GO:0019722

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Name calcium-mediated signaling
Categary Process
Go Slim No
Go Link GO:0019722
Unique Molecular Interactions 1848
Total Molecular Interactions 2630
Total Single Events 23649
Pain Genes Associated 62

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for calcium-mediated signaling. They are ordered first by their pain relevance and then by number of times they were reported for calcium-mediated signaling. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT254001 Binding of Cxcr4 and Mif 1 0.52 14.17 7.18
2 INT139706 Tnf Positive_regulation of Ltp 1 0.03 2.61 4.63
3 INT7022 Drd1a Positive_regulation of Npr1 6 0.05 0.26 4.32
4 INT182194 Binding of IL8 and CXCR2 10 0.56 7.14 4.16
5 INT136514 Binding of Grm1 and Grm5 4 0.12 1.8 3.9
6 INT61359 TNF Positive_regulation of NFKB1 11 0.63 6.66 3.89
7 INT113080 Drd1a Positive_regulation of Phosphorylation of Creb1 2 0.27 0.43 3.88
8 INT181455 Binding of Ccr5 and Ccl5 11 0.39 12.13 3.66
9 INT121651 Binding of CXCL12 and CXCR4 13 0.48 17.61 3.52
10 INT87491 CALCA Positive_regulation of Gene_expression of IL8 1 0.72 0.92 3.52
11 INT180984 IRF6 Positive_regulation of Localization of IL8 7 0.11 2.13 3.47
12 INT146412 Tnf Positive_regulation of Gene_expression of Trpv1 2 0.66 5.22 3.22
13 INT166134 Binding of Cxcl12 and Cxcr4 3 0.49 5.69 3.17
14 INT208572 Binding of IL8 and CXCR1 6 0.33 5.2 3.08
15 INT182635 Binding of CCR5 and CCL5 2 0.09 4.19 3
16 INT73821 CALCA Positive_regulation of Localization of IL8 1 0.25 2.37 2.91
17 INT140024 Tnf Positive_regulation of Gene_expression of Il1b 2 0.49 2.75 2.61
18 INT152501 Binding of Tnf and Tnfrsf1a 4 0.31 3 2.58
19 INT151826 Tnf Positive_regulation of TNF 1 0.04 3.38 2.51
20 INT107322 Positive_regulation of TRPV1 Positive_regulation of Localization of IL8 3 0.13 1.64 2.5
21 INT117532 SETBP1 Positive_regulation of Gene_expression of TNF 1 0.54 0.85 2.44
22 INT122163 Binding of TNF and TNFRSF1B 6 0.44 6.06 2.41
23 INT61733 Tlr4 Positive_regulation of Gene_expression of Tnf 3 0.26 1.99 2.36
24 INT139705 Negative_regulation of Tnf Positive_regulation of Ltp 1 0.03 1.19 2.3
25 INT279361 Binding of TNF and KLF1 4 0.00 3.72 2.19
26 INT94491 Il1b Positive_regulation of Gene_expression of Tnf 1 0.25 3.81 2.19
27 INT94504 Il6 Positive_regulation of Gene_expression of Tnf 1 0.30 3.8 2.19
28 INT86179 TNF Positive_regulation of Localization of IL6 5 0.35 1.66 2.17
29 INT77807 Edn1 Positive_regulation of Gene_expression of Ptgs2 1 0.33 0.53 2.1
30 INT148704 Binding of TNF and TNFRSF1A 5 0.44 3.3 2.09
31 INT196586 Negative_regulation of Mapk14 Negative_regulation of TNF 2 0.04 2.02 2.08
32 INT140032 Tnf Positive_regulation of Gene_expression of Ifng 2 0.43 2.23 2
33 INT140026 Il1b Positive_regulation of Gene_expression of Tnf 2 0.49 2.23 2
34 INT217042 IRF6 Positive_regulation of TNF 4 0.27 3.03 1.95
35 INT129212 RYBP Positive_regulation of Tnf 2 0.03 1.9 1.95
36 INT279359 Binding of ADA and TNF 1 0.20 2.61 1.91
37 INT91607 Binding of EDN1 and POMC 1 0.12 0 1.9
38 INT201940 Binding of IL8 and CXCL10 2 0.28 2.46 1.86
39 INT7023 Negative_regulation of Drd1a Positive_regulation of Npr1 2 0.05 0.1 1.81
40 INT199287 TNF Positive_regulation of Transcription of Oprm1 2 0.02 1.86 1.8
41 INT224432 TNF Positive_regulation of Gene_expression of VEGFA 1 0.13 5.83 1.8
