GO:0019855

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Name calcium channel inhibitor activity
Categary Function
Go Slim No
Go Link GO:0019855
Unique Molecular Interactions 41
Total Molecular Interactions 54
Total Single Events 1091
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for calcium channel inhibitor activity. They are ordered first by their pain relevance and then by number of times they were reported for calcium channel inhibitor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT255287 Binding of Stx1a and Vti1b 1 0.35 0 0.58
2 INT64514 Binding of TNNI3 and Mb 2 0.03 1.64 0.5
3 INT98214 Negative_regulation of Binding of TNNI3 and Mb 1 0.02 0.91 0.41
4 INT255285 Binding of Snap25 and Stx1a 1 0.07 0 0.33
5 INT312573 AMBP Negative_regulation of IL6 1 0.11 1.41 0.32
6 INT312571 AMBP Negative_regulation of Positive_regulation of IL6 1 0.11 1.41 0.32
7 INT255291 Binding of Napb and Stx1a 1 0.21 0 0.29
8 INT290847 Regulation of Binding of Stx1a and Fig4 1 0.05 0.26 0.24
9 INT98410 Binding of AMBP and Rf 1 0.02 0.95 0.22
10 INT290846 Binding of Stx1a and Fig4 1 0.07 0.26 0.22
11 INT151424 Tfrc Negative_regulation of Positive_regulation of Tnni3 1 0.21 0.98 0.2
12 INT142332 Binding of SERPINH1 and TNNI3 1 0.03 1.05 0.17
13 INT141322 Binding of PAPPA and TNNI3 1 0.09 0.98 0.16
14 INT312572 AMBP Negative_regulation of Gene_expression of IL6 1 0.11 0.66 0.14
15 INT312568 AMBP Regulation of Negative_regulation of PRSS1 1 0.02 0.95 0.12
16 INT312570 AMBP Regulation of Negative_regulation of ELANE 1 0.06 0.95 0.12
17 INT64513 Positive_regulation of Binding of TNNI3 and Mb 1 0.03 0.73 0.09
18 INT188964 Binding of AMBP and NAGLU 1 0.01 1.27 0.09
19 INT56377 AMBP Negative_regulation of Elane 1 0.00 1.43 0.08
20 INT191590 Binding of AMBP and Arsb 1 0.00 1.82 0.04
21 INT249421 Binding of Stx1a and Vamp2 1 0.10 0 0.04
22 INT249414 Binding of Stx1a and Dcaf12l2 1 0.00 0 0.04
23 INT249417 Binding of Stx1a and Napa 1 0.13 0 0
24 INT249426 Mbp Positive_regulation of Stx1a 1 0.10 0.11 0
25 INT247660 PER1 Positive_regulation of TNNI3 1 0.01 0.35 0
26 INT322246 Binding of Hcm and Tnni3 1 0.11 0.86 0
27 INT197813 Binding of AMBP and MEN1 1 0.00 0.51 0
28 INT197812 Binding of AMBP and RDBP 1 0.00 0.51 0
29 INT270316 Binding of AMBP and NHS 1 0.20 0.91 0
30 INT281321 STX1A Positive_regulation of Gene_expression of tf 1 0.07 0.96 0
31 INT249408 Mbp Positive_regulation of Localization of Stx1a 1 0.11 0.33 0
32 INT249405 Binding of Mbp and Stx1a 1 0.11 0 0
33 INT249420 Stx1a Positive_regulation of Binding of Snap25 1 0.13 0 0
34 INT249410 Vamp2 Regulation of Binding of Stx1a 1 0.06 0 0
35 INT145556 Binding of CST3 and TNNI3 1 0.25 0.11 0
36 INT80910 Binding of TNC and TNNI3 1 0.21 0.07 0
37 INT247661 PER1 Positive_regulation of Positive_regulation of TNNI3 1 0.01 0.41 0
38 INT178723 Binding of ALB and TNNI3 1 0.17 0.91 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for calcium channel inhibitor activity. They are ordered first by their pain relevance and then by number of times they were reported in calcium channel inhibitor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT9552 Positive_regulation of TNNI3 209 0.70 128.67 19.15
2 INT9550 Gene_expression of TNNI3 113 0.78 86.79 10.56
3 INT56374 Gene_expression of AMBP 34 0.54 35.85 6.25
4 INT16923 Positive_regulation of Tnni3 32 0.50 25.01 5.44
5 INT2072 Localization of AMBP 33 0.65 37.58 4.84
6 INT50872 Positive_regulation of Tnni3 24 0.64 13.51 3.95
7 INT56376 Negative_regulation of AMBP 29 0.35 21.49 2.59
8 INT89146 Localization of Tnni3 7 0.51 4.31 2.38
9 INT9547 Regulation of TNNI3 25 0.56 14.22 2.22
10 INT56375 Positive_regulation of AMBP 25 0.60 21.24 2.22
11 INT64538 Binding of TNNI3 17 0.48 11.65 1.83
12 INT82918 Binding of AMBP 23 0.39 23.31 1.71
13 INT85297 Positive_regulation of Gene_expression of TNNI3 29 0.50 29.77 1.68
