GO:0019987

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Name negative regulation of anti-apoptosis
Categary Process
Go Slim No
Go Link GO:0019987
Unique Molecular Interactions 104
Total Molecular Interactions 114
Total Single Events 1261
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of anti-apoptosis. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of anti-apoptosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT296793 Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.75 0.65
2 INT296790 Tlr9 Regulation of Bax 1 0.14 0.76 0.65
3 INT296791 Positive_regulation of Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.8 0.65
4 INT112699 Bid Regulation of Bax 1 0.25 0.51 0.61
5 INT155254 Col4a4 Regulation of Rtn4 1 0.00 0 0.54
6 INT125086 LPA Positive_regulation of Rtn4 1 0.00 0.36 0.54
7 INT238638 Gopc Negative_regulation of Gene_expression of Bax 1 0.04 0.85 0.45
8 INT155061 Stat3 Negative_regulation of Bax 1 0.22 3.71 0.34
9 INT110758 Tnfaip8 Positive_regulation of Positive_regulation of Nos2 1 0.14 0.88 0.34
10 INT110760 Tnfaip8 Positive_regulation of Positive_regulation of Nfkb1 1 0.14 0.87 0.34
11 INT110761 Tnfaip8 Positive_regulation of Nos2 1 0.13 0.88 0.34
12 INT110759 Tnfaip8 Positive_regulation of Nfkb1 1 0.13 0.87 0.34
13 INT69362 Binding of Pnoc and Rtn4 1 0.01 0 0.31
14 INT257744 Binding of PIK3R2 and SHC1 1 0.08 0.96 0.28
15 INT329529 Tnfaip8 Positive_regulation of Gene_expression of Csf2 1 0.07 0.35 0.28
16 INT141545 Binding of Bace1 and Rtn4 1 0.00 0.45 0.27
17 INT141550 Binding of Rtn4r and Rtn4 1 0.00 0.46 0.26
18 INT155158 Agtr2 Regulation of Rtn4 1 0.00 0.1 0.22
19 INT155063 Csf2 Negative_regulation of Gene_expression of Bax 1 0.27 1.46 0.18
20 INT155066 Csf2 Negative_regulation of Bax 1 0.12 1.89 0.17
21 INT349475 Regulation of Bax Regulation of Bcl2 1 0.07 1.35 0.17
22 INT336891 Epo Negative_regulation of Transcription of Bax 1 0.10 0.68 0.16
23 INT349476 Bax Regulation of Bcl2 1 0.07 1.33 0.15
24 INT345146 Binding of Trip6 and Siva1 1 0.02 1.6 0.14
25 INT273040 Vip Regulation of Bax 1 0.23 1.69 0.13
26 INT273041 Adcyap1 Regulation of Bax 1 0.21 1.69 0.13
27 INT226192 Protein_catabolism of Bax Positive_regulation of Gtf3a 1 0.00 0.53 0.12
28 INT139787 Negative_regulation of TNFAIP8 Positive_regulation of IKBKG 1 0.10 0.89 0.11
29 INT139783 TNFAIP8 Positive_regulation of IKBKG 1 0.12 0.88 0.11
30 INT285030 Binding of Bax and Slc25a4 1 0.03 0.84 0.11
31 INT139786 TNFAIP8 Positive_regulation of Phosphorylation of IKBKG 1 0.12 0.89 0.11
32 INT139789 TNFAIP8 Positive_regulation of Phosphorylation of NFKBIA 1 0.02 0.89 0.11
33 INT139788 TNFAIP8 Positive_regulation of NFKBIA 1 0.01 0.88 0.11
34 INT139792 TNFAIP8 Positive_regulation of Protein_catabolism of IKBKG 1 0.12 0.89 0.11
35 INT139785 TNFAIP8 Positive_regulation of Positive_regulation of NFKB1 1 0.19 0.89 0.11
36 INT259926 Tnfaip8 Positive_regulation of Jun 1 0.52 0.31 0.08
37 INT259930 Negative_regulation of Tnfaip8 Positive_regulation of Jun 1 0.48 0.31 0.08
38 INT285032 Bnip3 Positive_regulation of Bax 1 0.28 0.77 0.07
39 INT340401 Positive_regulation of Bax Positive_regulation of Binding of Hrk 1 0.01 0.79 0.07
40 INT150388 Binding of MEFV and SIVA1 1 0.31 0.92 0.07
41 INT340395 Binding of Bax and Tg(CAG-EGFP)D4Nagy 1 0.02 0.43 0.07