42 INT66504 Binding of Agt and Agtr1a 8 0.39 3.78 1.78
43 INT137207 Tnf Positive_regulation of Nfkb1 3 0.23 2.69 1.71
44 INT167427 Mapk8 Regulation of Regulation of Tnf 1 0.26 2.83 1.7
45 INT70148 Drd1a Positive_regulation of Localization of Acot1 1 0.14 0 1.7
46 INT89379 TNF Positive_regulation of Gene_expression of IL6 5 0.50 4.37 1.69
47 INT79778 Tlr4 Positive_regulation of Localization of TNF 4 0.08 4.21 1.61
48 INT167202 TNF Regulation of Gene_expression of Ngf 1 0.10 1.47 1.6
49 INT209853 TNF Regulation of Gene_expression of CD36 1 0.61 3.41 1.59
50 INT266767 SFTPA1 Positive_regulation of Gene_expression of TNF 1 0.01 1.69 1.59
51 INT136034 Edn1 Regulation of Trpv1 2 0.66 0.39 1.58
52 INT198653 TNF Positive_regulation of MIF 1 0.15 3.81 1.55
53 INT252633 Binding of TNF and Tnfrsf1b 4 0.05 3.66 1.54
54 INT151849 IL10 Negative_regulation of Gene_expression of IL8 4 0.14 3.26 1.54
55 INT167201 Gtf3a Regulation of TNF 1 0.01 1.39 1.52
56 INT158775 Regulation of Tnf Regulation of Ephb1 1 0.18 0.09 1.52
57 INT158777 Tnf Regulation of Ephb1 1 0.18 0.09 1.51
58 INT260897 CRH Positive_regulation of Localization of IL8 1 0.24 0.09 1.51
59 INT140029 Ifng Positive_regulation of Gene_expression of Tnf 1 0.43 1.69 1.5
60 INT174450 Positive_regulation of Binding of Cxcr3 and Smcp 1 0.18 2.83 1.49
61 INT293013 IL8 Positive_regulation of Positive_regulation of CA2 1 0.12 0.66 1.49
62 INT222185 Binding of Ccr1 and Ccl3 4 0.23 2.7 1.47
63 INT285569 TNF Negative_regulation of Gene_expression of Il6 1 0.03 2.83 1.46
64 INT72755 Tap1 Negative_regulation of TNF 1 0.43 2.45 1.46
65 INT150682 Pomc Regulation of Gene_expression of Eif2ak3 1 0.37 0.17 1.44
66 INT238005 Binding of Cxcr3 and Cxcl10 2 0.38 3.73 1.42
67 INT131156 Binding of RUNX1 and TNF 2 0.03 3.44 1.42
68 INT238009 Binding of Cxcr3 and Cxcl9 3 0.40 4.01 1.37
69 INT161513 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Tnf 1 0.33 0.27 1.35
70 INT160588 TNF Positive_regulation of Gene_expression of OPRM1 1 0.20 0.54 1.35
71 INT261463 Binding of Drd1a and Sftpd 1 0.12 0.13 1.35
72 INT56087 TNF Regulation of Gene_expression of SERPINE1 1 0.43 1.67 1.33
73 INT95275 Binding of Edn1 and Ece1 1 0.32 2.09 1.3
74 INT95274 Regulation of Binding of Edn1 and Ece1 1 0.39 2.09 1.3
75 INT186393 Binding of TNF and Tnfrsf1a 9 0.37 8.55 1.29
76 INT130333 FUT3 Negative_regulation of Positive_regulation of Tnf 1 0.01 0.36 1.29
77 INT70037 TNF Regulation of IL10 2 0.09 2.11 1.26
78 INT296796 Tbrs1 Positive_regulation of Gene_expression of TNF 1 0.00 1.58 1.26
79 INT136249 Drd1a Positive_regulation of Phosphorylation of Tff3 1 0.01 0.18 1.23
80 INT197092 TNF Regulation of VEGFA 4 0.21 2.78 1.22
81 INT131195 Creb1 Positive_regulation of Positive_regulation of Drd1a 2 0.27 0.61 1.22
82 INT77806 Edn1 Regulation of Gene_expression of Ptgs2 1 0.29 1.24 1.22
83 INT62596 Binding of Edn1 and Nppa 1 0.27 1.77 1.22
84 INT131807 Bpifa2 Positive_regulation of Localization of Tnf 1 0.32 2.09 1.22
85 INT70035 TNF Regulation of Negative_regulation of PRF1 1 0.05 1.42 1.21
86 INT70032 TNF Regulation of PRF1 1 0.05 1.42 1.21
87 INT70040 TNF Regulation of Negative_regulation of IL10 1 0.09 1.42 1.21
88 INT328743 TNF Positive_regulation of Mapk14 1 0.04 1.4 1.21
89 INT194619 Il15 Positive_regulation of Gene_expression of TNF 1 0.24 2.23 1.2
90 INT133046 TNF Positive_regulation of Positive_regulation of NFKB1 5 0.54 3.23 1.19
