GO:0020037

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Name heme binding
Categary Function
Go Slim No
Go Link GO:0020037
Unique Molecular Interactions 2124
Total Molecular Interactions 2628
Total Single Events 38969
Pain Genes Associated 146

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for heme binding. They are ordered first by their pain relevance and then by number of times they were reported for heme binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT98346 Negative_regulation of Binding of CPOX and PTGS1 1 0.10 2.91 6.54
2 INT317517 Binding of Nos1 and Oprm1 1 0.17 0.22 3.85
3 INT349583 Aap Positive_regulation of Gene_expression of Cyp2e1 1 0.18 1.57 3.59
4 INT108472 Binding of NOS1 and PNOC 1 0.32 0.64 3.27
5 INT349584 Binding of Cyp2e1 and Aap 1 0.10 1.56 3.24
6 INT317522 Akt1 Positive_regulation of Phosphorylation of Nos1 1 0.43 0.4 3.13
7 INT150632 Ea1 Negative_regulation of Mpo 1 0.17 1.55 2.9
8 INT349589 Aap Positive_regulation of Cyp2e1 1 0.21 1.84 2.71
9 INT251150 Binding of Nos1 and Dlg2 1 0.30 1.98 2.62
10 INT81657 Binding of CPOX and PTGS1 5 0.15 1.9 2.37
11 INT321477 Binding of Ubqln1 and Flvcr2 1 0.00 0.81 2.26
12 INT155984 Il1a Negative_regulation of Gene_expression of Cyp3a11 1 0.24 0.92 2.2
13 INT77807 Edn1 Positive_regulation of Gene_expression of Ptgs2 1 0.33 0.53 2.1
14 INT81295 Ifng Positive_regulation of Gene_expression of Nos2 4 0.39 0.87 2.05
15 INT53751 Positive_regulation of Cyp2e1 Positive_regulation of RYBP 1 0.14 0.89 1.98
16 INT14991 SFTPA1 Positive_regulation of Localization of MPO 1 0.11 1.65 1.92
17 INT129903 Nr1i2 Regulation of Cyp3a11 1 0.64 1.26 1.9
18 INT349658 Nos2 Regulation of Gene_expression of Nos1 1 0.63 2.86 1.84
19 INT168010 Asap1 Positive_regulation of HBG2 1 0.01 3.03 1.82
20 INT142899 Chn1 Negative_regulation of Positive_regulation of NOS1 1 0.01 1.07 1.75
21 INT37840 Binding of Cyp27b1 and Oprd1 1 0.01 0 1.73
22 INT92369 Binding of CYP2D6 and RYBP 1 0.25 0.15 1.73
23 INT278223 Binding of NOS3 and ACSM3 1 0.41 6.32 1.65
24 INT168612 Negative_regulation of Nos1 Negative_regulation of Positive_regulation of Mmp9 1 0.23 0.45 1.62
25 INT168607 Negative_regulation of Nos1 Negative_regulation of Mmp9 1 0.23 0.45 1.61
26 INT32937 Binding of Pgrmc1 and Dtnb 1 0.20 0 1.61
27 INT315284 PRKG1 Positive_regulation of Nos1 1 0.33 0.85 1.56
28 INT113337 EPO Positive_regulation of JAK2 1 0.76 2.8 1.55
29 INT249498 Src Positive_regulation of Phosphorylation of Grin2b 1 0.22 1.11 1.54
30 INT100784 RYBP Positive_regulation of CYP3A4 1 0.44 0 1.54
31 INT123899 Binding of CYP3A4 and UGT2B7 1 0.52 0 1.46
32 INT190773 Il4 Negative_regulation of Gene_expression of Ptgs2 1 0.06 1.26 1.45
33 INT190774 Il4 Negative_regulation of Positive_regulation of Ptgs2 1 0.06 1.26 1.45
34 INT134764 Ghrl Regulation of Gene_expression of NOS3 1 0.02 2.66 1.4
35 INT29599 Binding of Cyp21a1 and Adarb1 1 0.01 0 1.38
36 INT90221 Binding of CYP2D6 and Cyp1a2 1 0.03 0.09 1.31
