Localization of Gnaz 1 0.19 0 2.68
22 INT72013 Negative_regulation of Gnai2 5 0.35 0.09 2.44
23 INT179311 Transcription of GNAS 2 0.10 0.67 2.08
24 INT108903 Negative_regulation of GNAS 7 0.57 1.58 2.04
25 INT17390 Regulation of GNAI1 5 0.04 3.58 2.03
26 INT65993 Localization of Gnai1 1 0.46 0.08 2
27 INT112880 Positive_regulation of Gnaq 17 0.49 1.97 1.95
28 INT25871 Negative_regulation of Gnaz 3 0.23 0 1.89
29 INT301080 Binding of GNAT1 1 0.10 2.04 1.85
30 INT17387 Gene_expression of Gnaz 3 0.50 0.4 1.81
31 INT128168 Positive_regulation of Gna12 1 0.01 0 1.76
32 INT25192 Positive_regulation of Gene_expression of GNAI1 5 0.49 1.08 1.7
33 INT234827 Positive_regulation of RAB5A 3 0.59 0.54 1.69
34 INT110189 Regulation of Gnaq 3 0.02 0.26 1.63
35 INT71999 Negative_regulation of Gene_expression of Gnaq 3 0.41 0.08 1.56
36 INT128170 Gene_expression of Gna12 1 0.01 0 1.54
37 INT9953 Positive_regulation of Gnas 10 0.34 3.21 1.51
38 INT72008 Gene_expression of Gnai2 4 0.38 0.42 1.49
39 INT121347 Binding of GNAS 8 0.13 3.99 1.47
40 INT54190 Binding of Gnai1 2 0.34 0.28 1.47
41 INT94639 Negative_regulation of Gene_expression of Gnai1 1 0.02 0.08 1.46
42 INT162308 Phosphorylation of GNAS 3 0.01 1.71 1.4
43 INT264906 Localization of Gnaz 1 0.28 0 1.33
44 INT148562 Positive_regulation of GNAS 13 0.16 5.31 1.32
45 INT264899 Positive_regulation of Positive_regulation of Gnaz 1 0.19 0 1.32
46 INT94640 Gene_expression of Gnai1 1 0.04 0.08 1.29
47 INT25806 Binding of GNAI1 5 0.47 0.15 1.24
48 INT110188 Regulation of Gene_expression of Gnaq 2 0.25 0.85 1.22
49 INT77356 Positive_regulation of Gnai1 2 0.63 0.09 1.13
50 INT72002 Negative_regulation of Gnaq 7 0.35 0.2 1.02
51 INT79081 Negative_regulation of Gene_expression of Gnaz 1 0.03 0 0.98
52 INT77354 Negative_regulation of Gnai1 1 0.34 0 0.96
53 INT119214 Transcription of Gnai2 1 0.44 0.06 0.96
54 INT6708 Phosphorylation of GNAI1 2 0.25 0.36 0.93
55 INT269471 Positive_regulation of Binding of RAB5A 1 0.43 0 0.92
56 INT119213 Positive_regulation of Gnai2 1 0.42 0.06 0.88
57 INT96967 Positive_regulation of Positive_regulation of GNAI1 2 0.49 0.16 0.87
58 INT269481 Positive_regulation of Localization of RAB5A 1 0.43 0 0.86
59 INT128171 Positive_regulation of Gene_expression of Gna12 1 0.01 0 0.85
60 INT77353 Transcription of Gnai1 1 0.65 0 0.84
61 INT77355 Regulation of Transcription of Gnai1 1 0.41 0 0.84
62 INT110187 Regulation of Regulation of Gnaq 1 0.00 0.07 0.82
63 INT264911 Regulation of Gnaz 1 0.10 0 0.81
64 INT98869 Gene_expression of GNAT1 1 0.13 0.13 0.81
65 INT141915 Positive_regulation of Gene_expression of Gnaq 3 0.19 1.31 0.76
66 INT215783 Localization of Gnas 1 0.12 1.64 0.76
67 INT269483 Regulation of Gene_expression of RAB5A 1 0.38 0.14 0.76
68 INT128169 Regulation of Gene_expression of Gna12 1 0.01 0 0.7
69 INT148911 Positive_regulation of Positive_regulation of GNA13 1 0.08 0.28 0.68
70 INT148912 Positive_regulation of GNA13 1 0.12 0.28 0.68
71 INT96968 Regulation of Positive_regulation of GNAI1 1 0.07 0.17 0.66
72 INT249551 Negative_regulation of Transcription of GNAS 1 0.06 0.16 0.6
73 INT102009 Negative_regulation of Binding of Gnai1 1 0.39 0.1 0.59
74 INT269474 Negative_regulation of RAB5A 1 0.50 0 0.55
75 INT112881 Positive_regulation of Positive_regulation of Gnaq 2 0.49 0.86 0.54
76 INT141919 Positive_regulation of Transcription of Gnaq 1 0.21 1.05 0.49
77 INT141912 Negative_regulation of Transcription of Gnaq 1 0.18 1.07 0.49
78 INT141917 Transcription of Gnaq 1 0.29 1.05 0.49
