GO:0019901

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Name protein kinase binding
Categary Function
Go Slim No
Go Link GO:0019901
Unique Molecular Interactions 4112
Total Molecular Interactions 5420
Total Single Events 40142
Pain Genes Associated 344

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for protein kinase binding. They are ordered first by their pain relevance and then by number of times they were reported for protein kinase binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT206768 TP53 Positive_regulation of Ltp 2 0.01 5.83 10.21
2 INT338167 Binding of CDKN2A and MC1R 1 0.42 6.14 5.76
3 INT11599 Calca Positive_regulation of Npr1 5 0.19 0.3 4.8
4 INT296484 Binding of Gria2 and GRIP1 1 0.04 4.52 4.59
5 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
6 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
7 INT7022 Drd1a Positive_regulation of Npr1 6 0.05 0.26 4.32
8 INT130625 Prkcg Regulation of Prkaca 1 0.23 1.32 3.87
9 INT143946 Binding of Pebp1 and Mastl 1 0.00 2.04 3.82
10 INT180813 Ngf Positive_regulation of Sorbs1 1 0.04 2.09 3.79
11 INT181455 Binding of Ccr5 and Ccl5 11 0.39 12.13 3.66
12 INT128293 Negative_regulation of Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.34
13 INT128292 Nts Positive_regulation of Insr 1 0.03 0.99 3.34
14 INT128291 Vom1r68 Positive_regulation of Insr 1 0.00 0.99 3.33
15 INT128294 Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.33
16 INT69823 Binding of GHR and RYBP 1 0.01 0 3.23
17 INT102284 Binding of Grin1 and Grin2a 5 0.27 1.79 3.01
18 INT123451 Binding of YY1 and Adra2a 1 0.37 0 2.98
19 INT118158 Binding of Prkca and Prkcz 1 0.07 1.14 2.98
20 INT298456 Prkaca Positive_regulation of Phosphorylation of Adarb1 1 0.00 1.86 2.85
21 INT229497 Binding of Vim and Ndel1 1 0.33 3.5 2.81
22 INT170367 Binding of Grin1 and Grin2a 5 0.23 1.72 2.79
23 INT226118 Ghrl Regulation of Prkag1 1 0.08 0.72 2.72
24 INT154187 Il6 Positive_regulation of Gene_expression of Cd2 1 0.08 3.07 2.71
25 INT124547 Trib3 Regulation of Regulation of Th 1 0.02 0.79 2.64
26 INT351444 Grin1 Positive_regulation of Gria2 1 0.22 1.5 2.64
27 INT25708 Oprl1 Positive_regulation of Adra2a 1 0.25 0.15 2.63
28 INT111787 Cck Regulation of Gene_expression of Npr1 1 0.22 1.68 2.57
29 INT356289 Binding of Egfr and Egf 1 0.13 3.02 2.52
30 INT156799 Gria1 Regulation of Grm8 1 0.11 1.29 2.45
31 INT147659 Prkce Positive_regulation of TRPV1 1 0.04 1.42 2.43
32 INT121746 Prkaca Positive_regulation of Ephb1 2 0.23 0.92 2.35
33 INT251145 Binding of Grin2a and Dlg2 1 0.31 2.3 2.11
34 INT133946 Binding of DNM2 and OPRK1 1 0.11 0 2.1
35 INT281084 Prkaca Positive_regulation of Mapk1 2 0.25 0 2.06
36 INT33756 Akr1d1 Positive_regulation of Npr1 3 0.01 0 2.05
37 INT117821 Binding of Tacr1 and Cd4 1 0.34 0.86 2.02
38 INT21261 Penk Negative_regulation of Npr1 1 0.02 0 2
39 INT104855 Prkaca Regulation of TRPV1 3 0.06 1.52 1.92
40 INT112514 Binding of Prkaca and Trib3 1 0.03 1.18 1.9
41 INT186432 Prkaca Regulation of Creb1 1 0.14 0.45 1.9
42 INT95405 Trib3 Positive_regulation of Phosphorylation of Ephb1 3 0.08 1.33 1.89
43 INT151965 SORBS1 Positive_regulation of TRPV1 1 0.18 0 1.89
44 INT135582 Prok2 Positive_regulation of Localization of Prkce 1 0.06 1.02 1.87
45 INT13940 DNM2 Regulation of Localization of CGA 1 0.11 0 1.86