37 INT132412 Negative_regulation of Ngf Negative_regulation of Ptgs1 1 0.01 0.81 1.31
38 INT135830 Gch1 Regulation of Nos2 1 0.65 0 1.29
39 INT153923 Msr1 Positive_regulation of Gene_expression of Tdo2 1 0.00 0.89 1.28
40 INT105295 WAS Regulation of PTGS1 1 0.02 0.13 1.27
41 INT42580 CAT Negative_regulation of POMC 1 0.20 0.42 1.26
42 INT317569 Prkca Positive_regulation of Phosphorylation of Src 1 0.11 0 1.25
43 INT132465 Ltf Positive_regulation of Nos1 1 0.35 0.05 1.24
44 INT249487 Binding of Ephb1 and Src 1 0.17 0.74 1.23
45 INT103031 Calca Positive_regulation of Ptgs1 2 0.46 0.98 1.22
46 INT77806 Edn1 Regulation of Gene_expression of Ptgs2 1 0.29 1.24 1.22
47 INT299299 VEGFA Positive_regulation of SRC 1 0.20 0.91 1.2
48 INT142075 IL4 Negative_regulation of Binding of IDO1 1 0.02 2.07 1.19
49 INT142077 TGFB1 Negative_regulation of Binding of IDO1 1 0.15 2.07 1.19
50 INT111221 MMEL1 Negative_regulation of HMOX1 1 0.01 1 1.16
51 INT195117 Ptgs2 Positive_regulation of Gene_expression of Il6 1 0.10 3.26 1.16
52 INT76378 Binding of Cit and Flvcr2 1 0.09 0.17 1.15
53 INT231769 TNF Negative_regulation of Gene_expression of HMOX1 1 0.26 4.75 1.15
54 INT321478 Binding of Slc6a2 and Flvcr2 1 0.00 0.41 1.14
55 INT69504 Binding of Nos1 and Gatm 1 0.05 0 1.13
56 INT249488 Positive_regulation of Binding of Ephb1 and Src 1 0.23 0.68 1.12
57 INT142572 D5Pas1 Negative_regulation of Nos1 2 0.02 0.14 1.11
58 INT317527 Binding of Hint1 and Nos1 1 0.27 0.1 1.11
59 INT120323 Slc5a7 Negative_regulation of Flvcr2 1 0.02 0.43 1.1
60 INT264988 Binding of CYP2C19 and CYP3A4 1 0.18 0.72 1.09
61 INT130656 Tlr4 Positive_regulation of Cyba 1 0.00 0.05 1.09
62 INT120324 Hc3 Negative_regulation of Flvcr2 1 0.06 0.42 1.09
63 INT130657 Negative_regulation of Tlr4 Positive_regulation of Cyba 1 0.00 0.05 1.09
64 INT28186 CYP2E1 Regulation of Positive_regulation of RYBP 1 0.04 0.33 1.08
65 INT264987 Binding of CYP2C9 and CYP3A4 1 0.19 0.71 1.08
66 INT81583 Cyp3a23/3a1 Positive_regulation of st 1 0.04 0 1.08
67 INT81580 Cyp3a23/3a1 Positive_regulation of Nudt14 1 0.01 0 1.08
68 INT77083 Das Negative_regulation of Cyp2e1 1 0.20 0.59 1.06
69 INT56990 Cat Regulation of Efs 1 0.26 0 1.05
70 INT87855 Flvcr2 Positive_regulation of Localization of Abat 1 0.02 0 1.05
71 INT126401 ITIH4 Positive_regulation of Gene_expression of Ptgs2 1 0.00 1.05 1.04
72 INT65986 IL1B Positive_regulation of PTGS2 3 0.32 2.05 1.03
73 INT88875 Ifng Positive_regulation of Transcription of Nos2 1 0.02 0.27 1.03
74 INT132464 Ltf Negative_regulation of Positive_regulation of Nos1 1 0.33 0 1.03
75 INT121743 Negative_regulation of Src Negative_regulation of Ephb1 1 0.27 0 1.02
76 INT88887 IRF6 Positive_regulation of Transcription of Nos2 1 0.21 0.27 1.02
77 INT88874 Ifng Regulation of Nos2 1 0.01 0.26 1.01
78 INT119914 Olr1714 Negative_regulation of Nos1 1 0.02 0.47 1.01
79 INT88884 IRF6 Regulation of Nos2 1 0.12 0.26 1
80 INT154237 Binding of CYP2D6 and Ugt2b7 1 0.41 0.75 1
