GO:0019898

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Name extrinsic to membrane
Categary Component
Go Slim No
Go Link GO:0019898
Unique Molecular Interactions 105
Total Molecular Interactions 154
Total Single Events 1547
Pain Genes Associated 22

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for extrinsic to membrane. They are ordered first by their pain relevance and then by number of times they were reported for extrinsic to membrane. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69823 Binding of GHR and RYBP 1 0.01 0 3.23
2 INT69824 Negative_regulation of Binding of GHR and RYBP 1 0.01 0 1.14
3 INT72794 Cea Positive_regulation of MUC16 1 0.43 2.78 1.01
4 INT45279 Binding of CSF2 and GHR 1 0.05 0.07 0.93
5 INT73775 Binding of GH1 and GHR 4 0.35 0.68 0.8
6 INT73776 Regulation of Binding of GH1 and GHR 2 0.26 0.16 0.75
7 INT61165 Binding of Pag1 and Pcyt1a 1 0.01 0.33 0.73
8 INT113552 Binding of PLAU and PLAUR 4 0.31 3.09 0.72
9 INT61164 Binding of Pomc and Pcyt1a 1 0.17 0.24 0.61
10 INT242614 Binding of Gdnf and Gfra1 1 0.03 0 0.51
11 INT72793 MUC16 Positive_regulation of Cea 1 0.19 1.38 0.5
12 INT195192 Akr1d1 Regulation of Msn 1 0.01 0.34 0.47
13 INT92743 Binding of NF2 and LMOD1 1 0.00 0.08 0.46
14 INT242628 Binding of Gfra1 and Ret 1 0.03 0 0.46
15 INT242634 Binding of Gfra1 and Ntrk1 1 0.02 0 0.46
16 INT242615 Ret Positive_regulation of Gene_expression of Gfra1 1 0.04 0 0.46
17 INT106001 Binding of PLAUR and VTN 2 0.23 1.5 0.45
18 INT92744 Binding of ADRB2 and NF2 1 0.00 0.1 0.41
19 INT100598 PRNP Positive_regulation of Gene_expression of IL6 1 0.40 0.23 0.4
20 INT113560 Negative_regulation of Binding of FN1 and PLAUR 1 0.26 0.87 0.37
21 INT113556 Binding of FN1 and PLAUR 1 0.22 0.81 0.37
22 INT113553 Negative_regulation of Binding of PLAU and PLAUR 1 0.36 0.87 0.37
23 INT113547 Negative_regulation of Binding of PLAUR and VTN 1 0.26 0.87 0.37
24 INT242616 Gfra1 Regulation of Gene_expression of Gfra2 1 0.00 0 0.34
25 INT238632 Binding of EPB41 and Cask 1 0.44 0.78 0.27
26 INT245590 Ghr Positive_regulation of Gene_expression of Igf1 1 0.34 0.61 0.23
27 INT202183 PLAU Regulation of Protein_catabolism of PLAUR 1 0.11 1.25 0.21
28 INT202184 SERPINE1 Regulation of Protein_catabolism of PLAUR 1 0.23 1.25 0.21
29 INT326390 Binding of PROC and Ezr 1 0.00 1 0.17
30 INT242603 Binding of Gfra1 and Gopc 1 0.01 0 0.17
31 INT242640 Binding of BDNF and Gfra1 1 0.05 0 0.17
32 INT242606 Binding of Gfra1 and Nrtn 1 0.03 0 0.17
33 INT325952 Gene_expression of Ezr Positive_regulation of Mapk1 1 0.02 1.69 0.15
34 INT106008 Binding of PLAUR and Plaur 1 0.15 1.36 0.15
35 INT156057 UMOD Regulation of GABRG3 1 0.01 0.54 0.14
36 INT326379 Binding of Ezr and Slc9a3r2 2 0.03 0.34 0.13
37 INT150389 Binding of GFRA1 and MEFV 1 0.02 0.85 0.12
38 INT156056 AKR1C1 Negative_regulation of UMOD 1 0.03 0.41 0.1
39 INT115720 TNF Regulation of Gene_expression of PLAUR 1 0.49 0.56 0.09
