GO:0019695

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Name choline metabolic process
Categary Process
Go Slim No
Go Link GO:0019695
Unique Molecular Interactions 87
Total Molecular Interactions 119
Total Single Events 3778
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for choline metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for choline metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT54601 Binding of Mtor and Ache 1 0.20 0.8 1.58
2 INT251704 Ache Regulation of Gene_expression of Acot1 1 0.08 1.68 0.87
3 INT113250 Olr1259 Negative_regulation of Ache 1 0.01 0.38 0.83
4 INT46246 Tpsg1 Regulation of Ache 1 0.15 0.06 0.76
5 INT46247 Tpsg1 Regulation of Binding of Ache 1 0.15 0.06 0.76
6 INT18447 Binding of Ache and Chat 2 0.33 0.33 0.73
7 INT164476 Negative_regulation of Binding of Bche and Frl 1 0.02 0.48 0.51
8 INT164475 Binding of Bche and Frl 1 0.02 0.48 0.51
9 INT55639 Binding of Bche and Man2a2 1 0.02 0 0.45
10 INT132959 Binding of Chka and Trpv1 1 0.04 0 0.34
11 INT51630 Binding of ACHE and OPRM1 1 0.11 0 0.33
12 INT51628 Binding of ACHE and DRD3 1 0.15 0 0.33
13 INT31754 Prl Negative_regulation of Bche 1 0.35 0 0.32
14 INT31753 Prl Regulation of Bche 1 0.37 0 0.32
15 INT160225 Acot1 Negative_regulation of Ache 1 0.28 2.18 0.25
16 INT23626 Ache Regulation of Mir343 1 0.17 0 0.24
17 INT251665 LRP5 Negative_regulation of Ache 1 0.31 0.39 0.19
18 INT264101 Binding of CYP2D6 and Bche 1 0.07 0.33 0.18
19 INT70090 TGM1 Positive_regulation of Binding of Ache 1 0.03 0.59 0.15
20 INT141224 Ache Regulation of Acot1 1 0.09 0.29 0.14
21 INT27393 Tha1 Negative_regulation of Ache 1 0.15 0.24 0.14
22 INT42772 Penk Negative_regulation of Ache 1 0.06 0 0.14
23 INT210549 Binding of BCHE and Ache 1 0.01 0.82 0.12
24 INT235385 INCENP Negative_regulation of Bche 1 0.01 0.19 0.11
25 INT123101 Binding of APP and Ache 1 0.07 0.32 0.11
26 INT34497 Binding of Oprl1 and Ache 1 0.40 0 0.1
27 INT141223 Bche Regulation of Gene_expression of Acot1 1 0.09 0 0.1
28 INT141225 Bche Regulation of Acot1 1 0.09 0 0.1
29 INT233858 CHKA Positive_regulation of Gene_expression of CDKN1B 1 0.10 0.17 0.09
30 INT174104 Binding of HSPG2 and Ache 1 0.16 0.98 0.09
31 INT262714 ACOT1 Positive_regulation of Negative_regulation of ACHE 1 0.06 1.41 0.08
32 INT251712 Fig4 Regulation of Ache 1 0.02 0.23 0.08
33 INT251703 Fig4 Regulation of Localization of Ache 1 0.07 0.23 0.08
34 INT290158 Binding of Ache and Atp6v1e1 1 0.19 0 0.07
35 INT62030 Bche Regulation of Localization of CTSB 1 0.09 0.15 0.06
36 INT46677 H2-Q4 Negative_regulation of Bche 1 0.10 0.26 0.05
37 INT323392 SERPINH1 Negative_regulation of BCHE 1 0.02 0.52 0.04
38 INT330875 PLDN Negative_regulation of Gene_expression of Ache 1 0.01 0.85 0.03
39 INT251701 Bche Regulation of Gene_expression of Acot1 1 0.03 0.25 0.03