42 INT345173 Binding of Siva1 and Lpar2 1 0.05 0.75 0.06
43 INT340394 Binding of Bax and Bbc3 1 0.01 0.36 0.04
44 INT172902 Binding of Bax and Bcl2 5 0.30 3.19 0.03
45 INT297737 Cbr1 Positive_regulation of Bax 1 0.06 0.53 0.03
46 INT253575 Binding of Jak2 and Pik3r2 1 0.00 0 0.03
47 INT327404 Binding of Xiap and Siva1 1 0.02 1.97 0.03
48 INT333259 Bcl2 Regulation of Bax 1 0.03 0.32 0.03
49 INT224676 Binding of Bax and Mcl1 1 0.01 1.09 0.03
50 INT224690 Mcl1 Regulation of Bax 1 0.00 1.09 0.03
51 INT341376 Sod2 Regulation of Bax 1 0.09 0.99 0.03
52 INT172906 Binding of Bax and Bcl2l1 2 0.16 2.03 0
53 INT325770 Binding of EPOR and PIK3R2 1 0.01 0.18 0
54 INT203418 Enc1 Negative_regulation of Rtn4 1 0.08 0.58 0
55 INT285029 Binding of Bax and Bcl2l1 1 0.25 0.1 0
56 INT330047 Binding of Bax and Bcl2l11 1 0.13 0.62 0
57 INT191058 Binding of Bcl2 and Positive_regulation of Gene_expression of Bax 1 0.21 0.49 0
58 INT203406 Cap2 Negative_regulation of Rtn4 1 0.07 0.59 0
59 INT242483 Negative_regulation of Ciapin1 Negative_regulation of Positive_regulation of Bax 1 0.17 1.76 0
60 INT136914 Mapk8 Positive_regulation of Localization of Bax 1 0.51 0.12 0
61 INT203410 Vsnl1 Negative_regulation of Rtn4 1 0.18 0.58 0
62 INT322664 Prdm8 Positive_regulation of Gene_expression of Bax 1 0.01 1.1 0
63 INT285028 Binding of Bcl2 and Bax 1 0.32 0.1 0
64 INT345152 Binding of Lpar1 and Siva1 1 0.03 0.66 0
65 INT229821 Fos Positive_regulation of Bax 1 0.15 0.27 0
66 INT309517 Binding of Bax and Xrcc6 1 0.15 0.5 0
67 INT201761 BIK Positive_regulation of Positive_regulation of Bax 1 0.01 0.43 0
68 INT330052 Binding of Bax and Bid 1 0.15 0.62 0
69 INT322662 Binding of Bax and Pbrm1 1 0.08 0.9 0
70 INT172908 Binding of Bad and Bax 1 0.01 1.34 0
71 INT330057 Bid Positive_regulation of Bax 1 0.19 0.62 0
72 INT313426 Positive_regulation of Ppp2ca Positive_regulation of Bax 1 0.46 0.36 0
73 INT267252 Bax Regulation of Bak1 1 0.05 1.09 0
74 INT201765 Binding of BCL2L1 and Bax 1 0.00 0.28 0
75 INT201763 BID Positive_regulation of Positive_regulation of Bax 1 0.01 0.43 0
76 INT242476 Negative_regulation of Ciapin1 Positive_regulation of Bax 1 0.19 1.29 0
77 INT322670 Prdm8 Positive_regulation of Bax 1 0.01 1.1 0
78 INT275753 xn Regulation of Bax 1 0.05 1.31 0
79 INT333681 Trp53 Regulation of Negative_regulation of Bax 1 0.15 1.17 0
80 INT334718 Binding of NOS1 and Bax 1 0.02 0.87 0
81 INT330054 Bcl2l11 Positive_regulation of Bax 1 0.25 0.62 0
82 INT254090 EPO Negative_regulation of Gene_expression of Bax 1 0.10 0.63 0
83 INT340400 Binding of Bax and Mom6 1 0.04 0.28 0
84 INT275746 Binding of xn and Bax 1 0.05 2.57 0
85 INT340399 Binding of Bak1 and Bax 1 0.12 0.91 0
86 INT309518 Negative_regulation of Binding of Bax and Xrcc6 1 0.16 0.25 0
87 INT203396 Mllt11 Negative_regulation of Rtn4 1 0.09 0.58 0
88 INT203399 Olfm1 Negative_regulation of Rtn4 1 0.09 0.58 0
89 INT201768 BCL2L11 Positive_regulation of Positive_regulation of Bax 1 0.00 0.43 0
90 INT201743 Bad Positive_regulation of Positive_regulation of Bax 1 0.00 0.43 0
91 INT136915 RYBP Positive_regulation of Localization of Bax 1 0.01 0.12 0
92 INT322660 Binding of Bax and Prdm8 1 0.01 0.89 0
