GO:0019934

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Name cGMP-mediated signaling
Categary Process
Go Slim No
Go Link GO:0019934
Unique Molecular Interactions 345
Total Molecular Interactions 459
Total Single Events 5988
Pain Genes Associated 15

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cGMP-mediated signaling. They are ordered first by their pain relevance and then by number of times they were reported for cGMP-mediated signaling. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT81295 Ifng Positive_regulation of Gene_expression of Nos2 4 0.39 0.87 2.05
2 INT349658 Nos2 Regulation of Gene_expression of Nos1 1 0.63 2.86 1.84
3 INT209853 TNF Regulation of Gene_expression of CD36 1 0.61 3.41 1.59
4 INT135830 Gch1 Regulation of Nos2 1 0.65 0 1.29
5 INT14197 Pde2a Positive_regulation of Localization of Gh1 2 0.04 0 1.08
6 INT88875 Ifng Positive_regulation of Transcription of Nos2 1 0.02 0.27 1.03
7 INT88887 IRF6 Positive_regulation of Transcription of Nos2 1 0.21 0.27 1.02
8 INT88874 Ifng Regulation of Nos2 1 0.01 0.26 1.01
9 INT88884 IRF6 Regulation of Nos2 1 0.12 0.26 1
10 INT88886 IRF6 Positive_regulation of Nos2 1 0.22 0.26 1
11 INT88888 Regulation of IRF6 Positive_regulation of Nos2 1 0.20 0.26 1
12 INT209852 TNF Negative_regulation of Gene_expression of CD36 1 0.43 0.61 0.98
13 INT146579 Hba Negative_regulation of Gene_expression of Nos2 1 0.44 1.01 0.95
14 INT165280 Tnf Positive_regulation of Gene_expression of Nos2 1 0.24 1.02 0.91
15 INT108687 Nfkb1 Regulation of Positive_regulation of Nos2 1 0.50 1.28 0.88
16 INT108686 Nfkb1 Regulation of Nos2 1 0.69 1.27 0.88
17 INT297332 Apoe Negative_regulation of Gene_expression of Mpz 1 0.02 1.09 0.87
18 INT160412 Tat Positive_regulation of Transcription of Nos2 1 0.37 0.98 0.86
19 INT102931 Nos3 Positive_regulation of Nos2 1 0.43 1.63 0.83
20 INT152236 Tlr4 Regulation of Gene_expression of Nos2 3 0.19 0.64 0.82
21 INT88885 IRF6 Positive_regulation of Gene_expression of Nos2 1 0.21 0.1 0.81
22 INT88878 Negative_regulation of Nfkb1 Positive_regulation of Gene_expression of Nos2 1 0.06 0.1 0.81
23 INT349657 Nos2 Regulation of Regulation of Nos1 1 0.24 0.9 0.8
24 INT168455 Sult1a1 Negative_regulation of Nos2 1 0.08 1.99 0.79
25 INT168456 Arr3 Positive_regulation of Nos2 1 0.21 1.98 0.79
26 INT132889 Nfkb1 Regulation of Gene_expression of Nos2 1 0.16 0.21 0.79
27 INT132894 CHUK Regulation of Gene_expression of Nos2 1 0.00 0.21 0.79
28 INT208354 Binding of Apoe and Hdl1 12 0.13 8.37 0.77
29 INT128815 Mapk14 Regulation of Gene_expression of Nos2 1 0.21 0.46 0.74
30 INT159593 Regulation of Nfkb1 Positive_regulation of Gene_expression of Nos2 1 0.38 0.46 0.74
31 INT128813 Mapk8 Regulation of Gene_expression of Nos2 1 0.23 0.46 0.74
32 INT314203 Nos2 Positive_regulation of Gli3 1 0.19 1.27 0.73
33 INT187522 ATIC Negative_regulation of Gene_expression of Nos2 1 0.02 1.46 0.7
34 INT149983 Binding of Cpox and Nos2 1 0.30 0.54 0.69
35 INT220035 Nos1 Positive_regulation of Nos2 1 0.29 0.45 0.66
36 INT153921 Positive_regulation of Adra2a Regulation of Ednrb 1 0.01 0 0.66
37 INT209854 IL4 Positive_regulation of Gene_expression of CD36 1 0.51 1.2 0.65
38 INT135829 Cat2 Regulation of Nos2 1 0.47 0 0.65
39 INT266489 Dcps Positive_regulation of Gene_expression of Nos2 1 0.06 3.43 0.63
40 INT128812 Mapk8 Negative_regulation of Gene_expression of Nos2 1 0.19 0.37 0.61
41 INT128817 Ephb1 Negative_regulation of Gene_expression of Nos2 1 0.16 0.37 0.61
42 INT124831 Fbp1 Positive_regulation of Nos2 1 0.36 0.64 0.61