46 INT112517 Binding of Ephb1 and Prkaca 3 0.18 0.58 1.85
47 INT169468 Binding of Egfr and Spink3 1 0.37 3.73 1.83
48 INT7023 Negative_regulation of Drd1a Positive_regulation of Npr1 2 0.05 0.1 1.81
49 INT272616 Positive_regulation of Binding of Grin1 and Grin2a 2 0.30 1.36 1.8
50 INT66504 Binding of Agt and Agtr1a 8 0.39 3.78 1.78
51 INT332773 Positive_regulation of Prkaca Positive_regulation of Phosphorylation of Grin1 1 0.04 0.73 1.75
52 INT346217 Braf Positive_regulation of Phosphorylation of Map2k1 1 0.22 3.23 1.72
53 INT185143 Elane Positive_regulation of Pik3r1 1 0.01 0 1.72
54 INT139156 Binding of Gria1 and Gria2 1 0.23 0.64 1.72
55 INT186433 Trib3 Regulation of Phosphorylation of Creb1 1 0.03 0.32 1.71
56 INT68709 Positive_regulation of Crh Regulation of Npr1 1 0.03 0 1.71
57 INT18786 Binding of Adra2a and Nisch 2 0.19 0 1.7
58 INT169464 Akt1 Positive_regulation of Egfr 1 0.28 1.63 1.7
59 INT68710 Crh Regulation of Npr1 1 0.03 0 1.7
60 INT139433 Binding of Prkaca and Prkca 1 0.37 0.13 1.67
61 INT96296 Oprm1 Negative_regulation of Npr1 2 0.05 0.32 1.65
62 INT122286 Prkaca Negative_regulation of Negative_regulation of Calca 1 0.12 0.54 1.63
63 INT180812 Gdnf Positive_regulation of Gene_expression of Sorbs1 1 0.02 0.83 1.61
64 INT180811 Gdnf Positive_regulation of Regulation of Sorbs1 1 0.01 0.83 1.61
65 INT195930 OPRM1 Regulation of Prkaca 1 0.01 0 1.59
66 INT33757 Hmmr Positive_regulation of Npr1 1 0.01 0 1.59
67 INT168609 Binding of Itgb1 and Mmp9 1 0.02 0.41 1.58
68 INT81709 POMC Regulation of Gene_expression of ITGB2 1 0.40 0.34 1.57
69 INT89011 Lep Positive_regulation of Insr 1 0.19 2.41 1.57
70 INT81715 POMC Regulation of ITGB2 1 0.40 0.34 1.55
71 INT113337 EPO Positive_regulation of JAK2 1 0.76 2.8 1.55
72 INT249498 Src Positive_regulation of Phosphorylation of Grin2b 1 0.22 1.11 1.54
73 INT8734 Pebp1 Positive_regulation of Oprd1 1 0.01 0 1.54
74 INT241750 Binding of CD4 and ITIH4 14 0.18 5.72 1.53
75 INT174508 Binding of CD4 and HLA-B 1 0.14 4.68 1.53
76 INT256360 Car2 Positive_regulation of Localization of Rela 1 0.14 0 1.51
77 INT93781 Racgap1 Positive_regulation of Positive_regulation of Gnptab 1 0.02 0.07 1.49
78 INT93782 Racgap1 Positive_regulation of Rgs9 1 0.55 0.07 1.49
79 INT121741 Prkaca Negative_regulation of Positive_regulation of Creb1 1 0.10 0.2 1.49
80 INT93783 Racgap1 Positive_regulation of Gnptab 1 0.02 0.07 1.49
81 INT155497 Oprk1 Negative_regulation of Tenc1 1 0.08 0.34 1.48
82 INT112034 Gabrb3 Positive_regulation of Pik3r1 1 0.08 0.18 1.48
83 INT180804 Bdnf Positive_regulation of Gene_expression of Sorbs1 1 0.01 0 1.44
84 INT78974 Binding of Prkcg and Prkaca 2 0.31 0.35 1.4
85 INT180809 Ngf Positive_regulation of Positive_regulation of Sorbs1 1 0.03 0.84 1.4
86 INT180808 Ngf Positive_regulation of Gene_expression of Sorbs1 1 0.03 0.84 1.4
87 INT299311 Binding of RPTOR and RICTOR 1 0.38 0.21 1.4
88 INT138099 Binding of Grin2a and Insrr 1 0.01 0.36 1.39
89 INT262568 Prkaca Regulation of Trpv1 2 0.10 0.65 1.38
90 INT133933 Binding of DNM2 and TP53INP2 1 0.00 0 1.38
91 INT161191 CRX Regulation of Gene_expression of Trib3 1 0.00 2 1.38
92 INT50706 Phax Positive_regulation of Localization of Trib3 1 0.04 0.28 1.38
93 INT161185 NMS Regulation of Gene_expression of Trib3 1 0.03 2 1.38
