GO:0019229

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Name regulation of vasoconstriction
Categary Process
Go Slim No
Go Link GO:0019229
Unique Molecular Interactions 491
Total Molecular Interactions 686
Total Single Events 6000
Pain Genes Associated 30

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of vasoconstriction. They are ordered first by their pain relevance and then by number of times they were reported for regulation of vasoconstriction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT140347 Binding of ATP1A2 and Cacna1a 1 0.11 2.88 2.73
2 INT77807 Edn1 Positive_regulation of Gene_expression of Ptgs2 1 0.33 0.53 2.1
3 INT91607 Binding of EDN1 and POMC 1 0.12 0 1.9
4 INT66504 Binding of Agt and Agtr1a 8 0.39 3.78 1.78
5 INT326509 Binding of ACE and VWF 1 0.05 2.07 1.59
6 INT136034 Edn1 Regulation of Trpv1 2 0.66 0.39 1.58
7 INT108727 Binding of ATP1A2 and CACNA1A 2 0.34 1.97 1.37
8 INT95275 Binding of Edn1 and Ece1 1 0.32 2.09 1.3
9 INT95274 Regulation of Binding of Edn1 and Ece1 1 0.39 2.09 1.3
10 INT162343 Positive_regulation of KCNMA1 Positive_regulation of ACE 1 0.06 1.25 1.23
11 INT162344 KCNMA1 Positive_regulation of ACE 1 0.06 1.25 1.23
12 INT77806 Edn1 Regulation of Gene_expression of Ptgs2 1 0.29 1.24 1.22
13 INT62596 Binding of Edn1 and Nppa 1 0.27 1.77 1.22
14 INT201067 Binding of Edn1 and Ednra 2 0.18 1.36 1.18
15 INT24796 ACE Positive_regulation of Localization of HMMR 1 0.00 0.58 1.16
16 INT299985 BDKRB2 Regulation of Gene_expression of BDKRB1 1 0.21 0.75 1.16
17 INT160653 Binding of P2rx1 and Ptgfr 1 0.28 0.66 1.14
18 INT108409 AGT Positive_regulation of AGTR2 2 0.31 1.49 1.11
19 INT10238 Binding of EDN1 and Calca 1 0.00 1.07 1.06
20 INT352295 Binding of P2RY2 and Agtr1a 1 0.01 0.08 1.02
21 INT299986 BDKRB2 Regulation of Gene_expression of SPANXB1 1 0.29 0.51 1.02
22 INT69307 Prkcq Negative_regulation of TH1L 1 0.00 0.98 0.98
23 INT66712 Binding of BDKRB2 and KNG1 1 0.06 0.22 0.97
24 INT66711 Negative_regulation of Binding of BDKRB2 and KNG1 1 0.07 0.22 0.97
25 INT152084 Edn1 Negative_regulation of Positive_regulation of Trpv1 1 0.62 0.48 0.96
26 INT136033 Edn1 Positive_regulation of Trpv1 1 0.50 0.34 0.95
27 INT77859 EDN1 Positive_regulation of MC1R 2 0.64 0.34 0.94
28 INT215584 P2rx1 Regulation of Localization of Gabrg1 1 0.01 0 0.92
29 INT34457 AGT Positive_regulation of POMC 1 0.01 0 0.91
30 INT299990 BDKRB2 Positive_regulation of TRPV1 1 0.43 0.74 0.84
31 INT152083 Binding of Edn1 and Trpv1 1 0.38 0.67 0.83
32 INT153765 Positive_regulation of Edn1 Positive_regulation of Gtf3a 2 0.04 2.26 0.82
33 INT106859 EDN1 Positive_regulation of Transcription of MC1R 1 0.22 0 0.82
34 INT53377 Binding of Edn1 and Edn3 1 0.39 0 0.81
35 INT157918 TRPV1 Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
36 INT157913 Trpv1 Regulation of Gene_expression of Edn1 1 0.29 0.55 0.81
37 INT157915 Prkca Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
38 INT34458 AGT Negative_regulation of PENK 1 0.00 0 0.81
39 INT219911 Edn1 Regulation of Gene_expression of Trpv1 1 0.23 0.57 0.8
40 INT127876 ACE Positive_regulation of Protein_catabolism of CALCA 1 0.28 0.63 0.75
41 INT64117 Binding of Edn1 and Ins1 1 0.06 0.85 0.71
42 INT222493 Edn1 Positive_regulation of Localization of Prl 1 0.10 0 0.71
43 INT123077 Cacna1c Negative_regulation of Gene_expression of Dbi 1 0.05 0.71 0.7