91 INT113242 TNF Regulation of Transcription of OPRM1 2 0.45 1.53 1.19
92 INT201067 Binding of Edn1 and Ednra 2 0.18 1.36 1.18
93 INT314196 Ngf Positive_regulation of Tnf 1 0.50 1.98 1.18
94 INT231769 TNF Negative_regulation of Gene_expression of HMOX1 1 0.26 4.75 1.15
95 INT7024 Regulation of Drd1a Positive_regulation of Npr1 1 0.04 0.07 1.13
96 INT72754 Adamts7 Negative_regulation of TNF 1 0.28 1.64 1.13
97 INT89938 Tlr4 Positive_regulation of Gene_expression of TNF 6 0.25 1.3 1.12
98 INT83616 Binding of IL6 and IL8 5 0.09 5.8 1.11
99 INT237999 Binding of Cxcr3 and Cxcl11 2 0.45 3.49 1.11
100 INT212280 Vsnl1 Negative_regulation of Ltp 1 0.00 0.72 1.11
101 INT107264 Binding of TNF and NCR3 1 0.30 1.42 1.1
102 INT139704 Tnf Positive_regulation of Mapk14 1 0.22 0.73 1.1
103 INT107266 Binding of HLA-DRB1 and TNF 1 0.29 1.41 1.1
104 INT267597 IL10 Negative_regulation of Gene_expression of TNF 1 0.03 2.24 1.1
105 INT74185 Cck Negative_regulation of Drd1a 1 0.30 0.1 1.1
106 INT107267 Binding of HLA-A and TNF 1 0.34 1.41 1.1
107 INT94495 Tnf Positive_regulation of Gene_expression of Il6 1 0.30 1.9 1.09
108 INT151825 Tnf Positive_regulation of Mapk14 1 0.22 1.72 1.09
109 INT94500 Tnf Positive_regulation of Gene_expression of Il1b 1 0.25 1.9 1.09
110 INT139703 Tnf Positive_regulation of Mapk8 1 0.32 0.73 1.08
111 INT152502 Tnf Negative_regulation of Binding of Tnfrsf1a 1 0.37 0.6 1.08
112 INT119108 Binding of LTBR and TNF 2 0.15 1.47 1.07
113 INT212281 Vsnl1 Regulation of Ltp 1 0.00 1.32 1.07
114 INT114364 Hmgb1 Positive_regulation of Gene_expression of TNF 2 0.05 1.85 1.06
115 INT10238 Binding of EDN1 and Calca 1 0.00 1.07 1.06
116 INT120312 Ghrh Regulation of Tnf 1 0.26 0.95 1.05
117 INT120314 Ghrh Regulation of Positive_regulation of Tnf 1 0.43 0.95 1.05
118 INT152504 Binding of CR1 and Tnf 1 0.00 0.49 1.04
119 INT133650 Epo Negative_regulation of TNF 1 0.35 2.7 1.04
120 INT181450 Binding of Ccr5 and Ccl3 4 0.18 2.19 1.03
121 INT156245 NFKB1 Positive_regulation of Regulation of TNF 1 0.45 0.76 1.03
122 INT175553 Binding of CASR and CP 1 0.11 1.65 1.03
123 INT81545 Tnf Positive_regulation of Gtf3a 2 0.03 1.41 1.02
124 INT101381 POMC Regulation of Localization of IL8 1 0.28 1.49 1.02
125 INT352295 Binding of P2RY2 and Agtr1a 1 0.01 0.08 1.02
126 INT293008 IL8 Positive_regulation of Localization of CA2 1 0.11 0.71 1.01
127 INT7025 Positive_regulation of Drd1a Positive_regulation of Npr1 1 0.04 0.08 1.01
128 INT174451 Trav6-3 Regulation of Transcription of Cxcr3 1 0.06 1.86 1
129 INT278946 IL6 Regulation of Gene_expression of IL8 1 0.20 1.9 1
130 INT308804 Pld1 Positive_regulation of TNF 1 0.05 2.42 0.99
131 INT274895 Positive_regulation of Cbr2 Negative_regulation of Gene_expression of TNF 1 0.06 1.21 0.99
132 INT103651 IL1B Positive_regulation of Gene_expression of IL8 6 0.78 1.23 0.98
133 INT103796 IL1B Positive_regulation of Gene_expression of SELE 2 0.08 1 0.98
134 INT129216 Negative_regulation of RYBP Positive_regulation of Tnf 1 0.01 1.24 0.98
135 INT106248 Binding of CCR5 and YY1 1 0.54 0.19 0.98
136 INT311102 IL8 Positive_regulation of CXCR7 1 0.00 1.74 0.98
137 INT182022 TNF Positive_regulation of Gene_expression of Tnfrsf11b 1 0.06 1.56 0.98
138 INT311143 IL8 Positive_regulation of Cxcr1 1 0.04 1.74 0.98
139 INT209852 TNF Negative_regulation of Gene_expression of CD36 1 0.43 0.61 0.98
140 INT154255 Tnf Positive_regulation of IL1B 1 0.54 0.94 0.97
