GO:0019886

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Name antigen processing and presentation of exogenous peptide antigen via MHC class II
Categary Process
Go Slim No
Go Link GO:0019886
Unique Molecular Interactions 94
Total Molecular Interactions 127
Total Single Events 709
Pain Genes Associated 16

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for antigen processing and presentation of exogenous peptide antigen via MHC class II. They are ordered first by their pain relevance and then by number of times they were reported for antigen processing and presentation of exogenous peptide antigen via MHC class II. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT253988 Binding of Cd74 and Mif 1 0.36 6.57 2.52
2 INT32586 H2-Ab1 Regulation of Pomc 1 0.03 0.14 2.19
3 INT32585 H2-Ab1 Negative_regulation of Pomc 1 0.03 0.13 2
4 INT29093 Binding of H2-Ab1 and Rbm39 1 0.06 0 1.5
5 INT48101 RT1-DMb Positive_regulation of Penk 1 0.10 0 1.5
6 INT340439 Binding of HLA-DMA and SUGT1 1 0.00 4.1 1.16
7 INT145408 H2-Ab1 Negative_regulation of Gene_expression of Dbi 1 0.05 0 1.06
8 INT218062 Abat Negative_regulation of Ctse 1 0.03 0.25 0.89
9 INT86657 TNF Regulation of H2-Ab1 1 0.02 0.84 0.74
10 INT112218 Ntsr2 Positive_regulation of H2-Ab1 1 0.06 0 0.64
11 INT197050 Binding of HLA-DOA and HLA-E 2 0.08 1.73 0.58
12 INT195773 Binding of Cd74 and Mif 2 0.25 2.78 0.55
13 INT346205 Binding of CD74 and TPPP 1 0.02 0.87 0.51
14 INT17610 Binding of Ctse and Trh 1 0.27 0.89 0.49
15 INT119598 H2-Ab1 Regulation of Scn4a 1 0.00 0.09 0.46
16 INT195774 Binding of MIF and Cd74 1 0.02 1.15 0.46
17 INT340438 Binding of HLA-DMA and MRAP 1 0.02 1.69 0.43
18 INT174501 Binding of HLA-B and HLA-DOA 2 0.03 1.84 0.42
19 INT339511 Binding of Tlr4 and Traf6 1 0.05 0.12 0.38
20 INT339512 Negative_regulation of Binding of Tlr4 and Traf6 1 0.05 0.17 0.38
21 INT339506 Binding of Irak1 and Traf6 1 0.03 0.12 0.37
22 INT174459 IL8 Positive_regulation of Gene_expression of Cd74 1 0.00 0.61 0.35
23 INT324690 Binding of Traf6 and Ticam1 2 0.07 0.23 0.33
24 INT119603 H2-Ab1 Regulation of EDNRA 1 0.00 0.07 0.32
25 INT203089 Binding of Il1a and Traf6 1 0.04 0.66 0.32
26 INT119602 EDNRA Regulation of H2-Ab1 1 0.00 0.07 0.32
27 INT203086 Positive_regulation of Binding of Il1a and Traf6 1 0.06 0.67 0.32
28 INT258861 Binding of HLA-DOA and HLA-DRB1 2 0.14 1.88 0.28
29 INT171939 Binding of HLA-DOA and TNF 1 0.05 6.8 0.26
30 INT10363 Binding of Tmem33 and RT1-Db1 1 0.00 0.92 0.21
31 INT171938 Binding of HLA-DOA and ATP2C1 1 0.01 3.88 0.2
32 INT301282 Tnfsf11 Positive_regulation of Traf6 1 0.10 0.65 0.2
33 INT353808 HLA-DMA Regulation of HLA-B 1 0.00 1.72 0.19
34 INT217478 Binding of Tnfrsf11a and Traf6 1 0.39 1.22 0.17
35 INT258909 Binding of HLA-DOA and NDUFA2 1 0.03 1.44 0.15
36 INT188694 Traf6 Positive_regulation of Positive_regulation of Irf3 1 0.08 0.2 0.15
37 INT188700 Il6 Positive_regulation of H2-Eb1 1 0.01 0.18 0.14
38 INT43495 Cd74 Regulation of Gene_expression of Ifng 1 0.47 0 0.14
39 INT298052 Binding of Cd74 and Vip 1 0.00 1.05 0.13
40 INT87839 Binding of Cd74 and Dcn 1 0.36 0.21 0.13