79 INT81357 Regulation of Negative_regulation of Gnas 1 0.02 0.1 0.47
80 INT146402 Regulation of Gnat3 6 0.31 1.52 0.44
81 INT269462 Negative_regulation of Gene_expression of RAB5A 1 0.50 0 0.43
82 INT72014 Negative_regulation of Gene_expression of Gnai2 1 0.24 0 0.4
83 INT58439 Negative_regulation of Gene_expression of Gnat3 4 0.42 0.88 0.39
84 INT167238 Phosphorylation of RAB5A 1 0.80 0 0.38
85 INT77274 Protein_catabolism of Gnat3 1 0.83 0 0.34
86 INT278102 Binding of GNA15 1 0.01 0.16 0.32
87 INT137334 Binding of Gnat3 8 0.41 0.61 0.28
88 INT118873 Binding of GNA14 1 0.01 0.13 0.27
89 INT251390 Regulation of Gene_expression of Gnat3 2 0.28 0.52 0.26
90 INT149315 Binding of Gnaq 2 0.04 0 0.26
91 INT118875 Gene_expression of GNA14 1 0.02 0.09 0.26
92 INT113951 Positive_regulation of Gene_expression of Gnat3 2 0.13 0.26 0.25
93 INT124366 Gene_expression of GNA15 1 0.11 0 0.25
94 INT227591 Localization of GNAI1 1 0.05 0.11 0.24
95 INT108902 Localization of GNAS 5 0.13 1.31 0.23
96 INT118869 Phosphorylation of GNA14 1 0.02 0.15 0.23
97 INT208539 Positive_regulation of Gene_expression of Gnas 4 0.08 2.76 0.18
98 INT269478 Regulation of Binding of RAB5A 1 0.23 0 0.18
99 INT234810 Regulation of RAB5A 3 0.38 1.64 0.16
100 INT269473 Regulation of Localization of RAB5A 1 0.23 0 0.15
101 INT347057 Gene_expression of Gnat2 1 0.58 0.05 0.14
102 INT25137 Positive_regulation of Localization of Gnat3 1 0.40 0.21 0.14
103 INT11197 Positive_regulation of Negative_regulation of Gnat3 1 0.06 0.2 0.14
104 INT118872 Positive_regulation of GNA14 1 0.02 0.1 0.14
105 INT272710 Phosphorylation of Gnaq 1 0.09 0.12 0.12
106 INT269467 Negative_regulation of Localization of RAB5A 1 0.36 0 0.1
107 INT17388 Regulation of Gene_expression of Gnaz 1 0.29 0.4 0.09
108 INT199180 Transcription of Gnat3 1 0.47 0 0.09
109 INT173351 Binding of GNA13 1 0.08 0.05 0.08
110 INT107569 Transcription of Gnas 1 0.01 0 0.08
111 INT17392 Regulation of Gene_expression of GNAI1 1 0.02 0.5 0.07
112 INT35285 Regulation of Gnaz 1 0.06 0.09 0.07
113 INT179307 Regulation of GNAS 7 0.01 1.93 0.05
114 INT347059 Regulation of Gnat2 1 0.26 0 0.05
115 INT277277 Regulation of Gene_expression of Gnas 2 0.00 0.33 0.04
116 INT181632 Regulation of Binding of Gnat3 1 0.06 0.27 0.04
117 INT227570 Localization of Gnaq 1 0.07 0 0.04
118 INT227569 Negative_regulation of Positive_regulation of Gnaq 1 0.04 0.08 0.04
119 INT269479 Positive_regulation of Positive_regulation of RAB5A 1 0.43 0 0.03
120 INT177312 Negative_regulation of Gene_expression of GNAS 2 0.05 0.46 0
121 INT255830 Positive_regulation of Localization of GNAS 1 0.01 0.28 0
122 INT251391 Negative_regulation of Negative_regulation of Gnat3 1 0.18 0 0
123 INT202870 Negative_regulation of Negative_regulation of Gnas 1 0.01 0.53 0
124 INT179318 Regulation of Transcription of GNAS 1 0.01 0 0
125 INT291748 Negative_regulation of Positive_regulation of Gnat3 1 0.10 0 0
126 INT202861 Positive_regulation of Negative_regulation of Gnas 1 0.01 0.39 0
127 INT179310 Positive_regulation of Gene_expression of GNAS 1 0.01 0 0
128 INT351494 Positive_regulation of Protein_catabolism of GNAS 1 0.00 0.94 0
129 INT351518 Protein_catabolism of GNAS 1 0.01 1.29 0
130 INT255817 Positive_regulation of Positive_regulation of GNAS 1 0.01 0.85 0
131 INT249548 Negative_regulation of Positive_regulation of GNAS 1 0.06 0 0
132 INT291747 Regulation of Negative_regulation of Gnat3 1 0.12 0 0
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