GO:0019209

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Name kinase activator activity
Categary Function
Go Slim No
Go Link GO:0019209
Unique Molecular Interactions 115
Total Molecular Interactions 140
Total Single Events 1704
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for kinase activator activity. They are ordered first by their pain relevance and then by number of times they were reported for kinase activator activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT329956 Binding of IL2 and IL23R 1 0.33 4.58 1.21
2 INT88193 Binding of IL2 and IL4 1 0.13 1.7 1.2
3 INT21415 POMC Positive_regulation of Gene_expression of IL2 1 0.00 0.27 1
4 INT161306 POMC Negative_regulation of Transcription of IL2 1 0.24 0.27 0.85
5 INT161307 JUN Positive_regulation of IL2 1 0.14 0.25 0.84
6 INT161305 NFKB1 Positive_regulation of IL2 1 0.25 0.25 0.83
7 INT12883 Binding of IL2 and POMC 1 0.01 0 0.81
8 INT8411 IL2 Regulation of Gene_expression of Vip 1 0.00 0.27 0.8
9 INT266769 IL2 Positive_regulation of Localization of IL4 1 0.00 1.03 0.72
10 INT266765 IL2 Positive_regulation of Localization of IL10 1 0.01 1.03 0.72
11 INT27034 HERPUD1 Regulation of Gene_expression of IL2 1 0.38 0 0.71
12 INT13238 POMC Regulation of Gene_expression of IL2 1 0.09 0.26 0.59
13 INT74656 YY1 Positive_regulation of Localization of IL2 1 0.07 0.09 0.58
14 INT39210 TF Positive_regulation of Gene_expression of IL2 1 0.17 0.07 0.57
15 INT141362 EP300 Negative_regulation of Transcription of IL2 1 0.17 0 0.56
16 INT144598 Hrh2 Positive_regulation of IL2 1 0.01 0.08 0.56
17 INT95206 Binding of CSF2 and IL2 1 0.40 1.81 0.4
18 INT292891 IL2 Regulation of IL5 1 0.02 0.25 0.39
19 INT292889 IL2 Regulation of IL12A 1 0.01 0.25 0.39
20 INT292886 IL2 Regulation of IL8 1 0.03 0.25 0.39
21 INT172148 Binding of IL2 and TNF 2 0.05 0.67 0.37
22 INT172135 Binding of IL2 and IL6 1 0.01 0.57 0.37
23 INT27036 HERPUD1 Positive_regulation of Gene_expression of IL2 1 0.31 0 0.37
24 INT68119 Binding of IL2 and Oprd1 1 0.02 0 0.37
25 INT27032 ASNA1 Regulation of Gene_expression of IL2 1 0.03 0 0.36
26 INT320699 Gene_expression of Ptger2 Negative_regulation of Gene_expression of IL2 1 0.00 1.1 0.35
27 INT267589 IL2 Positive_regulation of Gene_expression of IL12A 1 0.01 0.69 0.34
28 INT39208 ALOX5 Regulation of Gene_expression of IL2 1 0.04 0.06 0.34
29 INT285565 Positive_regulation of Zeb1 Negative_regulation of IL2 1 0.02 0.62 0.33
30 INT285566 F8 Negative_regulation of IL2 1 0.00 0.62 0.33
31 INT285563 Zeb1 Negative_regulation of IL2 1 0.01 0.62 0.33
32 INT303993 Lep Positive_regulation of Gene_expression of IL2 1 0.15 0.24 0.33
33 INT34727 TNF Positive_regulation of Gene_expression of IL2 1 0.56 0.81 0.31
34 INT94076 ARSA Negative_regulation of Gene_expression of IL2 1 0.13 0.09 0.3
35 INT94072 ARSA Regulation of Gene_expression of IL2 1 0.07 0.09 0.29
36 INT62753 IL2 Regulation of POMC 1 0.27 0 0.28
37 INT19513 Prl Positive_regulation of IL2 1 0.41 0.8 0.27
38 INT68118 Binding of IL2 and OPRD1 1 0.35 0 0.26
39 INT189145 MTNR1B Positive_regulation of Gene_expression of IL2 1 0.02 0.3 0.26
40 INT351007 Binding of IL2 and IL2RA 1 0.33 1.33 0.26
41 INT307011 MT1JP Regulation of IL2 1 0.01 0 0.24
42 INT63196 INS Positive_regulation of IL2 1 0.10 0.3 0.23
43 INT63197 POMC Positive_regulation of IL2 1 0.16 0.3 0.23
44 INT164517 CABIN1 Positive_regulation of Transcription of IL2 1 0.13 0.35 0.22
45 INT63200 PTH Positive_regulation of IL2 1 0.24 0.29 0.22
46 INT318303 Negative_regulation of Myoz1 Negative_regulation of Transcription of IL2 1 0.00 0.75 0.21
47 INT141043 ZNF404 Negative_regulation of Transcription of IL2 1 0.01 0 0.21
48 INT299787 Binding of IL2 and ISG20 1 0.04 0.82 0.21