94 INT6466 Binding of Npr1 and Oprd1 1 0.01 0 1.37
95 INT290542 Crh Positive_regulation of Insr 1 0.02 0.36 1.36
96 INT180802 Gdnf Positive_regulation of Sorbs1 1 0.02 0.98 1.34
97 INT180807 Calca Regulation of Sorbs1 1 0.02 0 1.32
98 INT192080 Foxm1 Positive_regulation of Cnr1 2 0.14 0.72 1.3
99 INT299281 Binding of RPTOR and MAPKAP1 1 0.23 0.21 1.3
100 INT148778 Binding of Usf1 and Rtn1 1 0.40 0.85 1.3
101 INT124926 Negative_regulation of Prkaca Negative_regulation of Localization of Pag1 1 0.00 0.61 1.3
102 INT95406 Trib3 Positive_regulation of Ephb1 2 0.08 0.96 1.29
103 INT148775 Binding of Calca and Usf1 1 0.43 0.85 1.29
104 INT195929 Binding of OPRM1 and Prkaca 1 0.02 0.33 1.27
105 INT100816 PPP1R14C Regulation of Ppp1cc 1 0.08 0 1.27
106 INT143620 Ltp Positive_regulation of Npr1 1 0.01 0.16 1.26
107 INT84886 APC Regulation of PPARD 1 0.51 1.57 1.26
108 INT121464 Negative_regulation of Oprm1 Positive_regulation of Dnm2 1 0.34 0 1.26
109 INT124108 Binding of RYBP and Ccne1 1 0.09 0.34 1.26
110 INT317569 Prkca Positive_regulation of Phosphorylation of Src 1 0.11 0 1.25
111 INT251142 Binding of Dlg4 and Grin2a 3 0.30 0.5 1.24
112 INT121465 Binding of Dnm2 and Oprm1 1 0.23 0 1.24
113 INT162163 CDKN2A Positive_regulation of PLD2 1 0.24 0 1.24
114 INT141244 Fos Regulation of Prkaca 1 0.18 0.07 1.24
115 INT195926 Prkaca Positive_regulation of Trpv1 1 0.10 0.44 1.24
116 INT249487 Binding of Ephb1 and Src 1 0.17 0.74 1.23
117 INT42554 Oprl1 Regulation of Npr1 2 0.06 0 1.22
118 INT75229 Prkaca Positive_regulation of Phosphorylation of Oprm1 1 0.44 0 1.22
119 INT76163 Prkaca Positive_regulation of Phosphorylation of Oprm1 1 0.02 0.08 1.22
120 INT285185 Binding of Ca2 and Cd2 1 0.25 0.24 1.21
121 INT7186 Trib3 Negative_regulation of Positive_regulation of Ctsb 1 0.03 0 1.21
122 INT7184 Negative_regulation of Trib3 Negative_regulation of Positive_regulation of Ctsb 1 0.03 0 1.21
123 INT228681 Fkbp4 Negative_regulation of Trib3 1 0.00 0.57 1.2
124 INT281077 Binding of Gria2 and Gria3 2 0.24 0.35 1.19
125 INT70288 Negative_regulation of Atxn2l Positive_regulation of Racgap1 1 0.02 0.3 1.19
126 INT116730 Rac1 Regulation of Localization of Calca 1 0.13 1.32 1.19
127 INT55162 Binding of NFKB1 and RELA 10 0.30 2.82 1.18
128 INT107579 Kitl Negative_regulation of Grin2a 1 0.10 1.02 1.18
129 INT228680 Fkbp1a Negative_regulation of Trib3 1 0.01 0.56 1.18
130 INT150835 Gper Positive_regulation of Localization of Prkce 1 0.15 0.62 1.18
131 INT141245 Prkaca Regulation of Gene_expression of Th 1 0.15 0.17 1.17
132 INT85780 Prkaca Regulation of Prkcg 1 0.29 0.47 1.17
133 INT141246 Trib3 Regulation of Gene_expression of Th 1 0.02 0.17 1.17
134 INT146352 Binding of Rgs14 and Mors1 1 0.23 0.27 1.17
135 INT13205 Oprd1 Negative_regulation of Npr1 2 0.01 0 1.16
136 INT290667 Il6 Positive_regulation of Stat3 3 0.69 2.42 1.15
137 INT147447 ADCYAP1 Regulation of Localization of RELA 1 0.50 1.12 1.15
138 INT70289 Atxn2l Positive_regulation of Racgap1 1 0.04 0.29 1.15
139 INT69824 Negative_regulation of Binding of GHR and RYBP 1 0.01 0 1.14
140 INT123387 Binding of Camk2a and Gria2 1 0.13 0.32 1.14
141 INT348400 LPA Positive_regulation of Trib3 1 0.00 0.87 1.14
142 INT13204 Binding of Npr1 and Akr1d1 1 0.00 0 1.14