141 INT154254 Tnf Positive_regulation of Il6 1 0.36 0.94 0.97
142 INT275406 Binding of ITIH4 and Ccr5 1 0.09 2.88 0.97
143 INT275390 Binding of Ccr5 and Htatsf1 1 0.01 3.26 0.97
144 INT114320 TNF Positive_regulation of Gene_expression of Il6 1 0.07 1.73 0.97
145 INT275409 Binding of ITIH4 and Cxcr4 1 0.09 2.87 0.97
146 INT275386 Binding of Cxcr4 and Htatsf1 1 0.01 3.25 0.97
147 INT103133 TNF Positive_regulation of Gene_expression of IL8 2 0.48 1.26 0.96
148 INT278940 LEP Positive_regulation of Gene_expression of IL8 1 0.34 1.68 0.96
149 INT152084 Edn1 Negative_regulation of Positive_regulation of Trpv1 1 0.62 0.48 0.96
150 INT133652 Epo Negative_regulation of Gene_expression of TNF 1 0.35 2.64 0.96
151 INT87854 Binding of Drd1a and Positive_regulation of Localization of Abat 1 0.08 0 0.96
152 INT171264 TNF Positive_regulation of MMP1 2 0.10 2.05 0.95
153 INT188805 TNF Positive_regulation of Gene_expression of Crp 1 0.15 2.96 0.95
154 INT74184 Cck Regulation of Localization of Drd1a 1 0.32 0.06 0.95
155 INT182190 Binding of IL8 and CXCR4 1 0.26 1.25 0.95
156 INT136033 Edn1 Positive_regulation of Trpv1 1 0.50 0.34 0.95
157 INT182210 Binding of CXCR4 and CXCL13 1 0.32 1.25 0.95
158 INT100018 TNF Positive_regulation of MAPK1 3 0.24 1.56 0.94
159 INT133050 TNF Positive_regulation of Gene_expression of ICAM1 3 0.67 1.91 0.94
160 INT77859 EDN1 Positive_regulation of MC1R 2 0.64 0.34 0.94
161 INT299988 IL6 Positive_regulation of Localization of IL8 1 0.05 0.81 0.94
162 INT182206 Binding of CXCR5 and IL8 1 0.30 1.25 0.94
163 INT182024 TNF Positive_regulation of Gene_expression of Il6 1 0.05 1.58 0.94
164 INT129211 RYBP Positive_regulation of Gene_expression of Tnf 1 0.01 1.04 0.94
165 INT182205 Binding of CXCL5 and CXCR4 1 0.29 1.24 0.94
166 INT182195 Binding of CXCL1 and CXCR4 1 0.13 1.25 0.94
167 INT126766 Binding of PTGDS and PTGDR2 4 0.40 1.62 0.93
168 INT182196 Binding of IL8 and CXCL13 1 0.27 1.24 0.93
169 INT155259 RUNX1 Negative_regulation of Tnf 1 0.00 1.48 0.93
170 INT128652 ITIH4 Regulation of Gene_expression of CCR5 1 0.36 1.46 0.93
171 INT215650 Binding of Adora1 and Drd1a 2 0.39 0.54 0.92
172 INT250976 Binding of FMOD and IL8 1 0.08 1.26 0.91
173 INT165280 Tnf Positive_regulation of Gene_expression of Nos2 1 0.24 1.02 0.91
174 INT254242 TNF Positive_regulation of Gene_expression of DKK1 1 0.14 1.24 0.91
175 INT166135 Regulation of Binding of Cxcl12 and Cxcr4 1 0.30 0.9 0.91
176 INT136172 NPY Negative_regulation of Positive_regulation of Drd1a 1 0.21 0 0.91
177 INT221386 Tlr4 Positive_regulation of Gene_expression of IL8 6 0.14 3.53 0.9
178 INT7292 Binding of Drd1a and Penk 1 0.14 0 0.9
179 INT256646 Tnf Positive_regulation of Positive_regulation of Nfkb1 1 0.22 1.83 0.9
180 INT52760 Oprd1 Regulation of Drd1a 1 0.02 0 0.9
181 INT222988 TNF Positive_regulation of Protein_catabolism of COL1A1 1 0.01 1.66 0.9
182 INT211128 Binding of P4HB and TNF 1 0.09 0.97 0.9
183 INT211129 Negative_regulation of Binding of P4HB and TNF 1 0.10 0.97 0.9
184 INT120147 Tlr4 Positive_regulation of Tnf 3 0.39 2.14 0.89
185 INT80132 Binding of HLA-B and TNF 1 0.04 1.15 0.89
186 INT52762 Dll1 Regulation of Drd1a 1 0.10 0 0.89
187 INT142278 Slc8a1 Regulation of Tnf 1 0.14 0.07 0.89
188 INT167466 Ccdc80 Negative_regulation of Tnf 1 0.01 0.76 0.88
189 INT149559 Tgfb1 Positive_regulation of Gene_expression of Ccr5 1 0.00 0 0.88