81 INT317518 Src Regulation of Negative_regulation of Oprm1 1 0.16 0.07 1
82 INT317555 Nos1 Regulation of Negative_regulation of Oprm1 1 0.21 0.07 1
83 INT88886 IRF6 Positive_regulation of Nos2 1 0.22 0.26 1
84 INT88888 Regulation of IRF6 Positive_regulation of Nos2 1 0.20 0.26 1
85 INT112163 Calca Positive_regulation of Mpo 1 0.49 1.23 1
86 INT143915 Src Regulation of Rbm39 1 0.03 0.18 0.99
87 INT53750 Cyp2e1 Positive_regulation of RYBP 1 0.14 0.44 0.99
88 INT130232 Binding of Cat and Sod1 1 0.35 0.3 0.98
89 INT130231 Positive_regulation of Binding of Cat and Sod1 1 0.46 0.3 0.98
90 INT349592 GTF2H5 Negative_regulation of Cyp2c22 1 0.00 0.64 0.98
91 INT60213 Binding of Ptgs1 and Ptgs2 2 0.37 0.5 0.97
92 INT119276 Negative_regulation of CYBB Negative_regulation of Positive_regulation of ROS1 1 0.09 1.18 0.97
93 INT119275 Negative_regulation of CYBB Negative_regulation of Gene_expression of ROS1 1 0.09 1.18 0.97
94 INT121744 Src Positive_regulation of Positive_regulation of Ephb1 1 0.35 0 0.96
95 INT317567 Binding of Akt1 and Nos1 1 0.22 0 0.96
96 INT155985 Nfkb1 Negative_regulation of Gene_expression of Cyp11a1 1 0.10 0.53 0.95
97 INT52806 CYP2E1 Positive_regulation of RYBP 1 0.43 0.24 0.95
98 INT61037 Och Positive_regulation of Ptgs1 1 0.00 0 0.95
99 INT146579 Hba Negative_regulation of Gene_expression of Nos2 1 0.44 1.01 0.95
100 INT33976 Trmt2a Negative_regulation of Binding of Fads1 1 0.00 0 0.94
101 INT130282 Cyp3a23/3a1 Positive_regulation of Gene_expression of Npy 1 0.15 0 0.94
102 INT220031 Casp3 Positive_regulation of Gene_expression of Nos3 1 0.04 0 0.92
103 INT122269 Src Negative_regulation of Positive_regulation of Grin2b 1 0.27 0.44 0.92
104 INT165280 Tnf Positive_regulation of Gene_expression of Nos2 1 0.24 1.02 0.91
105 INT122266 Src Negative_regulation of Grin2b 1 0.27 0.43 0.91
106 INT68799 Cyp3a62 Negative_regulation of Cyp2d1 1 0.35 0 0.91
107 INT147474 Nfe2l2 Positive_regulation of Hmox1 1 0.43 0.38 0.9
108 INT279166 Binding of Cyp3a23/3a1 and Nr3c2 1 0.00 0.61 0.9
109 INT317530 Negative_regulation of Binding of Nos1 and Oprm1 1 0.21 0.06 0.9
110 INT119100 Positive_regulation of F2rl1 Positive_regulation of Positive_regulation of Ptgs1 1 0.03 0.56 0.9
111 INT56274 RYBP Negative_regulation of Cyp2e1 1 0.01 0.17 0.9
112 INT56273 RYBP Negative_regulation of Cyp1a2 1 0.01 0.17 0.9
113 INT168026 Positive_regulation of HBG2 Regulation of Gpt 1 0.01 0.15 0.89
114 INT108687 Nfkb1 Regulation of Positive_regulation of Nos2 1 0.50 1.28 0.88
115 INT28194 Nppb Positive_regulation of CYP2B6 1 0.50 0.05 0.88
116 INT108686 Nfkb1 Regulation of Nos2 1 0.69 1.27 0.88
117 INT168025 HBG2 Regulation of Gpt 1 0.01 0.15 0.88
118 INT119274 CYBB Positive_regulation of ROS1 1 0.11 1.11 0.88
119 INT62478 Binding of Penk and Flvcr2 1 0.09 0 0.87
120 INT354522 Binding of HBG2 and Wipi1 1 0.00 2.64 0.87
121 INT249491 Efnb2 Positive_regulation of Phosphorylation of Src 1 0.01 0.5 0.87
122 INT160412 Tat Positive_regulation of Transcription of Nos2 1 0.37 0.98 0.86
