GO:0019957

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Name C-C chemokine binding
Categary Function
Go Slim No
Go Link GO:0019957
Unique Molecular Interactions 161
Total Molecular Interactions 249
Total Single Events 1550
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for C-C chemokine binding. They are ordered first by their pain relevance and then by number of times they were reported for C-C chemokine binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT181455 Binding of Ccr5 and Ccl5 11 0.39 12.13 3.66
2 INT189488 Binding of Ccr1 and Ccl5 8 0.40 9.26 3.27
3 INT182635 Binding of CCR5 and CCL5 2 0.09 4.19 3
4 INT319003 Binding of CCR1 and CCL5 1 0.08 3.38 2.89
5 INT161224 Ccl2 Positive_regulation of Ccr2 1 0.52 2.09 1.88
6 INT222185 Binding of Ccr1 and Ccl3 4 0.23 2.7 1.47
7 INT222213 TFAM Positive_regulation of Gene_expression of Ccr1 1 0.02 3.96 1.4
8 INT181434 Binding of Ccr2 and Ccl2 1 0.27 6.06 1.04
9 INT181450 Binding of Ccr5 and Ccl3 4 0.18 2.19 1.03
10 INT167173 Binding of Ccl2 and Ccr2 2 0.30 1.15 0.98
11 INT106248 Binding of CCR5 and YY1 1 0.54 0.19 0.98
12 INT275406 Binding of ITIH4 and Ccr5 1 0.09 2.88 0.97
13 INT275390 Binding of Ccr5 and Htatsf1 1 0.01 3.26 0.97
14 INT128652 ITIH4 Regulation of Gene_expression of CCR5 1 0.36 1.46 0.93
15 INT149559 Tgfb1 Positive_regulation of Gene_expression of Ccr5 1 0.00 0 0.88
16 INT149560 Tgfb1 Positive_regulation of Ccr5 1 0.00 0 0.88
17 INT222243 Negative_regulation of Binding of Trpv1 and Ccr5 1 0.21 0.57 0.86
18 INT222244 Binding of Trpv1 and Ccr5 1 0.19 0.57 0.86
19 INT209035 Il2 Positive_regulation of Ccr1 1 0.00 0.38 0.73
20 INT209038 Il4 Positive_regulation of Ccr1 1 0.01 0.38 0.73
21 INT209065 Il3 Positive_regulation of Ccr1 1 0.00 0.38 0.73
22 INT209031 Il12b Positive_regulation of Ccr1 1 0.02 0.37 0.72
23 INT209041 Il10 Positive_regulation of Ccr1 1 0.01 0.37 0.72
24 INT209060 Il6 Positive_regulation of Ccr1 1 0.01 0.38 0.72
25 INT123494 Binding of Egr1 and Ccr5 1 0.04 0.94 0.71
26 INT222211 TFAM Positive_regulation of Ccr1 1 0.02 1.89 0.68
27 INT297307 Negative_regulation of Binding of Ccr1 and Ccl3 1 0.27 0.73 0.67
28 INT297313 Negative_regulation of Binding of Ccr1 and Ccl5 1 0.28 0.74 0.67
29 INT106247 Binding of CCR5 and CCL4 1 0.54 0.06 0.64
30 INT281130 Ccl2 Regulation of Gene_expression of Ccr2 1 0.04 1.09 0.64
31 INT281134 Ccl2 Positive_regulation of Gene_expression of Ccr2 1 0.08 1.09 0.64
32 INT281122 Ccl2 Regulation of Ccr2 1 0.04 1.09 0.63
33 INT244232 Binding of Ccr5 and Ccl4 3 0.17 1.48 0.55
34 INT97635 ABCF1 Positive_regulation of Localization of CCR1 1 0.05 0.51 0.55
35 INT222252 Positive_regulation of Binding of Ccr2 and Fig4 1 0.16 0.67 0.55
36 INT222246 Binding of Ccr2 and Tcf21 1 0.29 0.67 0.55