40 INT323395 Binding of BCHE and SERPINH1 1 0.02 0.74 0.03
41 INT46678 H2-Q4 Negative_regulation of Ache 1 0.10 0.12 0
42 INT307602 Binding of ACHE and LRP5 1 0.01 0.17 0
43 INT186689 Binding of ACHE and Edn1 1 0.28 0 0
44 INT225157 CDKN1A Regulation of CHKA 1 0.12 0.58 0
45 INT190492 Br Regulation of Ache 1 0.30 0.55 0
46 INT330876 PLDN Negative_regulation of Ache 1 0.01 0.45 0
47 INT262716 Binding of ACHE and BCHE 1 0.09 0.11 0
48 INT251702 Fig4 Regulation of Positive_regulation of Ache 1 0.07 0.42 0
49 INT50104 Bche Regulation of Localization of App 1 0.43 0.2 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for choline metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in choline metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4
2 INT1169 Negative_regulation of Bche 322 0.59 149.22 61.27
3 INT1079 Positive_regulation of Ache 104 0.70 23.52 30.28
4 INT2569 Gene_expression of Ache 120 0.78 26.29 26.89
5 INT276 Regulation of Ache 83 0.62 16.75 25.99
6 INT3060 Negative_regulation of Bche 94 0.59 46.75 18.51
7 INT1020 Negative_regulation of BCHE 109 0.59 44.86 16.4
8 INT19071 Localization of Ache 66 0.81 5.1 16.27
9 INT1752 Negative_regulation of Ache 109 0.59 42.05 15.73
10 INT1252 Binding of Ache 46 0.48 9.94 10.25
11 INT2976 Regulation of Bche 29 0.45 8.56 9.42
12 INT2597 Negative_regulation of ACHE 82 0.59 46.36 8.62
13 INT4060 Gene_expression of Bche 17 0.70 5.23 6.59
14 INT19072 Regulation of Gene_expression of Ache 14 0.62 2.74 5.29
15 INT20059 Protein_catabolism of Ache 15 0.98 3.73 4.87
16 INT10694 Binding of Bche 19 0.48 8.03 4.85
17 INT14502 Gene_expression of BCHE 40 0.67 18.52 4.6
18 INT1753 Gene_expression of Ache 38 0.78 15.31 4.58
19 INT11946 Transcription of Ache 18 0.69 2.62 4.13
20 INT3530 Regulation of BCHE 18 0.60 5.47 4.12
21 INT20455 Positive_regulation of Bche 15 0.59 7.22 3.7
22 INT8778 Regulation of Ache 17 0.62 3.7 3.57
23 INT28009 Positive_regulation of Gene_expression of Ache 15 0.70 5.46 3.26
24 INT55792 Regulation of Negative_regulation of Bche 11 0.57 1.78 3.21
25 INT8777 Positive_regulation of Ache 25 0.68 7.77 3.18
26 INT6063 Positive_regulation of Bche 17 0.66 6.07 3.08
27 INT22069 Positive_regulation of Localization of Ache 9 0.70 0.61 2.9
28 INT11892 Gene_expression of ACHE 10 0.68 1.32 2.63
29 INT1864 Regulation of Bche 18 0.47 6.18 2.44
30 INT27338 Regulation of ACHE 6 0.62 1.25 2.38
31 INT20263 Gene_expression of Chka 5 0.06 0.8 2.37
32 INT14890 Localization of ACHE 5 0.80 0.47 2.21
33 INT2570 Negative_regulation of Gene_expression of Ache 13 0.43 2.88 2.18
34 INT14503 Binding of BCHE 13 0.48 3.95 1.85
35 INT38201 Negative_regulation of Localization of Ache 8 0.59 2.35 1.82
36 INT38574 Binding of Ache 9 0.47 3.64 1.74
37 INT8757 Binding of ACHE 10 0.48 5.84 1.72
38 INT2847 Positive_regulation of Negative_regulation of Ache 8 0.49 1.09 1.65