190 INT134311 Tnf Positive_regulation of Protein_catabolism of Nfkbia 1 0.18 0.57 0.88
191 INT62956 CXCR2 Positive_regulation of IL8 1 0.30 0 0.88
192 INT149560 Tgfb1 Positive_regulation of Ccr5 1 0.00 0 0.88
193 INT116556 Olr1627 Negative_regulation of Regulation of Tnf 1 0.01 1.52 0.87
194 INT97795 IRF6 Positive_regulation of Localization of TNF 3 0.09 1.57 0.86
195 INT254004 Cxcl12 Positive_regulation of Cxcr4 1 0.47 1.29 0.86
196 INT152868 Tnf Regulation of Gene_expression of Trpv1 1 0.27 0.25 0.86
197 INT222243 Negative_regulation of Binding of Trpv1 and Ccr5 1 0.21 0.57 0.86
198 INT222244 Binding of Trpv1 and Ccr5 1 0.19 0.57 0.86
199 INT186672 IL8 Positive_regulation of Transcription of PTH 1 0.01 1.83 0.85
200 INT110315 Negative_regulation of ALOX5 Negative_regulation of Gene_expression of TNF 1 0.47 0.74 0.85

Single Events

The table below shows the top 100 pain related interactions that have been reported for calcium-mediated signaling. They are ordered first by their pain relevance and then by number of times they were reported in calcium-mediated signaling. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82
2 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98
3 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81
4 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68
5 INT6852 Localization of TNF 883 0.81 705.95 270.84
6 INT10832 Gene_expression of IL8 1050 0.78 698.72 270
7 INT6481 Binding of TNF 624 0.48 510.2 214.82
8 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210
9 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58
10 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1
11 INT9660 Regulation of TNF 363 0.62 312.94 139.99
12 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61
13 INT12339 Localization of IL8 437 0.81 251.87 117.39
14 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62
15 INT10166 Localization of Tnf 237 0.81 153.95 88.64
16 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99
17 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71
18 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54
19 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34
20 INT6489 Positive_regulation of Gene_expression of Tnf 140 0.70 92.31 67.85
21 INT6486 Positive_regulation of Tnf 168 0.70 123.47 66.05
22 INT52800 Negative_regulation of Gene_expression of Tnf 142 0.59 92.27 55.47
23 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18
24 INT5858 Positive_regulation of Drd1a 66 0.69 4.51 51.73
25 INT66029 Negative_regulation of Tnf 100 0.59 84.28 48.16
26 INT55670 Negative_regulation of Gene_expression of Tnf 83 0.59 57.16 46.33
27 INT5781 Gene_expression of Edn1 190 0.78 99.1 46
28 INT5307 Regulation of Tnf 87 0.62 78.71 43.4
29 INT13354 Transcription of TNF 108 0.72 85.81 42.32
30 INT88322 Gene_expression of CCR5 111 0.78 77.36 39.84
31 INT48222 Positive_regulation of Localization of IL8 123 0.59 78.04 37.2
32 INT168410 Gene_expression of Cxcr3 81 0.75 84.03 37.01
33 INT53577 Negative_regulation of Localization of TNF 110 0.59 59.28 35.23
34 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19
35 INT88318 Gene_expression of CXCR4 208 0.77 189.67 31.72
36 INT35406 Localization of Tnf 94 0.81 64.63 31.65
37 INT77652 Negative_regulation of Gene_expression of IL8 99 0.59 67.57 30.21
38 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43
