GO:0019210

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Name kinase inhibitor activity
Categary Function
Go Slim No
Go Link GO:0019210
Unique Molecular Interactions 37
Total Molecular Interactions 45
Total Single Events 172
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for kinase inhibitor activity. They are ordered first by their pain relevance and then by number of times they were reported for kinase inhibitor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT48341 Negative_regulation of Pde8a Regulation of Ahsg 1 0.22 0 0.9
2 INT48342 Pde8a Regulation of Ahsg 1 0.24 0 0.9
3 INT264137 IFNA1 Positive_regulation of Socs1 1 0.01 0.38 0.46
4 INT264135 Socs1 Positive_regulation of Protein_catabolism of TOLLIP 1 0.00 0.33 0.41
5 INT243641 Twist1 Positive_regulation of Socs1 1 0.14 0.13 0.31
6 INT243634 Twist1 Regulation of Socs1 1 0.14 0.13 0.31
7 INT315394 IFNA1 Positive_regulation of Gene_expression of Socs1 1 0.01 0.41 0.31
8 INT315398 IFNA1 Positive_regulation of Socs1 1 0.01 0.41 0.3
9 INT339510 Tlr4 Positive_regulation of Socs1 1 0.06 0.1 0.18
10 INT184086 Socs5 Negative_regulation of Binding of Jak1 1 0.20 0 0.16
11 INT226367 INCENP Negative_regulation of SOCS1 1 0.01 0.47 0.15
12 INT184098 Binding of Il4 and Socs5 1 0.09 2.05 0.15
13 INT339513 Binding of Socs1 and Eif2ak2 1 0.04 0.07 0.15
14 INT128705 Binding of Adrb2 and Ahsg 1 0.00 0.23 0.15
15 INT184122 Binding of Socs1 and Sh2 1 0.14 0 0.14
16 INT226378 INCENP Positive_regulation of Transcription of SOCS1 1 0.01 0.41 0.13
17 INT339500 Negative_regulation of Socs1 Positive_regulation of Eif2ak2 1 0.05 0.31 0.09
18 INT335772 MIR155 Regulation of SOCS1 1 0.01 0.29 0.09
19 INT188361 Il4 Positive_regulation of Socs1 1 0.14 0.15 0.08
20 INT184113 Socs1 Negative_regulation of Mthfd1 1 0.08 0.5 0.08
21 INT350708 Foxp3 Regulation of Socs1 1 0.08 0.21 0.07
22 INT184121 Socs1 Regulation of Mthfd1 1 0.05 0.44 0.07
23 INT128706 Binding of MET and Ahsg 1 0.28 0.34 0.07
24 INT273363 SOCS3 Regulation of Protein_catabolism of SOCS1 1 0.02 0 0.07
25 INT273364 SOCS3 Regulation of SOCS1 1 0.02 0 0.07
26 INT273371 JAK2 Regulation of Protein_catabolism of SOCS1 1 0.01 0 0.06
27 INT273365 JAK2 Regulation of SOCS1 1 0.01 0 0.06
28 INT184085 Socs1 Positive_regulation of Protein_catabolism of Insr 1 0.04 0.41 0.05
29 INT339499 Socs1 Regulation of Gene_expression of Eif2ak2 1 0.05 0.09 0
30 INT302321 Negative_regulation of Binding of Lrp6 and SOST 1 0.16 0.26 0
31 INT184137 Binding of Socs5 and Regulation of Hand2 1 0.09 1.01 0
32 INT302320 Binding of Lrp6 and SOST 1 0.18 0.26 0
33 INT339514 Socs1 Regulation of Eif2ak2 1 0.07 0.09 0
34 INT335887 Akt1 Regulation of Lrp6 1 0.06 0.15 0
35 INT335883 Binding of Lrp6 and Wnt5a 1 0.27 0.08 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for kinase inhibitor activity. They are ordered first by their pain relevance and then by number of times they were reported in kinase inhibitor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT53871 Gene_expression of Socs1 32 0.71 22.83 6.21