123 INT37839 Positive_regulation of Binding of Cyp27b1 and Oprd1 1 0.01 0 0.86
124 INT116559 Olr1627 Negative_regulation of Regulation of Ptgs2 1 0.01 1.52 0.86
125 INT136540 Binding of CYP2C9 and Ugt1a6a 1 0.27 0.81 0.86
126 INT120825 Adcyap1 Positive_regulation of Localization of Nos1 1 0.26 0.62 0.85
127 INT62479 Binding of Slc6a7 and Flvcr2 1 0.08 0 0.85
128 INT253995 Binding of Cxcl12 and Cyp3a23/3a1 1 0.06 1.28 0.85
129 INT149628 Il1b Regulation of Gene_expression of Ptgs2 1 0.30 0.84 0.84
130 INT102931 Nos3 Positive_regulation of Nos2 1 0.43 1.63 0.83
131 INT152236 Tlr4 Regulation of Gene_expression of Nos2 3 0.19 0.64 0.82
132 INT155761 Binding of Nos1 and Tjp1 1 0.13 1.01 0.82
133 INT317513 Oprm1 Regulation of Positive_regulation of Src 1 0.09 0.4 0.82
134 INT317570 Oprm1 Regulation of Src 1 0.04 0.4 0.82
135 INT185937 NOS2 Regulation of Prkaca 1 0.03 1.08 0.82
136 INT322266 Binding of LIG4 and NOS3 1 0.02 2.35 0.82
137 INT102932 Nos3 Positive_regulation of NOS1 1 0.03 1.63 0.82
138 INT155760 Binding of Nos1 and Dlg4 1 0.13 1.01 0.82
139 INT28185 CYP2B6 Positive_regulation of Positive_regulation of RYBP 1 0.29 0 0.82
140 INT65807 Nr3c1 Positive_regulation of Cyp3a23/3a1 1 0.14 0 0.82
141 INT56275 RYBP Positive_regulation of Negative_regulation of Cyp1a2 1 0.01 0.17 0.81
142 INT102630 Cyp3a62 Negative_regulation of Cyp1a2 1 0.40 0 0.81
143 INT235087 NOS1 Positive_regulation of Localization of ABAT 1 0.02 0.61 0.81
144 INT88885 IRF6 Positive_regulation of Gene_expression of Nos2 1 0.21 0.1 0.81
145 INT88878 Negative_regulation of Nfkb1 Positive_regulation of Gene_expression of Nos2 1 0.06 0.1 0.81
146 INT92372 CYP2B6 Positive_regulation of Binding of RYBP 1 0.17 0.09 0.81
147 INT349657 Nos2 Regulation of Regulation of Nos1 1 0.24 0.9 0.8
148 INT96501 Il11 Regulation of Gene_expression of NOS2 1 0.00 1.04 0.8
149 INT135781 Cyp3a23/3a1 Positive_regulation of Positive_regulation of Col1a1 1 0.01 0.78 0.8
150 INT62176 Binding of PTGS2 and Ptgs1 2 0.00 0.69 0.79
151 INT168455 Sult1a1 Negative_regulation of Nos2 1 0.08 1.99 0.79
152 INT130283 Cyp3a23/3a1 Positive_regulation of Transcription of Npy 1 0.10 0 0.79
153 INT168456 Arr3 Positive_regulation of Nos2 1 0.21 1.98 0.79
154 INT127383 Neo1 Regulation of Localization of Mpo 1 0.14 0.7 0.79
155 INT132889 Nfkb1 Regulation of Gene_expression of Nos2 1 0.16 0.21 0.79
156 INT105249 Cyb5b Positive_regulation of Localization of Prl 1 0.04 0 0.79
157 INT105250 Cyb5b Regulation of Localization of Gh1 1 0.00 0 0.79
158 INT132894 CHUK Regulation of Gene_expression of Nos2 1 0.00 0.21 0.79
159 INT200094 Negative_regulation of Jun Negative_regulation of Gene_expression of Ptgs2 1 0.01 2.87 0.78
160 INT117604 AKR1C1 Negative_regulation of Positive_regulation of Mpo 1 0.00 1.45 0.78
161 INT168457 Sult1a1 Positive_regulation of Cat 1 0.15 1.56 0.78
162 INT100783 Binding of CYP2B6 and CYP3A4 2 0.17 2 0.77
163 INT181615 SRC Positive_regulation of IRS1 1 0.01 0.98 0.77