44 INT63557 Binding of Edn1 and Edn3 1 0.23 0.63 0.7
45 INT324900 VEGFA Positive_regulation of Gene_expression of Edn1 1 0.06 1.61 0.69
46 INT141063 Agt Regulation of Agtr1a 1 0.28 1.18 0.68
47 INT278827 Binding of EDN1 and EDNRB 3 0.17 2.7 0.67
48 INT102350 P2rx1 Negative_regulation of Localization of Il6 1 0.32 0 0.67
49 INT259776 Fbn2 Regulation of Negative_regulation of Agtr1a 1 0.00 1.42 0.66
50 INT313702 Binding of Edn1 and Fig4 1 0.16 0 0.65
51 INT313698 Binding of Calca and Edn1 1 0.30 0 0.65
52 INT94020 Binding of EDN2 and INSRR 1 0.03 0 0.65
53 INT113780 AGT Positive_regulation of Positive_regulation of Nfkb1 1 0.00 1.25 0.64
54 INT151783 Regulation of Binding of Calca and P2rx1 1 0.42 0.51 0.64
55 INT151778 Binding of Calca and P2rx1 1 0.35 0.5 0.64
56 INT182266 EDN1 Positive_regulation of Gene_expression of MMP13 1 0.35 2.03 0.63
57 INT219919 EDNRA Negative_regulation of Edn1 1 0.15 0.36 0.63
58 INT178097 Binding of EDN1 and EDNRA 7 0.21 5.97 0.62
59 INT259768 Positive_regulation of Agtr1a Regulation of Etf1 1 0.00 1.32 0.62
60 INT21607 ACE Positive_regulation of ANGPT2 1 0.03 0.13 0.61
61 INT131642 Edn1 Positive_regulation of Positive_regulation of Insrr 1 0.01 0.44 0.6
62 INT178087 EDN1 Positive_regulation of MMP13 2 0.23 1.58 0.59
63 INT130162 Pomc Positive_regulation of Gene_expression of Edn1 1 0.25 0 0.58
64 INT181619 ACE Positive_regulation of KNG1 1 0.33 0.97 0.58
65 INT196879 Cpox Negative_regulation of Gene_expression of Tbxa2r 1 0.04 0.8 0.56
66 INT62597 Binding of Edn1 and Vip 1 0.23 0.79 0.54
67 INT34459 AGT Negative_regulation of MBTPS1 1 0.01 0 0.54
68 INT110474 YY1 Positive_regulation of Positive_regulation of EDN1 1 0.56 0.15 0.53
69 INT79809 Binding of Agtr1a and Adra1a 1 0.02 0.23 0.53
70 INT130160 Pomc Regulation of Edn1 1 0.25 0 0.53
71 INT132438 Binding of AGT and OXTR 1 0.08 1.03 0.53
72 INT19296 AGT Positive_regulation of Localization of AVP 1 0.38 0 0.5
73 INT21315 AGT Positive_regulation of Npy 1 0.03 0.15 0.5
74 INT278825 Positive_regulation of Binding of EDN1 and EDNRB 3 0.16 1.24 0.49
75 INT152282 Binding of Accn1 and Trpv1 1 0.10 0.42 0.49
76 INT94015 Binding of EDN1 and INSRR 1 0.04 0 0.49
77 INT94024 Binding of EDN1 and EDN3 1 0.27 0 0.49
78 INT152281 Binding of P2rx1 and Trpv1 1 0.15 0.42 0.49
79 INT94018 Binding of EDN2 and EDN3 1 0.19 0 0.48
80 INT99571 Edn1 Positive_regulation of Localization of Ednra 1 0.01 0.32 0.47
81 INT71839 Chrm3 Positive_regulation of Qrfp 1 0.09 0 0.47
82 INT110476 EDN1 Positive_regulation of Localization of PRKCZ 1 0.25 0.07 0.46
83 INT342633 ACE Regulation of Gene_expression of AGT 1 0.01 0.14 0.46
84 INT50497 Edn1 Positive_regulation of Pla2g1b 1 0.01 0.23 0.45
85 INT110475 EDN1 Regulation of PRKCA 1 0.05 0.07 0.45
86 INT219910 EDN1 Positive_regulation of Positive_regulation of EDNRA 1 0.00 0.3 0.45
87 INT151782 Phosphorylation of Creb1 Positive_regulation of Gene_expression of P2rx1 1 0.41 0.07 0.44
88 INT151781 Calca Positive_regulation of Gene_expression of P2rx1 1 0.50 0.07 0.44
89 INT354218 Igfbp7 Positive_regulation of Accn1 1 0.04 0.74 0.44
90 INT114341 Agt Positive_regulation of AGT 3 0.01 1.15 0.43
91 INT345288 AGT Positive_regulation of Localization of CCL2 1 0.01 1.5 0.43
92 INT345291 AGT Positive_regulation of CCL2 1 0.01 1.39 0.43
