GO:0019838

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Name growth factor binding
Categary Function
Go Slim No
Go Link GO:0019838
Unique Molecular Interactions 503
Total Molecular Interactions 964
Total Single Events 5659
Pain Genes Associated 47

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for growth factor binding. They are ordered first by their pain relevance and then by number of times they were reported for growth factor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT137918 Oprm1 Positive_regulation of Pdgfrb 1 0.41 0 3.31
2 INT354207 Igfbp7 Positive_regulation of Accn3 1 0.52 6.55 3.24
3 INT69823 Binding of GHR and RYBP 1 0.01 0 3.23
4 INT126717 Binding of Il6 and Il6st 3 0.21 3.35 2.22
5 INT334532 Sema3a Negative_regulation of Gene_expression of Nrp1 1 0.19 7.58 2
6 INT137917 Oprm1 Positive_regulation of Kdr 1 0.43 0 1.98
7 INT347396 RYBP Positive_regulation of Binding of Sdcbp 1 0.00 0.92 1.66
8 INT354210 Binding of Igfbp7 and Accn3 1 0.27 3.91 1.64
9 INT347397 RYBP Positive_regulation of Sdcbp 1 0.00 0.22 1.56
10 INT223156 Il6 Regulation of A2m 1 0.11 2.79 1.39
11 INT260833 Binding of NRP2 and Flt1 1 0.00 3.61 1.22
12 INT69824 Negative_regulation of Binding of GHR and RYBP 1 0.01 0 1.14
13 INT173059 Binding of KDR and VEGFA 43 0.43 29.63 1.1
14 INT333966 Binding of Il6r and Il6st 1 0.01 1.74 1.1
15 INT206074 Binding of IL6 and IL6ST 7 0.32 3.79 1.01
16 INT137920 Binding of Kdr and Oprm1 1 0.23 0 0.97
17 INT286798 Binding of Il6st and Cntf 1 0.10 1.34 0.97
18 INT45279 Binding of CSF2 and GHR 1 0.05 0.07 0.93
19 INT260842 Binding of NRP2 and Kdr 1 0.00 2.28 0.85
20 INT73775 Binding of GH1 and GHR 4 0.35 0.68 0.8
21 INT347391 Positive_regulation of RYBP Positive_regulation of Sdcbp 1 0.00 0.22 0.79
22 INT347398 RYBP Positive_regulation of Positive_regulation of Sdcbp 1 0.00 0.22 0.79
23 INT161951 Positive_regulation of TGFBR1 Positive_regulation of Gene_expression of Ngf 1 0.27 0.99 0.76
24 INT161945 TGFB2 Positive_regulation of TGFBR1 1 0.08 0.99 0.76
25 INT163830 ERBB2 Positive_regulation of MAPK1 1 0.06 1.63 0.76
26 INT73776 Regulation of Binding of GH1 and GHR 2 0.26 0.16 0.75
27 INT161950 TGFBR1 Negative_regulation of Localization of Ngf 1 0.23 1.01 0.72
28 INT260832 Binding of NRP2 and Nrp1 1 0.00 2.32 0.7
29 INT27526 Binding of Sdcbp and Eda 1 0.13 0 0.65
30 INT255690 Binding of VEGFA and Flt1 8 0.34 3.44 0.61
31 INT61507 Ghrhr Positive_regulation of Localization of Gh1 1 0.41 0 0.61
32 INT260821 NRP2 Positive_regulation of Gene_expression of TNF 1 0.01 1.48 0.56
33 INT260845 Binding of Flt1 and Positive_regulation of Gene_expression of TNF 1 0.36 1.5 0.56
34 INT171897 Binding of Bmpr2 and Il1 1 0.03 0.84 0.52
35 INT302644 ARSA Positive_regulation of Gene_expression of TGFBR1 1 0.04 0.29 0.51
36 INT97949 Negative_regulation of NRP2 Negative_regulation of Positive_regulation of CDC42 1 0.06 0.72 0.51
37 INT97952 Negative_regulation of NRP2 Negative_regulation of Positive_regulation of AKT1 1 0.03 0.72 0.51
38 INT302647 ARSA Positive_regulation of TGFBR1 1 0.03 0.29 0.51
39 INT210878 Binding of FLT1 and HBM 1 0.06 0.83 0.5
40 INT97950 Negative_regulation of NRP2 Negative_regulation of Positive_regulation of ST3GAL3 1 0.02 0.72 0.5
41 INT106074 IL1B Positive_regulation of Gene_expression of A2M 1 0.03 0.75 0.49