39 INT14891 Positive_regulation of ACHE 10 0.70 5.37 1.64
40 INT98096 Positive_regulation of CHKA 14 0.42 12.23 1.61
41 INT19181 Gene_expression of Bche 35 0.68 16.93 1.52
42 INT18320 Positive_regulation of Chka 5 0.22 3.56 1.42
43 INT20279 Positive_regulation of Negative_regulation of Bche 5 0.50 1.41 1.41
44 INT8476 Binding of Bche 10 0.37 4.38 1.29
45 INT37849 Negative_regulation of Negative_regulation of Ache 3 0.43 0.8 1.19
46 INT29772 Positive_regulation of Positive_regulation of Ache 3 0.50 0.09 1.18
47 INT27366 Negative_regulation of Negative_regulation of Ache 4 0.43 0.29 1.12
48 INT47027 Positive_regulation of BCHE 6 0.50 2.32 1.09
49 INT186520 Gene_expression of CHKA 8 0.56 8.22 1
50 INT44201 Negative_regulation of Chka 4 0.58 0.88 1
51 INT110129 Regulation of Chka 1 0.61 0.35 0.98
52 INT153629 Negative_regulation of CHKA 3 0.12 2.33 0.92
53 INT144273 Negative_regulation of Binding of Bche 2 0.59 2.21 0.89
54 INT112520 Negative_regulation of Regulation of Ache 2 0.28 1.02 0.87
55 INT19070 Regulation of Localization of Ache 5 0.62 0.39 0.84
56 INT115362 Localization of Chka 2 0.45 0.71 0.78
57 INT48481 Negative_regulation of Binding of Ache 4 0.36 1.76 0.76
58 INT11944 Positive_regulation of Transcription of Ache 3 0.48 1.68 0.75
59 INT46245 Regulation of Binding of Ache 1 0.25 0.06 0.75
60 INT60826 Negative_regulation of Positive_regulation of Ache 3 0.50 0.68 0.73
61 INT204075 Regulation of Gene_expression of CHKA 3 0.20 3.74 0.63
62 INT310648 Negative_regulation of Negative_regulation of BCHE 2 0.27 1.79 0.59
63 INT135044 Regulation of Gene_expression of Ache 2 0.31 0.85 0.58
64 INT144394 Protein_catabolism of ACHE 1 0.89 0.24 0.53
65 INT74235 Localization of Bche 2 0.54 0.1 0.52
66 INT4387 Phosphorylation of Ache 3 0.79 1.15 0.5
67 INT79516 Positive_regulation of Gene_expression of Bche 3 0.50 1 0.47
68 INT323400 Localization of BCHE 1 0.66 1.87 0.46
69 INT39873 Negative_regulation of Gene_expression of Ache 2 0.59 1.56 0.43
70 INT18319 Transcription of Chka 1 0.04 0.09 0.43
71 INT86052 Regulation of Transcription of Ache 1 0.12 0 0.41
72 INT86053 Positive_regulation of Binding of Ache 2 0.43 0 0.4
73 INT204535 Positive_regulation of Binding of Bche 1 0.16 0.74 0.39
74 INT94218 Positive_regulation of Regulation of Ache 2 0.40 0 0.38
75 INT107637 Regulation of Localization of Bche 1 0.27 0.1 0.37
76 INT156984 Negative_regulation of Positive_regulation of Bche 1 0.07 0.2 0.37
77 INT8776 Negative_regulation of Positive_regulation of Ache 2 0.43 1.17 0.36
78 INT45360 Negative_regulation of Binding of Bche 1 0.37 0.27 0.36
79 INT271775 Positive_regulation of Gene_expression of Ache 3 0.69 5.16 0.34
80 INT132957 Positive_regulation of Binding of Chka 1 0.05 0 0.34
81 INT132958 Binding of Chka 1 0.04 0 0.34
82 INT47026 Positive_regulation of Gene_expression of BCHE 1 0.44 0.23 0.34