93 INT313704 Smn1 Negative_regulation of Gene_expression of Edn1 1 0.32 0 0.42
94 INT170157 NPPC Regulation of CSF2 1 0.12 1.36 0.42
95 INT153766 Edn1 Positive_regulation of Gtf3a 1 0.04 1.25 0.41
96 INT182489 Gene_expression of AGTR2 Positive_regulation of Gene_expression of AGTR1 1 0.26 0.92 0.4
97 INT230724 EDN1 Positive_regulation of EDNRA 3 0.24 4.12 0.39
98 INT191493 Binding of AGTR1 and NLRP3 2 0.03 2.35 0.39
99 INT278932 Binding of Agtr1a and H3 1 0.00 0 0.39
100 INT332701 Binding of BDKRB1 and BDKRB2 1 0.01 0.5 0.39
101 INT50553 Negative_regulation of Ptgs1 Negative_regulation of Gene_expression of Tbxa2r 1 0.02 1.37 0.38
102 INT310600 Tbxa2r Positive_regulation of PLEK 1 0.53 0.45 0.38
103 INT139566 Binding of PLEK and Tbxa2r 1 0.01 1.14 0.38
104 INT99399 Penk Positive_regulation of Edn1 1 0.00 0 0.38
105 INT99400 Gast Positive_regulation of Edn1 1 0.00 0 0.38
106 INT185530 Binding of AGT and EDNRA 1 0.00 0.31 0.38
107 INT173704 Binding of PCOS1 and Edn1 1 0.01 0.99 0.37
108 INT313701 Calca Negative_regulation of Binding of Edn1 1 0.30 0.14 0.37
109 INT229222 Negative_regulation of ACE Negative_regulation of Protein_catabolism of KNG1 1 0.06 0.53 0.37
110 INT152314 Il18 Regulation of Edn1 1 0.02 0.22 0.36
111 INT140802 Accn2 Regulation of Transcription of Accn1 1 0.24 0 0.36
112 INT201068 Binding of Edn1 and Ednrb 2 0.18 1.23 0.35
113 INT152316 Ifng Regulation of Edn1 1 0.01 0.22 0.35
114 INT203395 Edn1 Positive_regulation of Vegfa 1 0.06 1.59 0.35
115 INT230786 Binding of AGT and ACE 4 0.15 2.53 0.34
116 INT161796 Binding of ECE1 and EDN1 2 0.21 2.23 0.34
117 INT330122 Agt Positive_regulation of Gene_expression of Agtr1a 1 0.03 0.69 0.34
118 INT136008 Binding of BDKRB2 and INSRR 1 0.01 0.17 0.34
119 INT330121 Agtr1a Positive_regulation of Gene_expression of Bdkrb1 1 0.05 0.68 0.34
120 INT329954 Binding of PRKCQ and SNRNP70 1 0.07 0.65 0.33
121 INT207576 RETN Positive_regulation of Gene_expression of EDN1 1 0.05 0.78 0.33
122 INT143567 Edn1 Regulation of Ptgs2 1 0.26 0.17 0.33
123 INT230852 ACE Regulation of KNG1 2 0.03 0.72 0.32
124 INT229363 Negative_regulation of Binding of Agt and Agtr1a 2 0.22 0.9 0.32
125 INT99842 Edn1 Negative_regulation of Localization of Ren 1 0.24 0.43 0.32
126 INT347517 Binding of Tbxa2r and ST7L 1 0.00 0 0.32
127 INT337327 KNG1 Positive_regulation of BDKRB2 1 0.21 0.4 0.32
128 INT67266 Edn1 Negative_regulation of Ece1 1 0.19 0.17 0.32
129 INT72445 Binding of AGT and REN 3 0.34 0.88 0.31
130 INT182262 EDN1 Positive_regulation of Gene_expression of NOS2 1 0.28 0.79 0.31
131 INT99843 Edn3 Negative_regulation of Localization of Ren 1 0.25 0.42 0.31
132 INT196883 Prkca Regulation of P2rx1 1 0.05 0.45 0.31
133 INT71519 Edn1 Positive_regulation of Gene_expression of Adarb1 1 0.02 0.48 0.31
134 INT265826 Binding of ACE and SERPINE1 1 0.24 1.08 0.3
135 INT224131 Binding of CAV1 and Agtr1a 1 0.00 0.08 0.3
136 INT258857 Binding of P2rx1 and P2ry2 1 0.22 0.81 0.29
137 INT200631 AGT Positive_regulation of Gene_expression of TGFB1 1 0.06 1.36 0.29
138 INT182499 Binding of AGTR1 and AGTR2 3 0.20 2.79 0.28
139 INT288911 AGT Positive_regulation of CYBB 3 0.07 2.96 0.28
140 INT191501 NLRP3 Positive_regulation of ECE1 1 0.01 1.09 0.28
141 INT191505 NLRP3 Positive_regulation of Protein_catabolism of EDN1 1 0.00 1.1 0.28
142 INT54639 Edn3 Negative_regulation of Edn2 1 0.00 0 0.28