40 INT266952 Binding of Aspscr1 and Ap2s1 1 0.01 0.51 0.08
41 INT238631 Regulation of Binding of EPB41 and Cask 1 0.29 0.24 0.07
42 INT325954 Binding of Cttn and Ezr 1 0.22 1.61 0.07
43 INT250153 Binding of PRNP and IKBKG 1 0.09 2.83 0.06
44 INT242633 Binding of Gfra1 and Skull19 1 0.02 0 0.06
45 INT242639 Binding of Gfra1 and ANTXR2 1 0.05 0 0.06
46 INT210827 Binding of EPB41 and TPM3 1 0.03 0.17 0.06
47 INT326377 Ezr Positive_regulation of Positive_regulation of Rhoa 1 0.05 0.16 0.06
48 INT167271 Binding of Ezr and Clic5 1 0.54 0.07 0.06
49 INT326378 Binding of Rhoa and Ezr 1 0.04 0.17 0.06
50 INT290676 Binding of CEACAM3 and MUC16 1 0.10 0.7 0.05
51 INT251944 Binding of GH1 and PRNP 1 0.09 1.14 0.05
52 INT225230 Ad Positive_regulation of Nf2 1 0.04 1.37 0.04
53 INT268798 Binding of Gh and Ghr 1 0.26 1.18 0.04
54 INT265881 GHRH Positive_regulation of GHR 1 0.05 0.05 0.03
55 INT354617 Binding of Ezr and Gpbar1 1 0.02 0 0.03
56 INT347577 Binding of MUC1 and MUC16 1 0.25 0.42 0
57 INT324347 Binding of UMOD and Scr 1 0.20 2.23 0
58 INT325945 Binding of Cd44 and Ezr 1 0.25 0.39 0
59 INT324342 UMOD Positive_regulation of Scr 1 0.17 1.29 0
60 INT175832 Binding of GML and SLC25A11 1 0.10 0 0
61 INT325942 Binding of Icam1 and Ezr 1 0.15 0.39 0
62 INT324312 Binding of GATM and UMOD 1 0.02 1.62 0
63 INT325949 Binding of Spn and Ezr 1 0.14 0.39 0
64 INT354566 F2 Positive_regulation of PRNP 1 0.00 0.05 0
65 INT208263 Binding of Sdc1 and Msn 1 0.08 0.15 0
66 INT193308 Binding of PRNP and TGFB1 1 0.01 0 0
67 INT260561 Binding of AFM and PRNP 1 0.22 0 0
68 INT173769 Dlat Regulation of Ghr 1 0.04 0 0
69 INT324346 Regulation of UMOD Positive_regulation of Scr 1 0.10 1.31 0
70 INT325948 Ezr Regulation of Pcx 1 0.00 0.84 0
71 INT328626 Binding of TBCE and MUC16 1 0.15 0.79 0
72 INT289510 Binding of ODF2 and Ezr 1 0.10 0.47 0
73 INT215246 Binding of Rab27a and Rph3a 1 0.07 0.26 0
74 INT266080 Binding of PAPPA and MUC16 1 0.40 0.74 0
75 INT324305 Binding of CST3 and UMOD 1 0.05 3.22 0
76 INT216465 Gh Positive_regulation of Ghr 1 0.26 0.23 0
77 INT266068 Binding of CHKB and MUC16 1 0.22 0.74 0
78 INT328627 Binding of LGALS3 and MUC16 1 0.04 0.73 0
79 INT324313 Binding of STC1 and UMOD 1 0.29 3.22 0
80 INT247003 Binding of Ghr and Gh1 1 0.00 0 0
81 INT324311 Binding of UMOD and SHROOM3 1 0.29 1.62 0
82 INT215239 Binding of Rab27a and Sytl4 1 0.26 0.26 0
83 INT325953 Ezr Positive_regulation of Mapk1 1 0.02 0.4 0
84 INT215241 Binding of Rab3a and Rph3a 1 0.00 0.26 0
85 INT321968 Rock1 Positive_regulation of EZR 1 0.42 1.02 0
86 INT344000 PROC Positive_regulation of PRNP 1 0.00 0.07 0
87 INT325955 Ezr Regulation of Mia1 1 0.09 1.68 0
88 INT324344 Positive_regulation of UMOD Regulation of Scr 1 0.24 0.29 0
89 INT325946 Gene_expression of Ezr Positive_regulation of Positive_regulation of Mapk1 1 0.02 0.28 0
90 INT256983 Binding of Cd9 and Ezr 1 0.06 0.12 0