43 INT297344 Apoe Regulation of Binding of Alms1 1 0.08 1.1 0.61
44 INT297340 Apoe Regulation of Binding of Smo 1 0.10 1.1 0.6
45 INT339072 Eae1 Positive_regulation of Gene_expression of Nos2 1 0.02 3.76 0.59
46 INT128810 Il1b Positive_regulation of Gene_expression of Nos2 1 0.04 0.31 0.59
47 INT143426 Positive_regulation of B4GALNT1 Negative_regulation of Gene_expression of Nos2 1 0.00 0.83 0.58
48 INT212813 Tlr4 Positive_regulation of Nos2 3 0.34 0.89 0.57
49 INT151459 Olr1745 Negative_regulation of Gene_expression of Nos2 1 0.04 0.82 0.57
50 INT297331 Apoe Negative_regulation of Gene_expression of Il6 1 0.14 0.61 0.57
51 INT78588 Positive_regulation of Binding of Nfkb1 and Nos2 1 0.01 0.33 0.56
52 INT81546 TNF Positive_regulation of Gene_expression of Nos2 1 0.04 0.54 0.56
53 INT78587 Binding of Nfkb1 and Nos2 1 0.01 0.33 0.55
54 INT254761 Igh-Dex Positive_regulation of Apoe 1 0.00 0.08 0.52
55 INT130157 Pomc Regulation of Gene_expression of Ednrb 1 0.14 0 0.52
56 INT78590 Nos2 Positive_regulation of PTGS1 2 0.00 0.85 0.5
57 INT116862 Apoe Positive_regulation of Il10 1 0.30 0.69 0.5
58 INT116863 Apoe Negative_regulation of Hand1 1 0.37 0.69 0.5
59 INT254768 DNMT1 Positive_regulation of Gene_expression of Apoe 1 0.02 0.05 0.49
60 INT132060 NBN Positive_regulation of Nos2 1 0.01 0.21 0.49
61 INT212806 Rngtt Negative_regulation of Gene_expression of Nos2 1 0.03 0.9 0.49
62 INT149652 Zfp36 Regulation of Nos2 1 0.09 0.42 0.47
63 INT197496 Binding of Apoe and Lrp1 4 0.22 2.32 0.46
64 INT314200 Positive_regulation of Binding of Nos2 and Tnf 1 0.42 0.34 0.46
65 INT314201 Binding of Nos2 and Tnf 1 0.31 0.33 0.46
66 INT354981 Cacna1a Negative_regulation of Gene_expression of Nos2 1 0.01 0.99 0.45
67 INT142608 Apoe Regulation of Gene_expression of Il6 1 0.25 1.01 0.44
68 INT116610 Positive_regulation of Lnpep Regulation of Nos2 1 0.16 0.62 0.44
69 INT116608 Lnpep Regulation of Nos2 1 0.14 0.62 0.44
70 INT148634 Abat Negative_regulation of Transcription of Nos2 1 0.19 0.52 0.44
71 INT212809 Il6 Positive_regulation of Gene_expression of Nos2 1 0.08 0.75 0.43
72 INT212810 Tlr4 Positive_regulation of Gene_expression of Nos2 1 0.03 0.74 0.43
73 INT275087 Pde2a Negative_regulation of stm 1 0.01 0.51 0.42
74 INT275104 Pde2a Negative_regulation of RTP3 1 0.00 0.51 0.42
75 INT116611 Lnpep Positive_regulation of Binding of Nos2 1 0.16 0.62 0.42
76 INT254760 Igh-Dex Positive_regulation of Gene_expression of Apoe 1 0.00 0 0.42
77 INT329085 Csf2 Positive_regulation of Apoe 1 0.00 1.23 0.42
78 INT135972 Nfkb1 Positive_regulation of Gene_expression of Nos2 1 0.04 0.54 0.41
79 INT156438 Cpox Positive_regulation of Nos2 3 0.14 1.24 0.4
80 INT97789 Positive_regulation of Cnr1 Negative_regulation of Gene_expression of Nos2 1 0.12 0.23 0.4
81 INT187487 Cebpg Positive_regulation of Gene_expression of Nos2 1 0.03 0.38 0.4
82 INT209858 TNF Regulation of Transcription of CD36 1 0.27 0 0.4
83 INT56876 Regulation of Binding of Cd36 and Gtpbp4 1 0.00 0 0.4
84 INT56875 Binding of Cd36 and Gtpbp4 1 0.00 0 0.4
85 INT81300 Tlr4 Positive_regulation of Gene_expression of Nos2 1 0.02 0.38 0.39
86 INT61954 IFNA1 Positive_regulation of Nos2 1 0.05 0.46 0.38
87 INT198652 F2 Positive_regulation of Gene_expression of CD36 1 0.03 1.32 0.37
88 INT168426 RYBP Regulation of Nos2 1 0.01 0.4 0.36
89 INT152315 Ifng Regulation of Ednrb 1 0.19 0.22 0.36
90 INT168424 Ptger2 Regulation of Binding of Nos2 1 0.22 0.52 0.36
91 INT97790 Foxm1 Negative_regulation of Gene_expression of Nos2 1 0.03 0.16 0.36