143 INT7024 Regulation of Drd1a Positive_regulation of Npr1 1 0.04 0.07 1.13
144 INT130627 Gnas Regulation of Prkaca 1 0.00 0 1.13
145 INT68157 Alox5 Positive_regulation of Positive_regulation of Pdpk1 1 0.01 0.64 1.13
146 INT196812 Ppp1r1b Negative_regulation of Ppp1cc 3 0.07 0.13 1.12
147 INT68154 Mthfs Positive_regulation of Pdpk1 1 0.01 0.63 1.12
148 INT68158 Pla2g1b Positive_regulation of Pdpk1 1 0.05 0.63 1.12
149 INT68159 Pla2g1b Positive_regulation of Positive_regulation of Pdpk1 1 0.05 0.64 1.12
150 INT68163 Mthfs Positive_regulation of Positive_regulation of Pdpk1 1 0.01 0.64 1.12
151 INT68165 Alox5 Positive_regulation of Pdpk1 1 0.01 0.63 1.12
152 INT249488 Positive_regulation of Binding of Ephb1 and Src 1 0.23 0.68 1.12
153 INT147660 Positive_regulation of Prkce Positive_regulation of TRPV1 1 0.04 0.69 1.12
154 INT109374 Ppp1cc Negative_regulation of Ppp2r1a 1 0.24 0 1.11
155 INT99691 Pdpk1 Positive_regulation of Positive_regulation of VEGFA 1 0.01 0.72 1.11
156 INT132683 Bdnf Positive_regulation of Phosphorylation of Grin2a 1 0.00 0.93 1.11
157 INT269189 Binding of Grin2a and Grin3a 2 0.25 1.05 1.09
158 INT269200 Prkaca Positive_regulation of Phosphorylation of Ceacam3 1 0.03 0.65 1.09
159 INT352453 Calca Positive_regulation of Trib3 1 0.00 0.8 1.08
160 INT352468 Calca Positive_regulation of Prkaca 1 0.11 0.8 1.08
161 INT96906 Plxna3 Regulation of Regulation of Prkaca 1 0.17 0.71 1.08
162 INT71176 Binding of ICAM1 and ITGB2 4 0.21 4.93 1.07
163 INT296458 Binding of Gria2 and Pick1 3 0.24 1.86 1.07
164 INT96905 Plxna3 Regulation of Regulation of Prkce 1 0.18 0.71 1.07
165 INT181493 TRPV4 Regulation of Gene_expression of NGF 1 0.24 0.7 1.07
166 INT269193 Prkcg Regulation of Phosphorylation of Grin2a 1 0.02 0.63 1.06
167 INT269192 Ephb1 Regulation of Phosphorylation of Grin2a 1 0.02 0.63 1.06
168 INT296460 Binding of Gria2 and Myo18a 1 0.01 1.49 1.06
169 INT269198 Prkaca Regulation of Phosphorylation of Grin2a 1 0.02 0.63 1.06
170 INT18828 DNM2 Positive_regulation of Localization of LTB4R 1 0.01 0.07 1.06
171 INT119887 Binding of Atf4 and Usf1 1 0.21 0.15 1.05
172 INT119888 Binding of Creb1 and Usf1 1 0.18 0.15 1.05
173 INT269199 Prkaca Positive_regulation of Phosphorylation of Grin1 1 0.03 0.56 1.05
174 INT180806 Ngf Positive_regulation of Regulation of Sorbs1 1 0.03 0.28 1.04
175 INT41175 Adra2a Regulation of Th 1 0.59 0 1.04
176 INT181450 Binding of Ccr5 and Ccl3 4 0.18 2.19 1.03
177 INT307047 Foxm1 Positive_regulation of Casp3 1 0.11 0.06 1.03
178 INT118859 GNA14 Positive_regulation of STAT3 1 0.01 0.38 1.03
179 INT33142 Pck1 Positive_regulation of Npr1 4 0.01 0.5 1.02
180 INT263232 Prkcg Positive_regulation of Trpv4 1 0.12 1.1 1.02
181 INT352295 Binding of P2RY2 and Agtr1a 1 0.01 0.08 1.02
182 INT121743 Negative_regulation of Src Negative_regulation of Ephb1 1 0.27 0 1.02
183 INT240453 Prkcg Positive_regulation of Positive_regulation of Prkaca 1 0.23 0.63 1.01
184 INT148327 Binding of Pkd1 and Trpv1 1 0.52 2.23 1.01
185 INT13502 Penk Positive_regulation of Npr1 1 0.02 0.19 1.01
186 INT13503 Regulation of Penk Positive_regulation of Npr1 1 0.02 0.19 1.01
187 INT240455 Ephb1 Positive_regulation of Positive_regulation of Prkaca 1 0.22 0.63 1.01
188 INT131173 Chrna7 Positive_regulation of Localization of Abat 1 0.10 0 1.01