91 INT304608 Binding of GYPA and Epb4.1 1 0.00 0.4 0
92 INT325947 Ezr Regulation of Zfp369 1 0.00 0.84 0
93 INT256989 Binding of Ezr and Slc9a3r1 1 0.10 0 0
94 INT215238 Binding of Rab3a and Sytl4 1 0.01 0.26 0
95 INT325950 Binding of Icam2 and Ezr 1 0.17 0.39 0
96 INT324341 UMOD Regulation of Scr 1 0.21 0.29 0
97 INT193307 Binding of PDGFA and PRNP 1 0.01 0 0
98 INT238630 Negative_regulation of Binding of EPB41 and Cask 1 0.45 0 0
99 INT268646 Prnp Positive_regulation of PRNP 1 0.08 0.42 0
100 INT354482 Binding of PRNP and Prnp 1 0.16 0.88 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for extrinsic to membrane. They are ordered first by their pain relevance and then by number of times they were reported in extrinsic to membrane. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT8547 Gene_expression of MUC16 116 0.78 75.97 12.18
2 INT8546 Positive_regulation of MUC16 99 0.69 74.98 11.26
3 INT46273 Gene_expression of PRNP 103 0.78 110.34 9.25
4 INT163054 Gene_expression of Msn 20 0.66 0.6 9.06
5 INT55957 Positive_regulation of PRNP 57 0.67 37.87 7.11
6 INT163052 Regulation of Msn 11 0.38 1.21 6.31
7 INT9895 Binding of GHR 18 0.36 4.8 5.65
8 INT242528 Gene_expression of Gfra1 15 0.09 1.17 5.61
9 INT15474 Gene_expression of PLAUR 36 0.75 22.32 4.63
10 INT139894 Negative_regulation of Msn 11 0.41 0.36 4.52
11 INT208287 Binding of Msn 10 0.41 0.33 4.31
12 INT95512 Transcription of Ghr 24 0.69 3.1 4.12
13 INT325930 Gene_expression of Ezr 75 0.77 59.77 4.06
14 INT11230 Regulation of MUC16 23 0.60 19.54 3.93
15 INT195187 Positive_regulation of Msn 5 0.49 0.38 3.66
16 INT59905 Gene_expression of Ghr 29 0.63 9.25 2.97
17 INT8545 Negative_regulation of MUC16 19 0.57 15.96 2.81
18 INT22019 Regulation of GHR 9 0.62 2.56 2.39
19 INT166490 Localization of Msn 9 0.80 0.61 2.32
20 INT16286 Positive_regulation of GHR 8 0.60 4.04 2.31
21 INT67352 Transcription of Ghr 8 0.61 1.55 2.3
22 INT35058 Positive_regulation of PLAUR 11 0.61 7.21 2.16
23 INT95510 Regulation of Ghr 1 0.45 0.21 2.07
24 INT4643 Negative_regulation of GHR 10 0.45 3.01 2
25 INT11033 Positive_regulation of Gene_expression of MUC16 21 0.69 15.75 1.89
26 INT167203 Binding of PRNP 25 0.48 20.09 1.84
27 INT4188 Binding of NF2 7 0.46 3.52 1.79
28 INT75316 Gene_expression of Ghr 6 0.78 1.24 1.68
29 INT22785 Negative_regulation of PRNP 12 0.57 5.09 1.57
30 INT325940 Positive_regulation of Gene_expression of Ezr 42 0.69 27.79 1.56
31 INT28300 Gene_expression of GHR 10 0.78 4.29 1.5
32 INT195185 Regulation of Regulation of Msn 3 0.38 0.29 1.46
33 INT67348 Negative_regulation of Ghr 8 0.40 2.84 1.43
34 INT141131 Positive_regulation of Gene_expression of PRNP 12 0.61 16.6 1.36
35 INT75315 Regulation of Ghr 4 0.22 1.5 1.34
36 INT61163 Binding of Pcyt1a 1 0.16 0.57 1.32
37 INT11887 Localization of MUC16 16 0.80 10.66 1.26
38 INT11266 Positive_regulation of UMOD 2 0.43 1.25 1.16