39 INT52801 Regulation of Gene_expression of Tnf 55 0.62 48.74 26.59
40 INT10836 Negative_regulation of IL8 95 0.59 52.59 24.71
41 INT13334 Gene_expression of Drd1a 43 0.62 7.73 24.43
42 INT10835 Regulation of IL8 79 0.49 53.04 24.14
43 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07
44 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8
45 INT13838 Positive_regulation of Drd1a 48 0.70 9.83 23.42
46 INT49196 Gene_expression of SELE 105 0.78 107.29 22.92
47 INT66753 Negative_regulation of Positive_regulation of Tnf 45 0.59 35.28 22.33
48 INT96741 Gene_expression of Cxcr4 62 0.78 32.3 22.14
49 INT8483 Positive_regulation of Positive_regulation of TNF 73 0.67 60.35 22.03
50 INT52106 Negative_regulation of Localization of IL8 57 0.52 22.81 20.8
51 INT53575 Regulation of Gene_expression of Tnf 46 0.62 34.35 20.63
52 INT53574 Regulation of Tnf 45 0.62 40.68 19.71
53 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59
54 INT66751 Negative_regulation of Localization of Tnf 48 0.59 26 19.36
55 INT5048 Binding of Edn1 55 0.47 18.86 19.16
56 INT66755 Transcription of Tnf 45 0.72 37.1 19.11
57 INT7680 Regulation of Drd1a 27 0.45 4.52 18.86
58 INT10833 Regulation of Gene_expression of IL8 68 0.62 38.74 18.46
59 INT167679 Gene_expression of Ccr5 74 0.75 59.03 18.16
60 INT71680 Gene_expression of CCL3 43 0.75 33.7 18.01
61 INT51779 Gene_expression of Drd1a 46 0.66 11.18 17.51
62 INT7020 Negative_regulation of Drd1a 25 0.57 1.84 17.1
63 INT48055 Gene_expression of Grm1 27 0.78 14.29 17.01
64 INT24225 Gene_expression of Alms1 93 0.62 52.75 16.93
65 INT10169 Positive_regulation of Localization of Tnf 44 0.70 27.71 16.75
66 INT10834 Binding of IL8 65 0.48 41.66 16.53
67 INT19929 Negative_regulation of Positive_regulation of TNF 52 0.59 38.16 16.51
68 INT49986 Transcription of Tnf 25 0.72 18.3 16.22
69 INT52107 Transcription of IL8 63 0.72 41.66 16.06
70 INT5859 Positive_regulation of Positive_regulation of Drd1a 20 0.55 2.05 15.61
71 INT12087 Regulation of Localization of TNF 44 0.62 28.71 15.17
72 INT89293 Positive_regulation of Gene_expression of CCR5 29 0.70 22.14 15
73 INT9191 Localization of EDN1 94 0.81 57.01 14.78
74 INT109031 Positive_regulation of Eif2ak3 44 0.69 21.11 14.72
75 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42
76 INT10173 Binding of Tnf 45 0.48 35.6 14.32
77 INT109034 Gene_expression of Eif2ak3 37 0.77 17.11 14.19
78 INT5806 Regulation of Edn1 63 0.62 23.46 13.88
79 INT6365 Localization of Edn1 56 0.81 18.84 13.83
80 INT36177 Binding of Alms1 70 0.31 35.47 13.81
81 INT79703 Gene_expression of Agtr1a 46 0.76 14.18 13.77
82 INT64048 Positive_regulation of Positive_regulation of Tnf 32 0.70 21.24 13.74
83 INT5207 Negative_regulation of Alms1 70 0.41 41.56 13.68
84 INT6478 Negative_regulation of Binding of TNF 36 0.58 30.42 13.31
85 INT20376 Gene_expression of Ccl3 39 0.75 45.42 13.15
86 INT89404 Regulation of Negative_regulation of TNF 30 0.45 24.47 12.71
87 INT21979 Negative_regulation of EDN1 52 0.58 24.65 12.55
88 INT35801 Regulation of Alms1 34 0.38 20.88 12.38
89 INT7682 Binding of Drd1a 22 0.48 1.8 11.83
90 INT53038 Positive_regulation of Agtr1a 35 0.67 23.76 11.68
91 INT100919 Positive_regulation of Grm1 21 0.70 7.82 11.55
92 INT51265 Phosphorylation of TNF 32 0.81 25.33 10.75
93 INT128364 Positive_regulation of Ccl3 20 0.70 23.96 10.65