189 INT186161 Prkaca Positive_regulation of Phosphorylation of Grin1 1 0.11 1.05 1.01
190 INT7025 Positive_regulation of Drd1a Positive_regulation of Npr1 1 0.04 0.08 1.01
191 INT320021 Prkaca Regulation of Positive_regulation of Kcnma1 1 0.00 0.54 1
192 INT63543 Binding of Adra2a and Serpini1 1 0.13 0 1
193 INT83987 Ngf Regulation of Atf2 1 0.52 0.49 1
194 INT317518 Src Regulation of Negative_regulation of Oprm1 1 0.16 0.07 1
195 INT263227 Positive_regulation of Prkcg Regulation of Trpv4 1 0.07 0.95 1
196 INT221747 Gtf3a Positive_regulation of Positive_regulation of Racgap1 1 0.00 0.33 1
197 INT317564 Pik3r1 Regulation of Negative_regulation of Oprm1 1 0.13 0.07 1
198 INT42555 Oprl1 Negative_regulation of Npr1 1 0.02 0 0.99
199 INT143915 Src Regulation of Rbm39 1 0.03 0.18 0.99
200 INT41659 IL31RA Regulation of PRL 1 0.22 1.07 0.98

Single Events

The table below shows the top 100 pain related interactions that have been reported for protein kinase binding. They are ordered first by their pain relevance and then by number of times they were reported in protein kinase binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1303 Negative_regulation of Npr1 278 0.55 35.1 156.78
2 INT4259 Positive_regulation of Npr1 262 0.70 49.37 123.11
3 INT52651 Positive_regulation of Prkaca 136 0.67 40.82 99.16
4 INT7180 Negative_regulation of Trib3 180 0.51 68.48 88.01
5 INT15898 Positive_regulation of Prkaca 199 0.70 50.89 87.54
6 INT5610 Positive_regulation of Insr 140 0.69 37.26 86.24
7 INT10534 Positive_regulation of Trib3 209 0.60 78.75 81.48
8 INT29708 Gene_expression of Gria1 177 0.78 56.36 77.37
9 INT49111 Negative_regulation of Prkaca 102 0.59 27.44 71.77
10 INT53964 Negative_regulation of Prkaca 131 0.58 38.76 69.52
11 INT5034 Negative_regulation of Insr 100 0.55 28.08 54.5
12 INT8071 Positive_regulation of Gria1 102 0.70 26.61 53.37
13 INT1232 Positive_regulation of Pdpk1 78 0.42 24.33 50.17
14 INT17915 Gene_expression of Insr 141 0.75 47.45 48.59
15 INT7059 Regulation of Adra2a 89 0.62 18.24 48.43
16 INT51627 Gene_expression of Grin2a 82 0.76 25.09 47.6
17 INT66383 Phosphorylation of Prkaca 143 0.80 30.85 43.38
18 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74
19 INT18992 Negative_regulation of Pdpk1 53 0.42 19.02 40.95
20 INT92515 Gene_expression of Grin2a 84 0.76 26.68 38.37
21 INT23330 Binding of Chrna7 79 0.48 10.06 35.5
22 INT7608 Positive_regulation of Adra2a 66 0.70 17.81 35.15
23 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05
24 INT109820 Gene_expression of Trpv4 121 0.78 39.69 33.11
25 INT89055 Phosphorylation of Prkaca 60 0.61 13.41 32.49
26 INT114173 Phosphorylation of Gria1 27 0.82 33.73 31.24
27 INT49001 Regulation of Gria1 51 0.56 18.28 31.22
28 INT8691 Localization of Insr 85 0.80 9.27 30.32
29 INT19396 Regulation of Rac1 66 0.53 37.41 30.01
30 INT64918 Gene_expression of Gria2 108 0.74 29.95 29.67
31 INT5300 Regulation of Insr 54 0.60 11.33 29.26
32 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8
33 INT56525 Gene_expression of Gria2 74 0.75 23.15 28.6
34 INT7779 Negative_regulation of Adra2a 47 0.58 9.45 28
35 INT66381 Regulation of Prkaca 40 0.62 13.38 27.96
36 INT7717 Positive_regulation of Adra2a 62 0.70 17.68 27.32
37 INT12681 Regulation of Trib3 76 0.53 23.92 26.58
