GO:0019956

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Name chemokine binding
Categary Function
Go Slim No
Go Link GO:0019956
Unique Molecular Interactions 49
Total Molecular Interactions 86
Total Single Events 729
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for chemokine binding. They are ordered first by their pain relevance and then by number of times they were reported for chemokine binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT176477 Binding of CXCR3 and CXCL10 14 0.25 10.61 5.87
2 INT161224 Ccl2 Positive_regulation of Ccr2 1 0.52 2.09 1.88
3 INT174450 Positive_regulation of Binding of Cxcr3 and Smcp 1 0.18 2.83 1.49
4 INT238005 Binding of Cxcr3 and Cxcl10 2 0.38 3.73 1.42
5 INT238009 Binding of Cxcr3 and Cxcl9 3 0.40 4.01 1.37
6 INT237999 Binding of Cxcr3 and Cxcl11 2 0.45 3.49 1.11
7 INT176474 Binding of CXCR3 and CXCL9 3 0.22 1.9 1.05
8 INT181434 Binding of Ccr2 and Ccl2 1 0.27 6.06 1.04
9 INT178663 Binding of CXCR3 and TH1L 2 0.04 2.24 1.01
10 INT174451 Trav6-3 Regulation of Transcription of Cxcr3 1 0.06 1.86 1
11 INT167173 Binding of Ccl2 and Ccr2 2 0.30 1.15 0.98
12 INT174454 Binding of Cxcr3 and Smcp 1 0.14 1.41 0.74
13 INT174455 Smcp Positive_regulation of Gene_expression of Cxcr3 1 0.17 1.31 0.71
14 INT275554 Binding of CXCL10 and Cxcr3 1 0.03 2.18 0.71
15 INT167505 Binding of CXCR3 and CXCL11 2 0.26 0.86 0.67
16 INT174453 Smcp Positive_regulation of Cxcr3 1 0.17 1.29 0.64
17 INT281130 Ccl2 Regulation of Gene_expression of Ccr2 1 0.04 1.09 0.64
18 INT281134 Ccl2 Positive_regulation of Gene_expression of Ccr2 1 0.08 1.09 0.64
19 INT281122 Ccl2 Regulation of Ccr2 1 0.04 1.09 0.63
20 INT174456 Binding of Cxcr3 and Cxcr1 1 0.31 1.24 0.58
21 INT174452 Binding of Cxcr2 and Cxcr3 1 0.31 1.23 0.58
22 INT222252 Positive_regulation of Binding of Ccr2 and Fig4 1 0.16 0.67 0.55
23 INT222246 Binding of Ccr2 and Tcf21 1 0.29 0.67 0.55
24 INT222249 Positive_regulation of Binding of Ccr2 and Tcf21 1 0.39 0.67 0.55
25 INT222245 Binding of Ccr2 and Fig4 1 0.12 0.67 0.55
26 INT238004 Positive_regulation of Binding of Cxcr3 and Cxcl11 1 0.30 1.86 0.51
27 INT281126 Binding of Ccr2 and Cxcr4 1 0.30 0.32 0.44
28 INT181448 Eae1 Positive_regulation of Gene_expression of Ccr2 1 0.04 4.98 0.42
29 INT187145 Positive_regulation of Binding of CXCR3 and CXCL10 1 0.33 0.56 0.4
30 INT187149 Positive_regulation of Binding of CXCR3 and CXCL9 1 0.29 0.56 0.4
31 INT163909 CCL2 Positive_regulation of Positive_regulation of Ccr2 1 0.05 0.19 0.36
32 INT275557 Negative_regulation of Binding of CXCL10 and Cxcr3 1 0.04 1.09 0.35
33 INT163908 CCL2 Positive_regulation of Ccr2 1 0.05 0.2 0.35
34 INT137168 IFNG Positive_regulation of Gene_expression of CXCR3 1 0.32 0.34 0.32
35 INT181435 Binding of Ccr2 and Hand2 1 0.17 1.81 0.32
