GO:0019887

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Name protein kinase regulator activity
Categary Function
Go Slim No
Go Link GO:0019887
Unique Molecular Interactions 85
Total Molecular Interactions 103
Total Single Events 809
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for protein kinase regulator activity. They are ordered first by their pain relevance and then by number of times they were reported for protein kinase regulator activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT84886 APC Regulation of PPARD 1 0.51 1.57 1.26
2 INT255336 Csnk2b Regulation of Phosphorylation of Nav1 1 0.10 0 1.03
3 INT255330 Nav1 Regulation of Phosphorylation of Csnk2b 1 0.10 0 0.97
4 INT323698 Gene_expression of MIR146A Regulation of FAF1 1 0.16 1.82 0.86
5 INT195778 Binding of APC and PROCR 7 0.19 3.78 0.73
6 INT255375 AIS Regulation of Negative_regulation of Csnk2b 1 0.02 0 0.69
7 INT255379 Csnk2b Positive_regulation of Positive_regulation of AIS 1 0.02 0 0.57
8 INT182150 Binding of APC and DCPS 1 0.02 1.14 0.48
9 INT114297 Apc Negative_regulation of Gene_expression of Fcer2a 1 0.03 0.96 0.48
10 INT255331 Csnk2b Regulation of Binding of Nav1 1 0.05 0 0.43
11 INT255374 Csnk2b Positive_regulation of AIS 1 0.02 0.09 0.39
12 INT84887 APC Negative_regulation of Gene_expression of PPARD 1 0.36 0.55 0.37
13 INT195665 APC Negative_regulation of F8 1 0.04 1.53 0.32
14 INT242164 Wnt2 Positive_regulation of Localization of Apc 1 0.13 1.53 0.32
15 INT195664 APC Negative_regulation of F5 1 0.08 1.51 0.31
16 INT63122 Binding of APC and Man2a2 1 0.01 0.15 0.3
17 INT255322 Binding of Dpep1 and Csnk2b 1 0.01 0 0.29
18 INT289954 Binding of APC and CD28 1 0.03 0.38 0.28
19 INT350813 Binding of Apc and Crp 1 0.18 1.12 0.27
20 INT235976 Binding of APC and Trav6-3 2 0.01 2.62 0.24
21 INT235974 Negative_regulation of Binding of APC and Trav6-3 1 0.00 1.15 0.24
22 INT235972 Negative_regulation of Binding of APC and Bcr 1 0.01 1.15 0.24
23 INT235973 Binding of APC and Bcr 1 0.01 1.14 0.24
24 INT323699 MIR146A Regulation of Gene_expression of FAF1 1 0.22 0.93 0.23
25 INT109408 Negative_regulation of APC Negative_regulation of Positive_regulation of RASGRP1 1 0.06 0.73 0.23
26 INT250783 APC Negative_regulation of SERPINE1 1 0.06 0.86 0.23
27 INT250782 APC Negative_regulation of F2 1 0.00 0.86 0.23
28 INT316111 APC Negative_regulation of SAE1 1 0.04 1.21 0.22
29 INT195663 APC Negative_regulation of Gene_expression of IL6 1 0.16 1.18 0.22
30 INT255329 Csnk2b Regulation of Binding of Nrcam 1 0.02 0 0.22
31 INT255316 Csnk2b Regulation of Binding of Dpep1 1 0.01 0 0.22
32 INT316110 Binding of APC and SAE1 1 0.03 1.16 0.2
33 INT323711 FAF1 Regulation of MIR146A 1 0.10 0.87 0.18
34 INT323706 Binding of FAF1 and MIR146A 1 0.13 0.87 0.18
35 INT334106 APC Negative_regulation of NFKB1 1 0.25 1.37 0.17
36 INT334108 APC Negative_regulation of TNF 1 0.13 1.36 0.17
37 INT255376 Binding of Csnk2b and AIS 1 0.02 0 0.14
38 INT289956 Binding of APC and ICAM1 1 0.04 0.5 0.13
39 INT242163 Wnt2 Positive_regulation of Regulation of Apc 1 0.13 0.71 0.13
40 INT184603 APC Negative_regulation of Gene_expression of TNF 1 0.09 0.97 0.13
41 INT316190 Apc Negative_regulation of Positive_regulation of Mapk1 1 0.33 0.66 0.12
42 INT277984 Negative_regulation of Epo Positive_regulation of Localization of Ptprc 1 0.02 0.77 0.12
43 INT184608 APC Regulation of Gene_expression of Nppa 1 0.06 1.11 0.12
44 INT299754 Binding of APC and CTLA4 2 0.08 0.97 0.11
45 INT262255 Binding of APC and F2R 1 0.05 3 0.1
46 INT323700 MIR146A Regulation of FAF1 1 0.22 0.69 0.09