143 INT191495 NLRP3 Positive_regulation of Protein_catabolism of ECE1 1 0.01 1.09 0.28
144 INT72820 EDN3 Positive_regulation of Avp 1 0.31 0.64 0.27
145 INT239226 Binding of Edn1 and Ednra 2 0.06 1.59 0.26
146 INT19839 Positive_regulation of Binding of Ptgis and Tbxa2r 1 0.00 0.2 0.26
147 INT180718 Binding of SARS and ACE2 3 0.12 7.76 0.25
148 INT19840 Binding of Ptgis and Tbxa2r 1 0.00 0.2 0.25
149 INT208037 Binding of Accn1 and Accn3 1 0.15 0.3 0.25
150 INT342456 AGT Positive_regulation of Gene_expression of CCL2 1 0.07 0.63 0.25
151 INT256227 Binding of EDN1 and VEGFA 1 0.18 2.92 0.25
152 INT208036 Binding of Cnga3 and Accn1 1 0.01 0.3 0.25
153 INT191500 ACE Positive_regulation of Localization of KNG1 1 0.10 0.17 0.24
154 INT178095 EDN1 Positive_regulation of MMP3 1 0.04 0.88 0.24
155 INT178076 EDN1 Positive_regulation of MMP2 1 0.04 0.88 0.24
156 INT178085 EDN1 Positive_regulation of MMP7 1 0.06 0.89 0.24
157 INT178141 EDN1 Positive_regulation of Timp1 1 0.30 0.89 0.24
158 INT41588 Binding of AGT and Lhb 1 0.00 0 0.24
159 INT178075 EDN1 Positive_regulation of PLAU 1 0.06 0.95 0.24
160 INT178104 EDN1 Positive_regulation of Localization of TIMP1 1 0.05 0.83 0.24
161 INT178094 Positive_regulation of EDN1 Positive_regulation of PLAU 1 0.06 0.95 0.24
162 INT178142 EDN1 Positive_regulation of Localization of Timp1 1 0.28 0.89 0.24
163 INT41589 Binding of AGT and Prl 1 0.00 0 0.24
164 INT178077 EDN1 Positive_regulation of MMP9 1 0.06 0.88 0.24
165 INT191492 Binding of AGT and NLRP3 1 0.01 0.35 0.23
166 INT182272 EDN1 Regulation of Gene_expression of MMP13 1 0.26 0.87 0.22
167 INT265828 ACE Regulation of Gene_expression of KNG1 1 0.32 0.83 0.22
168 INT146993 Binding of NPPA and NPPC 1 0.27 0.82 0.22
169 INT91686 Mb Positive_regulation of Edn1 1 0.03 0.29 0.22
170 INT182265 EDN1 Positive_regulation of NOS2 1 0.24 0.56 0.22
171 INT297257 Agtr1a Positive_regulation of Agtr2 1 0.27 0.59 0.22
172 INT354217 Arc Positive_regulation of Accn1 1 0.01 0.29 0.21
173 INT182263 EDN1 Positive_regulation of MMP1 1 0.15 0.43 0.21
174 INT354519 Cacna1c Regulation of Mri1 1 0.00 1.15 0.21
175 INT229360 Agt Positive_regulation of Agtr1a 2 0.48 1.26 0.2
176 INT354211 Igfbp7 Positive_regulation of Gene_expression of Accn1 1 0.04 0.29 0.2
177 INT354216 Binding of Accn3 and Positive_regulation of Gene_expression of Accn1 1 0.06 0.29 0.2
178 INT178074 EDN1 Positive_regulation of Phosphorylation of PXN 1 0.05 0.82 0.2
179 INT274094 EDN1 Positive_regulation of AGT 1 0.16 0.95 0.2
180 INT354225 Accn3 Positive_regulation of Gene_expression of Accn1 1 0.06 0.29 0.2
181 INT354214 Arc Positive_regulation of Gene_expression of Accn1 1 0.01 0.29 0.2
182 INT258017 Binding of AGT and ANGPT2 3 0.11 2.35 0.19
183 INT230749 Crp Regulation of Agtr1a 1 0.07 1.33 0.19
184 INT224086 Binding of Agtr1a and Hspa8 1 0.00 0.1 0.19
185 INT182258 EDN1 Positive_regulation of Positive_regulation of MMP1 1 0.15 0.47 0.19
186 INT182271 EDN1 Positive_regulation of Localization of MMP13 1 0.27 0.47 0.19
187 INT139565 Negative_regulation of Binding of PLEK and Tbxa2r 1 0.01 0.57 0.19
188 INT326940 Chrm3 Positive_regulation of Nalcn 1 0.06 0.21 0.19
189 INT219915 Edn1 Regulation of Positive_regulation of Trpv1 1 0.33 0 0.18
190 INT140096 Gtf3a Positive_regulation of Gene_expression of Edn1 1 0.02 0.44 0.18