94 INT60434 Negative_regulation of Positive_regulation of Tnf 20 0.46 10.01 10.64
95 INT87393 Gene_expression of Ccr5 19 0.65 11 10.51
96 INT99784 Positive_regulation of Cxcr3 22 0.66 22.44 10.36
97 INT10982 Negative_regulation of Agtr1a 42 0.58 22.42 10.29
98 INT10184 Regulation of EDN1 44 0.62 23.78 10.06
99 INT82769 Positive_regulation of Grm1 20 0.00 7.78 9.82
100 INT80110 Regulation of Positive_regulation of TNF 34 0.44 25.79 9.78
101 INT6361 Localization of Edn1 30 0.81 19.09 9.7
102 INT149069 Positive_regulation of Cxcr4 24 0.68 12.21 9.54
103 INT150678 Positive_regulation of Gene_expression of Eif2ak3 17 0.69 6.64 8.99
104 INT17101 Positive_regulation of Gene_expression of Edn1 24 0.69 24.9 8.86
105 INT12095 Negative_regulation of Edn1 26 0.59 12.01 8.79
106 INT48860 Regulation of Localization of Tnf 25 0.61 20.68 8.78
107 INT89292 Positive_regulation of CCR5 27 0.70 15.12 8.59
108 INT53573 Negative_regulation of Localization of Tnf 19 0.59 11.57 8.54
109 INT103845 Gene_expression of Cxcr3 13 0.60 10.65 8.5
110 INT10237 Binding of EDN1 40 0.48 16 8.48
111 INT16735 Localization of Drd1a 11 0.61 0.35 8.42
112 INT174422 Binding of Cxcr3 24 0.47 26.09 8.34
113 INT95414 Positive_regulation of Alms1 40 0.41 20.3 8.1
114 INT86411 Negative_regulation of Negative_regulation of TNF 24 0.42 17.6 7.89
115 INT10899 Positive_regulation of Gene_expression of Edn1 32 0.70 24.88 7.65
116 INT49490 Positive_regulation of Transcription of TNF 19 0.70 14.76 7.58
117 INT68299 Binding of Tnf 17 0.39 12.55 7.49
118 INT174432 Transcription of Cxcr3 8 0.68 15.73 7.32
119 INT83006 Gene_expression of AGTR1 59 0.75 54.46 7.27
120 INT66752 Positive_regulation of Transcription of Tnf 15 0.68 10.86 7.26
121 INT10104 Negative_regulation of Edn1 43 0.59 15.63 7.2
122 INT10478 Protein_catabolism of Alms1 25 0.47 12.95 7.19
123 INT153271 Localization of Ccl3 7 0.81 11.29 7.14
124 INT91758 Binding of CCR5 28 0.45 20.16 7.07
125 INT153268 Positive_regulation of Ccr5 25 0.66 19 7.02
126 INT22369 Negative_regulation of Drd1a 15 0.47 6.13 6.87
127 INT117186 Positive_regulation of CXCR4 29 0.69 24.19 6.84
128 INT94649 Gene_expression of Grm1 19 0.77 5.11 6.58
129 INT69985 Positive_regulation of Negative_regulation of TNF 21 0.50 13.26 6.31
130 INT107315 Negative_regulation of CCR5 22 0.57 13.82 6.11
131 INT172084 Positive_regulation of Binding of TNF 21 0.50 15.31 6.06
132 INT36757 Gene_expression of Eif2ak3 4 0.74 0.15 6.06
133 INT75832 Positive_regulation of Positive_regulation of IL8 30 0.70 20.77 6.05
134 INT21552 Regulation of Drd1a 10 0.57 3.7 6.05
135 INT126481 Gene_expression of Cxcr4 69 0.77 34.99 6
136 INT74422 Regulation of Localization of IL8 21 0.62 10.19 5.99
137 INT253974 Binding of Cxcr4 22 0.47 12.26 5.95
138 INT120089 Negative_regulation of Ccr5 7 0.58 10.36 5.91
139 INT67060 Negative_regulation of Transcription of TNF 17 0.59 12.94 5.88
140 INT117189 Binding of CXCR4 34 0.37 24.27 5.81
141 INT103847 Positive_regulation of Ccr5 11 0.55 6.04 5.79
142 INT181406 Binding of Ccr5 16 0.45 17 5.78
143 INT96744 Positive_regulation of Gene_expression of Cxcr4 14 0.68 7.92 5.75
144 INT6487 Positive_regulation of Positive_regulation of Tnf 21 0.56 16.06 5.64
145 INT75833 Negative_regulation of Positive_regulation of IL8 15 0.53 6.69 5.59
146 INT18366 Negative_regulation of Positive_regulation of Drd1a 6 0.42 0.49 5.54
147 INT58145 Positive_regulation of Localization of Tnf 20 0.67 13.33 5.44