92 INT152240 Nfasc Regulation of Gene_expression of Nos2 1 0.06 0.19 0.36
93 INT152313 Il18 Regulation of Ednrb 1 0.30 0.22 0.36
94 INT168423 Ptger2 Regulation of Nos2 1 0.13 0.52 0.36
95 INT201068 Binding of Edn1 and Ednrb 2 0.18 1.23 0.35
96 INT89500 Nos2 Positive_regulation of Il6 1 0.04 1.07 0.35
97 INT187488 Positive_regulation of Ros1 Positive_regulation of Gene_expression of Nos2 1 0.01 0.88 0.35
98 INT175319 Negative_regulation of Nos2 Negative_regulation of Positive_regulation of Pnlip 1 0.01 0.83 0.34
99 INT276214 Binding of Nos2 and Nfkb1 1 0.12 0.31 0.34
100 INT89505 Nos2 Positive_regulation of Ptgs2 1 0.05 1.07 0.34
101 INT354985 Cacna1a Regulation of Nos2 1 0.01 0.73 0.34
102 INT110758 Tnfaip8 Positive_regulation of Positive_regulation of Nos2 1 0.14 0.88 0.34
103 INT276209 Negative_regulation of Binding of Nos2 and Nfkb1 1 0.14 0.31 0.34
104 INT303126 Nos2 Positive_regulation of Gene_expression of Il6 1 0.13 4.38 0.34
105 INT89502 Positive_regulation of Nos2 Positive_regulation of Ptgs2 1 0.05 1.07 0.34
106 INT110761 Tnfaip8 Positive_regulation of Nos2 1 0.13 0.88 0.34
107 INT201484 Negative_regulation of Prkcg Negative_regulation of Positive_regulation of Ednrb 1 0.34 0.96 0.32
108 INT209855 NFE2L2 Positive_regulation of Gene_expression of CD36 1 0.27 0.72 0.32
109 INT115261 Gene_expression of Nos2 Positive_regulation of Positive_regulation of Npr1 1 0.05 0.67 0.31
110 INT334024 Ccl25 Positive_regulation of Gene_expression of CD36 1 0.31 0.36 0.31
111 INT354821 Nos2 Positive_regulation of Eif2ak2 1 0.06 0.64 0.3
112 INT333886 Binding of Lep and Positive_regulation of Gene_expression of Nos2 1 0.39 0.73 0.29
113 INT228530 Gopc Positive_regulation of Gene_expression of Nos2 2 0.22 0.67 0.28
114 INT156439 Positive_regulation of Cpox Positive_regulation of Nos2 1 0.14 0.52 0.28
115 INT254759 Igh-Dex Positive_regulation of Localization of Apoe 1 0.00 0.32 0.28
116 INT254769 Binding of LDLR and Apoe 1 0.03 0 0.28
117 INT334023 pma Positive_regulation of Gene_expression of CD36 1 0.04 0.31 0.28
118 INT349506 S100a8 Positive_regulation of Gene_expression of Nos2 1 0.02 0.67 0.28
119 INT297338 Apoe Regulation of Gnb5 1 0.06 1.12 0.27
120 INT71309 Il1a Positive_regulation of Nos2 1 0.21 0.26 0.26
121 INT314305 Ptger2 Positive_regulation of Nos2 1 0.00 0.07 0.26
122 INT209849 TNF Positive_regulation of Gene_expression of CD36 1 0.69 0.18 0.25
123 INT254772 DNMT1 Positive_regulation of Apoe 1 0.02 0 0.25
124 INT78293 Binding of Apoe and Ldlr 1 0.20 0.25 0.24
125 INT78295 Binding of Ptpra and Apoe 1 0.42 0.25 0.24
126 INT127101 Memo1 Negative_regulation of Gene_expression of Nos2 1 0.10 0.55 0.24
127 INT198643 CD36 Positive_regulation of CADM1 1 0.01 1.07 0.24
128 INT297334 Gnb5 Regulation of Apoe 1 0.09 0.83 0.24
129 INT327321 Binding of Elavl1 and Nos2 1 0.05 0.6 0.24
130 INT78294 Negative_regulation of Binding of Ptpra and Apoe 1 0.48 0.25 0.24
131 INT254773 PPARA Positive_regulation of Gene_expression of Apoe 1 0.01 0.07 0.24
132 INT78292 Negative_regulation of Binding of Apoe and Ldlr 1 0.23 0.25 0.24
133 INT327320 Positive_regulation of Binding of Elavl1 and Nos2 1 0.06 0.6 0.24
134 INT235125 PDE2A Negative_regulation of Twist1 1 0.00 0.99 0.24
135 INT331767 Hand1 Positive_regulation of Nos2 1 0.08 0.48 0.23
136 INT273055 Plat Positive_regulation of Gene_expression of Nos2 1 0.01 1.34 0.23
137 INT132382 Nos2 Positive_regulation of PTGS2 1 0.02 0.1 0.23
138 INT201273 Nos2 Regulation of Nos1 1 0.17 0.99 0.23
139 INT254774 DNMT1 Positive_regulation of Localization of Apoe 1 0.01 0.31 0.23