47 INT270203 Binding of CD28 and Apc 1 0.04 0.58 0.08
48 INT270197 Binding of Apc and Cd86 1 0.02 0.58 0.08
49 INT270198 Binding of Apc and Cd80 1 0.02 0.58 0.08
50 INT176095 Binding of Apc and EC 1 0.04 0.51 0.05
51 INT120574 Binding of Apc and Egfr 1 0.27 1.02 0.05
52 INT334107 Binding of APC and APCS 1 0.16 1.52 0.04
53 INT133489 CREB1 Positive_regulation of Csnk2b 1 0.08 0.42 0.03
54 INT133490 AKT1 Positive_regulation of Csnk2b 1 0.02 0.42 0.03
55 INT133491 CREB1 Positive_regulation of Phosphorylation of Csnk2b 1 0.08 0.42 0.03
56 INT213034 Hdl1 Positive_regulation of Apc 1 0.08 1.21 0
57 INT341502 Negative_regulation of Binding of Apc and Pdcd1 1 0.00 0.53 0
58 INT191096 Negative_regulation of Binding of Apc and Esr1 1 0.05 1.07 0
59 INT301675 Binding of APC and HLA-E 1 0.01 1.48 0
60 INT286112 Binding of Apc and Afap1 1 0.05 0.71 0
61 INT265233 Binding of APC and FKBP1A 1 0.08 0.41 0
62 INT213007 Hdl1 Regulation of Regulation of Apc 1 0.08 1.24 0
63 INT301674 Binding of APC and CD80 1 0.01 0.53 0
64 INT249850 Binding of Ptprc and Cd34 1 0.13 0.48 0
65 INT195661 Binding of APC and PROC 1 0.23 0.89 0
66 INT253019 APC Positive_regulation of Protein_catabolism of Pttg1 1 0.06 0 0
67 INT253012 APC Positive_regulation of Binding of Pttg1 1 0.06 0 0
68 INT268342 Binding of APC and ANKS1B 1 0.01 0.92 0
69 INT191095 Positive_regulation of Binding of Apc and Esr1 1 0.06 1.08 0
70 INT301677 Binding of APC and CD8A 1 0.03 1.48 0
71 INT265232 Regulation of Binding of APC and FKBP1A 1 0.08 0.41 0
72 INT268395 Binding of APC and Kras 1 0.04 1.21 0
73 INT213009 Hdl1 Positive_regulation of Positive_regulation of Apc 1 0.09 1.14 0
74 INT323708 Binding of CASP8 and FAF1 1 0.07 0.73 0
75 INT80660 INS Positive_regulation of APC 1 0.32 0.65 0
76 INT283362 AXIN2 Negative_regulation of APC 1 0.10 1.67 0
77 INT191098 Binding of Apc and Esr1 1 0.04 1.06 0
78 INT323705 Binding of FAS and FAF1 1 0.42 1.46 0
79 INT195659 APC Positive_regulation of Gene_expression of PROC 1 0.26 0.31 0
80 INT213025 Vtn Positive_regulation of Apc 1 0.01 1.19 0
81 INT213054 Hdl1 Regulation of Apc 1 0.05 1.24 0
82 INT80659 Positive_regulation of INS Positive_regulation of APC 1 0.32 0.65 0
83 INT236721 Binding of Apc and Ctnnd2 1 0.25 1.03 0
84 INT252909 FZR1 Positive_regulation of APC 1 0.06 0.08 0
85 INT341501 Binding of Apc and Pdcd1 1 0.00 0.52 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for protein kinase regulator activity. They are ordered first by their pain relevance and then by number of times they were reported in protein kinase regulator activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT133478 Phosphorylation of Csnk2b 29 0.37 1.19 18.73
2 INT57057 Gene_expression of APC 131 0.78 122.24 8.7
3 INT16631 Negative_regulation of APC 46 0.57 30.53 7.11
4 INT3819 Positive_regulation of Apc 36 0.69 27.03 6.02
5 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22
6 INT57064 Positive_regulation of APC 72 0.66 48.5 5.08
7 INT3817 Negative_regulation of Apc 29 0.58 22.12 3.91
8 INT63121 Binding of APC 29 0.41 23.02 3.8
9 INT255369 Regulation of Phosphorylation of Csnk2b 1 0.20 0 2.63
10 INT255372 Negative_regulation of Csnk2b 1 0.26 0.07 2.46
11 INT255370 Gene_expression of Csnk2b 1 0.35 0.08 1.88
12 INT133480 Positive_regulation of Phosphorylation of Csnk2b 3 0.23 1.01 1.82
13 INT3818 Regulation of Apc 13 0.39 12.52 1.68
14 INT22329 Gene_expression of Ptprc 36 0.66 15.84 1.59
15 INT220177 Binding of Apc 21 0.37 15.34 1.37
16 INT110434 Positive_regulation of Gene_expression of Apc 20 0.50 11.37 1.3