93 INT100425 Bax Regulation of Pcbd1 1 0.06 0.06 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of anti-apoptosis. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of anti-apoptosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5923 Negative_regulation of Rtn4 50 0.36 24.19 27.2
2 INT100423 Gene_expression of Bax 141 0.75 98.43 24.48
3 INT56239 Positive_regulation of Rtn4 20 0.26 14.05 18.8
4 INT5922 Gene_expression of Rtn4 27 0.48 12.7 17.86
5 INT109511 Gene_expression of Bax 133 0.78 113.22 14.36
6 INT53070 Regulation of Rtn4 15 0.22 9.35 13.77
7 INT102110 Positive_regulation of Gene_expression of Bax 42 0.67 35.77 9.51
8 INT102106 Positive_regulation of Bax 48 0.67 30.62 9.28
9 INT102107 Negative_regulation of Gene_expression of Bax 30 0.57 29.48 7.33
10 INT98837 Positive_regulation of Bax 72 0.61 63.14 6.41
11 INT145929 Regulation of Bax 20 0.60 18.12 5.35
12 INT109513 Positive_regulation of Gene_expression of Bax 37 0.67 29.52 5.06
13 INT75546 Transcription of Rtn4 1 0.06 2.87 5.03
14 INT99504 Negative_regulation of Bax 19 0.56 8.89 4.44
15 INT123752 Regulation of Bax 19 0.60 16.45 4
16 INT112692 Localization of Bax 31 0.80 20.97 3.98
17 INT156676 Gene_expression of Rtn4 14 0.65 5.78 3.16
18 INT102146 Phosphorylation of Bax 4 0.66 3.48 2.35
19 INT232842 Gene_expression of Tnfaip8 15 0.66 5.81 2.34
20 INT129742 Regulation of Positive_regulation of Rtn4 2 0.05 2.51 2.33
21 INT154970 Localization of Bax 15 0.74 11.12 2.11
22 INT98836 Transcription of Bax 6 0.69 5.04 1.96
23 INT134442 Transcription of Bax 14 0.67 7.6 1.9
24 INT135540 Negative_regulation of Bax 16 0.48 11.8 1.89
25 INT134443 Binding of Bax 10 0.47 5.62 1.84
26 INT104883 Positive_regulation of Positive_regulation of Bax 4 0.45 4.05 1.74
27 INT143669 Gene_expression of TNFAIP8 1 0.00 1.77 1.61
28 INT143668 Regulation of Gene_expression of TNFAIP8 1 0.00 1.77 1.61
29 INT146785 Positive_regulation of Localization of Bax 7 0.69 6.16 1.47
30 INT109512 Negative_regulation of Gene_expression of Bax 12 0.42 8.04 1.44
31 INT235907 Regulation of Negative_regulation of Rtn4 1 0.07 2.93 1.42
32 INT112695 Negative_regulation of Protein_catabolism of Bax 3 0.36 1.72 1.3
33 INT154969 Positive_regulation of Localization of Bax 4 0.64 3.42 1.27
34 INT5920 Binding of Rtn4 6 0.36 0.66 1.21
35 INT112693 Protein_catabolism of Bax 5 0.74 3.17 1.2
36 INT141189 Negative_regulation of Transcription of Bax 1 0.41 1.42 1.14
37 INT163963 Negative_regulation of Transcription of Rtn4 1 0.03 0.45 1.06
38 INT175507 Regulation of Gene_expression of Bax 13 0.50 10.91 0.95
39 INT104333 Negative_regulation of Positive_regulation of Rtn4 1 0.03 0.42 0.84
40 INT144697 Regulation of Gene_expression of Bax 8 0.37 9.5 0.81
41 INT329508 Positive_regulation of Gene_expression of Tnfaip8 1 0.43 1.33 0.77
42 INT104457 Negative_regulation of Gene_expression of Rtn4 1 0.01 0.64 0.71
43 INT97644 Localization of TNFAIP8 2 0.38 0.39 0.64
44 INT329513 Negative_regulation of Gene_expression of Tnfaip8 1 0.37 0.42 0.53
45 INT176242 Binding of Bax 10 0.42 10.18 0.52
46 INT139838 Negative_regulation of TNFAIP8 1 0.18 0.47 0.52
47 INT102108 Protein_catabolism of Bax 8 0.64 5.69 0.48
48 INT134446 Positive_regulation of Binding of Bax 1 0.49 0.72 0.48
49 INT240033 Phosphorylation of PIK3R2 1 0.02 1.82 0.45
50 INT5921 Positive_regulation of Gene_expression of Rtn4 1 0.26 0.35 0.42
51 INT152059 Regulation of Transcription of Bax 1 0.26 0.07 0.42