140 INT133163 Nos2 Regulation of Tnf 1 0.36 0.97 0.22
141 INT209856 IL1A Negative_regulation of Transcription of CD36 1 0.26 0.1 0.22
142 INT209848 TNF Positive_regulation of CD36 1 0.46 0.24 0.22
143 INT159351 Negative_regulation of Binding of Nos1 and Nos2 1 0.27 0.34 0.22
144 INT104846 TNF Positive_regulation of Nos2 1 0.10 0.83 0.22
145 INT333397 CFD Negative_regulation of Gene_expression of Nos2 1 0.04 0.8 0.22
146 INT159348 Binding of Nos1 and Nos2 1 0.23 0.29 0.22
147 INT252357 Binding of THBS1 and Cd36 2 0.01 2.4 0.21
148 INT159350 Zfp956 Negative_regulation of Nos2 1 0.03 0.3 0.21
149 INT183644 Nos2 Positive_regulation of Gene_expression of Macf1 1 0.05 0.84 0.21
150 INT209851 TGFB2 Negative_regulation of Gene_expression of CD36 1 0.16 0.16 0.21
151 INT209857 IL10 Negative_regulation of Gene_expression of CD36 1 0.31 0.16 0.2
152 INT134494 Binding of APOE and Alb 1 0.11 0.45 0.2
153 INT30071 Gm8212 Regulation of Pde3a 1 0.00 0 0.2
154 INT252330 Binding of Cd36 and Cd47 2 0.10 0.72 0.19
155 INT222568 Vip Negative_regulation of Transcription of Nos2 1 0.06 0.3 0.19
156 INT222473 Mzb1 Negative_regulation of Transcription of Nos2 1 0.04 0.29 0.19
157 INT81302 Tlr4 Negative_regulation of Gene_expression of Nos2 1 0.02 0.18 0.18
158 INT81298 Ifng Negative_regulation of Gene_expression of Nos2 1 0.40 0.18 0.18
159 INT135973 Dpys Negative_regulation of Gene_expression of Nos2 1 0.06 0.26 0.17
160 INT135974 S100a4 Negative_regulation of Nos2 1 0.00 0.26 0.17
161 INT81297 Positive_regulation of Pparg Regulation of Gene_expression of Nos2 1 0.23 0.17 0.17
162 INT135971 S100a4 Negative_regulation of Gene_expression of Nos2 1 0.00 0.26 0.17
163 INT208360 Binding of Abca1 and Apoe 1 0.15 0.74 0.17
164 INT197499 Binding of Apoe and Tfrc 1 0.14 1.54 0.17
165 INT119130 Binding of Nos2 and Ptgs2 1 0.33 0.07 0.17
166 INT331766 Binding of Arg1 and Nos2 1 0.17 0.6 0.17
167 INT135970 Dpys Negative_regulation of Nos2 1 0.05 0.25 0.17
168 INT344832 Hmgb1 Positive_regulation of Gene_expression of Nos2 1 0.12 0.82 0.17
169 INT232005 Binding of Cd36 and Tsp1 2 0.25 1.81 0.16
170 INT290670 Binding of Nos2 and Ppara 1 0.17 0.41 0.16
171 INT122528 Apoe Regulation of Eno2 1 0.05 0.29 0.16
172 INT264276 Binding of Ednrb and P2rx1 1 0.00 0.17 0.16
173 INT261577 Nos2 Negative_regulation of Gene_expression of Il6 1 0.01 1 0.16
174 INT122529 Apoe Regulation of S100B 1 0.18 0.29 0.16
175 INT303122 Nos2 Positive_regulation of Gene_expression of Gpt 1 0.37 1.86 0.16
176 INT297345 Apoe Negative_regulation of Csf2 1 0.17 0.66 0.16
177 INT303129 Nos2 Positive_regulation of Gene_expression of Gpt 1 0.17 1.86 0.16
178 INT199105 Decr1 Positive_regulation of Positive_regulation of Nos2 1 0.01 0.23 0.16
179 INT263179 PDE3A Regulation of COPD 1 0.00 1 0.15
180 INT94864 Regulation of Litaf Positive_regulation of Nos2 1 0.05 0.05 0.15
181 INT94865 Litaf Positive_regulation of Nos2 1 0.08 0.05 0.15
182 INT263177 Binding of PDE3A and COPD 1 0.01 1 0.15
183 INT303128 Tnrc6a Regulation of Gene_expression of Nos2 1 0.00 0.57 0.14
184 INT89940 Ednrb Positive_regulation of Positive_regulation of TNF 1 0.01 0.09 0.14
185 INT139343 Il1b Positive_regulation of Nos2 1 0.09 1.26 0.14
186 INT297333 Apoe Negative_regulation of Positive_regulation of Tlr4 1 0.10 1.02 0.14
187 INT297343 Binding of Apoe and Tlr4 1 0.09 0.94 0.14
188 INT194975 Negative_regulation of Alox5 Negative_regulation of Gene_expression of Nos2 1 0.13 0.69 0.13
189 INT297339 Tlr4 Negative_regulation of Gene_expression of Apoe 1 0.10 0.73 0.13