17 INT90771 Positive_regulation of Ptprc 20 0.48 8.43 1.27
18 INT102073 Regulation of Gene_expression of APC 5 0.45 6.09 1.15
19 INT102074 Positive_regulation of Gene_expression of APC 20 0.50 13.66 1.1
20 INT147464 Binding of Ptprc 13 0.36 15.18 0.98
21 INT242134 Localization of Apc 8 0.74 4.83 0.88
22 INT255360 Binding of Csnk2b 1 0.17 0.16 0.88
23 INT323735 Regulation of FAF1 1 0.21 1.69 0.8
24 INT323724 Gene_expression of FAF1 9 0.61 6.92 0.73
25 INT57062 Regulation of APC 24 0.58 14.3 0.7
26 INT80674 Negative_regulation of Gene_expression of APC 16 0.59 18.14 0.69
27 INT255359 Regulation of Negative_regulation of Csnk2b 1 0.12 0 0.69
28 INT109505 Regulation of Ptprc 3 0.32 2.45 0.58
29 INT72869 Regulation of Negative_regulation of APC 2 0.36 1.7 0.54
30 INT151720 Negative_regulation of Positive_regulation of Apc 3 0.37 2.15 0.46
31 INT152151 Regulation of Gene_expression of Apc 4 0.44 3.87 0.42
32 INT255362 Localization of Csnk2b 1 0.34 0.08 0.42
33 INT220170 Regulation of Positive_regulation of Apc 1 0.10 0.46 0.35
34 INT118243 Transcription of APC 4 0.45 3.33 0.33
35 INT184605 Positive_regulation of Transcription of APC 2 0.19 2.39 0.33
36 INT225667 Transcription of Apc 3 0.52 3.73 0.32
37 INT195672 Localization of APC 7 0.74 3.76 0.3
38 INT147463 Positive_regulation of Binding of Ptprc 2 0.35 0.95 0.3
39 INT255358 Regulation of Gene_expression of Csnk2b 1 0.20 0 0.29
40 INT323743 Positive_regulation of Gene_expression of FAF1 1 0.55 3.05 0.29
41 INT80059 Negative_regulation of Ptprc 8 0.41 1.85 0.25
42 INT255364 Regulation of Csnk2b 1 0.12 0 0.22
43 INT225666 Regulation of Transcription of Apc 1 0.29 0.33 0.22
44 INT173166 Negative_regulation of Binding of APC 3 0.40 3.01 0.19
45 INT57065 Negative_regulation of Positive_regulation of APC 3 0.22 2.43 0.17
46 INT228603 Positive_regulation of Positive_regulation of Apc 1 0.24 0.24 0.17
47 INT175046 Negative_regulation of Gene_expression of Ptprc 2 0.30 0.8 0.13
48 INT250790 Negative_regulation of Localization of APC 2 0.13 2.3 0.13
49 INT250792 Positive_regulation of Localization of APC 1 0.15 0.48 0.13
50 INT242140 Regulation of Localization of Apc 1 0.12 0.12 0.11
51 INT242819 Negative_regulation of Gene_expression of Apc 4 0.37 5.6 0.1
52 INT268372 Phosphorylation of APC 3 0.81 3.39 0.09
53 INT175042 Localization of Ptprc 2 0.53 1.41 0.09
54 INT133479 Negative_regulation of Phosphorylation of Csnk2b 1 0.14 0.61 0.09
55 INT175044 Positive_regulation of Gene_expression of Ptprc 1 0.35 3.61 0.06
56 INT195679 Positive_regulation of Positive_regulation of APC 6 0.50 4.43 0.05
57 INT235057 Positive_regulation of Negative_regulation of Apc 2 0.30 0.66 0.05
58 INT242139 Protein_catabolism of Apc 1 0.17 0.27 0.03
59 INT323733 Binding of FAF1 1 0.29 0.05 0.03
60 INT195681 Positive_regulation of Negative_regulation of APC 5 0.47 3.9 0
61 INT175043 Regulation of Gene_expression of Ptprc 1 0.36 0.27 0
62 INT337657 Negative_regulation of Negative_regulation of APC 1 0.37 0.99 0
63 INT104591 Negative_regulation of Negative_regulation of Apc 1 0.04 0.16 0
64 INT337673 Regulation of Positive_regulation of APC 1 0.38 1.44 0
65 INT191087 Regulation of Regulation of Apc 1 0.06 1.02 0
66 INT283365 Positive_regulation of Binding of APC 1 0.50 1.43 0
67 INT259807 Transcription of Ptprc 1 0.04 0.67 0
68 INT337667 Regulation of Transcription of APC 1 0.23 1 0
69 INT286093 Regulation of Binding of Apc 1 0.39 1.08 0
70 INT175045 Positive_regulation of Positive_regulation of Ptprc 1 0.35 1.35 0
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