GO:0019932

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Name second-messenger-mediated signaling
Categary Process
Go Slim No
Go Link GO:0019932
Unique Molecular Interactions 30
Total Molecular Interactions 37
Total Single Events 975
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for second-messenger-mediated signaling. They are ordered first by their pain relevance and then by number of times they were reported for second-messenger-mediated signaling. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT196879 Cpox Negative_regulation of Gene_expression of Tbxa2r 1 0.04 0.8 0.56
2 INT50553 Negative_regulation of Ptgs1 Negative_regulation of Gene_expression of Tbxa2r 1 0.02 1.37 0.38
3 INT310600 Tbxa2r Positive_regulation of PLEK 1 0.53 0.45 0.38
4 INT139566 Binding of PLEK and Tbxa2r 1 0.01 1.14 0.38
5 INT347517 Binding of Tbxa2r and ST7L 1 0.00 0 0.32
6 INT19839 Positive_regulation of Binding of Ptgis and Tbxa2r 1 0.00 0.2 0.26
7 INT19840 Binding of Ptgis and Tbxa2r 1 0.00 0.2 0.25
8 INT139565 Negative_regulation of Binding of PLEK and Tbxa2r 1 0.01 0.57 0.19
9 INT347518 Regulation of Binding of Tbxa2r and ST7L 1 0.00 0 0.17
10 INT172903 Fgf2 Positive_regulation of Gene_expression of Tbxa2r 1 0.03 0.58 0.15
11 INT172913 VEGFA Positive_regulation of Gene_expression of Tbxa2r 1 0.02 0.57 0.15
12 INT102380 Ptgs1 Negative_regulation of Binding of Tbxa2r 1 0.04 0.16 0.14
13 INT57586 Tbxa2r Regulation of Positive_regulation of Uae1 1 0.08 0.52 0.13
14 INT44978 Gfra1 Negative_regulation of Tbxa2r 1 0.00 0.44 0.12
15 INT267927 asa Negative_regulation of Gene_expression of Tbxa2r 1 0.00 0.78 0.12
16 INT353318 NOS1 Positive_regulation of Localization of Tbxa2r 1 0.04 0.71 0.12
17 INT42073 Binding of PPBP and Tbxa2r 1 0.01 0.26 0.1
18 INT256570 Bglap Positive_regulation of Gene_expression of Gck 1 0.48 0.43 0.04
19 INT331961 Binding of Tbxa2r and Tymp 1 0.03 0.07 0.03
20 INT228592 Pck1 Regulation of Positive_regulation of Gck 1 0.02 0.05 0
21 INT239349 Hdl1 Negative_regulation of Tbxa2r 1 0.03 3.37 0
22 INT228589 G6pc Regulation of Positive_regulation of Gck 1 0.03 0.05 0
23 INT331957 Tbxa2r Positive_regulation of Gene_expression of Tymp 1 0.04 0.08 0
24 INT342439 PPP2CA Negative_regulation of PRMT1 1 0.12 0.63 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for second-messenger-mediated signaling. They are ordered first by their pain relevance and then by number of times they were reported in second-messenger-mediated signaling. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT17381 Gene_expression of Tbxa2r 146 0.78 65.01 34.15
2 INT2978 Gene_expression of Tbxa2r 76 0.77 28.4 21.27
3 INT11859 Positive_regulation of Tbxa2r 44 0.61 22.62 9.61
4 INT18145 Positive_regulation of Gene_expression of Tbxa2r 30 0.66 18.91 9.52
5 INT5458 Negative_regulation of Tbxa2r 31 0.54 10.58 8.89
6 INT19107 Positive_regulation of Tbxa2r 23 0.62 12.54 8.44
7 INT19829 Negative_regulation of Gene_expression of Tbxa2r 32 0.56 12.78 8.3
8 INT34009 Binding of Tbxa2r 33 0.36 17.98 8.01
9 INT20348 Negative_regulation of Tbxa2r 47 0.59 19.88 7.68
10 INT11042 Localization of Tbxa2r 26 0.76 10.15 7.24