191 INT171386 Edn1 Positive_regulation of Mapk1 1 0.05 0.13 0.18
192 INT60778 Edn1 Positive_regulation of EDNRA 1 0.00 0 0.18
193 INT284450 Edn1 Positive_regulation of Gene_expression of MMP9 1 0.01 0.3 0.18
194 INT140094 Ifng Regulation of Gene_expression of Edn1 1 0.18 0.44 0.18
195 INT178092 EDN3 Positive_regulation of PTK2 1 0.01 1.02 0.17
196 INT229223 Binding of AGT and FAS 1 0.08 0.91 0.17
197 INT347518 Regulation of Binding of Tbxa2r and ST7L 1 0.00 0 0.17
198 INT36568 AGT Positive_regulation of FBF1 1 0.39 0.5 0.17
199 INT323757 Negative_regulation of ACE2 Negative_regulation of ANG 1 0.18 1.73 0.17
200 INT269333 Binding of BDKRB2 and NOS3 1 0.02 0 0.17

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of vasoconstriction. They are ordered first by their pain relevance and then by number of times they were reported in regulation of vasoconstriction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48
2 INT5781 Gene_expression of Edn1 190 0.78 99.1 46
3 INT64436 Gene_expression of P2rx1 93 0.78 32.69 36.12
4 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19
5 INT17381 Gene_expression of Tbxa2r 146 0.78 65.01 34.15
6 INT70776 Positive_regulation of P2rx1 62 0.62 32.55 30.75
7 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43
8 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07
9 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8
10 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73
11 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91
12 INT2978 Gene_expression of Tbxa2r 76 0.77 28.4 21.27
13 INT6848 Gene_expression of BDKRB2 40 0.75 17.19 20.04
14 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59
15 INT5048 Binding of Edn1 55 0.47 18.86 19.16
16 INT1533 Negative_regulation of AGT 105 0.42 46.54 16.92
17 INT9191 Localization of EDN1 94 0.81 57.01 14.78
18 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42
19 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19
20 INT5806 Regulation of Edn1 63 0.62 23.46 13.88
21 INT6365 Localization of Edn1 56 0.81 18.84 13.83
22 INT79703 Gene_expression of Agtr1a 46 0.76 14.18 13.77
23 INT90942 Regulation of P2rx1 31 0.61 16.61 13.69
24 INT3962 Regulation of AGT 50 0.62 20.96 13.01
25 INT21979 Negative_regulation of EDN1 52 0.58 24.65 12.55
26 INT53038 Positive_regulation of Agtr1a 35 0.67 23.76 11.68
27 INT66718 Positive_regulation of BDKRB2 21 0.64 9.89 11.6
28 INT398 Localization of AGT 45 0.78 16.97 11.54
29 INT68290 Gene_expression of Accn1 32 0.73 7.36 11.23
30 INT8065 Binding of AGT 54 0.48 20.54 10.85
31 INT10982 Negative_regulation of Agtr1a 42 0.58 22.42 10.29
32 INT10184 Regulation of EDN1 44 0.62 23.78 10.06
33 INT6361 Localization of Edn1 30 0.81 19.09 9.7
34 INT11859 Positive_regulation of Tbxa2r 44 0.61 22.62 9.61
35 INT18145 Positive_regulation of Gene_expression of Tbxa2r 30 0.66 18.91 9.52
36 INT20664 Binding of ACE 60 0.48 35.27 9.16
37 INT5458 Negative_regulation of Tbxa2r 31 0.54 10.58 8.89
38 INT17101 Positive_regulation of Gene_expression of Edn1 24 0.69 24.9 8.86
39 INT12095 Negative_regulation of Edn1 26 0.59 12.01 8.79
40 INT70775 Positive_regulation of Positive_regulation of P2rx1 15 0.49 8.65 8.49
41 INT10237 Binding of EDN1 40 0.48 16 8.48
42 INT19107 Positive_regulation of Tbxa2r 23 0.62 12.54 8.44
43 INT13085 Positive_regulation of ACE 50 0.70 44.2 8.31