37 INT222249 Positive_regulation of Binding of Ccr2 and Tcf21 1 0.39 0.67 0.55
38 INT222245 Binding of Ccr2 and Fig4 1 0.12 0.67 0.55
39 INT264269 Binding of ANC and Darc 1 0.09 1.47 0.52
40 INT275387 Binding of Lamp1 and Ccr5 1 0.01 1.45 0.52
41 INT275405 Binding of GOLPH3 and Ccr5 1 0.00 1.46 0.52
42 INT149652 Zfp36 Regulation of Nos2 1 0.09 0.42 0.47
43 INT275407 Binding of ERVW-1 and Ccr5 1 0.00 1.74 0.46
44 INT178664 Binding of CCR5 and TH1L 1 0.04 1.04 0.44
45 INT281126 Binding of Ccr2 and Cxcr4 1 0.30 0.32 0.44
46 INT181448 Eae1 Positive_regulation of Gene_expression of Ccr2 1 0.04 4.98 0.42
47 INT181080 Binding of Cx3cr1 and Darc 1 0.00 1.09 0.39
48 INT181081 Binding of Ccr1 and Darc 1 0.01 1.08 0.39
49 INT189493 Tnf Positive_regulation of Localization of Darc 1 0.00 0.53 0.37
50 INT123511 TIAF1 Positive_regulation of Gene_expression of Ccr5 1 0.00 0.6 0.37
51 INT163909 CCL2 Positive_regulation of Positive_regulation of Ccr2 1 0.05 0.19 0.36
52 INT123495 Negative_regulation of Binding of Egr1 and Ccr5 1 0.03 0.48 0.36
53 INT123493 Regulation of Binding of Egr1 and Ccr5 1 0.03 0.48 0.36
54 INT163908 CCL2 Positive_regulation of Ccr2 1 0.05 0.2 0.35
55 INT189492 Ifng Positive_regulation of Localization of Darc 1 0.00 0.53 0.34
56 INT189489 Il1b Positive_regulation of Localization of Darc 1 0.00 0.53 0.34
57 INT189494 Negative_regulation of Ccr5 Negative_regulation of Gene_expression of Hand1 1 0.16 0.66 0.32
58 INT181435 Binding of Ccr2 and Hand2 1 0.17 1.81 0.32
59 INT244233 Ccr1 Positive_regulation of Cxcr1 1 0.16 0.08 0.32
60 INT284229 Binding of ITIH4 and Ccr5 1 0.10 0.27 0.31
61 INT306107 Binding of CCL2 and Ccr2 1 0.06 0 0.28
62 INT322966 Binding of IL8 and Darc 1 0.02 0.45 0.27
63 INT268766 Tlr4 Positive_regulation of Gene_expression of Ccr1 1 0.04 0.4 0.26
64 INT275553 Negative_regulation of Binding of Ccr5 and Ccl3 1 0.05 0.73 0.26
65 INT268768 Mip Regulation of Positive_regulation of Ccr1 1 0.44 0.83 0.23
66 INT170993 IL10 Positive_regulation of Gene_expression of CCR1 1 0.12 0.34 0.22
67 INT181445 Binding of Ccr5 and Hand1 1 0.12 1.01 0.22
68 INT278390 Hps5 Positive_regulation of Darc 1 0.01 0.49 0.22
69 INT182634 Binding of CCR5 and MIP 2 0.39 1.29 0.2
70 INT158209 Binding of CCR1 and AHSA1 1 0.17 0.3 0.2
71 INT158225 Binding of CCR1 and MAPK1 1 0.18 0.3 0.2
72 INT158231 TNFSF14 Positive_regulation of CCR1 1 0.07 0.3 0.2
73 INT158210 Binding of CCR1 and TNFSF14 1 0.05 0.3 0.2
74 INT158212 Negative_regulation of Binding of CCR1 and AHSA1 1 0.20 0.3 0.2
75 INT158200 Positive_regulation of Binding of CCR1 and AHSA1 1 0.23 0.3 0.2
76 INT158201 Positive_regulation of Binding of CCR1 and TNFSF14 1 0.07 0.3 0.2
77 INT158221 Positive_regulation of Binding of CCR1 and MAPK1 1 0.25 0.3 0.2
