GO:0019907

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Name cyclin-dependent protein kinase activating kinase holoenzyme complex
Categary Component
Go Slim No
Go Link GO:0019907
Unique Molecular Interactions 21
Total Molecular Interactions 33
Total Single Events 267
Pain Genes Associated 4

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cyclin-dependent protein kinase activating kinase holoenzyme complex. They are ordered first by their pain relevance and then by number of times they were reported for cyclin-dependent protein kinase activating kinase holoenzyme complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT122823 ERCC2 Regulation of Negative_regulation of OPRM1 1 0.23 0.17 0.63
2 INT27871 Binding of FCGR1B and HSPD1 1 0.01 1.93 0.56
3 INT27872 Positive_regulation of Binding of FCGR1B and HSPD1 1 0.01 1.93 0.56
4 INT142947 Binding of ERCC2 and OPRM1 1 0.05 0.3 0.32
5 INT111909 Binding of HSPD1 and CCT4 1 0.29 0.48 0.25
6 INT111908 Binding of HSPD1 and AP4B1 1 0.03 0.48 0.25
7 INT231763 Binding of HSPD1 and TLR2 1 0.12 2 0.19
8 INT251492 Binding of HSPD1 and SOD1 1 0.02 1.45 0.18
9 INT231765 Binding of HSPD1 and TLR4 1 0.13 1.94 0.16
10 INT103557 Binding of ERCC2 and TP53 1 0.40 1 0.13
11 INT192358 CRP Regulation of Positive_regulation of HSPD1 1 0.15 2.46 0.1
12 INT192352 CRP Regulation of HSPD1 1 0.15 2.46 0.1
13 INT192354 Binding of CRP and HSPD1 1 0.12 1.28 0
14 INT320632 Ptger2 Regulation of Gene_expression of Hspd1 1 0.00 0.41 0
15 INT230712 Binding of Mnat1 and Ccnh 1 0.34 0.09 0
16 INT149429 ERCC2 Negative_regulation of Localization of IL8 1 0.05 0.38 0
17 INT227840 Binding of ERCC2 and ERCC6 1 0.11 0.66 0
18 INT149431 ERCC2 Negative_regulation of Localization of Il6 1 0.14 0.2 0
19 INT227831 Binding of ERCC2 and PGBD3 1 0.07 0.23 0
20 INT149432 ERCC2 Regulation of Localization of Il6 1 0.15 1.06 0
21 INT149428 ERCC2 Regulation of Localization of IL8 1 0.05 0.53 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cyclin-dependent protein kinase activating kinase holoenzyme complex. They are ordered first by their pain relevance and then by number of times they were reported in cyclin-dependent protein kinase activating kinase holoenzyme complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT111335 Gene_expression of HSPD1 57 0.75 55.51 10.38
2 INT103899 Gene_expression of ERCC2 14 0.65 7.85 5.49
3 INT27880 Positive_regulation of HSPD1 17 0.65 18.16 2.23
4 INT152436 Positive_regulation of Gene_expression of HSPD1 12 0.67 10.06 2.16
5 INT27881 Binding of HSPD1 10 0.31 9.2 1.78
6 INT103900 Positive_regulation of ERCC2 7 0.58 3.47 1.78
7 INT53775 Gene_expression of Hspd1 21 0.78 31.25 1.38
8 INT53776 Positive_regulation of Hspd1 17 0.70 10.64 1.23
9 INT112891 Regulation of Gene_expression of HSPD1 2 0.43 3.98 1.17
10 INT142950 Protein_catabolism of ERCC2 2 0.25 1.45 1.14
11 INT215363 Regulation of HSPD1 4 0.51 2.74 0.99
12 INT53774 Positive_regulation of Gene_expression of Hspd1 7 0.70 6.99 0.6
13 INT53778 Regulation of Gene_expression of Hspd1 2 0.58 3.61 0.52
14 INT134070 Binding of ERCC2 3 0.27 0.76 0.51
15 INT103901 Regulation of ERCC2 1 0.23 0.51 0.4
16 INT306291 Localization of HSPD1 1 0.31 0.81 0.36
17 INT166356 Negative_regulation of HSPD1 4 0.55 3 0.23
18 INT235538 Positive_regulation of Binding of HSPD1 1 0.08 1.15 0.19
19 INT53777 Negative_regulation of Positive_regulation of Hspd1 1 0.59 0.58 0.12
20 INT192360 Positive_regulation of Positive_regulation of HSPD1 1 0.29 0.77 0.11
21 INT109025 Negative_regulation of Hspd1 2 0.55 1.48 0.1
22 INT109020 Positive_regulation of Negative_regulation of Hspd1 1 0.39 0.76 0.1
23 INT215368 Regulation of Positive_regulation of HSPD1 1 0.38 0.51 0.09
24 INT200136 Negative_regulation of ERCC2 1 0.37 1.91 0.07
25 INT221986 Localization of Hspd1 1 0.52 1.8 0.06
26 INT291906 Positive_regulation of Negative_regulation of ERCC2 1 0.40 0 0.03
27 INT230665 Gene_expression of Ccnh 8 0.76 2.77 0
28 INT230670 Positive_regulation of Gene_expression of Ccnh 2 0.49 0.87 0
29 INT230477 Binding of Hspd1 2 0.34 1.09 0
30 INT230649 Regulation of Ccnh 1 0.44 0.36 0
31 INT320629 Regulation of Hspd1 1 0.58 0.68 0
32 INT230664 Regulation of Gene_expression of Ccnh 1 0.39 0.81 0
33 INT149430 Localization of ERCC2 1 0.43 0.76 0
34 INT230657 Phosphorylation of Ccnh 1 0.27 0.29 0
35 INT320630 Negative_regulation of Gene_expression of Hspd1 1 0.55 1.3 0
36 INT230660 Binding of Ccnh 1 0.36 0.09 0
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