42 INT106072 NFKB1 Positive_regulation of Gene_expression of A2M 1 0.19 0.75 0.49
43 INT292814 Binding of VEGFA and Kdr 8 0.18 3.63 0.48
44 INT354218 Igfbp7 Positive_regulation of Accn1 1 0.04 0.74 0.44
45 INT126018 Binding of Lifr and Tnf 1 0.06 1.61 0.43
46 INT354221 Igfbp7 Positive_regulation of Accn2 1 0.11 0.57 0.42
47 INT81991 Bmpr2 Positive_regulation of Gene_expression of ODF1 1 0.03 1.59 0.41
48 INT36340 Binding of NRP2 and Penk 1 0.04 0.07 0.39
49 INT163831 ERBB2 Positive_regulation of CCND1 1 0.03 0.82 0.38
50 INT328821 Binding of Il6st and Jak1 1 0.05 0 0.38
51 INT328827 Binding of Jak2 and Il6st 1 0.05 0 0.38
52 INT328824 Binding of Il6st and TYK2 1 0.02 0 0.38
53 INT337156 Kdr Positive_regulation of Gtf3a 1 0.01 0.77 0.35
54 INT287380 Binding of VEGFA and Kdr 12 0.18 11.97 0.34
55 INT194860 BMPR2 Positive_regulation of IL1B 1 0.01 0.61 0.34
56 INT304339 Negative_regulation of CD79A Positive_regulation of NRP2 1 0.06 0.86 0.33
57 INT190683 Binding of A2M and INS 4 0.11 4.97 0.32
58 INT304338 CD79A Positive_regulation of NRP2 1 0.08 0.84 0.32
59 INT206704 Negative_regulation of Binding of KDR and VEGFA 4 0.39 5.18 0.3
60 INT222301 Binding of ERBB2 and ESR1 5 0.36 5.07 0.29
61 INT202313 Gene_expression of PDGFB Positive_regulation of Positive_regulation of Pdgfrb 1 0.14 1 0.29
62 INT260841 Il6 Positive_regulation of Localization of NRP2 1 0.00 0.7 0.29
63 INT355038 NRP1 Negative_regulation of CKAP4 1 0.02 1.23 0.29
64 INT202314 Gene_expression of PDGFB Positive_regulation of Phosphorylation of Pdgfrb 1 0.14 1 0.29
65 INT260837 NRP2 Negative_regulation of Negative_regulation of Bcl2 1 0.00 0.9 0.28
66 INT94849 A2M Negative_regulation of Gene_expression of COL7A1 1 0.01 0.27 0.28
67 INT337162 Binding of Kdr and Iqgap1 1 0.32 0.98 0.28
68 INT191718 Binding of FLT1 and VEGFA 35 0.50 12.18 0.27
69 INT320794 Binding of VEGFA and Flt4 4 0.08 3.04 0.27
70 INT260840 NRP2 Positive_regulation of Gene_expression of Bcl2 1 0.00 0.85 0.24
71 INT41950 Ptger1 Positive_regulation of Localization of A2m 1 0.19 0.46 0.24
72 INT41949 Ptger1 Positive_regulation of Gene_expression of A2m 1 0.19 0.46 0.24
73 INT323436 VEGFA Regulation of Kdr 1 0.03 0.77 0.23
74 INT245590 Ghr Positive_regulation of Gene_expression of Igf1 1 0.34 0.61 0.23
75 INT260835 NRP2 Positive_regulation of Eif2ak3 1 0.00 0.73 0.23
76 INT188200 IL6ST Positive_regulation of STAT3 1 0.25 0.38 0.23
77 INT334522 Ngf Positive_regulation of Nrp1 1 0.19 0.93 0.22
78 INT171903 Binding of TNF and Lifr 1 0.01 0.35 0.22
79 INT260844 NRP2 Positive_regulation of Akt1 1 0.00 0.73 0.22
80 INT291352 Positive_regulation of CXCL12 Positive_regulation of ERBB2 1 0.17 0.88 0.22
81 INT334525 Ngf Positive_regulation of Gene_expression of Nrp1 1 0.19 0.93 0.22
82 INT354220 Igfbp7 Positive_regulation of Gene_expression of Accn3 1 0.33 0.29 0.2
83 INT354211 Igfbp7 Positive_regulation of Gene_expression of Accn1 1 0.04 0.29 0.2
84 INT260827 Binding of Flt1 and Pgf 1 0.27 0.6 0.2
85 INT173430 Binding of FLT4 and VEGFA 10 0.25 9.38 0.19
86 INT351086 Negative_regulation of ERBB2 Positive_regulation of Gene_expression of ESR1 1 0.10 0.75 0.19
87 INT138026 Binding of Osmr and Il31 1 0.22 0.16 0.19
88 INT354223 Binding of Car2 and Igfbp7 1 0.02 0.4 0.19