36 INT137160 TLR7 Positive_regulation of Gene_expression of CXCR3 1 0.35 0.34 0.32
37 INT137158 TLR5 Positive_regulation of Gene_expression of CXCR3 1 0.32 0.34 0.32
38 INT137170 CXCL9 Positive_regulation of Binding of CXCR3 1 0.44 0.31 0.31
39 INT252599 Negative_regulation of Cxcl10 Negative_regulation of Gene_expression of Cxcr3 1 0.45 0.49 0.29
40 INT306107 Binding of CCL2 and Ccr2 1 0.06 0 0.28
41 INT344165 Regulation of Binding of Cxcr3 and Cxcl9 1 0.30 0.47 0.25
42 INT238010 Binding of Cxcr3 and Hand1 1 0.12 1.55 0.19
43 INT181440 Binding of Ccr2 and Eae1 1 0.03 1.3 0.19
44 INT331686 Binding of CXCR3 and M1 1 0.08 0.43 0.16
45 INT352416 Ccl2 Positive_regulation of Ccr2 1 0.23 0.26 0.14
46 INT238007 Binding of Cxcr3 and Saa 1 0.14 0.95 0.11
47 INT342459 CXCR3 Positive_regulation of CRTC1 1 0.00 0.59 0.11
48 INT222248 Binding of Cxcr3 and Cxcl10 1 0.35 0.48 0.09
49 INT165772 Binding of CXCR3 and TNFSF14 1 0.36 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for chemokine binding. They are ordered first by their pain relevance and then by number of times they were reported in chemokine binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT168410 Gene_expression of Cxcr3 81 0.75 84.03 37.01
2 INT121663 Gene_expression of CXCR3 76 0.77 50.96 30.62
3 INT88046 Gene_expression of Ccr2 38 0.76 33.76 28.07
4 INT102545 Gene_expression of Ccr2 42 0.78 61.43 19.81
5 INT151434 Positive_regulation of Ccr2 26 0.68 18.34 16.34
6 INT99784 Positive_regulation of Cxcr3 22 0.66 22.44 10.36
7 INT161222 Positive_regulation of Ccr2 13 0.55 13.77 8.89
8 INT88047 Positive_regulation of Gene_expression of Ccr2 15 0.60 10.5 8.63
9 INT103845 Gene_expression of Cxcr3 13 0.60 10.65 8.5
10 INT174422 Binding of Cxcr3 24 0.47 26.09 8.34
11 INT171742 Positive_regulation of CXCR3 17 0.58 12.26 7.72
12 INT174432 Transcription of Cxcr3 8 0.68 15.73 7.32
13 INT102548 Negative_regulation of Ccr2 14 0.59 19.84 7.22
14 INT171749 Positive_regulation of Gene_expression of CXCR3 18 0.58 11.03 6.51
15 INT174427 Positive_regulation of Gene_expression of Cxcr3 8 0.66 10.7 4.66
16 INT161221 Positive_regulation of Positive_regulation of Ccr2 3 0.50 4.55 3.98
17 INT222241 Binding of Ccr2 5 0.42 4.09 3.71
18 INT137180 Binding of CXCR3 10 0.41 4.24 3.53
19 INT281144 Regulation of Gene_expression of Ccr2 2 0.44 2.38 3.29
20 INT222237 Negative_regulation of Gene_expression of Ccr2 3 0.37 3.39 2.91
21 INT103848 Positive_regulation of Cxcr3 4 0.54 3.12 2.88
22 INT151436 Regulation of Ccr2 4 0.44 2.81 2.82
23 INT222226 Negative_regulation of Ccr2 6 0.57 3.69 2.66
24 INT174438 Positive_regulation of Transcription of Cxcr3 1 0.66 4.58 2.64
25 INT146504 Regulation of Ccr2 5 0.39 3.58 2.21
26 INT181341 Binding of Ccr2 8 0.32 6.47 1.77
27 INT174425 Positive_regulation of Positive_regulation of Cxcr3 3 0.48 3.05 1.71