41 INT262642 Binding of HLA-DOA and HLA-DQB3 1 0.00 0.63 0.13
42 INT311737 Plat Regulation of Positive_regulation of Fcgr2b 1 0.31 0.71 0.13
43 INT180345 Binding of HLA-DMA and HLA-DRB4 1 0.00 1.51 0.12
44 INT334254 Binding of Traf6 and Gtf3a 1 0.00 0.18 0.11
45 INT217470 Traf6 Positive_regulation of Ngf 1 0.36 0.52 0.1
46 INT311735 Binding of Plat and Fcgr2b 1 0.29 0.65 0.1
47 INT217477 Traf6 Positive_regulation of Binding of Nup62 1 0.32 0.47 0.09
48 INT323071 Binding of RT1-DOa and Ppara 1 0.13 0.74 0.09
49 INT230065 Binding of TOR1A and HLA-DOA 1 0.00 1.65 0.09
50 INT149185 Regulation of H2-Ab1 Regulation of Trpv1 1 0.34 0.52 0.08
51 INT149184 H2-Ab1 Regulation of Trpv1 1 0.34 0.52 0.08
52 INT337084 Negative_regulation of Binding of Cd74 and Mif 1 0.29 1.64 0.08
53 INT262639 Binding of HLA-DOA and AICDA 1 0.01 2.85 0.07
54 INT262637 Binding of C2 and HLA-DOA 1 0.01 0.5 0.07
55 INT331310 Binding of HLA-A and HLA-DOA 1 0.00 0.85 0.06
56 INT262638 Binding of HLA-DQB1 and AICDA 1 0.03 1.34 0.06
57 INT323043 Binding of CYP21A1P and HLA-DOA 1 0.04 1.48 0.06
58 INT323042 Binding of CYP21A2 and HLA-DOA 1 0.04 1.49 0.06
59 INT217471 Binding of Nup62 and Traf6 1 0.26 0 0.05
60 INT334265 Binding of Traf6 and Irak4 1 0.19 0.24 0.05
61 INT329045 Binding of Unc93b1 and Tlr3 1 0.03 0.7 0.05
62 INT262643 Binding of HLA-DQB1 and HLA-DRB1 1 0.10 0.45 0.05
63 INT201729 Traf6 Positive_regulation of Phosphorylation of Nfkb1 1 0.00 0.45 0.04
64 INT201733 Traf6 Positive_regulation of Protein_catabolism of Nfkbib 1 0.00 0.44 0.04
65 INT201750 Traf6 Positive_regulation of Cib1 1 0.00 0.37 0.04
66 INT275125 Binding of HLA-DOA and HSPG2 1 0.01 1.42 0.04
67 INT201746 Traf6 Positive_regulation of Map4k4 1 0.00 0.37 0.04
68 INT348820 Cd74 Regulation of Gene_expression of TFDP3 1 0.07 0.16 0.04
69 INT201739 Traf6 Positive_regulation of Localization of Nfkb1 1 0.00 0.45 0.04
70 INT331309 Binding of HLA-DOA and HLA-G 1 0.00 0.16 0.03
71 INT236078 Binding of AGER and HLA-DMA 1 0.08 0.81 0
72 INT228108 Il10 Negative_regulation of H2-Eb1 1 0.04 1.38 0
73 INT335239 Binding of HLA-DOA and PMEL 1 0.04 0.68 0
74 INT110162 Binding of HLA-B and HLA-DQB1 1 0.09 0 0
75 INT319921 Binding of HLA-DOA and ITIH4 1 0.00 0.07 0
76 INT258910 Binding of HLA-DQA1 and HLA-DQB1 1 0.17 0.22 0
77 INT348020 Binding of Traf6 and Irak2 1 0.13 0.05 0
78 INT348037 Irak2 Positive_regulation of Binding of Traf6 1 0.18 0.05 0
79 INT236079 Binding of AGER and HLA-DQB1 1 0.25 1.06 0
80 INT335241 Binding of GZMA and HLA-DOA 1 0.00 0.13 0
81 INT236077 Binding of HLA-DQB1 and TNF 1 0.29 1.06 0
82 INT180350 Binding of HLA-DMA and ENAM 1 0.00 1.85 0
83 INT236076 Binding of HLA-DQB1 and LTA 1 0.25 1.06 0
84 INT185354 Binding of Egfr and H2-Ab1 1 0.42 0.69 0
85 INT323252 Binding of H2-Ab1 and Isl1 1 0.00 0.6 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for antigen processing and presentation of exogenous peptide antigen via MHC class II. They are ordered first by their pain relevance and then by number of times they were reported in antigen processing and presentation of exogenous peptide antigen via MHC class II. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT11766 Negative_regulation of H2-Ab1 15 0.43 5.27 12.32