89 INT197097 IL1B Regulation of FLT4 1 0.03 0.66 0.19
90 INT138025 Binding of Osmr and Il31ra 1 0.22 0.16 0.19
91 INT197098 TNF Regulation of FLT4 1 0.14 0.66 0.19
92 INT294694 REM1 Positive_regulation of LIFR 1 0.01 0.24 0.18
93 INT351088 Negative_regulation of ERBB2 Positive_regulation of FOXO3 1 0.17 0.66 0.18
94 INT258399 Binding of IL6R and IL6ST 1 0.06 0.61 0.18
95 INT222300 Binding of ERBB2 and PGR 2 0.34 1.89 0.17
96 INT128221 Binding of IL6ST and Il6 2 0.00 0.73 0.17
97 INT206081 IL6ST Negative_regulation of IL6 1 0.11 0.81 0.17
98 INT172232 CALCRL Positive_regulation of Gene_expression of NRP1 1 0.02 0.07 0.17
99 INT115610 Binding of ERBB2 and KLF1 1 0.02 2.12 0.17
100 INT172237 TAS2R14 Positive_regulation of Gene_expression of NRP1 1 0.01 0.07 0.17
101 INT251347 Binding of Bmpr2 and Limk1 1 0.18 1.51 0.16
102 INT215902 Igfbp2 Positive_regulation of Igfals 1 0.15 0.8 0.15
103 INT350713 MIR219-1 Negative_regulation of Pdgfra 1 0.00 0.4 0.15
104 INT334531 Nrp1 Negative_regulation of Gene_expression of Il4 1 0.08 0.48 0.14
105 INT144027 Binding of Slc6a4 and Pdgfrb 1 0.23 0.25 0.14
106 INT94850 A2M Negative_regulation of Gene_expression of PIP 1 0.01 0.14 0.14
107 INT334534 Nrp1 Negative_regulation of Gene_expression of Sema3a 1 0.17 0.48 0.14
108 INT175398 Binding of ERBB2 and VEGFA 2 0.16 1.34 0.13
109 INT252571 Rpe Positive_regulation of Positive_regulation of Sdcbp 1 0.04 2.27 0.13
110 INT260834 Negative_regulation of Binding of VEGFA and Flt1 1 0.15 0.5 0.13
111 INT271345 Negative_regulation of PIGF Negative_regulation of FLT1 1 0.02 1.17 0.13
112 INT334528 Nrp1 Negative_regulation of Sema3a 1 0.17 0.47 0.13
113 INT158014 Binding of FLT1 and PGF 2 0.27 0.9 0.12
114 INT230761 VEGFA Positive_regulation of Kdr 2 0.02 2.16 0.12
115 INT192330 UBR7 Negative_regulation of Positive_regulation of PDGFRB 1 0.01 0.54 0.12
116 INT230760 VEGFA Positive_regulation of Flt1 1 0.03 0.96 0.12
117 INT337155 Binding of Kdr and Ros1 1 0.06 0.46 0.12
118 INT279799 ATP6V0A2 Regulation of ERBB3 1 0.00 1.77 0.12
119 INT289660 Tnfrsf1a Negative_regulation of Transcription of Flt4 1 0.03 0.62 0.12
120 INT337159 Binding of ecs and Kdr 1 0.04 0.46 0.12
121 INT289657 Tnfrsf1a Negative_regulation of Gene_expression of Flt4 1 0.03 0.63 0.12
122 INT211996 Erbb3 Positive_regulation of Nrg1 2 0.03 0.67 0.11
123 INT236401 Binding of Flt1 and Mthfs 1 0.01 0.28 0.11
124 INT236403 Binding of Flt1 and Negative_regulation of Gene_expression of VEGFA 1 0.04 0.3 0.11
125 INT303084 Binding of Mafk and Sdcbp 1 0.04 0.37 0.1
126 INT224026 P2RY6 Positive_regulation of NRP2 1 0.10 0.98 0.1
127 INT190684 Binding of A2M and IGF1 1 0.16 1.54 0.1
128 INT349860 Binding of Cntf and Lifr 1 0.39 0.22 0.1
129 INT252572 Rpe Positive_regulation of Sdcbp 1 0.04 1.12 0.09
130 INT299955 Binding of KDR and FTSJ3 1 0.04 1.07 0.09
131 INT299538 Lifr Positive_regulation of Ak5 1 0.07 0.23 0.09
132 INT341826 Binding of ERBB2 and TNC 1 0.18 0.63 0.09
133 INT299555 Lifr Positive_regulation of Gene_expression of TGFB1 1 0.03 0.23 0.09
134 INT313741 Negative_regulation of NOS1 Positive_regulation of Sdcbp 1 0.00 0.78 0.09
135 INT318210 MUC5AC Negative_regulation of Phosphorylation of Flt1 1 0.07 0.98 0.09
136 INT158012 Binding of ENG and FLT1 1 0.21 0.39 0.09