28 INT102550 Positive_regulation of Gene_expression of Ccr2 6 0.69 4.53 1.67
29 INT124548 Negative_regulation of Gene_expression of Cxcr3 2 0.33 1.22 1.64
30 INT174443 Negative_regulation of Gene_expression of Cxcr3 4 0.41 4.83 1.62
31 INT103846 Regulation of Gene_expression of Cxcr3 2 0.35 2.09 1.52
32 INT181373 Negative_regulation of Gene_expression of Ccr2 5 0.59 5.92 1.44
33 INT103849 Positive_regulation of Gene_expression of Cxcr3 4 0.40 1.9 1.44
34 INT281139 Phosphorylation of Ccr2 2 0.79 1.2 1.18
35 INT281141 Positive_regulation of Phosphorylation of Ccr2 2 0.49 1.2 1.18
36 INT174439 Regulation of Gene_expression of Cxcr3 2 0.43 3.24 1.17
37 INT222235 Localization of Ccr2 7 0.73 5.32 1.12
38 INT174447 Regulation of Cxcr3 1 0.60 2.68 1.12
39 INT151435 Negative_regulation of Positive_regulation of Ccr2 1 0.53 0.7 1.08
40 INT187153 Negative_regulation of Gene_expression of CXCR3 3 0.36 2.25 0.98
41 INT161223 Negative_regulation of Positive_regulation of Ccr2 1 0.43 0.83 0.81
42 INT174437 Localization of Cxcr3 3 0.71 2.36 0.79
43 INT171741 Localization of CXCR3 2 0.44 2.38 0.79
44 INT226405 Negative_regulation of Cxcr3 3 0.23 2.79 0.77
45 INT222239 Transcription of Ccr2 2 0.61 1.15 0.73
46 INT322699 Negative_regulation of Cxcr3 1 0.26 0.17 0.62
47 INT187151 Regulation of Gene_expression of CXCR3 1 0.23 1.03 0.61
48 INT187152 Negative_regulation of Positive_regulation of CXCR3 1 0.36 1.05 0.6
49 INT167506 Regulation of CXCR3 1 0.27 0.43 0.53
50 INT222242 Positive_regulation of Transcription of Ccr2 1 0.44 0.66 0.52
51 INT217328 Positive_regulation of Localization of CXCR3 1 0.23 1.67 0.51
52 INT236350 Transcription of Ccr2 2 0.72 3.59 0.49
53 INT165780 Transcription of CXCR3 2 0.45 0.51 0.47
54 INT201953 Negative_regulation of CXCR3 1 0.24 0.44 0.47
55 INT201958 Negative_regulation of Binding of CXCR3 1 0.24 0.81 0.47
56 INT272877 Localization of Ccr2 2 0.75 1.68 0.46
57 INT281147 Regulation of Binding of Ccr2 1 0.39 0.86 0.46
58 INT252596 Positive_regulation of Binding of Cxcr3 1 0.49 1.19 0.41
59 INT163905 Positive_regulation of Positive_regulation of Ccr2 1 0.13 0.16 0.37
60 INT340642 Regulation of Gene_expression of Ccr2 1 0.62 2.26 0.35
61 INT222232 Binding of Cxcr3 1 0.29 0.52 0.35
62 INT275519 Negative_regulation of Binding of Cxcr3 1 0.12 1.09 0.35
63 INT344158 Positive_regulation of Localization of Cxcr3 1 0.40 1.15 0.34
64 INT344162 Regulation of Localization of Cxcr3 1 0.36 1.13 0.34
65 INT236358 Regulation of Transcription of Ccr2 1 0.24 1 0.09
66 INT237988 Negative_regulation of Phosphorylation of Cxcr3 1 0.32 0.65 0.07
67 INT352409 Regulation of Positive_regulation of Ccr2 1 0.44 0.15 0.07
68 INT237993 Phosphorylation of Cxcr3 1 0.61 0.65 0.07
69 INT124550 Regulation of Cxcr3 1 0.07 0 0
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