39 INT85621 Regulation of PRNP 16 0.60 8.7 1.15
40 INT95511 Negative_regulation of Transcription of Ghr 1 0.43 0 1.15
41 INT61512 Regulation of Binding of GHR 2 0.05 0.89 1.1
42 INT11506 Binding of MUC16 20 0.48 22.89 1.03
43 INT37687 Binding of PLAUR 8 0.29 3.61 1.03
44 INT95514 Negative_regulation of Ghr 3 0.36 1.3 0.99
45 INT122769 Gene_expression of GFRA1 1 0.00 0.71 0.95
46 INT153327 Gene_expression of Aspscr1 5 0.57 3.28 0.91
47 INT95507 Negative_regulation of Gene_expression of Ghr 3 0.33 0.49 0.91
48 INT318079 Negative_regulation of Gene_expression of Msn 1 0.08 0 0.9
49 INT216456 Positive_regulation of Ghr 6 0.41 4.96 0.85
50 INT225221 Negative_regulation of Nf2 1 0.57 18.06 0.83
51 INT59884 Gene_expression of UMOD 4 0.78 2.32 0.82
52 INT102262 Localization of NF2 1 0.14 0.6 0.79
53 INT287270 Binding of Ezr 8 0.36 1.78 0.76
54 INT245584 Positive_regulation of Gene_expression of Ghr 5 0.41 3.46 0.75
55 INT100601 Localization of PRNP 17 0.66 13.61 0.71
56 INT73783 Regulation of Gene_expression of GHR 1 0.45 0 0.7
57 INT52901 Localization of PLAUR 2 0.49 1.92 0.68
58 INT242557 Negative_regulation of Gene_expression of Gfra1 1 0.05 0.47 0.68
59 INT11032 Positive_regulation of Positive_regulation of MUC16 2 0.49 2.38 0.67
60 INT242546 Negative_regulation of Gfra1 1 0.07 0.31 0.66
61 INT35541 Transcription of MUC16 3 0.69 6.44 0.65
62 INT11889 Regulation of Gene_expression of MUC16 5 0.62 3.24 0.63
63 INT202848 Gene_expression of Nf2 5 0.59 4.93 0.63
64 INT35059 Protein_catabolism of PLAUR 5 0.88 4.61 0.61
65 INT94881 Negative_regulation of Gene_expression of MUC16 4 0.42 2.51 0.61
66 INT95506 Negative_regulation of Transcription of Ghr 1 0.15 0 0.6
67 INT341654 Localization of UMOD 1 0.73 2.2 0.57
68 INT106004 Positive_regulation of Gene_expression of PLAUR 9 0.67 5.96 0.56
69 INT95508 Negative_regulation of Gene_expression of Ghr 1 0.59 0 0.56
70 INT175068 Localization of Ezr 1 0.19 0 0.5
71 INT113564 Regulation of PLAUR 3 0.48 5.15 0.41
72 INT173752 Positive_regulation of Ghr 3 0.57 2.21 0.41
73 INT130966 Binding of EZR 2 0.36 0.24 0.41
74 INT82331 Positive_regulation of Positive_regulation of GHR 1 0.00 0.06 0.4
75 INT106005 Regulation of Gene_expression of PLAUR 2 0.59 2.66 0.39
76 INT280865 Positive_regulation of Protein_catabolism of Msn 1 0.35 0 0.38
77 INT324332 Binding of UMOD 7 0.41 7.07 0.35
78 INT289505 Negative_regulation of Ezr 2 0.43 3.04 0.35
79 INT28299 Negative_regulation of Gene_expression of GHR 1 0.03 0.1 0.35
80 INT280863 Protein_catabolism of Msn 1 0.62 0 0.35
81 INT238585 Binding of EPB41 1 0.47 0.06 0.31
82 INT251949 Negative_regulation of Gene_expression of PRNP 6 0.43 4.16 0.3
83 INT280862 Positive_regulation of Localization of Msn 1 0.35 0 0.3
84 INT335949 Positive_regulation of Positive_regulation of PRNP 2 0.25 0.82 0.29
85 INT67350 Binding of Ghr 9 0.43 1.83 0.28
86 INT325934 Localization of Ezr 1 0.80 3.78 0.27
