GO:0019005

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Name SCF ubiquitin ligase complex
Categary Component
Go Slim No
Go Link GO:0019005
Unique Molecular Interactions 50
Total Molecular Interactions 64
Total Single Events 119
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for SCF ubiquitin ligase complex. They are ordered first by their pain relevance and then by number of times they were reported for SCF ubiquitin ligase complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT72229 Binding of NFKBIL1 and BTRC 1 0.00 0 0.73
2 INT240192 RBX1 Negative_regulation of BDNF 1 0.08 0.13 0.52
3 INT72230 Binding of BTRC and EMID1 1 0.00 0 0.49
4 INT72227 Binding of BTRC and AP1M2 1 0.00 0 0.49
5 INT240193 RBX1 Positive_regulation of Gene_expression of BDNF 1 0.10 0 0.43
6 INT20221 Binding of Grcc10 and Fbxo6 1 0.00 0 0.42
7 INT72231 Negative_regulation of Binding of NFKBIL1 and BTRC 1 0.00 0 0.24
8 INT224431 TNF Positive_regulation of Gene_expression of FBXO2 1 0.47 0.35 0.22
9 INT224452 Il1 Positive_regulation of Gene_expression of FBXO2 1 0.37 0.35 0.22
10 INT87037 Binding of FBXO6 and Col5a3 1 0.00 0.48 0.09
11 INT184134 Binding of Cish and Rbx1 1 0.10 0 0.03
12 INT219409 CCNF Regulation of E2F2 1 0.22 0.11 0
13 INT276382 Binding of CIB1 and Skp2 1 0.01 0.57 0
14 INT219405 CCNF Regulation of PCNA 1 0.20 0.11 0
15 INT219425 CCNA2 Regulation of SKP2 1 0.11 0.11 0
16 INT271982 Binding of Skp2 and Psmd9 1 0.01 0.68 0
17 INT219410 CCNF Regulation of HNF4A 1 0.01 0.11 0
18 INT219411 CCNF Regulation of SKP2 1 0.22 0.11 0
19 INT272000 Binding of Skp2 and Hecw1 1 0.01 0.11 0
20 INT276379 Binding of SKP2 and Cdkn1b 1 0.02 0.57 0
21 INT271979 Skp2 Positive_regulation of Protein_catabolism of Psmd9 1 0.01 0.35 0
22 INT219413 CDK2 Regulation of SKP2 1 0.23 0.11 0
23 INT263588 SPIC Positive_regulation of TRIM21 1 0.00 0.28 0
24 INT276336 Skp2 Regulation of Cdkn1b 1 0.00 0.57 0
25 INT271984 Binding of Tsc2 and Skp2 1 0.06 0.34 0
26 INT276374 Skp2 Regulation of Protein_catabolism of CIB1 1 0.00 0.58 0
27 INT276335 Binding of Cdkn1b and Skp2 1 0.00 0.57 0
28 INT276302 Binding of SKP2 and CIB1 1 0.03 0.57 0
29 INT276393 Skp2 Regulation of CIB1 1 0.00 0.57 0
30 INT271987 Tsc2 Regulation of Skp2 1 0.10 0.28 0
31 INT271986 Tsc1 Regulation of Skp2 1 0.13 0.14 0
32 INT219415 CCNE2 Regulation of SKP2 1 0.11 0.11 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for SCF ubiquitin ligase complex. They are ordered first by their pain relevance and then by number of times they were reported in SCF ubiquitin ligase complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT54749 Binding of BTRC 7 0.09 0.88 2.9
2 INT54750 Gene_expression of BTRC 4 0.14 0.99 1.55
3 INT224447 Gene_expression of FBXO2 7 0.75 7.33 1.31
4 INT50855 Gene_expression of TRIM21 4 0.65 3.07 0.71
5 INT106608 Regulation of Gene_expression of SKP2 1 0.50 0.26 0.63
6 INT106603 Gene_expression of SKP2 5 0.63 6.99 0.62
7 INT240206 Negative_regulation of RBX1 1 0.08 0.15 0.51
8 INT306885 Positive_regulation of SKP2 1 0.21 0.6 0.45
9 INT203568 Regulation of SKP2 3 0.26 1.61 0.38
10 INT224449 Positive_regulation of Gene_expression of FBXO2 3 0.49 1.72 0.24
11 INT72235 Negative_regulation of BTRC 3 0.02 0 0.24
12 INT341554 Gene_expression of CCNF 1 0.39 0.67 0.24
13 INT26381 Positive_regulation of Fbxo6 1 0.04 0 0.22
14 INT341545 Negative_regulation of Gene_expression of CCNF 1 0.22 0.62 0.21
15 INT224448 Positive_regulation of FBXO2 1 0.49 0.72 0.19
16 INT20209 Binding of Fbxo6 2 0.00 2.05 0.17
17 INT134909 Positive_regulation of TRIM21 1 0.67 0.95 0.16
18 INT87034 Positive_regulation of FBXO6 2 0.38 0.89 0.14
19 INT233867 Negative_regulation of SKP2 3 0.24 2.25 0.13
20 INT341552 Positive_regulation of Gene_expression of CCNF 1 0.25 0.25 0.11
21 INT233872 Negative_regulation of Negative_regulation of SKP2 2 0.24 0.94 0.08
22 INT341561 Regulation of Gene_expression of CCNF 1 0.23 0.19 0.07
23 INT167444 Localization of CCNF 1 0.73 0.28 0.07
24 INT203608 Negative_regulation of CCNF 2 0.35 0.44 0.03
25 INT249790 Protein_catabolism of Skp2 2 0.58 1.02 0.03
26 INT203609 Binding of CCNF 1 0.08 0.32 0.03
27 INT249798 Positive_regulation of Localization of Skp2 1 0.41 0.56 0.03
28 INT203613 Positive_regulation of Negative_regulation of CCNF 1 0.10 0.33 0.03
29 INT249791 Localization of Skp2 1 0.62 0.55 0.03
30 INT20206 Gene_expression of Fbxo6 2 0.01 0.08 0
31 INT25419 Regulation of FBXO6 2 0.04 1.16 0
32 INT295098 Localization of Fbxo6 1 0.01 0.05 0
33 INT303351 Binding of Rbx1 1 0.18 0 0
34 INT263602 Negative_regulation of TRIM21 1 0.01 0.28 0
35 INT244184 Binding of FBXO2 1 0.03 0 0
36 INT276328 Negative_regulation of Skp2 1 0.04 0.56 0
37 INT87036 Gene_expression of FBXO6 1 0.00 0.17 0
38 INT235469 Positive_regulation of Gene_expression of SKP2 1 0.26 1.24 0
39 INT271903 Positive_regulation of Protein_catabolism of Skp2 1 0.14 0.47 0
40 INT244181 Localization of FBXO2 1 0.05 0 0
41 INT271920 Negative_regulation of Protein_catabolism of Skp2 1 0.12 0.37 0
42 INT249786 Gene_expression of Skp2 1 0.59 0.13 0
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