83 INT186521 Regulation of CHKA 3 0.37 0.69 0.29
84 INT255780 Negative_regulation of Negative_regulation of ACHE 2 0.43 1.28 0.24
85 INT48022 Protein_catabolism of BCHE 1 0.87 0 0.24
86 INT15483 Protein_catabolism of Bche 2 0.86 0 0.23
87 INT174101 Protein_catabolism of Ache 3 0.66 2.45 0.22
88 INT353827 Protein_catabolism of Bche 1 0.05 0 0.2
89 INT1255 Regulation of Binding of Ache 1 0.02 0 0.19
90 INT127535 Transcription of Bche 2 0.67 1.16 0.17
91 INT35620 Positive_regulation of Negative_regulation of ACHE 1 0.48 0 0.17
92 INT147953 Positive_regulation of Positive_regulation of Ache 2 0.46 0.08 0.16
93 INT251700 Positive_regulation of Protein_catabolism of Ache 1 0.46 0.44 0.14
94 INT7652 Localization of Ache 2 0.80 0 0.13
95 INT52420 Negative_regulation of Protein_catabolism of Ache 1 0.04 0.44 0.12
96 INT270427 Negative_regulation of Binding of ACHE 2 0.42 1.82 0.11
97 INT52411 Regulation of Negative_regulation of Bche 3 0.20 1.47 0.1
98 INT224235 Negative_regulation of Positive_regulation of CHKA 1 0.14 3.61 0.09
99 INT4388 Negative_regulation of Phosphorylation of Ache 1 0.37 0.07 0.09
100 INT186574 Negative_regulation of Gene_expression of ACHE 1 0.37 0.51 0.08
101 INT281418 Regulation of Negative_regulation of Ache 2 0.43 1.15 0.07
102 INT63966 Negative_regulation of Gene_expression of BCHE 1 0.43 0 0.07
103 INT271774 Regulation of Positive_regulation of Ache 1 0.27 0 0.06
104 INT210526 Phosphorylation of Ache 1 0.21 0.29 0.05
105 INT264054 Negative_regulation of Negative_regulation of Bche 6 0.41 2.49 0.04
106 INT216263 Regulation of Gene_expression of BCHE 1 0.44 0.6 0.04
107 INT246310 Regulation of Negative_regulation of Ache 1 0.27 0 0.04
108 INT264096 Negative_regulation of Binding of Ache 1 0.20 0.78 0.03
109 INT251698 Regulation of Regulation of Ache 1 0.60 0.26 0.03
110 INT74052 Localization of Bche 2 0.36 0.51 0
111 INT220701 Regulation of Negative_regulation of ACHE 2 0.25 1.06 0
112 INT282107 Negative_regulation of Transcription of Bche 1 0.41 0.19 0
113 INT307610 Positive_regulation of Phosphorylation of ACHE 1 0.08 0.2 0
114 INT19017 Negative_regulation of Positive_regulation of ACHE 1 0.42 0.09 0
115 INT282106 Regulation of Transcription of Bche 1 0.44 0.63 0
116 INT190489 Positive_regulation of Binding of Ache 1 0.46 0.2 0
117 INT233870 Positive_regulation of Gene_expression of CHKA 1 0.09 0.5 0
118 INT287536 Positive_regulation of Negative_regulation of BCHE 1 0.04 0.58 0
119 INT186519 Localization of CHKA 1 0.67 3.57 0
120 INT246099 Negative_regulation of Negative_regulation of Bche 1 0.31 0.66 0
121 INT201682 Protein_catabolism of CHKA 1 0.05 0.82 0
122 INT201684 Negative_regulation of Gene_expression of CHKA 1 0.03 0.33 0
123 INT997 Phosphorylation of Bche 1 0.53 0.17 0
124 INT307614 Phosphorylation of ACHE 1 0.14 0.2 0
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