GO:0019959

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Name interleukin-8 binding
Categary Function
Go Slim No
Go Link GO:0019959
Unique Molecular Interactions 70
Total Molecular Interactions 115
Total Single Events 564
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for interleukin-8 binding. They are ordered first by their pain relevance and then by number of times they were reported for interleukin-8 binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT182194 Binding of IL8 and CXCR2 10 0.56 7.14 4.16
2 INT208572 Binding of IL8 and CXCR1 6 0.33 5.2 3.08
3 INT223156 Il6 Regulation of A2m 1 0.11 2.79 1.39
4 INT254210 Binding of Cxcr2 and Ccl2 1 0.08 2.39 1.25
5 INT250777 Binding of Cxcl10 and Cxcr1 1 0.14 3.1 1.04
6 INT311143 IL8 Positive_regulation of Cxcr1 1 0.04 1.74 0.98
7 INT239539 Binding of CXCR2 and CALCRL 1 0.00 0.38 0.98
8 INT182203 Binding of CXCL1 and CXCR2 1 0.14 1.25 0.95
9 INT182207 Binding of CXCR2 and CXCL13 1 0.42 1.26 0.95
10 INT182208 Binding of CXCR2 and CXCL12 1 0.29 1.26 0.95
11 INT182193 Binding of CXCR2 and CXCL5 1 0.30 1.25 0.94
12 INT182197 Binding of CXCR2 and CCL16 1 0.00 1.24 0.94
13 INT62956 CXCR2 Positive_regulation of IL8 1 0.30 0 0.88
14 INT201945 Binding of CXCR1 and CXCR2 3 0.14 0.84 0.8
15 INT183698 Binding of Cxcr2 and Cxcl1 3 0.33 3.26 0.76
16 INT182202 Binding of CXCR2 and CXCR4 1 0.31 1.15 0.72
17 INT83956 Binding of Cxcl2 and Cxcr1 1 0.19 0.98 0.71
18 INT83957 Binding of Cxcr2 and Cxcl2 1 0.33 0.97 0.7
19 INT318737 Binding of CXCR1 and CXCL6 1 0.25 1.37 0.67
20 INT318738 Binding of CXCR2 and CXCL6 1 0.32 1.39 0.67
21 INT174456 Binding of Cxcr3 and Cxcr1 1 0.31 1.24 0.58
22 INT174452 Binding of Cxcr2 and Cxcr3 1 0.31 1.23 0.58
23 INT97636 ABCF1 Positive_regulation of Localization of CXCR1 1 0.35 0.45 0.51
24 INT106074 IL1B Positive_regulation of Gene_expression of A2M 1 0.03 0.75 0.49
25 INT106072 NFKB1 Positive_regulation of Gene_expression of A2M 1 0.19 0.75 0.49
26 INT99789 Cxcl10 Positive_regulation of Cxcr2 1 0.53 0.28 0.46
27 INT99790 Ifng Positive_regulation of Cxcr2 1 0.12 0.28 0.46
28 INT253996 Binding of Cxcr2 and Cxcr4 1 0.18 0.81 0.44
29 INT303858 DDR1 Positive_regulation of CXCR2 1 0.11 1.5 0.42
30 INT222214 TFAM Positive_regulation of Cxcr1 1 0.03 1.13 0.37
31 INT239540 Binding of CXCR2 and MYC 1 0.15 0.09 0.33
32 INT190683 Binding of A2M and INS 4 0.11 4.97 0.32
33 INT244234 Cxcr2 Positive_regulation of Cxcr1 1 0.16 0.08 0.32
34 INT244233 Ccr1 Positive_regulation of Cxcr1 1 0.16 0.08 0.32
35 INT239558 Binding of CXCR2 and Hopx 1 0.06 0.44 0.31
36 INT239537 CXCR2 Regulation of MYC 1 0.15 0.05 0.29
37 INT94849 A2M Negative_regulation of Gene_expression of COL7A1 1 0.01 0.27 0.28
38 INT137166 IL8 Positive_regulation of CXCR2 1 0.24 0.28 0.27
39 INT201075 Binding of TNF and Cxcr1 1 0.00 0.31 0.26
40 INT321223 CXCR1 Positive_regulation of NFKB1 1 0.00 1.02 0.25
41 INT41950 Ptger1 Positive_regulation of Localization of A2m 1 0.19 0.46 0.24
42 INT41949 Ptger1 Positive_regulation of Gene_expression of A2m 1 0.19 0.46 0.24
43 INT339287 Binding of Cxcr2 and Cxcl1 1 0.29 0.48 0.24
44 INT62090 CXCR1 Positive_regulation of HSPG2 1 0.54 0.18 0.23
45 INT239536 Binding of CXCR2 and NCOR2 1 0.00 0 0.2
46 INT283429 Nt5e Regulation of Gene_expression of Cxcr1 1 0.00 0.22 0.2