44 INT19829 Negative_regulation of Gene_expression of Tbxa2r 32 0.56 12.78 8.3
45 INT34009 Binding of Tbxa2r 33 0.36 17.98 8.01
46 INT95172 Localization of P2rx1 14 0.78 6.77 7.81
47 INT20348 Negative_regulation of Tbxa2r 47 0.59 19.88 7.68
48 INT10899 Positive_regulation of Gene_expression of Edn1 32 0.70 24.88 7.65
49 INT83006 Gene_expression of AGTR1 59 0.75 54.46 7.27
50 INT11042 Localization of Tbxa2r 26 0.76 10.15 7.24
51 INT90943 Negative_regulation of P2rx1 13 0.42 8.21 7.22
52 INT10104 Negative_regulation of Edn1 43 0.59 15.63 7.2
53 INT114014 Positive_regulation of Gene_expression of P2rx1 13 0.69 7.77 7.15
54 INT11858 Localization of Tbxa2r 39 0.80 21.24 7.09
55 INT42038 Localization of ACE 26 0.80 8.88 7.06
56 INT91351 Gene_expression of P2rx1 28 0.75 5.89 6.78
57 INT16359 Positive_regulation of Gene_expression of AGT 30 0.49 28.27 6.14
58 INT83095 Regulation of Gene_expression of BDKRB2 2 0.59 4.06 5.39
59 INT102891 Positive_regulation of AGTR1 31 0.67 30.57 5.29
60 INT107386 Negative_regulation of AGTR1 37 0.55 35.94 5.15
61 INT48277 Regulation of BDKRB2 9 0.59 2.69 5.05
62 INT19639 Negative_regulation of Gene_expression of Tbxa2r 17 0.55 7.69 5.01
63 INT17803 Regulation of Edn1 14 0.54 4.75 4.71
64 INT81086 Positive_regulation of Accn1 8 0.65 7.51 4.62
65 INT3332 Protein_catabolism of AGT 23 0.87 3.17 4.39
66 INT26477 Regulation of ACE 26 0.45 16.31 4.33
67 INT75440 Regulation of Binding of Edn1 4 0.38 1.41 4.33
68 INT144396 Positive_regulation of P2rx1 11 0.49 3.25 4.23
69 INT53040 Binding of Agtr1a 22 0.47 7.36 4.15
70 INT95171 Binding of P2rx1 12 0.36 4.69 3.92
71 INT1722 Protein_catabolism of ACE 10 0.88 2.61 3.76
72 INT9077 Regulation of Tbxa2r 13 0.45 5.49 3.75
73 INT5782 Gene_expression of Edn3 17 0.67 3.38 3.65
74 INT95272 Regulation of Gene_expression of Edn1 19 0.53 17.85 3.42
75 INT53347 Localization of BDKRB2 5 0.75 4.96 3.39
76 INT48902 Gene_expression of ACE2 22 0.78 17.91 3.24
77 INT111195 Negative_regulation of Gene_expression of Agtr1a 7 0.58 3.2 3.16
78 INT66720 Negative_regulation of BDKRB2 5 0.57 1.92 3.11
79 INT55033 Localization of Edn3 7 0.80 1.4 3.05
80 INT108728 Regulation of ATP1A2 4 0.45 3.65 3.04
81 INT186507 Localization of ATP1A2 2 0.74 3.35 3.04
82 INT53348 Binding of BDKRB2 7 0.37 2.85 3
83 INT53374 Binding of Edn1 17 0.43 11.66 2.98
84 INT26833 Negative_regulation of P2rx1 9 0.41 1.5 2.89
85 INT72253 Positive_regulation of Accn1 8 0.63 2.64 2.73
86 INT100014 Negative_regulation of Gene_expression of EDN1 17 0.42 7.85 2.71
87 INT75551 Localization of Accn1 6 0.68 1.75 2.58
88 INT63846 Gene_expression of Prkcq 1 0.73 1.11 2.58
89 INT25166 Regulation of Tbxa2r 12 0.43 5.94 2.47
90 INT72254 Gene_expression of Accn1 9 0.71 3.24 2.46
91 INT17857 Negative_regulation of Gene_expression of AGT 25 0.46 21.16 2.45
92 INT63418 Regulation of Agtr1a 8 0.44 3.67 2.43
93 INT114011 Negative_regulation of ATP1A2 5 0.45 6.12 2.41
94 INT17243 Positive_regulation of Gene_expression of Tbxa2r 7 0.55 4.7 2.37
95 INT27988 Negative_regulation of Positive_regulation of AGT 11 0.42 5.71 2.27
96 INT136190 Transcription of Accn1 5 0.61 2.75 2.24
97 INT19286 Negative_regulation of Cacna1c 11 0.46 5.12 2.22
98 INT55853 Positive_regulation of Positive_regulation of Edn1 11 0.61 6.5 2.21
99 INT121435 Negative_regulation of Gene_expression of P2rx1 3 0.43 1.82 2.21