11 INT11858 Localization of Tbxa2r 39 0.80 21.24 7.09
12 INT19639 Negative_regulation of Gene_expression of Tbxa2r 17 0.55 7.69 5.01
13 INT9077 Regulation of Tbxa2r 13 0.45 5.49 3.75
14 INT25166 Regulation of Tbxa2r 12 0.43 5.94 2.47
15 INT17243 Positive_regulation of Gene_expression of Tbxa2r 7 0.55 4.7 2.37
16 INT95621 Gene_expression of Gck 6 0.64 1.06 2.26
17 INT129871 Positive_regulation of Gene_expression of Gck 1 0.28 0.15 2.19
18 INT9076 Regulation of Gene_expression of Tbxa2r 7 0.61 1.16 1.92
19 INT28210 Negative_regulation of Localization of Tbxa2r 6 0.49 2.09 1.58
20 INT34008 Positive_regulation of Binding of Tbxa2r 5 0.42 1.97 1.46
21 INT34936 Negative_regulation of Binding of Tbxa2r 8 0.44 2.85 1.34
22 INT22409 Regulation of Gene_expression of Tbxa2r 4 0.30 1.53 1.16
23 INT105346 Gene_expression of Gck 5 0.71 3.05 1.14
24 INT28212 Regulation of Localization of Tbxa2r 2 0.01 0.49 1.09
25 INT28211 Positive_regulation of Localization of Tbxa2r 4 0.44 1.73 0.7
26 INT28209 Positive_regulation of Localization of Tbxa2r 4 0.58 1.36 0.64
27 INT131609 Binding of Tbxa2r 3 0.24 1.33 0.55
28 INT35872 Negative_regulation of Localization of Tbxa2r 5 0.56 1.38 0.52
29 INT37908 Regulation of Negative_regulation of Tbxa2r 1 0.38 0.94 0.44
30 INT19542 Negative_regulation of Positive_regulation of Tbxa2r 2 0.50 0.52 0.42
31 INT110914 Negative_regulation of Protein_catabolism of Tbxa2r 1 0.00 0.28 0.42
32 INT110915 Protein_catabolism of Tbxa2r 1 0.01 0.28 0.42
33 INT131608 Negative_regulation of Negative_regulation of Tbxa2r 1 0.33 0 0.42
34 INT131607 Positive_regulation of Binding of Tbxa2r 1 0.32 0 0.39
35 INT105342 Positive_regulation of Gene_expression of Gck 2 0.46 0.83 0.36
36 INT105343 Negative_regulation of Gene_expression of Gck 1 0.39 0 0.36
37 INT105345 Localization of Gck 1 0.60 0 0.33
38 INT105341 Regulation of Gck 1 0.25 0 0.3
39 INT70493 Positive_regulation of Negative_regulation of Tbxa2r 1 0.02 0.07 0.19
40 INT95619 Negative_regulation of Gck 3 0.39 0.88 0.16
41 INT200943 Negative_regulation of PPP2CA 1 0.10 0.13 0.14
42 INT38920 Positive_regulation of Positive_regulation of Tbxa2r 1 0.01 0.25 0.13
43 INT150107 Negative_regulation of Gck 2 0.31 0.89 0.12
44 INT297431 Phosphorylation of Gck 2 0.54 0.29 0.11
45 INT347469 Regulation of Binding of Tbxa2r 1 0.07 0.09 0.09
46 INT329321 Positive_regulation of Positive_regulation of Tbxa2r 1 0.26 1.76 0.07
47 INT95623 Negative_regulation of Gene_expression of Gck 3 0.39 0.91 0.05
48 INT347468 Protein_catabolism of Tbxa2r 1 0.19 0.24 0.05
49 INT240929 Positive_regulation of Gck 1 0.42 0 0.04
50 INT200617 Positive_regulation of Negative_regulation of Tbxa2r 1 0.10 0.63 0.04
51 INT228573 Transcription of Gck 2 0.26 0.05 0
52 INT228582 Positive_regulation of Gck 2 0.13 0.88 0
53 INT345441 Positive_regulation of Transcription of Gck 1 0.18 0 0
54 INT345448 Binding of Gck 1 0.13 0 0
55 INT345449 Regulation of Transcription of Gck 1 0.16 0 0
56 INT256565 Regulation of Gene_expression of Gck 1 0.45 1.64 0
57 INT342452 Gene_expression of PPP2CA 1 0.20 0.49 0
58 INT342450 Positive_regulation of PPP2CA 1 0.15 1.07 0
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