164 INT347394 RYBP Positive_regulation of Lpo 1 0.02 0 0.77
165 INT134049 Jak2 Positive_regulation of Gsk3b 1 0.37 0.22 0.77
166 INT56272 Cyp2e1 Positive_regulation of Cyp1a2 1 0.52 0.17 0.77
167 INT97863 Binding of NOS1 and GRHPR 1 0.05 0.23 0.77
168 INT90120 Jun Positive_regulation of Gene_expression of Nos1 1 0.38 0.39 0.76
169 INT28187 CYP2B6 Positive_regulation of RYBP 1 0.31 0.35 0.76
170 INT134043 Jak2 Positive_regulation of Akt1 1 0.31 0.22 0.76
171 INT134051 Jak2 Positive_regulation of Stat3 1 0.44 0.22 0.76
172 INT90117 Jun Regulation of Gene_expression of Nos1 1 0.21 0.39 0.76
173 INT90125 Nfkb1 Regulation of Gene_expression of Nos1 1 0.17 0.39 0.76
174 INT158068 Positive_regulation of Pparg Positive_regulation of Positive_regulation of PTGS2 1 0.01 0.28 0.76
175 INT81299 Ifng Positive_regulation of Gene_expression of Hmox1 1 0.52 0.75 0.76
176 INT123556 Shfm1 Regulation of Mpo 1 0.09 0.88 0.76
177 INT90116 Nfkb1 Positive_regulation of Gene_expression of Nos1 1 0.32 0.39 0.76
178 INT90959 PPIG Regulation of CYP2C9 1 0.43 0 0.75
179 INT158607 Ns5atp9 Positive_regulation of Mpo 1 0.35 1.85 0.75
180 INT88921 Positive_regulation of CYP2D6 Negative_regulation of ANTXR1 1 0.00 0.8 0.75
181 INT108611 Adra2a Regulation of Gene_expression of Nos1 1 0.10 0 0.75
182 INT88922 CYP2D6 Negative_regulation of ANTXR1 1 0.00 0.8 0.75
183 INT128815 Mapk14 Regulation of Gene_expression of Nos2 1 0.21 0.46 0.74
184 INT133675 NPY6R Negative_regulation of SRC 1 0.17 0.75 0.74
185 INT218935 Cyp3a23/3a1 Regulation of Bcl2 1 0.00 1.08 0.74
186 INT159593 Regulation of Nfkb1 Positive_regulation of Gene_expression of Nos2 1 0.38 0.46 0.74
187 INT128813 Mapk8 Regulation of Gene_expression of Nos2 1 0.23 0.46 0.74
188 INT213026 Hdl1 Positive_regulation of Nos3 5 0.16 7.92 0.73
189 INT218933 Cyp3a23/3a1 Regulation of Alpi 1 0.00 1.07 0.73
190 INT92370 Binding of CYP2B6 and CYP2D6 1 0.21 0 0.73
191 INT119314 Ptgs1 Regulation of Gene_expression of Ptger2 1 0.01 0.6 0.73
192 INT38512 Binding of Cyp2c22 and Atp6v1c2 1 0.00 0.17 0.73
193 INT314203 Nos2 Positive_regulation of Gli3 1 0.19 1.27 0.73
194 INT220033 Casp3 Positive_regulation of Gene_expression of Nos1 1 0.05 0.52 0.72
195 INT317547 Src Positive_regulation of Positive_regulation of Grin1 1 0.17 0 0.72
196 INT148453 Gene_expression of Inhbe Positive_regulation of Src 1 0.06 0.68 0.72
197 INT65985 IL1B Positive_regulation of Gene_expression of PTGS2 3 0.23 2.62 0.71
198 INT186674 Binding of BGLAP and CYP27A1 1 0.01 1.91 0.71
199 INT261378 Nsdhl Negative_regulation of Gene_expression of Flvcr2 1 0.01 0.34 0.7
200 INT28184 Binding of CYP1A2 and CYP2D6 1 0.00 0 0.7

Single Events

The table below shows the top 100 pain related interactions that have been reported for heme binding. They are ordered first by their pain relevance and then by number of times they were reported in heme binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26
2 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85