190 INT89939 Ednrb Regulation of Gene_expression of TNF 1 0.00 0.09 0.13
191 INT135941 Positive_regulation of PDE2A Positive_regulation of Gene_expression of PRKG1 1 0.13 0.8 0.13
192 INT194976 Alox5 Regulation of Gene_expression of Nos2 1 0.07 0.56 0.12
193 INT156588 Hst1 Positive_regulation of Gene_expression of Nos2 1 0.27 0.48 0.12
194 INT328313 Binding of CD36 and LDLR 1 0.00 0.63 0.11
195 INT328370 Binding of CD36 and Fabp1 1 0.01 0.64 0.11
196 INT208361 Positive_regulation of Binding of Apoe and Hdl1 1 0.12 1.22 0.1
197 INT135943 Positive_regulation of PRKG1 Regulation of PDE2A 1 0.08 0.73 0.1
198 INT151423 Tfrc Positive_regulation of Gene_expression of Nos2 1 0.24 0.49 0.1
199 INT212807 Rngtt Negative_regulation of Nos2 1 0.03 0.08 0.1
200 INT297346 Apoe Negative_regulation of Localization of TNF 1 0.48 0.26 0.1

Single Events

The table below shows the top 100 pain related interactions that have been reported for cGMP-mediated signaling. They are ordered first by their pain relevance and then by number of times they were reported in cGMP-mediated signaling. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08
2 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07
3 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87
4 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43
5 INT64636 Positive_regulation of Gene_expression of Nos2 242 0.70 147.52 79.53
6 INT48952 Negative_regulation of Nos2 204 0.59 101.73 53.15
7 INT49017 Negative_regulation of Gene_expression of Nos2 169 0.59 80.64 52.67
8 INT85943 Negative_regulation of Nos2 161 0.59 108.56 42.65
9 INT77434 Positive_regulation of Gene_expression of Nos2 151 0.69 96.76 38.94
10 INT84825 Gene_expression of CD36 121 0.78 43.73 33.23
11 INT92837 Negative_regulation of Gene_expression of Nos2 116 0.59 59.67 31.82
12 INT116861 Gene_expression of Apoe 182 0.78 100.41 27.26
13 INT61953 Transcription of Nos2 101 0.72 46.64 25.49
14 INT89854 Regulation of Nos2 49 0.61 42.58 24.1
15 INT70503 Regulation of Gene_expression of Nos2 71 0.62 44 24.01
16 INT66281 Transcription of Nos2 81 0.71 39.49 20.37
17 INT61949 Regulation of Nos2 74 0.58 34.08 16.7
18 INT77433 Regulation of Gene_expression of Nos2 49 0.62 35.07 16.33
19 INT142621 Positive_regulation of Gene_expression of CD36 38 0.70 15.18 13.4
20 INT97381 Negative_regulation of Positive_regulation of Nos2 34 0.59 16.66 11.6
21 INT48956 Negative_regulation of Positive_regulation of Nos2 34 0.46 13.15 11.15
22 INT55014 Positive_regulation of Ednrb 31 0.70 16.61 9.68
23 INT70850 Positive_regulation of Transcription of Nos2 30 0.70 18.95 9.68
24 INT209866 Regulation of Gene_expression of CD36 27 0.60 10.04 8.42
25 INT116605 Binding of Nos2 28 0.37 16.88 8.18
26 INT72337 Positive_regulation of Positive_regulation of Nos2 37 0.65 17.02 8.11
27 INT112191 Positive_regulation of Transcription of Nos2 22 0.66 12.4 7.74
28 INT85751 Positive_regulation of Positive_regulation of Nos2 40 0.60 23.53 7.72
29 INT197493 Localization of Apoe 61 0.79 27.48 7.06
30 INT142264 Positive_regulation of Apoe 47 0.50 26.35 6.94
31 INT182351 Positive_regulation of Gene_expression of Apoe 38 0.50 19.78 6.72
32 INT78178 Gene_expression of Ednrb 21 0.75 7.1 6.37
33 INT63042 Binding of Apoe 59 0.48 31.23 5.88
34 INT164656 Negative_regulation of Gene_expression of CD36 24 0.57 6.51 5.39
35 INT188852 Gene_expression of Pde2a 13 0.19 6.44 5.35
36 INT112190 Regulation of Negative_regulation of Nos2 8 0.62 5.83 5.09
37 INT73608 Localization of Nos2 21 0.75 9.58 5.05