78 INT158230 Negative_regulation of Binding of CCR1 and TNFSF14 1 0.06 0.3 0.2
79 INT158219 Negative_regulation of Binding of CCR1 and MAPK1 1 0.21 0.3 0.2
80 INT181440 Binding of Ccr2 and Eae1 1 0.03 1.3 0.19
81 INT23585 Binding of KRIT1 and CCR1 1 0.40 0.97 0.19
82 INT278407 Hps5 Positive_regulation of Gene_expression of Darc 1 0.01 0.22 0.19
83 INT244240 Binding of IL8 and Ccr5 1 0.03 0.05 0.18
84 INT322962 Binding of Darc and Gpbar1 1 0.01 0.69 0.18
85 INT172250 Binding of APLNR and CCR1 1 0.12 0 0.17
86 INT284230 Positive_regulation of Binding of ITIH4 and Ccr5 1 0.10 0 0.17
87 INT88311 ITIH4 Positive_regulation of CCR5 1 0.49 1.57 0.16
88 INT284226 Negative_regulation of Binding of Ccr5 and Hivan1 1 0.01 0.27 0.14
89 INT284217 Binding of Ccr5 and Hivan1 1 0.01 0.27 0.14
90 INT352417 Ccl2 Positive_regulation of Ccr5 1 0.06 0.26 0.14
91 INT352416 Ccl2 Positive_regulation of Ccr2 1 0.23 0.26 0.14
92 INT333652 Binding of Ccr5 and Msc 1 0.10 0.07 0.13
93 INT268765 Tlr4 Positive_regulation of Positive_regulation of Ccr1 1 0.04 0.27 0.13
94 INT284219 Binding of Ccr5 and Avpr1b 1 0.01 0.46 0.12
95 INT284208 Binding of Ccr5 and Eclc 1 0.08 0.3 0.12
96 INT241748 CCR5 Regulation of CD4 1 0.21 0.39 0.11
97 INT284220 Binding of Ccr5 and Mela 1 0.12 0.23 0.1
98 INT284222 Binding of Ccr5 and Musd1 1 0.01 0.5 0.07
99 INT284216 Binding of Ccr5 and Arhgap4 1 0.02 0.31 0.07
100 INT319786 Ccbp2 Positive_regulation of Negative_regulation of Dio1 1 0.09 0.94 0.05
101 INT284209 Negative_regulation of Binding of Ccr5 and Mela 1 0.14 0.12 0.05
102 INT251296 Binding of CCR5 and ITIH4 1 0.16 0.08 0.04
103 INT284225 Binding of Cd4 and Ccr5 1 0.30 0.26 0.04
104 INT241749 ITIH4 Negative_regulation of Binding of CCR5 1 0.16 0.71 0.04
105 INT183767 Csf2 Negative_regulation of Transcription of CCR5 1 0.17 0.92 0.03
106 INT260946 Zfp36 Negative_regulation of Binding of Elavl1 1 0.21 0.11 0.03
107 INT183758 INCENP Negative_regulation of Transcription of CCR5 1 0.00 0.93 0.03
108 INT319787 Binding of Dio1 and Ccbp2 1 0.06 0.92 0.03
109 INT121652 Binding of CCR5 and CXCL12 1 0.33 0.2 0
110 INT328477 Mkrn1 Positive_regulation of CCR5 1 0.01 0.69 0
111 INT165781 Binding of TNFSF14 and Darc 1 0.00 0 0
112 INT285641 Zfp36 Negative_regulation of Egr1 1 0.06 0.28 0
113 INT336168 Binding of CCR5 and HIVEP1 1 0.01 0.44 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for C-C chemokine binding. They are ordered first by their pain relevance and then by number of times they were reported in C-C chemokine binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT88322 Gene_expression of CCR5 111 0.78 77.36 39.84
2 INT88046 Gene_expression of Ccr2 38 0.76 33.76 28.07
3 INT141612 Gene_expression of Ccr1 92 0.77 72.09 24.14
4 INT102545 Gene_expression of Ccr2 42 0.78 61.43 19.81