137 INT165157 Gli1 Regulation of Igfbp5 1 0.24 0.07 0.09
138 INT250661 Binding of EGF and ERBB2 2 0.11 0.82 0.08
139 INT309904 Binding of ERBB2 and TXK 1 0.01 0.23 0.08
140 INT320785 Binding of Flt1 and Kdr 1 0.15 0.67 0.08
141 INT355009 Cntf Positive_regulation of Il6st 1 0.02 0.69 0.08
142 INT244639 AGK Negative_regulation of PDGFRB 1 0.01 0.69 0.08
143 INT354213 Igfbp7 Regulation of Accn3 1 0.18 0.17 0.08
144 INT189550 Binding of BMPR2 and PAH 1 0.06 2.68 0.08
145 INT244638 AGK Negative_regulation of KDR 1 0.00 0.68 0.08
146 INT355010 Lif Positive_regulation of Il6st 1 0.02 0.69 0.08
147 INT143118 TFF2 Regulation of FLT1 1 0.37 0.63 0.08
148 INT339111 Binding of ERBB2 and JUP 1 0.38 0.62 0.07
149 INT143120 Negative_regulation of VEGFB Positive_regulation of FLT1 1 0.36 0.58 0.07
150 INT354209 Igfbp7 Regulation of Positive_regulation of Accn3 1 0.29 0.15 0.07
151 INT300446 VEGFA Positive_regulation of Flt1 1 0.09 2.62 0.07
152 INT298006 CHDM Positive_regulation of Gene_expression of PDGFRB 1 0.16 1.08 0.07
153 INT192329 UBR7 Negative_regulation of Phosphorylation of PDGFRB 1 0.01 0.06 0.07
154 INT143121 VEGFB Positive_regulation of FLT1 1 0.42 0.58 0.07
155 INT241144 PGF Positive_regulation of FLT1 1 0.40 1.03 0.07
156 INT265750 Binding of FLT1 and KDR 1 0.37 0.54 0.07
157 INT293813 ERBB2 Positive_regulation of Positive_regulation of AR 1 0.09 0.45 0.07
158 INT158013 Binding of FLT1 and VEGFC 1 0.23 0.34 0.07
159 INT143119 Positive_regulation of VEGFB Positive_regulation of FLT1 1 0.30 0.58 0.07
160 INT339101 ERBB2 Positive_regulation of TGFA 1 0.33 0.68 0.06
161 INT292811 Zfp787 Negative_regulation of Phosphorylation of Kdr 1 0.01 0.45 0.06
162 INT279291 PDGFA Positive_regulation of PDGFRB 1 0.16 1.02 0.06
163 INT339099 ERBB2 Positive_regulation of IGF2R 1 0.33 0.67 0.06
164 INT320795 Flt1 Negative_regulation of VEGFA 1 0.29 0.29 0.06
165 INT298699 Kdr Regulation of Tek 1 0.11 0.28 0.06
166 INT298701 Manea Regulation of Tek 1 0.03 0.28 0.06
167 INT339105 ERBB2 Positive_regulation of EGFR 1 0.37 0.68 0.06
168 INT339110 ERBB2 Positive_regulation of GATA6 1 0.31 0.67 0.06
169 INT105268 VEGFA Positive_regulation of KDR 2 0.18 0.22 0.05
170 INT105267 Negative_regulation of VEGFA Positive_regulation of KDR 1 0.16 0.22 0.05
171 INT251778 Negative_regulation of TXK Positive_regulation of KDR 1 0.03 0.99 0.05
172 INT345371 Binding of Flt4 and Kdr 1 0.10 1.12 0.05
173 INT355586 Binding of LTBP1 and ANGPTL4 1 0.10 2.15 0.05
174 INT279287 PDGFRB Regulation of CDCP1 1 0.01 0.98 0.05
175 INT355589 Binding of EGFR and LTBP1 1 0.11 2.15 0.05
176 INT303059 Binding of Syt1 and Sdcbp 1 0.04 0.19 0.05
177 INT251779 TXK Positive_regulation of KDR 1 0.03 0.99 0.05
178 INT173051 Binding of VEGFA and NRP1 16 0.44 1.29 0.04
179 INT213903 Binding of EGFR and ERBB2 10 0.37 5.03 0.04
180 INT173053 Binding of VEGFA and NRP2 3 0.12 1.36 0.04
181 INT279284 TXK Regulation of KDR 3 0.05 2.22 0.04
182 INT173056 Binding of NRP2 and NRP1 2 0.24 0.61 0.04
183 INT315913 VEGFA Regulation of KDR 1 0.03 0.32 0.04
184 INT200428 Sdcbp Positive_regulation of Gene_expression of Gfap 1 0.04 0.15 0.04
185 INT292083 Binding of KDR and TXK 1 0.04 1.52 0.04
186 INT198923 Gene_expression of Lrp8 Positive_regulation of Gene_expression of Lifr 1 0.01 0 0.04