14 INT171816 Gene_expression of Stx1a 5 0.20 1.67 1.65
15 INT63959 Regulation of Tnni3 11 0.21 4.69 1.57
16 INT77383 Gene_expression of Tnni3 8 0.65 4.14 1.55
17 INT60552 Localization of TNNI3 56 0.79 20.05 1.44
18 INT75183 Negative_regulation of TNNI3 19 0.53 9.34 1.32
19 INT65324 Gene_expression of Tnni3 12 0.66 7.97 1.25
20 INT50873 Regulation of Tnni3 4 0.13 2.36 1.22
21 INT256412 Negative_regulation of Localization of AMBP 1 0.04 6.09 1.14
22 INT76471 Negative_regulation of Tnni3 5 0.09 1.51 0.98
23 INT50878 Positive_regulation of Positive_regulation of TNNI3 7 0.50 5.57 0.97
24 INT184882 Regulation of AMBP 5 0.34 3.3 0.94
25 INT201222 Positive_regulation of STX1A 1 0.45 0.51 0.93
26 INT161775 Negative_regulation of Localization of Tnni3 1 0.23 0.85 0.86
27 INT171818 Localization of Stx1a 1 0.08 0.22 0.85
28 INT225056 Positive_regulation of Gene_expression of AMBP 4 0.37 5.45 0.75
29 INT68650 Negative_regulation of Tnni3 8 0.37 1.01 0.73
30 INT256411 Phosphorylation of AMBP 1 0.08 10.3 0.73
31 INT213381 Gene_expression of STX1A 5 0.65 3.41 0.71
32 INT161376 Protein_catabolism of TNNI3 7 1.00 3.92 0.67
33 INT287853 Phosphorylation of Tnni3 1 0.63 0.87 0.56
34 INT65323 Positive_regulation of Positive_regulation of Tnni3 5 0.36 1.93 0.46
35 INT249396 Binding of Stx1a 9 0.15 0.23 0.42
36 INT234083 Gene_expression of Stx1a 10 0.64 1.41 0.41
37 INT188967 Negative_regulation of Binding of AMBP 2 0.03 2.7 0.39
38 INT133717 Positive_regulation of Gene_expression of Tnni3 1 0.11 0.54 0.36
39 INT133718 Negative_regulation of Positive_regulation of Tnni3 1 0.09 0.38 0.36
40 INT158967 Positive_regulation of Gene_expression of Tnni3 2 0.49 1.31 0.34
41 INT92313 Negative_regulation of Gene_expression of TNNI3 3 0.41 3.07 0.28
42 INT81901 Binding of Tnni3 2 0.07 0.62 0.27
43 INT290851 Regulation of Stx1a 1 0.09 0.26 0.24
44 INT256413 Positive_regulation of Localization of AMBP 1 0.05 0.68 0.21
45 INT64080 Positive_regulation of Stx1a 3 0.08 0 0.2
46 INT239841 Regulation of Protein_catabolism of TNNI3 1 0.32 1.6 0.2
47 INT85574 Negative_regulation of Negative_regulation of Tnni3 1 0.29 0.1 0.19
48 INT50871 Positive_regulation of Positive_regulation of Tnni3 1 0.05 0.53 0.17
49 INT91650 Binding of Tnni3 2 0.36 0.73 0.15
50 INT90693 Transcription of TNNI3 2 0.55 1.56 0.15
51 INT103943 Regulation of Positive_regulation of TNNI3 1 0.25 0.4 0.15
52 INT64081 Regulation of Stx1a 3 0.25 0.07 0.14
53 INT101021 Regulation of Positive_regulation of Tnni3 2 0.12 0.88 0.14
54 INT287860 Regulation of Phosphorylation of Tnni3 1 0.21 0.16 0.12
55 INT290852 Binding of Stx1a 1 0.13 0 0.11
56 INT287850 Positive_regulation of Phosphorylation of Tnni3 1 0.54 0.09 0.11
57 INT334306 Positive_regulation of Stx1a 1 0.10 0.65 0.11
58 INT320951 Negative_regulation of Gene_expression of Stx1a 1 0.40 0.56 0.11
59 INT353248 Negative_regulation of Positive_regulation of TNNI3 1 0.42 0.52 0.1
60 INT100628 Localization of Tnni3 1 0.18 0.73 0.09
61 INT86366 Phosphorylation of TNNI3 1 0.04 0.51 0.09
62 INT72267 Positive_regulation of Regulation of TNNI3 1 0.44 0.4 0.07
63 INT247662 Positive_regulation of Localization of TNNI3 7 0.68 2.51 0.05
64 INT320948 Negative_regulation of Stx1a 1 0.41 0.41 0.04
65 INT243247 Localization of Stx1a 3 0.42 0.53 0
66 INT209579 Regulation of Localization of TNNI3 2 0.60 0.79 0
67 INT249387 Positive_regulation of Regulation of Stx1a 1 0.20 0.07 0
68 INT256648 Negative_regulation of Gene_expression of AMBP 1 0.02 0.59 0
69 INT287835 Negative_regulation of Phosphorylation of Tnni3 1 0.33 0 0
70 INT249380 Positive_regulation of Phosphorylation of Stx1a 1 0.19 0.07 0
71 INT252138 Binding of STX1A 1 0.35 0 0
72 INT127513 Positive_regulation of Negative_regulation of TNNI3 1 0.21 0.14 0
73 INT249400 Negative_regulation of Binding of Stx1a 1 0.17 0.08 0
74 INT249375 Phosphorylation of Stx1a 1 0.33 0.07 0
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