49 INT39209 TMSB4XP5 Positive_regulation of Gene_expression of IL2 1 0.07 0 0.21
50 INT34903 CALM1 Negative_regulation of Gene_expression of IL2 1 0.18 0 0.2
51 INT226528 BTPs Negative_regulation of Gene_expression of IL2 1 0.04 0.22 0.19
52 INT292625 IL2 Positive_regulation of Gene_expression of IL9 1 0.11 0.29 0.19
53 INT353037 IL4 Positive_regulation of IL2 1 0.02 0.99 0.16
54 INT303980 Lep Positive_regulation of Transcription of IL2 1 0.10 0.24 0.16
55 INT353038 IL4 Positive_regulation of Localization of IL2 1 0.02 0.99 0.16
56 INT49608 IL2 Positive_regulation of Alpk1 1 0.01 1.47 0.14
57 INT289958 Binding of IL2 and IL2RB 1 0.02 0.59 0.12
58 INT39207 LBR Positive_regulation of Gene_expression of IL2 1 0.23 0 0.11
59 INT352030 Binding of NR3C1 and IL2 1 0.15 0.5 0.11
60 INT286969 IL2 Regulation of Gene_expression of FOXP3 1 0.04 1.05 0.1
61 INT333095 Localization of IL2 Negative_regulation of Negative_regulation of CD8A 1 0.10 0.8 0.09
62 INT194730 Negative_regulation of MAPK1 Negative_regulation of Gene_expression of IL2 1 0.06 0 0.09
63 INT33809 IL2 Regulation of Regulation of LIPE 1 0.23 0.09 0.09
64 INT333099 Localization of IL2 Negative_regulation of Negative_regulation of CD4 1 0.14 0.8 0.09
65 INT33806 IL2 Regulation of ADRB3 1 0.28 0.08 0.09
66 INT159852 Gene_expression of IL2 Regulation of Gene_expression of ACTN1 1 0.03 0.16 0.07
67 INT278059 XRCC1 Positive_regulation of Gene_expression of IL2 1 0.01 1.06 0.07
68 INT159854 Gene_expression of IL2 Regulation of Gene_expression of CDC42EP5 1 0.01 0.16 0.07
69 INT33807 IL2 Negative_regulation of Negative_regulation of LIPE 1 0.16 0.06 0.07
70 INT333092 Binding of CD4 and IL2 1 0.01 0.17 0.07
71 INT159853 Gene_expression of IL2 Regulation of Gene_expression of RHO 1 0.17 0.16 0.07
72 INT333098 Binding of CD8A and IL2 1 0.01 0.17 0.07
73 INT159851 Positive_regulation of RHOA Positive_regulation of Gene_expression of IL2 1 0.15 0.15 0.06
74 INT286966 IL2 Positive_regulation of Binding of STAT3 1 0.04 0.5 0.06
75 INT194678 IL2 Positive_regulation of Positive_regulation of MAPK1 1 0.05 0 0.06
76 INT194664 Negative_regulation of MAPK1 Negative_regulation of IL2 1 0.06 0 0.05
77 INT60089 IL2 Regulation of IFNA2 1 0.25 0.09 0.05
78 INT351010 ISG20 Positive_regulation of Transcription of IL2 1 0.31 0.46 0.05
79 INT336388 Binding of IL2 and ALPK1 1 0.06 0.73 0.05
80 INT351009 IL2RG Positive_regulation of Transcription of IL2 1 0.27 0.44 0.05
81 INT351008 IL2RB Positive_regulation of Gene_expression of IL2 1 0.18 0.42 0.05
82 INT268674 IL2 Positive_regulation of XRCC1 1 0.08 0.75 0.05
83 INT194694 MAPK1 Negative_regulation of Gene_expression of IL2 1 0.04 0 0.04
84 INT331172 Binding of IFNA1 and IL2 1 0.00 0.46 0.04
85 INT35172 IL2 Positive_regulation of Gene_expression of IFNG 1 0.01 0.27 0.04
86 INT176326 IL2 Positive_regulation of Gene_expression of MUC1 1 0.08 0.71 0.04
87 INT286962 IL2 Regulation of Gene_expression of CD4 1 0.01 0.45 0.04
88 INT270206 Hdl1 Positive_regulation of Gene_expression of IL2 1 0.01 0.35 0.03
89 INT60088 IFNA2 Positive_regulation of IL2 1 0.12 0.07 0.03
90 INT211191 CD28 Positive_regulation of Gene_expression of IL2 1 0.15 0.15 0.03
91 INT199665 Binding of Fxn and Lamtor3 1 0.00 0.16 0.03
92 INT235493 SFTPA1 Positive_regulation of Gene_expression of IL2 1 0.04 0 0.03
93 INT104864 IL2 Positive_regulation of NXT1 1 0.08 0 0
94 INT130222 IL2 Positive_regulation of Il2rb 1 0.00 0 0
95 INT181169 TAPBP Negative_regulation of MALT1 1 0.00 0.48 0
96 INT210707 Binding of IFNA2 and IL2 1 0.06 0.91 0
97 INT340515 HIVEP1 Regulation of IL2 1 0.01 0.32 0
98 INT235491 SFTPA1 Regulation of Gene_expression of IL2 1 0.02 0.23 0
99 INT294521 Binding of IL2 and p53 1 0.40 0.1 0
100 INT111768 IL2 Positive_regulation of Localization of CRH 1 0.02 0 0