187 INT202310 Binding of PDGFB and Pdgfrb 1 0.11 0.39 0.04
188 INT292092 Binding of PDGFRB and TXK 1 0.05 1.53 0.04
189 INT265771 NRP1 Positive_regulation of VEGFA 1 0.46 0 0.04
190 INT311925 Binding of NRP2 and SEMA3A 1 0.26 0.06 0.04
191 INT213901 EGFR Positive_regulation of ERBB2 1 0.52 0.41 0.04
192 INT339112 Binding of ERBB2 and TAB2 1 0.00 0.05 0.04
193 INT223086 Binding of Pdgfb and Pdgfrb 1 0.33 0.46 0.04
194 INT265764 NRP1 Positive_regulation of FLT1 1 0.45 0 0.04
195 INT241143 VEGFA Positive_regulation of FLT1 1 0.20 0.51 0.04
196 INT315915 VEGFA Regulation of NRP1 1 0.22 0.32 0.04
197 INT265745 FLT1 Positive_regulation of Binding of KLKB1 1 0.04 0.36 0.04
198 INT265772 Binding of KDR and NRP1 1 0.29 0 0.04
199 INT292094 Binding of FLT4 and TXK 1 0.02 1.53 0.04
200 INT292095 Negative_regulation of Binding of KDR and TXK 1 0.04 1.53 0.04

Single Events

The table below shows the top 100 pain related interactions that have been reported for growth factor binding. They are ordered first by their pain relevance and then by number of times they were reported in growth factor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT35711 Positive_regulation of Sdcbp 110 0.60 50.45 22.11
2 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79
3 INT35120 Gene_expression of Sdcbp 68 0.67 21.33 13.96
4 INT134625 Gene_expression of Kdr 116 0.71 53.13 10.09
5 INT103154 Gene_expression of FLT1 138 0.76 58.5 7.41
6 INT134624 Gene_expression of Flt1 77 0.66 48.86 7.27
7 INT35712 Regulation of Sdcbp 19 0.23 5.3 6.58
8 INT37745 Positive_regulation of Gene_expression of Sdcbp 22 0.60 5.15 6.02
9 INT9895 Binding of GHR 18 0.36 4.8 5.65
10 INT354202 Gene_expression of Igfbp7 1 0.45 8.29 5.58
11 INT213741 Gene_expression of Kdr 60 0.75 44.24 5.35
12 INT15376 Positive_regulation of Gene_expression of ERBB2 215 0.70 168.54 5.23
13 INT103155 Gene_expression of KDR 78 0.66 50.53 4.38
14 INT35122 Negative_regulation of Sdcbp 43 0.51 22.01 4.34
15 INT95512 Transcription of Ghr 24 0.69 3.1 4.12
16 INT100372 Gene_expression of Flt1 47 0.71 24.33 4.09
17 INT44789 Binding of Sdcbp 10 0.36 1.65 4.01
18 INT41942 Gene_expression of A2m 9 0.36 9.98 3.96
19 INT151421 Negative_regulation of Positive_regulation of Sdcbp 11 0.30 6.61 3.32
20 INT89986 Gene_expression of Il6st 5 0.56 2.35 3.15
21 INT91173 Gene_expression of Pdgfrb 33 0.65 32.55 3.09
22 INT59905 Gene_expression of Ghr 29 0.63 9.25 2.97
23 INT178457 Positive_regulation of LIFR 12 0.56 3.98 2.9
24 INT132773 Negative_regulation of Acvr2b 3 0.41 1.55 2.87
25 INT354201 Positive_regulation of Igfbp7 1 0.40 5.32 2.87
26 INT354205 Positive_regulation of Gene_expression of Igfbp7 1 0.40 4.02 2.87
27 INT8095 Gene_expression of ERBB3 47 0.77 24.85 2.82
28 INT10141 Gene_expression of A2M 11 0.35 9.37 2.75
29 INT172186 Gene_expression of IL6ST 20 0.75 11.63 2.67
30 INT699 Positive_regulation of A2M 16 0.66 10.49 2.5
31 INT354204 Binding of Igfbp7 1 0.32 4.44 2.49
32 INT178458 Negative_regulation of LIFR 13 0.47 8.75 2.48
33 INT137908 Phosphorylation of Pdgfrb 14 0.81 8.44 2.45
34 INT36338 Gene_expression of NRP2 29 0.67 6.47 2.4
35 INT22019 Regulation of GHR 9 0.62 2.56 2.39
36 INT16286 Positive_regulation of GHR 8 0.60 4.04 2.31
37 INT67352 Transcription of Ghr 8 0.61 1.55 2.3