38 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39
39 INT96904 Regulation of Prkaca 33 0.44 10.86 24.51
40 INT47459 Gene_expression of Rac1 101 0.68 45.27 24.33
41 INT101225 Positive_regulation of Gria2 62 0.64 28.1 23.93
42 INT76249 Gene_expression of Gria1 67 0.75 15.07 22.78
43 INT83797 Gene_expression of Bcl2l1 124 0.77 94.55 22.39
44 INT15326 Phosphorylation of Trib3 83 0.55 30.96 22.27
45 INT8248 Binding of Adra2a 43 0.48 6.72 22.17
46 INT49623 Negative_regulation of Gria1 39 0.59 12.4 21.59
47 INT10536 Gene_expression of Trib3 67 0.66 27.08 21.58
48 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31
49 INT129987 Phosphorylation of Gria1 63 0.80 20.65 21.02
50 INT112029 Positive_regulation of Pik3r1 90 0.67 38.76 20.95
51 INT89805 Gene_expression of Prkaca 45 0.77 11.03 20.77
52 INT48769 Regulation of Pdpk1 20 0.35 9.78 20.36
53 INT112174 Gene_expression of Trpv4 47 0.78 26.26 20.09
54 INT7017 Regulation of Npr1 45 0.52 3.38 20.05
55 INT3030 Gene_expression of Adra2a 37 0.68 5.58 19.76
56 INT4260 Negative_regulation of Positive_regulation of Npr1 29 0.43 4.39 19.57
57 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44
58 INT12725 Positive_regulation of Racgap1 66 0.68 32.74 19.29
59 INT9552 Positive_regulation of TNNI3 209 0.70 128.67 19.15
60 INT101188 Gene_expression of Rela 81 0.56 23.43 19.15
61 INT90612 Positive_regulation of Grin2a 33 0.65 15.11 18.84
62 INT14114 Binding of Adra2a 30 0.48 4.24 18.53
63 INT167679 Gene_expression of Ccr5 74 0.75 59.03 18.16
64 INT29709 Positive_regulation of Gene_expression of Gria1 36 0.69 9.43 17.83
65 INT107454 Positive_regulation of Stat3 43 0.68 19.63 17.69
66 INT6461 Gene_expression of Npr1 35 0.75 10.38 17.58
67 INT12875 Regulation of Adra2a 26 0.45 7.51 17.35
68 INT119233 Positive_regulation of Trpv4 65 0.70 20.21 17.3
69 INT95930 Negative_regulation of Gria2 63 0.56 18.37 17.04
70 INT26972 Negative_regulation of Tenc1 57 0.57 56.71 16.87
71 INT9299 Positive_regulation of Positive_regulation of Npr1 32 0.53 6.65 16.72
72 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71
73 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65
74 INT22900 Positive_regulation of Cd4 126 0.67 82.77 16.43
75 INT10918 Gene_expression of ITGB2 93 0.76 71.8 16.34
76 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33
77 INT62861 Regulation of Gria2 45 0.60 13.35 16.07
78 INT80972 Gene_expression of Tp53 104 0.78 102.74 16.02
79 INT65659 Positive_regulation of STAT3 132 0.70 69.56 15.95
80 INT112027 Gene_expression of Pik3r1 58 0.75 30.9 15.95
81 INT124371 Negative_regulation of Gsk3b 170 0.55 87.92 15.51
82 INT38253 Localization of Trib3 35 0.63 10.28 15.42
83 INT7531 Positive_regulation of Eef1a1 29 0.62 8.16 15.41
84 INT143276 Phosphorylation of Gria2 42 0.80 16.07 15.2
85 INT5674 Gene_expression of Adra2a 34 0.77 6.14 15.13
86 INT23212 Positive_regulation of Rac1 46 0.55 32.85 15.1
87 INT114172 Positive_regulation of Phosphorylation of Gria1 8 0.63 15.73 14.99
88 INT10709 Negative_regulation of CD4 106 0.59 95.6 14.89
89 INT129584 Positive_regulation of Stat3 97 0.68 87.07 14.86
90 INT114510 Positive_regulation of Gria2 36 0.57 14.91 14.85
91 INT93482 Localization of Rela 56 0.78 24.52 14.82
92 INT14647 Positive_regulation of Grin2a 26 0.67 4.69 14.8