2 INT3699 Gene_expression of H2-Ab1 24 0.74 12.06 11.82
3 INT2956 Binding of H2-Ab1 19 0.37 3.1 11.18
4 INT23402 Binding of HLA-DOA 74 0.48 52.01 10.89
5 INT73642 Positive_regulation of Ctse 12 0.44 5.57 6.79
6 INT10568 Regulation of H2-Ab1 9 0.20 1.86 6.79
7 INT14054 Positive_regulation of H2-Ab1 10 0.69 2.98 6.25
8 INT23401 Gene_expression of HLA-DOA 91 0.30 38.21 5.52
9 INT20676 Gene_expression of Ctse 16 0.77 10.59 4.68
10 INT253970 Positive_regulation of Cd74 3 0.48 8.16 4.09
11 INT123908 Positive_regulation of HLA-DQB1 12 0.21 10.5 3.71
12 INT79477 Binding of HLA-DMA 19 0.26 13.78 3.47
13 INT187168 Binding of Cd74 13 0.27 11.2 3.44
14 INT115232 Negative_regulation of Ctse 2 0.36 1.29 3.37
15 INT167039 Gene_expression of Cd74 24 0.40 17.12 2.84
16 INT271447 Positive_regulation of Positive_regulation of HLA-DQB1 1 0.06 5.87 2.8
17 INT79476 Gene_expression of HLA-DMA 23 0.38 9.5 2.76
18 INT243350 Binding of CD74 2 0.11 4.86 2.72
19 INT44851 Gene_expression of RT1-DMb 3 0.52 2.2 2.1
20 INT155015 Positive_regulation of HLA-DOA 6 0.23 4.45 1.92
21 INT253975 Binding of Cd74 4 0.27 4.57 1.88
22 INT58069 Transcription of H2-Ab1 2 0.50 1.06 1.59
23 INT150156 Positive_regulation of Gene_expression of HLA-DOA 7 0.20 4.07 1.5
24 INT99861 Positive_regulation of Regulation of H2-Ab1 1 0.21 0.8 1.49
25 INT271443 Regulation of Cd74 1 0.33 2.73 1.4
26 INT271448 Regulation of HLA-DQB1 1 0.06 2.73 1.4
27 INT105122 Regulation of Ctse 4 0.27 0.57 1.23
28 INT298979 Gene_expression of Traf6 5 0.31 1.75 1.21
29 INT108077 Regulation of Regulation of H2-Ab1 1 0.04 0 1.1
30 INT136005 Positive_regulation of Gene_expression of Ctse 1 0.47 0.07 1.07
31 INT156891 Positive_regulation of Transcription of Ctse 1 0.28 0 1.03
32 INT156890 Transcription of Ctse 1 0.39 0 1.02
33 INT110163 Binding of HLA-DQB1 8 0.25 4.71 0.98
34 INT11765 Positive_regulation of Gene_expression of H2-Ab1 3 0.41 0.36 0.97
35 INT116058 Gene_expression of Cd74 2 0.56 0.55 0.89
36 INT174420 Positive_regulation of Gene_expression of Cd74 3 0.20 1.92 0.81
37 INT323068 Gene_expression of RT1-DOa 1 0.25 5.74 0.74
38 INT139944 Transcription of RT1-DMb 1 0.11 0.87 0.68
39 INT14053 Regulation of Positive_regulation of H2-Ab1 1 0.09 0.32 0.63
40 INT188799 Positive_regulation of Protein_catabolism of Traf6 2 0.19 1.98 0.62
41 INT116060 Negative_regulation of Gene_expression of Cd74 1 0.12 0 0.61
42 INT14052 Positive_regulation of Positive_regulation of H2-Ab1 1 0.10 0.31 0.61
43 INT285551 Negative_regulation of HLA-DQB1 1 0.03 1.08 0.54
44 INT271439 Positive_regulation of Localization of Cd74 1 0.36 1.01 0.52
45 INT218059 Localization of Ctse 1 0.49 0.22 0.5
46 INT271435 Localization of Cd74 1 0.54 0.95 0.49
47 INT152682 Negative_regulation of Gene_expression of H2-Ab1 4 0.34 3.3 0.46
48 INT174418 Regulation of Gene_expression of Cd74 1 0.04 0.9 0.46
49 INT188800 Protein_catabolism of Traf6 2 0.40 1.6 0.45
50 INT229587 Positive_regulation of Gene_expression of RT1-DMb 1 0.06 1.7 0.45
51 INT201091 Regulation of HLA-DOA 5 0.20 3.6 0.44