100 INT47543 Positive_regulation of Chrm3 11 0.38 5.23 2.17
101 INT99951 Regulation of Accn1 5 0.26 2.65 2.1
102 INT49253 Regulation of Gene_expression of EDN1 11 0.61 3.92 2.07
103 INT165083 Positive_regulation of Positive_regulation of Accn1 1 0.47 3.91 2.07
104 INT112368 Positive_regulation of Cacna1c 8 0.46 2.94 1.97
105 INT215166 Binding of P2rx1 5 0.35 0.41 1.97
106 INT26311 Negative_regulation of ACE2 8 0.59 16.35 1.94
107 INT33096 Negative_regulation of Gene_expression of ACE 9 0.43 2.84 1.93
108 INT49259 Regulation of Localization of EDN1 8 0.61 6.29 1.92
109 INT9076 Regulation of Gene_expression of Tbxa2r 7 0.61 1.16 1.92
110 INT76834 Negative_regulation of Gene_expression of Edn1 4 0.43 1.76 1.88
111 INT79815 Positive_regulation of Localization of Edn1 7 0.68 2.07 1.79
112 INT182505 Positive_regulation of Gene_expression of AGTR1 12 0.65 13.18 1.77
113 INT22335 Regulation of Negative_regulation of ACE 10 0.44 7.01 1.77
114 INT8661 Positive_regulation of Positive_regulation of EDN1 10 0.66 10.9 1.76
115 INT173700 Negative_regulation of Binding of Edn1 2 0.58 0.41 1.76
116 INT146948 Negative_regulation of Positive_regulation of P2rx1 2 0.34 2.23 1.74
117 INT103959 Gene_expression of ATP1A2 3 0.67 2.47 1.68
118 INT149435 Regulation of Positive_regulation of P2rx1 2 0.30 1.55 1.67
119 INT14842 Negative_regulation of Binding of EDN1 4 0.57 0.67 1.66
120 INT28210 Negative_regulation of Localization of Tbxa2r 6 0.49 2.09 1.58
121 INT123076 Gene_expression of Cacna1c 7 0.37 1.91 1.56
122 INT181579 Phosphorylation of Edn1 1 0.71 8.59 1.51
123 INT15407 Positive_regulation of Positive_regulation of Edn1 5 0.62 3.69 1.49
124 INT182514 Binding of AGTR1 18 0.47 13.35 1.48
125 INT24768 Negative_regulation of Gene_expression of Edn1 10 0.43 2.85 1.48
126 INT151777 Regulation of Gene_expression of P2rx1 3 0.60 1.97 1.48
127 INT65640 Positive_regulation of Localization of Edn1 2 0.42 2.16 1.48
128 INT15048 Regulation of Cacna1c 4 0.29 3.26 1.47
129 INT34008 Positive_regulation of Binding of Tbxa2r 5 0.42 1.97 1.46
130 INT114013 Binding of ATP1A2 3 0.47 3.51 1.46
131 INT65452 Negative_regulation of Cacna1c 8 0.09 0.8 1.44
132 INT34768 Negative_regulation of Negative_regulation of AGT 10 0.25 2.79 1.42
133 INT159464 Negative_regulation of Accn1 4 0.37 1.07 1.41
134 INT182511 Regulation of AGTR1 7 0.44 8.25 1.4
135 INT118581 Positive_regulation of ATP1A2 3 0.21 1.81 1.4
136 INT8067 Negative_regulation of Binding of AGT 12 0.25 10.33 1.39
137 INT61223 Positive_regulation of Negative_regulation of ACE 6 0.49 5.92 1.37
138 INT83553 Positive_regulation of Positive_regulation of Agtr1a 3 0.59 4.12 1.37
139 INT34936 Negative_regulation of Binding of Tbxa2r 8 0.44 2.85 1.34
140 INT215162 Phosphorylation of P2rx1 2 0.43 0.12 1.34
141 INT77752 Binding of Cacna1c 3 0.22 0.22 1.31
142 INT120406 Positive_regulation of Positive_regulation of BDKRB2 2 0.27 1.48 1.28
143 INT11241 Transcription of AGT 4 0.52 1.83 1.27
144 INT72250 Binding of Accn1 3 0.44 2.87 1.27
145 INT155662 Positive_regulation of Localization of P2rx1 2 0.47 1.92 1.26
146 INT91914 Binding of Accn1 3 0.36 0.44 1.24
147 INT63849 Regulation of Gene_expression of Prkcq 1 0.58 0.62 1.24
148 INT63847 Regulation of Prkcq 1 0.42 0.5 1.23
149 INT74849 Positive_regulation of Chrm3 5 0.64 1.71 1.2