93 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66
94 INT8989 Binding of Npr1 25 0.36 5.52 14.58
95 INT124372 Gene_expression of Gsk3b 164 0.75 95.64 14.35
96 INT61864 Regulation of Gene_expression of Gria1 24 0.62 13.27 14.3
97 INT77619 Gene_expression of Prkaca 43 0.75 8.55 14.13
98 INT94774 Regulation of CDKN2A 43 0.60 44.41 13.99
99 INT26733 Gene_expression of Pdpk1 17 0.48 5.74 13.91
100 INT79703 Gene_expression of Agtr1a 46 0.76 14.18 13.77
101 INT27627 Binding of Rac1 41 0.41 22.88 13.68
102 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61
103 INT14768 Negative_regulation of Positive_regulation of Insr 16 0.56 5.51 13.59
104 INT49538 Binding of Gria1 22 0.47 2.66 13.35
105 INT144646 Positive_regulation of Rela 53 0.67 27.78 13.2
106 INT10016 Negative_regulation of CD8A 81 0.42 56.68 13.15
107 INT89842 Phosphorylation of Src 34 0.69 9.57 13.08
108 INT114420 Negative_regulation of Pik3r1 67 0.54 34.86 12.82
109 INT52905 Gene_expression of Cd4 84 0.78 45.68 12.75
110 INT103997 Phosphorylation of Grin2a 17 0.64 10.75 12.67
111 INT107875 Phosphorylation of Stat3 49 0.80 13.18 12.66
112 INT74838 Positive_regulation of Sorbs1 18 0.34 6.93 12.63
113 INT6322 Gene_expression of Ceacam1 46 0.75 32.13 12.46
114 INT100799 Negative_regulation of Grin2a 27 0.57 7.33 12.2
115 INT110988 Gene_expression of Insr 58 0.42 42.12 12.18
116 INT111948 Positive_regulation of Gria1 23 0.61 7.55 12.03
117 INT26973 Gene_expression of Tenc1 59 0.66 27.19 12
118 INT8533 Regulation of Sorbs1 9 0.27 3.01 11.98
119 INT36287 Binding of CD4 96 0.47 58.93 11.88
120 INT16659 Gene_expression of Eef1a1 34 0.64 6.1 11.85
121 INT53038 Positive_regulation of Agtr1a 35 0.67 23.76 11.68
122 INT51625 Regulation of Gene_expression of Grin2a 12 0.60 3.28 11.6
123 INT69029 Gene_expression of PTPRC 127 0.75 74.26 11.57
124 INT78970 Positive_regulation of Positive_regulation of Prkaca 14 0.47 3.06 11.49
125 INT5630 Localization of Pdpk1 10 0.45 5.21 11.36
126 INT88650 Negative_regulation of Prkce 13 0.57 11.93 11.16
127 INT259165 Phosphorylation of Gria2 4 0.65 11.65 11.07
128 INT57069 Regulation of Gria2 28 0.44 10.11 11.06
129 INT91357 Regulation of Dnm2 5 0.61 0 11.06
130 INT11794 Gene_expression of Cd2 27 0.76 17.31 10.99
131 INT23675 Negative_regulation of Binding of Chrna7 18 0.37 0.5 10.74
132 INT9550 Gene_expression of TNNI3 113 0.78 86.79 10.56
133 INT151168 Gene_expression of Pten 60 0.78 35.63 10.54
134 INT87393 Gene_expression of Ccr5 19 0.65 11 10.51
135 INT51626 Transcription of Grin2a 16 0.68 1.65 10.5
136 INT100379 Positive_regulation of HIF1A 69 0.69 57.31 10.4
137 INT93036 Negative_regulation of Grin2a 23 0.50 7.1 10.32
138 INT91948 Positive_regulation of Prkce 16 0.64 11.36 10.32
139 INT64193 Regulation of Grin2a 19 0.54 2.98 10.31
140 INT16404 Regulation of CD4 54 0.61 33.05 10.29
141 INT10982 Negative_regulation of Agtr1a 42 0.58 22.42 10.29
142 INT99505 Gene_expression of Bcl2l1 42 0.77 33.12 10.15
143 INT12455 Negative_regulation of Adra2a 30 0.54 5.63 10.14
144 INT10019 Binding of CD8A 57 0.36 31.49 10.08
145 INT8072 Localization of Gria1 17 0.75 2.62 10.04
146 INT13606 Negative_regulation of Negative_regulation of Npr1 13 0.40 1.21 10.01
147 INT33127 Positive_regulation of Phosphorylation of Trib3 26 0.17 14.04 10