148 INT113153 Regulation of Grm1 6 0.44 4.11 5.41
149 INT113112 Negative_regulation of CXCR4 39 0.58 28.28 5.36
150 INT102891 Positive_regulation of AGTR1 31 0.67 30.57 5.29
151 INT62525 Positive_regulation of SELE 38 0.70 46 5.25
152 INT27805 Regulation of Avpr1a 5 0.60 3.11 5.19
153 INT107386 Negative_regulation of AGTR1 37 0.55 35.94 5.15
154 INT62832 Negative_regulation of Gene_expression of SELE 16 0.49 10.6 5.12
155 INT92054 Positive_regulation of Transcription of Tnf 8 0.50 4.93 5.05
156 INT75831 Positive_regulation of Transcription of IL8 21 0.63 13.56 4.98
157 INT62822 Positive_regulation of Gene_expression of SELE 22 0.66 28.04 4.97
158 INT101925 Binding of Drd1a 9 0.43 1.82 4.97
159 INT100920 Positive_regulation of Gene_expression of Grm1 7 0.70 5.88 4.87
160 INT91055 Negative_regulation of Grm1 7 0.45 5.14 4.87
161 INT166878 Regulation of Ccl3 9 0.44 8.21 4.81
162 INT137336 Phosphorylation of Eif2ak3 14 0.79 4.72 4.78
163 INT55698 Regulation of Binding of TNF 13 0.44 8.98 4.74
164 INT17803 Regulation of Edn1 14 0.54 4.75 4.71
165 INT153269 Binding of Ccl3 10 0.48 8.87 4.69
166 INT174427 Positive_regulation of Gene_expression of Cxcr3 8 0.66 10.7 4.66
167 INT48567 Transcription of Drd1a 7 0.51 2.44 4.54
168 INT100520 Regulation of Grm1 8 0.44 1.3 4.48
169 INT113078 Phosphorylation of Drd1a 4 0.30 0.77 4.45
170 INT75440 Regulation of Binding of Edn1 4 0.38 1.41 4.33
171 INT13333 Regulation of Gene_expression of Drd1a 8 0.36 3.37 4.28
172 INT62526 Negative_regulation of SELE 17 0.51 15.24 4.19
173 INT53040 Binding of Agtr1a 22 0.47 7.36 4.15
174 INT79234 Positive_regulation of CCL3 15 0.67 11.43 4.15
175 INT74814 Binding of Grm1 5 0.45 2.69 4.1
176 INT5602 Positive_regulation of Eif2ak3 9 0.66 0 4.04
177 INT28983 Regulation of Htr2b 3 0.22 0.26 3.96
178 INT66754 Negative_regulation of Transcription of Tnf 11 0.43 8.43 3.93
179 INT68255 Regulation of Positive_regulation of IL8 12 0.41 5.71 3.91
180 INT103843 Positive_regulation of Gene_expression of Ccr5 5 0.42 2.31 3.89
181 INT23088 Phosphorylation of Tnf 15 0.79 9.85 3.82
182 INT144083 Positive_regulation of Gene_expression of Ccl3 10 0.50 8.16 3.81
183 INT172173 Protein_catabolism of TNF 16 0.96 9.95 3.79
184 INT108761 Localization of Alms1 24 0.70 13.92 3.74
185 INT175555 Gene_expression of CASR 17 0.78 14.83 3.73
186 INT95272 Regulation of Gene_expression of Edn1 19 0.53 17.85 3.42
187 INT181357 Negative_regulation of Ccl3 12 0.59 13.09 3.38
188 INT62901 Positive_regulation of Gene_expression of Drd1a 2 0.57 0.66 3.35
189 INT95785 Positive_regulation of Positive_regulation of Grm1 6 0.49 3.59 3.3
190 INT65427 Regulation of Positive_regulation of Tnf 7 0.60 3.49 3.22
191 INT111195 Negative_regulation of Gene_expression of Agtr1a 7 0.58 3.2 3.16
192 INT13335 Negative_regulation of Gene_expression of Drd1a 6 0.34 0.8 3.16
193 INT96740 Transcription of Cxcr4 6 0.68 2.96 3.12
194 INT38013 Gene_expression of Casr 30 0.73 6.03 3.09
195 INT103674 Positive_regulation of Gene_expression of CXCR4 32 0.69 37.1 3.08
196 INT74506 Localization of Casr 16 0.76 1.95 3.06
197 INT18365 Positive_regulation of Regulation of Drd1a 4 0.50 1.74 3.04
198 INT53374 Binding of Edn1 17 0.43 11.66 2.98
199 INT166879 Localization of Ccr5 4 0.71 3.62 2.97
200 INT103848 Positive_regulation of Cxcr3 4 0.54 3.12 2.88
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