150 INT47644 Positive_regulation of Localization of AGT 4 0.45 1.24 1.2
151 INT132283 Regulation of P2rx1 3 0.13 0 1.2
152 INT17802 Transcription of Edn1 6 0.24 6.31 1.18
153 INT22409 Regulation of Gene_expression of Tbxa2r 4 0.30 1.53 1.16
154 INT63856 Positive_regulation of Gene_expression of Prkcq 1 0.47 0.53 1.16
155 INT115621 Positive_regulation of Binding of AGT 1 0.02 0 1.15
156 INT160652 Positive_regulation of Binding of P2rx1 1 0.36 0.67 1.15
157 INT148072 Gene_expression of Agtr1a 5 0.75 9.41 1.13
158 INT87233 Gene_expression of ECE1 12 0.65 3.54 1.12
159 INT49258 Negative_regulation of Positive_regulation of EDN1 10 0.43 7.24 1.12
160 INT28212 Regulation of Localization of Tbxa2r 2 0.01 0.49 1.09
161 INT66452 Positive_regulation of Cacna1c 6 0.19 2.56 1.08
162 INT61123 Localization of Edn2 1 0.55 0.27 1.05
163 INT281919 Localization of ACE2 4 0.75 2.69 1.02
164 INT182516 Negative_regulation of Negative_regulation of ACE 9 0.42 6.84 0.99
165 INT107288 Positive_regulation of ACE2 4 0.66 5.48 0.99
166 INT69803 Regulation of Localization of Edn1 3 0.62 0.79 0.98
167 INT267071 Positive_regulation of Gene_expression of P2rx1 2 0.49 1.77 0.98
168 INT182512 Positive_regulation of Positive_regulation of AGTR1 5 0.47 4.88 0.97
169 INT78935 Localization of Cacna1c 3 0.48 1.25 0.97
170 INT106960 Gene_expression of Chrm3 15 0.69 6.29 0.96
171 INT49255 Protein_catabolism of EDN1 5 0.99 2.66 0.95
172 INT69422 Positive_regulation of Negative_regulation of EDN1 2 0.43 0.96 0.95
173 INT49254 Transcription of EDN1 5 0.69 2.42 0.94
174 INT127103 Negative_regulation of Gene_expression of P2rx1 5 0.41 0.46 0.91
175 INT192123 Transcription of P2rx1 4 0.27 1.24 0.91
176 INT148401 Regulation of Chrm3 3 0.19 1.19 0.91
177 INT152081 Phosphorylation of Edn1 1 0.53 0.39 0.9
178 INT73950 Negative_regulation of Chrm3 1 0.41 0 0.88
179 INT89669 Negative_regulation of Positive_regulation of Prkcq 1 0.08 0.23 0.87
180 INT89668 Positive_regulation of Prkcq 1 0.09 0.22 0.86
181 INT61591 Negative_regulation of Localization of EDN1 11 0.59 2.09 0.85
182 INT229710 Localization of Agtr1a 3 0.60 0.57 0.84
183 INT6243 Regulation of Edn3 2 0.35 0.2 0.83
184 INT68289 Positive_regulation of Gene_expression of Accn1 2 0.45 0.34 0.83
185 INT83995 Positive_regulation of Gene_expression of ACE 8 0.68 8.09 0.82
186 INT57433 Positive_regulation of Binding of EDN1 3 0.49 0.62 0.82
187 INT143673 Regulation of Gene_expression of Accn1 4 0.43 0.81 0.78
188 INT80118 Gene_expression of NPPC 2 0.68 4.14 0.77
189 INT186681 Gene_expression of Edn2 2 0.09 1.01 0.76
190 INT290271 Negative_regulation of Binding of BDKRB2 1 0.37 0.99 0.76
191 INT21943 Positive_regulation of Positive_regulation of AGT 6 0.46 3.29 0.75
192 INT34715 Regulation of Regulation of AGT 2 0.37 0.96 0.75
193 INT61122 Regulation of Regulation of Edn3 1 0.35 0.2 0.75
194 INT61121 Regulation of Regulation of Edn1 1 0.43 0.2 0.75
195 INT102894 Localization of AGTR1 5 0.73 1.75 0.74
196 INT342130 Negative_regulation of Localization of ACE2 1 0.01 1.16 0.74
197 INT8614 Negative_regulation of Edn2 3 0.06 0.07 0.73
198 INT123075 Positive_regulation of Gene_expression of Cacna1c 1 0.05 0.73 0.73
199 INT59970 Positive_regulation of Binding of Edn1 2 0.40 1.11 0.71
200 INT28211 Positive_regulation of Localization of Tbxa2r 4 0.44 1.73 0.7
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