38 INT61950 Regulation of Positive_regulation of Nos2 17 0.43 9.01 4.87
39 INT121471 Negative_regulation of Pde3a 24 0.34 13.79 4.73
40 INT55758 Positive_regulation of Apoe 15 0.70 11.71 4.69
41 INT29519 Gene_expression of Ednrb 8 0.66 1.99 4.55
42 INT92133 Negative_regulation of Ednrb 8 0.42 1.7 4.44
43 INT89784 Regulation of Transcription of Nos2 14 0.42 8.39 4.24
44 INT152312 Positive_regulation of Ednrb 7 0.49 1.46 4.04
45 INT15033 Gene_expression of Apoe 18 0.78 14.97 3.75
46 INT104624 Negative_regulation of Apoe 26 0.59 19.25 3.71
47 INT52047 Gene_expression of APOE 50 0.78 34.75 3.52
48 INT26702 Transcription of CD36 17 0.70 3.56 3.49
49 INT61952 Negative_regulation of Transcription of Nos2 17 0.54 5.1 3.34
50 INT72141 Binding of Apoe 11 0.37 10.91 3.27
51 INT84222 Regulation of Ednrb 4 0.45 2.24 3.25
52 INT126223 Binding of Nos2 17 0.37 6 3.22
53 INT97710 Localization of Apoe 1 0.79 7.18 3.2
54 INT75815 Positive_regulation of PDE2A 10 0.40 5.1 3.15
55 INT116235 Negative_regulation of Transcription of Nos2 23 0.58 7.91 3.14
56 INT85750 Regulation of Positive_regulation of Nos2 10 0.54 7.78 2.83
57 INT30172 Positive_regulation of Pde2a 3 0.39 0.55 2.77
58 INT72757 Negative_regulation of Negative_regulation of Nos2 8 0.42 4.23 2.68
59 INT50080 Binding of APOE 38 0.45 29.61 2.67
60 INT89852 Localization of Nos2 22 0.78 14.89 2.56
61 INT128774 Regulation of Gene_expression of Ednrb 3 0.46 1 2.56
62 INT97713 Negative_regulation of Apoe 4 0.59 4.57 2.52
63 INT79609 Positive_regulation of Negative_regulation of Nos2 5 0.49 3.6 2.43
64 INT198662 Positive_regulation of CD36 14 0.68 7.73 2.36
65 INT208344 Positive_regulation of Localization of Apoe 22 0.48 9.6 2.27
66 INT142265 Regulation of Apoe 20 0.60 9.52 2.23
67 INT78177 Negative_regulation of Gene_expression of Ednrb 4 0.41 1.04 2.16
68 INT26706 Positive_regulation of Transcription of CD36 8 0.68 3.32 2.12
69 INT84060 Regulation of Apoe 4 0.62 3.33 2.05
70 INT94285 Negative_regulation of CD36 10 0.43 6.61 1.98
71 INT199084 Gene_expression of Cd36 31 0.53 16.94 1.94
72 INT64530 Negative_regulation of Positive_regulation of Pde2a 1 0.36 0 1.81
73 INT119905 Negative_regulation of PDE3A 5 0.18 5 1.77
74 INT12781 Regulation of Pde2a 4 0.23 1.14 1.69
75 INT201475 Negative_regulation of Positive_regulation of Ednrb 6 0.42 3.74 1.66
76 INT64529 Localization of Pde2a 1 0.59 0 1.63
77 INT96814 Negative_regulation of APOE 13 0.59 10.64 1.61
78 INT1580 Negative_regulation of Pde2a 7 0.52 3.26 1.59
79 INT181574 Phosphorylation of Nos2 9 0.70 2.92 1.55
80 INT188855 Positive_regulation of Gene_expression of Pde2a 5 0.12 1.97 1.53
81 INT114298 Positive_regulation of Gene_expression of Ednrb 4 0.36 0.79 1.42
82 INT217388 Negative_regulation of Gene_expression of Apoe 11 0.59 6.07 1.4
83 INT60772 Negative_regulation of Ednrb 8 0.41 4.56 1.39
84 INT61951 Regulation of Negative_regulation of Nos2 5 0.58 3.08 1.39
85 INT97716 Transcription of Apoe 3 0.53 2.61 1.36
86 INT73938 Gene_expression of Cd36 20 0.76 12.27 1.35
87 INT14195 Localization of Pde2a 4 0.16 0.34 1.33
88 INT215380 Positive_regulation of Gene_expression of Cd36 12 0.47 8.51 1.3
89 INT144392 Negative_regulation of Negative_regulation of Nos2 2 0.42 1.83 1.24
90 INT97715 Regulation of Gene_expression of Apoe 3 0.62 1.98 1.23
91 INT113336 Positive_regulation of Gene_expression of Apoe 3 0.70 1.79 1.23
92 INT217390 Negative_regulation of Positive_regulation of Apoe 3 0.37 1.95 1.05
93 INT7834 Gene_expression of Pde2a 5 0.51 1.9 1.01
94 INT97714 Negative_regulation of Localization of Apoe 1 0.58 1.83 0.97