148 INT115614 Binding of Gria2 25 0.43 8.97 9.91
149 INT169997 Positive_regulation of Gene_expression of Tp53 37 0.70 47.3 9.85
150 INT96298 Negative_regulation of Gria1 25 0.57 10.61 9.7
151 INT66382 Positive_regulation of Phosphorylation of Prkaca 33 0.49 7.05 9.69
152 INT23676 Gene_expression of Chrna7 47 0.75 23.66 9.51
153 INT114874 Gene_expression of Stat3 78 0.76 53.99 9.49
154 INT72148 Positive_regulation of Prkce 17 0.68 5.06 9.44
155 INT259169 Positive_regulation of Phosphorylation of Gria2 3 0.40 9.98 9.34
156 INT106595 Negative_regulation of Dnm2 10 0.58 0.15 9.29
157 INT135372 Positive_regulation of Gsk3b 72 0.70 50.03 9.28
158 INT78769 Regulation of Grin2a 16 0.58 5.22 9.28
159 INT10533 Positive_regulation of Positive_regulation of Trib3 24 0.42 6.59 9.2
160 INT40609 Binding of Prkaca 23 0.36 3.42 9.19
161 INT8535 Localization of Sorbs1 9 0.80 2.71 9.07
162 INT163054 Gene_expression of Msn 20 0.66 0.6 9.06
163 INT89845 Positive_regulation of Src 19 0.44 7.5 9.01
164 INT50055 Negative_regulation of Rac1 36 0.50 19.74 8.98
165 INT20371 Gene_expression of Cd8a 125 0.60 67.59 8.97
166 INT71478 Positive_regulation of Positive_regulation of Prkaca 21 0.37 5.14 8.85
167 INT26487 Positive_regulation of Npr1 17 0.70 10.01 8.78
168 INT66213 Localization of RELA 63 0.78 14.71 8.77
169 INT57057 Gene_expression of APC 131 0.78 122.24 8.7
170 INT19185 Negative_regulation of Cd4 80 0.51 61.32 8.51
171 INT91370 Phosphorylation of STAT3 123 0.82 49.25 8.42
172 INT4991 Positive_regulation of Vim 74 0.69 69.84 8.33
173 INT195203 Binding of Tenc1 14 0.32 13.97 8.28
174 INT114873 Phosphorylation of Stat3 63 0.82 30.19 8.23
175 INT124702 Positive_regulation of Trpv4 21 0.69 7.14 8.2
176 INT60285 Negative_regulation of Racgap1 27 0.56 21.71 8.14
177 INT72539 Gene_expression of Sorbs1 10 0.78 4.98 8.14
178 INT78766 Negative_regulation of Gria2 20 0.52 6.27 8.12
179 INT18736 Gene_expression of Ptpn6 19 0.59 4.44 8.06
180 INT142526 Positive_regulation of Gene_expression of Prkaca 12 0.46 2.48 8.05
181 INT135443 Phosphorylation of Map2k1 11 0.80 2.44 8.01
182 INT171367 Phosphorylation of Map2k1 31 0.58 32.87 8
183 INT6384 Regulation of Eef1a1 21 0.61 2.95 7.97
184 INT116707 Positive_regulation of Mapk4 8 0.21 9.83 7.96
185 INT104013 Negative_regulation of Gene_expression of Pdpk1 4 0.31 2.36 7.89
186 INT135441 Positive_regulation of Map2k1 15 0.67 6.6 7.87
187 INT116706 Phosphorylation of Mapk4 9 0.25 8.5 7.79
188 INT72884 Positive_regulation of Tenc1 13 0.42 14.01 7.67
189 INT14207 Gene_expression of DNM2 20 0.67 5.76 7.64
190 INT113705 Gene_expression of Egfr 228 0.78 149.05 7.59
191 INT131359 Positive_regulation of Gene_expression of Cd4 40 0.58 22.43 7.53
192 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49
193 INT92138 Binding of CDKN2A 28 0.37 25.64 7.47
194 INT182440 Gene_expression of CCNE2 39 0.53 22.07 7.44
195 INT103909 Gene_expression of NOD2 37 0.77 21.9 7.36
196 INT18909 Positive_regulation of Cd8a 92 0.60 56.55 7.35
197 INT102572 Gene_expression of Ccnd1 79 0.69 56.37 7.34
198 INT30920 Positive_regulation of Gene_expression of Insr 14 0.66 2.91 7.32
199 INT9491 Positive_regulation of Ptpn6 11 0.51 2.33 7.32
200 INT73181 Gene_expression of Hspb1 24 0.78 15.84 7.31
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