5 INT167679 Gene_expression of Ccr5 74 0.75 59.03 18.16
6 INT151434 Positive_regulation of Ccr2 26 0.68 18.34 16.34
7 INT89293 Positive_regulation of Gene_expression of CCR5 29 0.70 22.14 15
8 INT165773 Gene_expression of Darc 37 0.75 22.28 14.84
9 INT87393 Gene_expression of Ccr5 19 0.65 11 10.51
10 INT161222 Positive_regulation of Ccr2 13 0.55 13.77 8.89
11 INT88047 Positive_regulation of Gene_expression of Ccr2 15 0.60 10.5 8.63
12 INT89292 Positive_regulation of CCR5 27 0.70 15.12 8.59
13 INT166881 Positive_regulation of Ccr1 31 0.69 18.14 7.9
14 INT102548 Negative_regulation of Ccr2 14 0.59 19.84 7.22
15 INT91758 Binding of CCR5 28 0.45 20.16 7.07
16 INT153268 Positive_regulation of Ccr5 25 0.66 19 7.02
17 INT93144 Gene_expression of CCR1 18 0.75 14.69 6.84
18 INT141611 Positive_regulation of Gene_expression of Ccr1 25 0.69 20.32 6.42
19 INT107315 Negative_regulation of CCR5 22 0.57 13.82 6.11
20 INT120089 Negative_regulation of Ccr5 7 0.58 10.36 5.91
21 INT103847 Positive_regulation of Ccr5 11 0.55 6.04 5.79
22 INT181406 Binding of Ccr5 16 0.45 17 5.78
23 INT181022 Binding of Ccr1 15 0.37 10.69 5.37
24 INT150237 Localization of Ccr1 10 0.75 9.25 4.72
25 INT161221 Positive_regulation of Positive_regulation of Ccr2 3 0.50 4.55 3.98
26 INT65700 Localization of CCR1 7 0.51 4 3.91
27 INT103843 Positive_regulation of Gene_expression of Ccr5 5 0.42 2.31 3.89
28 INT222241 Binding of Ccr2 5 0.42 4.09 3.71
29 INT281144 Regulation of Gene_expression of Ccr2 2 0.44 2.38 3.29
30 INT166879 Localization of Ccr5 4 0.71 3.62 2.97
31 INT222237 Negative_regulation of Gene_expression of Ccr2 3 0.37 3.39 2.91
32 INT151436 Regulation of Ccr2 4 0.44 2.81 2.82
33 INT110233 Regulation of Gene_expression of CCR5 6 0.34 7.14 2.76
34 INT106433 Regulation of CCR5 11 0.59 6.93 2.75
35 INT222226 Negative_regulation of Ccr2 6 0.57 3.69 2.66
36 INT87395 Binding of Ccr5 5 0.29 2.5 2.6
37 INT165776 Binding of Darc 11 0.42 3.94 2.4
38 INT113775 Negative_regulation of Gene_expression of CCR5 6 0.43 3.97 2.28
39 INT181356 Positive_regulation of Gene_expression of Ccr5 11 0.66 8.3 2.24
40 INT23588 Positive_regulation of CCR1 6 0.67 4.44 2.24
41 INT165774 Transcription of Darc 2 0.01 2.95 2.23
42 INT146504 Regulation of Ccr2 5 0.39 3.58 2.21
43 INT181402 Negative_regulation of Ccr1 8 0.42 7 2.2
44 INT96743 Transcription of Ccr5 2 0.54 2.72 2.17
45 INT112970 Regulation of Ccr1 8 0.29 7.77 1.93
46 INT181341 Binding of Ccr2 8 0.32 6.47 1.77
47 INT247710 Gene_expression of Ccbp2 3 0.34 10.57 1.75
48 INT87394 Negative_regulation of Ccr5 3 0.32 1.3 1.74
49 INT102550 Positive_regulation of Gene_expression of Ccr2 6 0.69 4.53 1.67
50 INT157840 Regulation of Darc 4 0.02 2.35 1.47
51 INT157663 Negative_regulation of Darc 4 0.37 1.92 1.46