95 INT73939 Negative_regulation of Cd36 7 0.57 6.3 0.95
96 INT188851 Regulation of Gene_expression of Pde2a 1 0.04 0.75 0.94
97 INT89856 Positive_regulation of Localization of Nos2 6 0.49 1.79 0.9
98 INT92836 Regulation of Transcription of Nos2 3 0.58 1.79 0.85
99 INT89776 Positive_regulation of Pde2a 2 0.47 2.84 0.81
100 INT178485 Binding of Cd36 11 0.22 6.65 0.8
101 INT142597 Regulation of Binding of Apoe 1 0.34 2.21 0.8
102 INT98275 Negative_regulation of PDE2A 4 0.17 3.96 0.79
103 INT177533 Negative_regulation of Binding of Pde3a 1 0.21 2.46 0.76
104 INT197495 Negative_regulation of Localization of Apoe 6 0.43 2.19 0.73
105 INT44612 Positive_regulation of APOE 16 0.67 5.73 0.72
106 INT27077 Binding of CD36 4 0.37 2.14 0.72
107 INT270428 Negative_regulation of Binding of APOE 2 0.41 1.16 0.7
108 INT113335 Regulation of Transcription of Apoe 1 0.27 0.51 0.7
109 INT183161 Regulation of Pde2a 2 0.05 0.5 0.67
110 INT175580 Localization of APOE 10 0.76 18.84 0.65
111 INT162911 Gene_expression of PDE3A 2 0.24 2.47 0.65
112 INT97708 Regulation of Localization of Apoe 1 0.61 2.06 0.62
113 INT114299 Transcription of Ednrb 2 0.19 0.32 0.59
114 INT113334 Positive_regulation of Positive_regulation of Apoe 1 0.50 0.6 0.56
115 INT75814 Regulation of Positive_regulation of PDE2A 1 0.23 0.26 0.56
116 INT142620 Regulation of CD36 6 0.62 0.72 0.54
117 INT96037 Positive_regulation of Localization of Nos2 2 0.49 0.78 0.52
118 INT197322 Protein_catabolism of Apoe 6 0.71 3.52 0.51
119 INT349037 Regulation of Phosphorylation of Nos2 1 0.39 1.02 0.51
120 INT229773 Positive_regulation of Regulation of Nos2 3 0.41 2.97 0.5
121 INT217370 Phosphorylation of Apoe 2 0.63 1.8 0.49
122 INT108735 Regulation of Localization of Nos2 3 0.42 0.52 0.46
123 INT162903 Localization of PDE2A 2 0.61 0.89 0.45
124 INT96816 Regulation of APOE 8 0.45 6.62 0.44
125 INT121469 Binding of Pde3a 2 0.23 1.42 0.44
126 INT216759 Binding of PDE2A 1 0.00 0.08 0.44
127 INT201478 Regulation of Positive_regulation of Ednrb 1 0.35 0.68 0.44
128 INT186288 Negative_regulation of Binding of Nos2 3 0.35 1.08 0.42
129 INT149650 Protein_catabolism of Nos2 3 0.55 0.79 0.42
130 INT208368 Negative_regulation of Regulation of Nos2 1 0.42 0.35 0.42
131 INT280670 Localization of Cd36 1 0.61 0.65 0.41
132 INT280675 Regulation of Localization of Cd36 1 0.32 0.57 0.41
133 INT131106 Positive_regulation of Positive_regulation of Ednrb 1 0.15 0.91 0.4
134 INT97712 Negative_regulation of Transcription of Apoe 1 0.43 1.05 0.4
135 INT235457 Negative_regulation of Regulation of Nos2 3 0.42 1.55 0.39
136 INT126571 Positive_regulation of Cd36 3 0.41 1.19 0.38
137 INT201476 Positive_regulation of Negative_regulation of Ednrb 1 0.49 0.62 0.36
138 INT235122 Negative_regulation of Positive_regulation of PDE2A 1 0.01 0.72 0.35
139 INT235113 Positive_regulation of Negative_regulation of PDE2A 1 0.01 0.72 0.35
140 INT135945 Positive_regulation of Positive_regulation of PDE2A 2 0.12 0.78 0.34
141 INT131542 Negative_regulation of Gene_expression of APOE 6 0.40 3.92 0.33
142 INT10801 Localization of CD36 3 0.73 2.12 0.32
143 INT209865 Negative_regulation of Transcription of CD36 1 0.57 0.15 0.32
144 INT219588 Negative_regulation of Gene_expression of Pde3a 1 0.25 0 0.32
145 INT106275 Regulation of Localization of Nos2 1 0.25 0.38 0.32
146 INT219563 Gene_expression of Pde3a 1 0.39 0 0.32
147 INT311128 Positive_regulation of Regulation of Apoe 1 0.30 0.3 0.3
148 INT233881 Positive_regulation of Cd36 8 0.48 4.68 0.29