47 INT283431 Lcn2 Regulation of Gene_expression of Cxcr1 1 0.01 0.22 0.2
48 INT280260 Tgfb1 Positive_regulation of Cxcr1 1 0.07 1.78 0.19
49 INT280261 Tgfb1 Positive_regulation of Gene_expression of Cxcr1 1 0.05 1.81 0.19
50 INT272931 Binding of IL8 and Cxcr1 1 0.07 0.65 0.18
51 INT322965 Binding of IL8 and Cxcr2 1 0.28 0.51 0.18
52 INT273792 Cxcr2 Positive_regulation of Nfasc 1 0.08 0.29 0.17
53 INT183697 Ducm1 Positive_regulation of Gene_expression of Cxcr2 1 0.05 0.2 0.16
54 INT344919 Ufm1 Regulation of Cxcr1 1 0.00 0.46 0.15
55 INT94850 A2M Negative_regulation of Gene_expression of PIP 1 0.01 0.14 0.14
56 INT190684 Binding of A2M and IGF1 1 0.16 1.54 0.1
57 INT248185 Binding of Cxcr2 and DRGX 1 0.01 0 0.09
58 INT183701 Negative_regulation of Cxcr2 Negative_regulation of Ducm1 1 0.03 0.45 0.07
59 INT326127 Binding of CXCL3 and CXCR1 1 0.13 1.16 0.05
60 INT349287 A2m Negative_regulation of Prtn3 1 0.00 0.4 0.03
61 INT127731 Binding of A2m and Mif 1 0.19 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for interleukin-8 binding. They are ordered first by their pain relevance and then by number of times they were reported in interleukin-8 binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT28642 Gene_expression of CXCR2 60 0.78 38.69 18.11
2 INT83950 Gene_expression of Cxcr1 31 0.59 27.76 13.91
3 INT66606 Gene_expression of CXCR1 34 0.75 27.79 11.36
4 INT123382 Gene_expression of Cxcr2 12 0.69 4.62 8.62
5 INT83954 Binding of Cxcr2 21 0.37 17.27 7.65
6 INT83951 Gene_expression of Cxcr2 31 0.71 19.36 7.24
7 INT62958 Positive_regulation of CXCR2 14 0.59 8.61 4.92
8 INT99785 Positive_regulation of Cxcr2 10 0.53 8.03 4.89
9 INT174428 Positive_regulation of Cxcr1 8 0.53 8.1 4.79
10 INT124980 Gene_expression of Cxcr1 2 0.63 7.08 4.06
11 INT41942 Gene_expression of A2m 9 0.36 9.98 3.96
12 INT28640 Positive_regulation of Gene_expression of CXCR2 8 0.69 5.51 2.91
13 INT123384 Binding of Cxcr2 4 0.33 1.33 2.81
14 INT117143 Negative_regulation of Gene_expression of Cxcr1 4 0.33 5.35 2.78
15 INT162380 Negative_regulation of CXCR2 11 0.57 6.98 2.76
16 INT10141 Gene_expression of A2M 11 0.35 9.37 2.75
17 INT208588 Binding of CXCR2 11 0.48 6.43 2.68
18 INT174419 Transcription of Cxcr1 4 0.55 4.68 2.52
19 INT699 Positive_regulation of A2M 16 0.66 10.49 2.5
20 INT97640 Positive_regulation of CXCR1 5 0.49 3.77 2.17
21 INT23352 Negative_regulation of A2M 10 0.33 8.35 2.16
22 INT182243 Regulation of CXCR2 4 0.39 2.59 1.94
23 INT174421 Positive_regulation of Gene_expression of Cxcr1 2 0.53 2.58 1.75
24 INT41639 Positive_regulation of A2m 7 0.46 4.52 1.74
25 INT174430 Regulation of Cxcr1 1 0.21 5.03 1.73
26 INT3249 Regulation of A2M 7 0.39 3.29 1.61
27 INT174445 Regulation of Gene_expression of Cxcr1 3 0.35 2.52 1.39
28 INT208592 Binding of CXCR1 3 0.36 2.26 1.32
29 INT41944 Positive_regulation of Gene_expression of A2m 2 0.23 2.56 1.29
30 INT99788 Regulation of Cxcr2 3 0.41 2.25 1.27
31 INT174435 Transcription of Cxcr2 1 0.53 2.16 1.19
32 INT41947 Regulation of A2m 2 0.29 1.08 1.14
33 INT99779 Positive_regulation of Positive_regulation of Cxcr2 2 0.46 1.62 1.13
34 INT150854 Negative_regulation of Cxcr2 7 0.54 4.12 1.06
35 INT86931 Gene_expression of A2m 3 0.16 4.81 1.04
36 INT221055 Negative_regulation of CXCR1 3 0.23 1.61 0.99
37 INT183686 Binding of Cxcr1 5 0.35 1.8 0.98