101 INT235492 SFTPA1 Positive_regulation of Localization of IL2 1 0.04 0 0
102 INT202599 Binding of IL2 and PTPN5 1 0.03 0.12 0
103 INT272775 IL2 Positive_regulation of Gene_expression of IGHG3 1 0.01 0.16 0
104 INT321788 IL2 Negative_regulation of Localization of IFN1@ 1 0.23 0.09 0
105 INT202600 IL2 Regulation of HIVEP1 1 0.01 0.5 0
106 INT270145 TNF Positive_regulation of IL2 1 0.01 0.53 0
107 INT181216 IL2 Positive_regulation of Gpi1 1 0.00 0.15 0
108 INT340516 CD4 Regulation of IL2 1 0.04 0.32 0
109 INT293362 CSH1 Negative_regulation of Gene_expression of IL2 1 0.01 0.12 0
110 INT235495 PLAT Positive_regulation of Gene_expression of IL2 1 0.05 0 0
111 INT104865 IL2 Positive_regulation of TH1L 1 0.38 0 0
112 INT104863 IL2 Positive_regulation of ZAK 1 0.19 0 0
113 INT294522 Binding of IL2 and MDM2 1 0.40 0.2 0
114 INT294525 Binding of IL2 and PDB1 1 0.40 0.1 0
115 INT283461 Binding of IL2 and SLC4A2 1 0.01 0.98 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for kinase activator activity. They are ordered first by their pain relevance and then by number of times they were reported in kinase activator activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69
2 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67
3 INT10763 Localization of IL2 157 0.80 81.11 33.21
4 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7
5 INT9993 Positive_regulation of Gene_expression of IL2 131 0.69 46.27 30.04
6 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96
7 INT15796 Regulation of IL2 66 0.61 25.43 20.62
8 INT10000 Regulation of Gene_expression of IL2 56 0.45 15.33 16.2
9 INT51014 Transcription of IL2 42 0.71 21.56 12.7
10 INT22383 Binding of IL2 59 0.48 39.06 8.56
11 INT58459 Negative_regulation of Localization of IL2 13 0.41 6.46 4.88
12 INT29138 Positive_regulation of Localization of IL2 25 0.50 10.06 3.89
13 INT22831 Negative_regulation of Positive_regulation of IL2 7 0.55 1.7 2.62
14 INT141367 Negative_regulation of Transcription of IL2 9 0.32 2.07 2.43
15 INT20289 Regulation of Localization of IL2 7 0.26 1.23 2.24
16 INT199591 Protein_catabolism of IL2 2 0.05 1.2 1.81
17 INT97108 Phosphorylation of IL2 5 0.73 2.47 1.7
18 INT88746 Positive_regulation of Transcription of IL2 7 0.51 2.14 1.6
19 INT152190 Positive_regulation of Phosphorylation of IL2 1 0.23 0.2 1.41
20 INT87029 Positive_regulation of Positive_regulation of IL2 8 0.50 8.17 1.36
21 INT97261 Negative_regulation of Regulation of IL2 2 0.26 1.04 1.17
22 INT112004 Positive_regulation of Negative_regulation of IL2 3 0.50 1.56 1.08
23 INT22830 Negative_regulation of Binding of IL2 4 0.55 4.8 1.06
24 INT19279 Negative_regulation of Negative_regulation of IL2 3 0.43 1.62 0.79
25 INT61623 Regulation of Positive_regulation of IL2 1 0.21 0.33 0.65
26 INT44600 Gene_expression of MALT1 6 0.75 6.14 0.42
27 INT298430 Positive_regulation of Protein_catabolism of IL2 1 0.03 0.85 0.26
28 INT293350 Regulation of Binding of IL2 2 0.22 0.87 0.23
29 INT203894 Localization of Lamtor3 1 0.10 0.65 0.19
30 INT276401 Localization of MALT1 1 0.60 3.62 0.18
31 INT229187 Binding of MALT1 2 0.31 1.48 0.09
32 INT181172 Positive_regulation of MALT1 1 0.01 0.27 0.08
33 INT57480 Regulation of Negative_regulation of IL2 1 0.45 0.37 0.07
34 INT244650 Positive_regulation of Binding of IL2 1 0.20 1.39 0.05
35 INT276397 Positive_regulation of Localization of MALT1 1 0.37 1.17 0.04
36 INT276400 Positive_regulation of Binding of MALT1 1 0.37 1.09 0.04
37 INT276403 Regulation of MALT1 3 0.34 3.37 0.03
38 INT235499 Regulation of Regulation of IL2 1 0.27 0 0.03
39 INT337565 Regulation of Transcription of IL2 1 0.45 0.51 0.03
40 INT240133 Phosphorylation of Lamtor3 1 0.01 0.1 0
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