52 INT254172 Negative_regulation of Gene_expression of Cd74 1 0.24 1.03 0.44
53 INT239036 Positive_regulation of HLA-DMA 4 0.67 1.44 0.4
54 INT136443 Negative_regulation of Binding of H2-Ab1 1 0.30 0.65 0.39
55 INT323067 Positive_regulation of Gene_expression of RT1-DOa 1 0.16 2.03 0.39
56 INT144659 Phosphorylation of H2-Ab1 1 0.01 0 0.39
57 INT62874 Gene_expression of CD74 1 0.00 0.64 0.37
58 INT217464 Binding of Traf6 5 0.29 1.28 0.35
59 INT203075 Positive_regulation of Traf6 1 0.16 0.67 0.32
60 INT203074 Positive_regulation of Positive_regulation of Traf6 1 0.16 0.67 0.32
61 INT323064 Positive_regulation of RT1-DOa 1 0.16 0.9 0.29
62 INT137615 Regulation of Gene_expression of H2-Ab1 2 0.59 1.32 0.28
63 INT3912 Localization of HLA-DMA 2 0.35 1.09 0.27
64 INT210927 Positive_regulation of Traf6 4 0.32 0.99 0.22
65 INT254173 Transcription of Traf6 1 0.25 0.26 0.21
66 INT323069 Regulation of Gene_expression of RT1-DOa 1 0.20 3.28 0.2
67 INT174520 Negative_regulation of Gene_expression of HLA-DOA 10 0.14 2.62 0.17
68 INT221116 Regulation of HLA-DMA 4 0.05 0.7 0.17
69 INT291908 Negative_regulation of HLA-DMA 1 0.08 0.14 0.17
70 INT188688 Regulation of Traf6 1 0.24 0.15 0.15
71 INT140260 Positive_regulation of RT1-DMb 1 0.03 0 0.15
72 INT311718 Positive_regulation of Fcgr2b 1 0.30 0.68 0.12
73 INT131015 Negative_regulation of Cd74 1 0.17 0.25 0.12
74 INT222906 Localization of HLA-DOA 5 0.25 2.41 0.08
75 INT291910 Positive_regulation of Gene_expression of HLA-DMA 1 0.10 0.06 0.08
76 INT257933 Negative_regulation of Positive_regulation of H2-Ab1 1 0.05 0.14 0.08
77 INT258875 Regulation of Gene_expression of HLA-DOA 1 0.01 0.32 0.08
78 INT324127 Positive_regulation of Cd74 2 0.07 1.34 0.04
79 INT323066 Binding of RT1-DOa 1 0.12 1.64 0.04
80 INT329052 Gene_expression of Unc93b1 1 0.04 0.74 0.04
81 INT262647 Protein_catabolism of HLA-DOA 1 0.06 0.68 0.03
82 INT191162 Negative_regulation of HLA-DOA 3 0.12 1.24 0
83 INT194148 Positive_regulation of CD74 2 0.27 0.68 0
84 INT258915 Gene_expression of HLA-DQB1 2 0.44 0.72 0
85 INT323065 Regulation of RT1-DOa 1 0.15 2.94 0
86 INT247117 Localization of HLA-DQB1 1 0.01 1.53 0
87 INT324126 Negative_regulation of Binding of Cd74 1 0.08 0.31 0
88 INT178216 Transcription of HLA-DMA 1 0.01 0.97 0
89 INT298986 Positive_regulation of Gene_expression of Traf6 1 0.23 0.4 0
90 INT249711 Regulation of Regulation of HLA-DMA 1 0.02 0 0
91 INT258922 Negative_regulation of Binding of HLA-DOA 1 0.14 0.41 0
92 INT221120 Regulation of Gene_expression of HLA-DMA 1 0.00 0.62 0
93 INT201090 Regulation of Regulation of HLA-DOA 1 0.20 0.93 0
94 INT187455 Gene_expression of H2-Eb1 1 0.27 0.21 0
95 INT298982 Positive_regulation of Positive_regulation of Traf6 1 0.23 0.4 0
96 INT258919 Regulation of Binding of HLA-DOA 1 0.15 0.22 0
97 INT324125 Positive_regulation of Binding of Cd74 1 0.09 0.62 0
98 INT258921 Negative_regulation of Negative_regulation of HLA-DOA 1 0.12 0.38 0
99 INT258912 Positive_regulation of Binding of HLA-DOA 1 0.17 0.41 0
100 INT291903 Negative_regulation of Binding of HLA-DMA 1 0.08 0 0
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