38 INT92291 Localization of CXCR1 4 0.73 3.06 0.98
39 INT182220 Regulation of Positive_regulation of CXCR2 2 0.39 1.29 0.91
40 INT28641 Regulation of Gene_expression of CXCR2 1 0.45 1.9 0.91
41 INT41946 Localization of A2m 1 0.38 1.81 0.89
42 INT134099 Negative_regulation of Gene_expression of CXCR2 1 0.04 0.81 0.87
43 INT145029 Positive_regulation of Localization of Cxcr1 1 0.21 0.23 0.83
44 INT174431 Positive_regulation of Transcription of Cxcr2 1 0.36 1.44 0.83
45 INT145030 Localization of Cxcr1 1 0.32 0.23 0.83
46 INT174416 Negative_regulation of Gene_expression of Cxcr2 2 0.33 2.06 0.82
47 INT109109 Localization of Cxcr1 1 0.16 0.85 0.79
48 INT99776 Positive_regulation of Gene_expression of Cxcr2 2 0.64 1.7 0.74
49 INT41943 Positive_regulation of Positive_regulation of A2m 2 0.22 1.19 0.74
50 INT174458 Regulation of CXCR1 1 0.00 1.5 0.73
51 INT174457 Transcription of CXCR1 2 0.57 1.14 0.71
52 INT41945 Negative_regulation of A2m 2 0.27 0.35 0.68
53 INT189322 Binding of A2M 7 0.29 12.1 0.66
54 INT99786 Localization of Cxcr2 2 0.69 0.86 0.56
55 INT239556 Positive_regulation of Phosphorylation of CXCR2 1 0.18 0.11 0.53
56 INT239543 Phosphorylation of CXCR1 1 0.59 0.1 0.53
57 INT239553 Positive_regulation of Phosphorylation of CXCR1 1 0.50 0.11 0.53
58 INT277204 Positive_regulation of Binding of Cxcr2 1 0.39 1.37 0.53
59 INT239544 Phosphorylation of CXCR2 1 0.29 0.1 0.53
60 INT97643 Positive_regulation of Localization of CXCR1 1 0.49 0.45 0.52
61 INT167366 Positive_regulation of A2m 1 0.02 0.43 0.49
62 INT182214 Transcription of CXCR2 1 0.59 0.45 0.47
63 INT99783 Positive_regulation of Localization of Cxcr2 1 0.46 0.22 0.45
64 INT174444 Positive_regulation of Transcription of Cxcr1 1 0.36 0.79 0.42
65 INT311120 Negative_regulation of Binding of Cxcr1 1 0.35 0.75 0.42
66 INT311118 Binding of Cxcr1 1 0.39 0.75 0.42
67 INT311135 Negative_regulation of Gene_expression of Cxcr1 1 0.48 0.8 0.38
68 INT133819 Localization of CXCR2 3 0.61 1.64 0.37
69 INT288336 Positive_regulation of Gene_expression of A2m 1 0.12 1.73 0.37
70 INT183684 Regulation of Gene_expression of Cxcr2 1 0.57 1.42 0.37
71 INT48772 Localization of A2M 3 0.78 2.83 0.35
72 INT248175 Positive_regulation of Cxcr2 1 0.35 0 0.27
73 INT311116 Regulation of Gene_expression of Cxcr1 1 0.22 0.54 0.26
74 INT46524 Negative_regulation of Gene_expression of A2M 2 0.02 1.45 0.23
75 INT41948 Negative_regulation of Localization of A2m 1 0.20 0.46 0.23
76 INT311126 Regulation of Cxcr1 1 0.50 0.52 0.23
77 INT346981 Positive_regulation of Gene_expression of CXCR1 1 0.05 1.18 0.22
78 INT323976 Regulation of Gene_expression of CXCR1 1 0.06 1.52 0.21
79 INT209091 Regulation of Regulation of Cxcr1 1 0.04 1.19 0.2
80 INT183691 Negative_regulation of Cxcr1 1 0.08 0.58 0.19
81 INT3248 Positive_regulation of Positive_regulation of A2M 1 0.46 0.25 0.17
82 INT23708 Regulation of Regulation of A2M 1 0.02 0.68 0.17
83 INT167367 Binding of A2m 1 0.01 0.13 0.15
84 INT311139 Transcription of Cxcr1 1 0.43 0.18 0.1
85 INT193490 Negative_regulation of Gene_expression of A2m 1 0.06 0.56 0.1
86 INT248176 Localization of Cxcr2 1 0.52 0 0.06
87 INT199219 Negative_regulation of Positive_regulation of A2M 1 0.29 1.94 0.03
88 INT236257 Regulation of Gene_expression of A2m 1 0.14 0 0
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