52 INT135802 Positive_regulation of Negative_regulation of Bax 2 0.41 0.57 0.4
53 INT161528 Localization of Tnfaip8 2 0.64 1.27 0.38
54 INT204069 Negative_regulation of Positive_regulation of Bax 5 0.31 3.08 0.34
55 INT169538 Negative_regulation of Localization of Bax 3 0.49 1.41 0.34
56 INT184482 Positive_regulation of Positive_regulation of Bax 5 0.41 4.7 0.33
57 INT221191 Negative_regulation of Localization of Bax 4 0.38 2.85 0.33
58 INT150396 Gene_expression of SIVA1 1 0.75 2.34 0.32
59 INT329515 Regulation of Gene_expression of Tnfaip8 1 0.39 0.65 0.3
60 INT102111 Positive_regulation of Protein_catabolism of Bax 2 0.45 1.14 0.27
61 INT135543 Negative_regulation of Positive_regulation of Bax 5 0.30 6.4 0.23
62 INT235908 Localization of Rtn4 1 0.08 0.25 0.23
63 INT259919 Positive_regulation of Tnfaip8 2 0.49 0.67 0.21
64 INT226977 Positive_regulation of Gene_expression of Rtn4 1 0.51 1.1 0.19
65 INT300463 Regulation of Regulation of Bax 1 0.29 1.33 0.18
66 INT242278 Localization of SIVA1 1 0.01 1.07 0.17
67 INT242277 Positive_regulation of SIVA1 1 0.01 1.08 0.17
68 INT329521 Negative_regulation of Tnfaip8 1 0.37 0.06 0.14
69 INT216038 Binding of Rtn4 1 0.40 0.8 0.13
70 INT161527 Negative_regulation of Localization of Tnfaip8 1 0.01 1.02 0.12
71 INT336888 Negative_regulation of Transcription of Bax 1 0.07 0.68 0.11
72 INT190553 Regulation of Siva1 2 0.16 1.05 0.09
73 INT304137 Regulation of Localization of Bax 2 0.24 1.7 0.09
74 INT284321 Gene_expression of PIK3R2 1 0.20 0.97 0.09
75 INT161526 Positive_regulation of Localization of Tnfaip8 1 0.01 0.95 0.09
76 INT327394 Binding of Siva1 2 0.04 2.62 0.08
77 INT259912 Negative_regulation of Positive_regulation of Tnfaip8 1 0.41 0.31 0.08
78 INT307466 Positive_regulation of Phosphorylation of Bax 1 0.15 0.76 0.07
79 INT216029 Positive_regulation of Binding of Rtn4 1 0.38 0.33 0.06
80 INT284333 Positive_regulation of PIK3R2 1 0.12 0.42 0.05
81 INT268622 Regulation of Negative_regulation of Bax 1 0.12 0.81 0.05
82 INT309494 Negative_regulation of Binding of Bax 2 0.38 1.31 0.04
83 INT340387 Regulation of Positive_regulation of Bax 1 0.27 0.61 0.04
84 INT340390 Regulation of Binding of Bax 1 0.54 0.59 0.04
85 INT123525 Phosphorylation of Bax 3 0.41 1.18 0.03
86 INT236921 Positive_regulation of Positive_regulation of Pik3r2 1 0.01 0.13 0.03
87 INT176247 Positive_regulation of Phosphorylation of Bax 1 0.12 0.42 0.03
88 INT216031 Positive_regulation of Rtn4 1 0.57 0.79 0.03
89 INT236919 Positive_regulation of Pik3r2 1 0.01 0.13 0.03
90 INT150397 Binding of SIVA1 1 0.36 0.46 0.03
91 INT348459 Positive_regulation of TNFAIP8 1 0.27 1.04 0
92 INT330041 Positive_regulation of Regulation of Bax 1 0.29 1.63 0
93 INT333213 Regulation of Transcription of Bax 1 0.11 0.14 0
94 INT268311 Negative_regulation of Regulation of Pik3r2 1 0.45 0.44 0
95 INT268303 Negative_regulation of Pik3r2 1 0.33 0.22 0
96 INT268309 Regulation of Pik3r2 1 0.47 0.22 0
97 INT322640 Positive_regulation of Binding of Bax 1 0.12 0.88 0
98 INT234056 Positive_regulation of Transcription of Bax 1 0.35 0.36 0
99 INT348462 Positive_regulation of Positive_regulation of TNFAIP8 1 0.27 1.06 0
100 INT292860 Positive_regulation of Siva1 1 0.12 1.2 0
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