87 INT225219 Positive_regulation of Gene_expression of Nf2 1 0.43 1.27 0.27
88 INT115708 Phosphorylation of PRNP 2 0.71 1.61 0.26
89 INT238584 Positive_regulation of Binding of EPB41 1 0.49 0 0.24
90 INT67349 Localization of Ghr 6 0.66 2.53 0.23
91 INT67351 Positive_regulation of Localization of Ghr 2 0.44 0.78 0.23
92 INT210859 Gene_expression of EPB41 8 0.75 1.46 0.21
93 INT102102 Binding of GFRA1 2 0.05 2.75 0.21
94 INT182647 Positive_regulation of EPB41 2 0.01 0.77 0.2
95 INT242573 Regulation of Gene_expression of Gfra1 1 0.05 0.47 0.2
96 INT11888 Positive_regulation of Localization of MUC16 3 0.47 1.87 0.19
97 INT325939 Regulation of Gene_expression of Ezr 1 0.61 5.27 0.19
98 INT71119 Positive_regulation of Positive_regulation of PLAUR 1 0.09 0.1 0.19
99 INT152521 Gene_expression of Ezr 1 0.47 2.95 0.18
100 INT280867 Regulation of Positive_regulation of Msn 1 0.19 0.05 0.17
101 INT325414 Regulation of Regulation of PRNP 1 0.26 0.7 0.16
102 INT75314 Regulation of Gene_expression of Ghr 3 0.26 0.42 0.15
103 INT202855 Regulation of Nf2 2 0.05 0.79 0.15
104 INT129118 Negative_regulation of NF2 2 0.56 1.89 0.15
105 INT115722 Negative_regulation of Gene_expression of PLAUR 1 0.56 0.45 0.15
106 INT280864 Positive_regulation of Binding of Msn 1 0.35 0 0.15
107 INT220367 Regulation of Positive_regulation of Ghr 1 0.44 0.45 0.14
108 INT22020 Regulation of Positive_regulation of GHR 1 0.39 1.03 0.14
109 INT115575 Regulation of Gene_expression of Pcyt1a 1 0.28 0 0.13
110 INT223953 Localization of Aspscr1 1 0.10 1.05 0.13
111 INT115576 Regulation of Pcyt1a 1 0.38 0 0.13
112 INT287283 Gene_expression of EZR 1 0.01 0.14 0.12
113 INT274516 Regulation of EPB41 1 0.01 0.14 0.12
114 INT225224 Positive_regulation of Nf2 1 0.59 3.4 0.12
115 INT268793 Protein_catabolism of Ghr 1 0.69 0.54 0.12
116 INT208920 Regulation of Ezr 6 0.61 2.97 0.11
117 INT3293 Negative_regulation of UMOD 1 0.35 0.36 0.11
118 INT225222 Negative_regulation of Negative_regulation of Nf2 1 0.41 1.55 0.11
119 INT245586 Phosphorylation of Ghr 1 0.44 0.35 0.1
120 INT274519 Protein_catabolism of EPB41 1 0.01 0.18 0.1
121 INT173756 Positive_regulation of Transcription of Ghr 3 0.36 0.83 0.09
122 INT268791 Positive_regulation of Protein_catabolism of Ghr 1 0.39 0.29 0.09
123 INT293049 Positive_regulation of Localization of PRNP 1 0.07 2.67 0.09
124 INT325927 Phosphorylation of Ezr 1 0.82 2.74 0.09
125 INT303459 Transcription of PRNP 4 0.69 1.44 0.08
126 INT242555 Binding of Gfra1 1 0.04 0 0.08
127 INT152522 Regulation of Gene_expression of Ezr 1 0.16 1.03 0.08
128 INT46700 Negative_regulation of Pcyt1a 1 0.42 0.26 0.08
129 INT354480 Regulation of Gene_expression of PRNP 1 0.39 1.96 0.08
130 INT354479 Positive_regulation of Transcription of PRNP 1 0.50 0.4 0.08
131 INT115577 Gene_expression of Pcyt1a 3 0.42 0 0.07
132 INT200180 Negative_regulation of Localization of Ghr 3 0.35 0.89 0.07