2 INT184054 Negative_regulation of Gene_expression of Socs1 7 0.53 9.18 2.22
3 INT184042 Negative_regulation of Socs1 9 0.46 8.1 1.88
4 INT184068 Positive_regulation of Socs1 7 0.51 4.03 1.73
5 INT254250 Regulation of Socs1 5 0.06 3.04 1.66
6 INT184052 Localization of Socs1 3 0.59 4.07 1.54
7 INT108519 Binding of Lrp6 8 0.44 1.47 1.19
8 INT48338 Gene_expression of Ahsg 2 0.52 0.25 1.16
9 INT33495 Regulation of Ahsg 1 0.23 0 0.86
10 INT48339 Regulation of Localization of Ahsg 1 0.21 0 0.86
11 INT48337 Localization of Ahsg 1 0.54 0 0.85
12 INT184014 Binding of Socs1 2 0.34 0.97 0.84
13 INT254249 Transcription of Socs1 2 0.29 1.6 0.74
14 INT184019 Gene_expression of Socs5 6 0.53 4.94 0.72
15 INT89363 Positive_regulation of Ahsg 2 0.11 1.11 0.63
16 INT184017 Positive_regulation of Gene_expression of Socs1 7 0.63 2.47 0.62
17 INT165542 Gene_expression of Socs1 2 0.32 1.31 0.62
18 INT36619 Gene_expression of SOCS1 9 0.44 4.83 0.55
19 INT129635 Positive_regulation of SOCS1 3 0.49 0.92 0.49
20 INT129636 Transcription of SOCS1 2 0.52 1.29 0.45
21 INT89367 Negative_regulation of Ahsg 2 0.14 0.85 0.36
22 INT315375 Positive_regulation of Gene_expression of Socs1 1 0.21 0.41 0.31
23 INT335875 Regulation of Lrp6 1 0.57 0.43 0.27
24 INT165579 Regulation of Gene_expression of Ahsg 1 0.01 0.25 0.26
25 INT165577 Positive_regulation of Gene_expression of Ahsg 1 0.04 0.25 0.26
26 INT165544 Negative_regulation of Gene_expression of Socs1 1 0.03 0.84 0.24
27 INT165543 Negative_regulation of Socs1 1 0.03 0.55 0.18
28 INT335861 Localization of Lrp6 1 0.69 0.54 0.17
29 INT184073 Regulation of Gene_expression of Socs1 1 0.41 1.32 0.15
30 INT335807 Localization of SOCS1 1 0.36 0.41 0.15
31 INT226477 Positive_regulation of Transcription of SOCS1 1 0.21 0.41 0.13
32 INT268281 Negative_regulation of SOCS1 3 0.21 1.12 0.08
33 INT343445 Binding of SOCS1 1 0.02 0.07 0.08
34 INT184004 Protein_catabolism of Socs1 1 0.60 0.4 0.07
35 INT226391 Positive_regulation of Gene_expression of Socs5 1 0.11 0.81 0.07
36 INT273400 Protein_catabolism of SOCS1 1 0.05 0 0.06
37 INT335865 Positive_regulation of Phosphorylation of Lrp6 1 0.64 0.46 0.05
38 INT335862 Phosphorylation of Lrp6 1 0.76 0.37 0.05
39 INT339485 Positive_regulation of Negative_regulation of Socs1 1 0.11 0.1 0.05
40 INT339475 Phosphorylation of Socs1 1 0.17 0.16 0.04
41 INT128703 Binding of Ahsg 1 0.26 0.17 0.03
42 INT335872 Positive_regulation of Gene_expression of Lrp6 1 0.46 0.18 0
43 INT347117 Negative_regulation of Binding of Lrp6 1 0.28 0.5 0
44 INT335866 Regulation of Transcription of Lrp6 1 0.42 0.25 0
45 INT288192 Regulation of Transcription of Socs1 1 0.15 0 0
46 INT157837 Phosphorylation of Ahsg 1 0.01 0 0
47 INT335881 Gene_expression of Lrp6 1 0.62 0.09 0
48 INT184034 Binding of Socs5 1 0.24 2.05 0
49 INT335873 Transcription of Lrp6 1 0.64 0.25 0
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