38 INT134626 Positive_regulation of Gene_expression of Kdr 20 0.63 14.63 2.29
39 INT240113 Gene_expression of Nrp1 11 0.30 10.88 2.24
40 INT163545 Gene_expression of PDGFRB 39 0.78 25.5 2.2
41 INT176088 Gene_expression of Tek 39 0.65 14.25 2.19
42 INT23352 Negative_regulation of A2M 10 0.33 8.35 2.16
43 INT128210 Positive_regulation of Positive_regulation of Sdcbp 6 0.08 3.88 2.08
44 INT95510 Regulation of Ghr 1 0.45 0.21 2.07
45 INT100371 Positive_regulation of Flt1 11 0.63 6.42 2.02
46 INT4643 Negative_regulation of GHR 10 0.45 3.01 2
47 INT134628 Gene_expression of Flt4 9 0.48 7.52 1.94
48 INT137906 Positive_regulation of Phosphorylation of Pdgfrb 6 0.50 2.55 1.94
49 INT143127 Positive_regulation of FLT1 44 0.66 21.7 1.92
50 INT144020 Positive_regulation of Pdgfrb 30 0.69 24.8 1.92
51 INT136503 Negative_regulation of KDR 46 0.48 43.1 1.86
52 INT35121 Negative_regulation of Gene_expression of Sdcbp 6 0.43 2.4 1.83
53 INT104912 Gene_expression of Acvr2a 8 0.63 4.48 1.81
54 INT48792 Regulation of ERBB2 48 0.57 36.56 1.8
55 INT162725 Binding of Kdr 13 0.42 8.86 1.79
56 INT143983 Gene_expression of Lifr 9 0.47 6.26 1.79
57 INT41639 Positive_regulation of A2m 7 0.46 4.52 1.74
58 INT196158 Binding of NRP2 16 0.06 7.03 1.73
59 INT113676 Gene_expression of NRP1 22 0.72 10.81 1.71
60 INT21788 Positive_regulation of ERBB2 49 0.66 28.88 1.68
61 INT75316 Gene_expression of Ghr 6 0.78 1.24 1.68
62 INT255663 Binding of Flt1 11 0.32 6.92 1.64
63 INT3249 Regulation of A2M 7 0.39 3.29 1.61
64 INT81982 Gene_expression of Bmpr2 36 0.60 14.58 1.55
65 INT253403 Positive_regulation of Il6st 2 0.28 2.07 1.54
66 INT28300 Gene_expression of GHR 10 0.78 4.29 1.5
67 INT159091 Positive_regulation of Regulation of Sdcbp 1 0.40 0.16 1.5
68 INT52962 Binding of ERBB2 77 0.47 50.03 1.49
69 INT133422 Binding of IL6ST 10 0.40 4.9 1.49
70 INT167085 Negative_regulation of ERBB2 67 0.57 44.6 1.48
71 INT67348 Negative_regulation of Ghr 8 0.40 2.84 1.43
72 INT159009 Regulation of Il6st 2 0.18 2 1.41
73 INT199550 Negative_regulation of Flt1 18 0.37 12.57 1.37
74 INT100373 Negative_regulation of Gene_expression of Flt1 11 0.53 10 1.37
75 INT45233 Positive_regulation of Binding of Sdcbp 1 0.07 0 1.36
76 INT154026 Negative_regulation of Regulation of Sdcbp 1 0.37 0 1.35
77 INT96838 Negative_regulation of Gene_expression of ERBB2 25 0.57 15.83 1.34
78 INT199567 Binding of Kdr 18 0.47 13.81 1.34
79 INT75315 Regulation of Ghr 4 0.22 1.5 1.34
80 INT41944 Positive_regulation of Gene_expression of A2m 2 0.23 2.56 1.29
81 INT131255 Positive_regulation of Transcription of Lifr 1 0.01 0.99 1.28
82 INT131252 Transcription of Lifr 1 0.02 0.99 1.28
83 INT144019 Negative_regulation of Pdgfrb 21 0.58 14.93 1.26
84 INT75923 Positive_regulation of IL6ST 5 0.45 2.49 1.21
85 INT105270 Positive_regulation of KDR 25 0.49 11.49 1.2
86 INT31572 Negative_regulation of FLT1 21 0.48 16.49 1.18
87 INT95511 Negative_regulation of Transcription of Ghr 1 0.43 0 1.15
88 INT41947 Regulation of A2m 2 0.29 1.08 1.14
89 INT134627 Positive_regulation of Gene_expression of Flt1 9 0.49 7.16 1.12
90 INT61512 Regulation of Binding of GHR 2 0.05 0.89 1.1
91 INT86931 Gene_expression of A2m 3 0.16 4.81 1.04
92 INT200556 Regulation of Kdr 8 0.28 6.04 1.01
93 INT44787 Negative_regulation of Binding of Sdcbp 3 0.43 0.73 1.01