149 INT175687 Transcription of Apoe 4 0.72 2.12 0.29
150 INT96815 Regulation of Gene_expression of APOE 2 0.62 1.1 0.29
151 INT132377 Negative_regulation of Binding of Nos2 5 0.29 0.75 0.28
152 INT97711 Positive_regulation of Transcription of Apoe 1 0.46 1.06 0.27
153 INT254756 Regulation of Positive_regulation of Apoe 1 0.20 0.22 0.26
154 INT117878 Positive_regulation of Regulation of Nos2 3 0.41 1.35 0.25
155 INT124200 Negative_regulation of Localization of Nos2 1 0.22 0.7 0.25
156 INT227750 Positive_regulation of Binding of Nos2 1 0.18 0.8 0.23
157 INT323964 Negative_regulation of Binding of Apoe 1 0.39 0.35 0.22
158 INT198892 Regulation of Binding of Apoe 6 0.45 2.94 0.21
159 INT193810 Phosphorylation of APOE 2 0.27 1.13 0.2
160 INT30069 Regulation of Pde3a 1 0.06 0 0.2
161 INT55013 Localization of Ednrb 2 0.16 0.98 0.18
162 INT263126 Negative_regulation of Binding of PDE3A 1 0.13 0.62 0.18
163 INT98276 Regulation of PDE2A 2 0.07 1.54 0.17
164 INT219576 Positive_regulation of Gene_expression of Pde3a 1 0.29 0 0.17
165 INT254754 Regulation of Localization of Apoe 1 0.20 0.39 0.17
166 INT254755 Positive_regulation of Transcription of Apoe 1 0.16 0.41 0.16
167 INT183632 Phosphorylation of Nos2 3 0.61 0.79 0.15
168 INT242342 Regulation of Ednrb 1 0.09 2.03 0.15
169 INT96772 Positive_regulation of Gene_expression of APOE 5 0.66 5.44 0.14
170 INT198894 Regulation of Gene_expression of Apoe 2 0.44 0.56 0.14
171 INT161414 Negative_regulation of Localization of Nos2 2 0.30 0.9 0.13
172 INT84749 Gene_expression of PDE2A 3 0.73 0.84 0.12
173 INT104623 Regulation of Negative_regulation of Apoe 2 0.45 0.73 0.12
174 INT135946 Positive_regulation of Gene_expression of PDE2A 1 0.12 0.77 0.12
175 INT326081 Negative_regulation of Localization of APOE 1 0.56 2.23 0.11
176 INT135944 Regulation of Regulation of PDE2A 1 0.07 0.73 0.1
177 INT209861 Regulation of Transcription of CD36 1 0.44 0 0.09
178 INT300643 Positive_regulation of Binding of APOE 1 0.44 0.8 0.09
179 INT263134 Binding of PDE3A 1 0.15 0.47 0.09
180 INT44609 Negative_regulation of Positive_regulation of APOE 1 0.16 0.9 0.09
181 INT80630 Protein_catabolism of PDE2A 2 0.19 0.91 0.08
182 INT291956 Positive_regulation of Negative_regulation of Nos2 1 0.41 0.54 0.08
183 INT199067 Negative_regulation of Gene_expression of Cd36 3 0.28 0.9 0.07
184 INT111440 Negative_regulation of Gene_expression of Pde2a 1 0.20 1.14 0.07
185 INT205147 Regulation of Phosphorylation of APOE 1 0.06 0.34 0.07
186 INT97709 Positive_regulation of Localization of Apoe 1 0.68 1.02 0.07
187 INT324892 Binding of Ednrb 1 0.06 0.32 0.06
188 INT183439 Protein_catabolism of Pde2a 1 0.14 0.84 0.05
189 INT233879 Negative_regulation of Positive_regulation of Cd36 1 0.12 0.81 0.05
190 INT208336 Positive_regulation of Binding of Apoe 1 0.48 0.7 0.05
191 INT208333 Positive_regulation of Positive_regulation of Apoe 1 0.48 0.65 0.05
192 INT183425 Negative_regulation of Protein_catabolism of Pde2a 1 0.09 0.84 0.05
193 INT196696 Negative_regulation of Cd36 5 0.18 5.5 0.04
194 INT206043 Transcription of Cd36 4 0.37 2.59 0.04
195 INT183433 Regulation of Localization of Pde2a 1 0.09 0.34 0.04
196 INT242952 Regulation of Gene_expression of Cd36 1 0.31 0.71 0.04
197 INT142622 Positive_regulation of Regulation of CD36 2 0.47 0.14 0.03
198 INT263142 Positive_regulation of Negative_regulation of PDE3A 1 0.15 0.15 0.03
199 INT264273 Localization of Ednrb 1 0.01 0 0.03
200 INT326070 Regulation of Localization of APOE 1 0.58 1.21 0.03
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