133 INT53489 Regulation of NF2 2 0.44 1.34 0.06
134 INT106006 Positive_regulation of Transcription of PLAUR 1 0.41 1.59 0.06
135 INT106007 Transcription of PLAUR 1 0.47 1.58 0.06
136 INT267029 Regulation of Gene_expression of Msn 1 0.00 0.1 0.05
137 INT102101 Positive_regulation of GFRA1 1 0.07 0.35 0.05
138 INT184168 Localization of GHR 1 0.08 0.34 0.05
139 INT237215 Regulation of Localization of MUC16 2 0.42 1.27 0.04
140 INT225217 Positive_regulation of Positive_regulation of Nf2 1 0.43 1.07 0.04
141 INT225218 Positive_regulation of Negative_regulation of Nf2 1 0.40 1.07 0.04
142 INT356345 Negative_regulation of Negative_regulation of Ghr 1 0.35 0.24 0.04
143 INT325931 Negative_regulation of Gene_expression of Ezr 1 0.58 3.57 0.04
144 INT225227 Gene_expression of NF2 4 0.65 4.49 0.03
145 INT325937 Positive_regulation of Ezr 1 0.50 2.17 0.03
146 INT293047 Protein_catabolism of PRNP 1 0.57 2 0.03
147 INT175071 Binding of Ezr 2 0.12 0.07 0
148 INT211345 Binding of Aspscr1 1 0.06 2.16 0
149 INT339354 Negative_regulation of Negative_regulation of MUC16 1 0.36 0.44 0
150 INT319565 Positive_regulation of Gene_expression of GHR 1 0.25 0.4 0
151 INT173755 Binding of Ghr 1 0.14 0 0
152 INT181205 Negative_regulation of Binding of GHR 1 0.07 0.2 0
153 INT196178 Localization of GFRA1 1 0.01 0.25 0
154 INT175836 Gene_expression of GML 1 0.38 0 0
155 INT188131 Negative_regulation of Regulation of PRNP 1 0.41 0.06 0
156 INT293048 Regulation of Protein_catabolism of PRNP 1 0.06 1.01 0
157 INT344005 Regulation of Positive_regulation of PRNP 1 0.20 0.08 0
158 INT325935 Regulation of Regulation of Ezr 1 0.45 0.14 0
159 INT290473 Positive_regulation of Regulation of PLAUR 1 0.24 1.71 0
160 INT75317 Regulation of Gene_expression of Ghr 1 0.03 0.26 0
161 INT240690 Positive_regulation of Binding of PRNP 1 0.07 0.53 0
162 INT166491 Regulation of Localization of Msn 1 0.45 0 0
163 INT238583 Regulation of Binding of EPB41 1 0.44 0 0
164 INT138907 Negative_regulation of PLAUR 1 0.02 0 0
165 INT138906 Regulation of Negative_regulation of PLAUR 1 0.01 0 0
166 INT267044 Negative_regulation of Gene_expression of Pcyt1a 1 0.03 0 0
167 INT215229 Gene_expression of Sytl4 1 0.31 0.44 0
168 INT175835 Protein_catabolism of GML 1 0.50 0 0
169 INT325933 Regulation of Phosphorylation of Ezr 1 0.45 0.75 0
170 INT289452 Positive_regulation of NF2 1 0.01 0.08 0
171 INT325932 Positive_regulation of Positive_regulation of Ezr 1 0.50 0.28 0
172 INT321735 Negative_regulation of Epb4.1 1 0.42 0.07 0
173 INT325936 Positive_regulation of Phosphorylation of Ezr 1 0.69 0.62 0
174 INT274520 Regulation of Positive_regulation of EPB41 1 0.01 0 0
175 INT274518 Positive_regulation of Positive_regulation of EPB41 1 0.01 0 0
176 INT321966 Positive_regulation of EZR 1 0.45 1 0
177 INT222723 Negative_regulation of Localization of PRNP 1 0.05 2.06 0
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