52 INT133633 Positive_regulation of Darc 7 0.38 2.01 1.44
53 INT181373 Negative_regulation of Gene_expression of Ccr2 5 0.59 5.92 1.44
54 INT281139 Phosphorylation of Ccr2 2 0.79 1.2 1.18
55 INT281141 Positive_regulation of Phosphorylation of Ccr2 2 0.49 1.2 1.18
56 INT189479 Positive_regulation of Gene_expression of Darc 5 0.31 3.06 1.17
57 INT241757 Localization of CCR5 6 0.71 5.7 1.14
58 INT268754 Negative_regulation of Gene_expression of Ccr1 5 0.43 2.76 1.13
59 INT222235 Localization of Ccr2 7 0.73 5.32 1.12
60 INT151435 Negative_regulation of Positive_regulation of Ccr2 1 0.53 0.7 1.08
61 INT157841 Localization of Darc 3 0.01 2.42 1.02
62 INT268753 Negative_regulation of Positive_regulation of Ccr1 1 0.42 2.59 0.96
63 INT87396 Negative_regulation of Gene_expression of Ccr5 1 0.12 1.02 0.92
64 INT189482 Regulation of Gene_expression of Ccr5 4 0.44 3.38 0.86
65 INT160410 Positive_regulation of Positive_regulation of Ccr5 2 0.38 1.31 0.83
66 INT161223 Negative_regulation of Positive_regulation of Ccr2 1 0.43 0.83 0.81
67 INT181359 Transcription of Ccr1 4 0.53 1.66 0.8
68 INT268746 Positive_regulation of Binding of Ccr1 1 0.50 1.81 0.79
69 INT222239 Transcription of Ccr2 2 0.61 1.15 0.73
70 INT171946 Positive_regulation of Binding of CCR5 1 0.47 3.86 0.66
71 INT115892 Positive_regulation of Phosphorylation of Ccr5 1 0.00 0 0.66
72 INT115896 Phosphorylation of Ccr5 1 0.01 0 0.65
73 INT181364 Regulation of Ccr5 3 0.32 1.81 0.62
74 INT189481 Regulation of Gene_expression of Ccr1 3 0.45 1.97 0.58
75 INT172297 Binding of CCR1 1 0.36 0.08 0.56
76 INT97637 Positive_regulation of Localization of CCR1 1 0.08 0.51 0.55
77 INT247739 Binding of Ccbp2 1 0.11 0 0.54
78 INT222242 Positive_regulation of Transcription of Ccr2 1 0.44 0.66 0.52
79 INT260124 Positive_regulation of Positive_regulation of CCR5 1 0.14 0.84 0.51
80 INT103844 Regulation of Gene_expression of Ccr5 1 0.22 0.55 0.51
81 INT181376 Negative_regulation of Gene_expression of Ccr5 3 0.41 2.12 0.49
82 INT149643 Binding of Zfp36 2 0.29 0.45 0.49
83 INT236350 Transcription of Ccr2 2 0.72 3.59 0.49
84 INT182225 Transcription of CCR1 1 0.57 0.45 0.47
85 INT272877 Localization of Ccr2 2 0.75 1.68 0.46
86 INT181397 Transcription of Ccr5 2 0.62 1.33 0.46
87 INT281147 Regulation of Binding of Ccr2 1 0.39 0.86 0.46
88 INT87392 Regulation of Ccr5 1 0.17 0.53 0.46
89 INT165775 Positive_regulation of Transcription of Darc 2 0.00 0.79 0.45
90 INT204827 Positive_regulation of Zfp36 1 0.26 0.33 0.43
91 INT222240 Positive_regulation of Transcription of Ccr5 1 0.37 0.7 0.4
92 INT268761 Positive_regulation of Positive_regulation of Ccr1 1 0.43 1.51 0.39
93 INT163905 Positive_regulation of Positive_regulation of Ccr2 1 0.13 0.16 0.37