94 INT116797 Gene_expression of Osmr 9 0.73 1.12 1
95 INT260471 Positive_regulation of Gene_expression of Kdr 9 0.61 8.37 0.99
96 INT37746 Regulation of Gene_expression of Sdcbp 4 0.53 0.9 0.99
97 INT95514 Negative_regulation of Ghr 3 0.36 1.3 0.99
98 INT85963 Gene_expression of LIFR 23 0.75 9 0.98
99 INT197105 Negative_regulation of FLT4 13 0.42 11.48 0.92
100 INT156351 Positive_regulation of Flt1 22 0.51 20.05 0.91
101 INT213917 Negative_regulation of Phosphorylation of ERBB2 9 0.54 8.68 0.91
102 INT95507 Negative_regulation of Gene_expression of Ghr 3 0.33 0.49 0.91
103 INT41946 Localization of A2m 1 0.38 1.81 0.89
104 INT162783 Binding of LIFR 1 0.36 1.52 0.86
105 INT216456 Positive_regulation of Ghr 6 0.41 4.96 0.85
106 INT149291 Negative_regulation of NRP1 5 0.40 2.64 0.84
107 INT71649 Localization of ERBB2 23 0.78 13.63 0.83
108 INT178455 Localization of LIFR 6 0.61 2.24 0.83
109 INT173100 Binding of KDR 39 0.39 22.48 0.81
110 INT176588 Phosphorylation of ERBB2 27 0.78 16.37 0.81
111 INT119102 Gene_expression of PDGFRA 13 0.75 11.99 0.81
112 INT196182 Localization of NRP2 9 0.46 3.61 0.8
113 INT297469 Regulation of Binding of Kdr 1 0.54 2.01 0.8
114 INT200855 Positive_regulation of Kdr 14 0.45 11.14 0.77
115 INT149298 Protein_catabolism of NRP1 2 0.82 1.52 0.77
116 INT161947 Positive_regulation of TGFBR1 2 0.52 1.6 0.76
117 INT159982 Negative_regulation of ERBB3 11 0.26 8.44 0.75
118 INT245584 Positive_regulation of Gene_expression of Ghr 5 0.41 3.46 0.75
119 INT81396 Regulation of Gene_expression of ERBB2 14 0.43 10.73 0.74
120 INT41943 Positive_regulation of Positive_regulation of A2m 2 0.22 1.19 0.74
121 INT114604 Positive_regulation of Acvr2a 2 0.41 0 0.73
122 INT164756 Negative_regulation of PDGFRB 32 0.57 21.69 0.72
123 INT289649 Regulation of Gene_expression of Flt4 1 0.21 0.66 0.72
124 INT139205 Binding of NRP1 27 0.45 4.34 0.71
125 INT127684 Negative_regulation of Kdr 6 0.37 3.19 0.7
126 INT3536 Positive_regulation of Nrp1 2 0.19 0.93 0.7
127 INT73783 Regulation of Gene_expression of GHR 1 0.45 0 0.7
128 INT265800 Localization of NRP1 14 0.75 3.66 0.69
129 INT196155 Binding of Nrp1 5 0.16 2.38 0.69
130 INT171364 Localization of Pdgfrb 6 0.37 4.98 0.68
131 INT91172 Positive_regulation of Gene_expression of Pdgfrb 4 0.38 2.83 0.68
132 INT41945 Negative_regulation of A2m 2 0.27 0.35 0.68
133 INT129195 Transcription of Sdcbp 3 0.10 1.94 0.67
134 INT294699 Negative_regulation of Localization of LIFR 2 0.04 1.52 0.67
135 INT178489 Negative_regulation of Kdr 31 0.42 25.65 0.66
136 INT189322 Binding of A2M 7 0.29 12.1 0.66
137 INT171380 Positive_regulation of Localization of Pdgfrb 1 0.21 0.48 0.66
138 INT260823 Positive_regulation of Gene_expression of Nrp1 3 0.19 2.14 0.65
139 INT333965 Binding of Il6st 1 0.08 0.9 0.65
140 INT100374 Positive_regulation of Positive_regulation of Flt1 1 0.09 0.99 0.62
141 INT61506 Localization of Ghrhr 1 0.51 0 0.61
142 INT289655 Regulation of Flt4 1 0.29 0.63 0.6
143 INT95506 Negative_regulation of Transcription of Ghr 1 0.15 0 0.6
144 INT144922 Gene_expression of TGFBR1 4 0.72 0.19 0.57
145 INT181790 Gene_expression of FLT4 13 0.72 11.73 0.56
146 INT95508 Negative_regulation of Gene_expression of Ghr 1 0.59 0 0.56
147 INT178456 Positive_regulation of Gene_expression of LIFR 7 0.50 2.74 0.54
148 INT110924 Regulation of BMPR2 3 0.17 1.75 0.54
149 INT134629 Positive_regulation of Gene_expression of Flt4 3 0.32 2.13 0.52
150 INT143125 Binding of FLT1 48 0.40 13.6 0.51
151 INT144024 Negative_regulation of Phosphorylation of Pdgfrb 6 0.42 3.48 0.51
152 INT255665 Localization of Flt1 5 0.63 7.65 0.51
153 INT109390 Regulation of Gene_expression of Flt1 4 0.41 4.08 0.51
154 INT199342 Regulation of Igfbp2 5 0.60 3.3 0.5
155 INT97962 Negative_regulation of NRP2 2 0.08 0.91 0.5
156 INT167366 Positive_regulation of A2m 1 0.02 0.43 0.49
157 INT73200 Positive_regulation of PDGFRB 10 0.67 9.67 0.48
158 INT200421 Localization of Sdcbp 5 0.22 0.72 0.48
159 INT79935 Negative_regulation of Nrp1 3 0.17 1.36 0.46
160 INT112379 Positive_regulation of Gene_expression of NRP2 3 0.50 0.18 0.46
161 INT188230 Negative_regulation of IL6ST 3 0.33 0.49 0.45
162 INT158019 Positive_regulation of Gene_expression of FLT1 20 0.68 9.73 0.44
163 INT218293 Gene_expression of Acvr2b 14 0.76 4.22 0.44
164 INT149293 Negative_regulation of Protein_catabolism of NRP1 1 0.05 0.93 0.44
165 INT192342 Phosphorylation of PDGFRB 11 0.80 1.68 0.43
166 INT292795 Regulation of Kdr 5 0.40 3.86 0.42
167 INT173752 Positive_regulation of Ghr 3 0.57 2.21 0.41
168 INT199332 Binding of Igfbp2 2 0.36 1.46 0.41
169 INT176085 Regulation of Tek 6 0.37 3.36 0.4
170 INT354200 Negative_regulation of Igfbp7 1 0.25 0.79 0.4
171 INT255662 Regulation of Positive_regulation of Flt1 1 0.29 2.57 0.4
172 INT82331 Positive_regulation of Positive_regulation of GHR 1 0.00 0.06 0.4
173 INT131773 Regulation of KDR 12 0.49 12.01 0.39
174 INT292484 Negative_regulation of TGFBR1 3 0.19 0.75 0.39
175 INT192344 Negative_regulation of Phosphorylation of PDGFRB 4 0.54 1.26 0.38
176 INT182014 Positive_regulation of Lifr 1 0.06 0.47 0.38
177 INT196002 Positive_regulation of Flt4 4 0.22 3.51 0.37
178 INT288336 Positive_regulation of Gene_expression of A2m 1 0.12 1.73 0.37
179 INT148797 Phosphorylation of KDR 7 0.80 5.15 0.36
180 INT176079 Positive_regulation of Tek 6 0.41 3.15 0.36
181 INT136518 Regulation of IL6ST 2 0.29 0.31 0.36
182 INT48772 Localization of A2M 3 0.78 2.83 0.35
183 INT28299 Negative_regulation of Gene_expression of GHR 1 0.03 0.1 0.35
184 INT150330 Gene_expression of BMPR2 7 0.29 4.22 0.34
185 INT251324 Binding of Bmpr2 5 0.23 2.99 0.34
186 INT201967 Positive_regulation of Bmpr2 4 0.31 1.24 0.34
187 INT288109 Localization of Kdr 4 0.46 2.84 0.33
188 INT173097 Localization of KDR 20 0.73 12.73 0.31
189 INT179687 Negative_regulation of Gene_expression of KDR 6 0.22 5.37 0.31
190 INT143442 Positive_regulation of NRP1 11 0.57 2.62 0.3
191 INT156411 Gene_expression of Pdgfra 8 0.75 5.5 0.3
192 INT192348 Positive_regulation of Gene_expression of PDGFRB 5 0.64 3.57 0.3
193 INT142132 Positive_regulation of Erbb3 3 0.27 0.82 0.3
194 INT171885 Binding of Lifr 2 0.34 2.27 0.3
195 INT21789 Positive_regulation of ERBB3 7 0.47 4.26 0.29
196 INT222720 Negative_regulation of Localization of Sdcbp 1 0.07 0.72 0.29
197 INT67350 Binding of Ghr 9 0.43 1.83 0.28
198 INT144021 Binding of Pdgfrb 9 0.37 5.53 0.28
199 INT199343 Positive_regulation of Igfbp2 8 0.67 7.85 0.28
200 INT126195 Transcription of Il6st 1 0.39 0.2 0.28
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