94 INT322707 Protein_catabolism of Ccr5 1 0.22 0.32 0.37
95 INT171023 Negative_regulation of Gene_expression of CCR1 2 0.37 1.53 0.36
96 INT157842 Positive_regulation of Localization of Darc 1 0.00 0.58 0.36
97 INT340642 Regulation of Gene_expression of Ccr2 1 0.62 2.26 0.35
98 INT221044 Positive_regulation of Negative_regulation of CCR5 1 0.19 0.62 0.35
99 INT322958 Negative_regulation of Gene_expression of Darc 1 0.03 0.17 0.34
100 INT322959 Positive_regulation of Binding of Darc 1 0.03 0.08 0.3
101 INT171025 Negative_regulation of Localization of CCR1 1 0.37 0.4 0.25
102 INT268747 Positive_regulation of Localization of Ccr1 1 0.43 0.8 0.23
103 INT189474 Regulation of Positive_regulation of Darc 1 0.00 0.41 0.22
104 INT104449 Transcription of CCR5 4 0.53 2.73 0.21
105 INT268750 Positive_regulation of Transcription of Ccr1 2 0.46 0.26 0.21
106 INT23591 Regulation of CCR1 1 0.26 0.96 0.19
107 INT268764 Regulation of Positive_regulation of Ccr1 1 0.45 0.83 0.18
108 INT327283 Negative_regulation of Zfp36 1 0.39 0.5 0.18
109 INT322957 Protein_catabolism of Darc 1 0.04 0.43 0.18
110 INT181340 Negative_regulation of Negative_regulation of Ccr1 1 0.28 0.67 0.18
111 INT284203 Positive_regulation of Negative_regulation of Ccr5 1 0.41 0.41 0.18
112 INT107316 Negative_regulation of Positive_regulation of CCR5 2 0.41 1.96 0.17
113 INT158243 Positive_regulation of Positive_regulation of CCR1 1 0.39 0.26 0.17
114 INT158248 Negative_regulation of Positive_regulation of CCR1 1 0.36 0.26 0.17
115 INT284206 Negative_regulation of Negative_regulation of Ccr5 1 0.40 0 0.12
116 INT241759 Negative_regulation of Binding of CCR5 2 0.41 0.94 0.11
117 INT285555 Positive_regulation of Gene_expression of CCR1 1 0.16 1.11 0.1
118 INT236358 Regulation of Transcription of Ccr2 1 0.24 1 0.09
119 INT322703 Negative_regulation of Binding of Ccr5 1 0.32 0.41 0.09
120 INT260907 Phosphorylation of Zfp36 1 0.54 0.47 0.08
121 INT268757 Phosphorylation of Ccr1 1 0.81 0.08 0.08
122 INT352409 Regulation of Positive_regulation of Ccr2 1 0.44 0.15 0.07
123 INT260911 Regulation of Phosphorylation of Zfp36 1 0.30 0.23 0.04
124 INT284205 Phosphorylation of Ccr5 1 0.59 0.08 0.04
125 INT183763 Negative_regulation of Transcription of CCR5 1 0.15 0.92 0.03
126 INT260926 Regulation of Zfp36 2 0.21 0.47 0
127 INT319784 Regulation of Gene_expression of Ccbp2 1 0.13 0.8 0
128 INT319777 Positive_regulation of Localization of Ccbp2 1 0.14 0.24 0
129 INT149645 Positive_regulation of Gene_expression of Zfp36 1 0.14 0 0
130 INT319781 Negative_regulation of Ccbp2 1 0.05 0.8 0
131 INT149639 Gene_expression of Zfp36 1 0.22 0 0
132 INT319779 Localization of Ccbp2 1 0.22 1.8 0
133 INT319776 Positive_regulation of Ccbp2 1 0.14 0.8 0
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