3 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08
4 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6
5 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07
6 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87
7 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51
8 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85
9 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71
10 INT8413 Gene_expression of Ptgs1 248 0.78 110.17 108.58
11 INT49171 Gene_expression of Nos1 241 0.78 140.7 104.76
12 INT940 Negative_regulation of Ptgs1 219 0.59 104.34 95.97
13 INT74058 Gene_expression of Nos1 260 0.78 80.04 95.71
14 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43
15 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32
16 INT64636 Positive_regulation of Gene_expression of Nos2 242 0.70 147.52 79.53
17 INT2431 Positive_regulation of Mpo 275 0.70 211.99 78.47
18 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91
19 INT15613 Negative_regulation of Ptgs2 160 0.59 71.08 65.08
20 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6
21 INT9196 Gene_expression of PTGS1 215 0.77 96.99 60.5
22 INT79093 Positive_regulation of Nos1 101 0.70 46.89 59.61
23 INT49170 Negative_regulation of Nos1 116 0.59 60.66 58.87
24 INT52692 Gene_expression of Ptgs2 160 0.78 85.06 55.73
25 INT48952 Negative_regulation of Nos2 204 0.59 101.73 53.15
26 INT5759 Positive_regulation of Ptgs1 127 0.69 53.45 53.04
27 INT52611 Negative_regulation of Ptgs2 142 0.59 66.31 52.71
28 INT49017 Negative_regulation of Gene_expression of Nos2 169 0.59 80.64 52.67
29 INT64110 Positive_regulation of Gene_expression of Nos1 68 0.70 58.11 51.64
30 INT83199 Gene_expression of Nos3 193 0.78 100.72 51.57
31 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51
32 INT49028 Positive_regulation of Nos1 102 0.70 34.73 51.05
33 INT53083 Gene_expression of Ptgs2 153 0.78 90.04 50.39
34 INT7093 Negative_regulation of CYP2B6 146 0.58 37.3 48.39
35 INT8465 Regulation of Ptgs1 100 0.57 36.03 44.41
36 INT85943 Negative_regulation of Nos2 161 0.59 108.56 42.65
37 INT65245 Gene_expression of Nos3 121 0.78 98.14 41.56
38 INT2429 Negative_regulation of Mpo 128 0.59 93.76 39.57
39 INT77434 Positive_regulation of Gene_expression of Nos2 151 0.69 96.76 38.94
40 INT55135 Positive_regulation of Gene_expression of PTGS2 137 0.70 80.32 38.46
41 INT56870 Gene_expression of CYP2D6 87 0.78 8.83 37.53
42 INT64558 Negative_regulation of Nos1 88 0.58 26.76 36.78
43 INT10796 Gene_expression of CYP2B6 131 0.77 30.14 35.27
44 INT79060 Gene_expression of NOS2 116 0.78 69.25 34.84
45 INT4403 Binding of CYP2B6 113 0.48 21.17 33.83
46 INT20307 Positive_regulation of Cyp2e1 70 0.70 23.59 32.49
47 INT73982 Gene_expression of Hmox1 141 0.78 119.43 32.17
48 INT92837 Negative_regulation of Gene_expression of Nos2 116 0.59 59.67 31.82
49 INT86780 Positive_regulation of Hmox1 145 0.70 117.09 31.18
50 INT10797 Binding of CYP2D6 86 0.48 15.09 31.16
51 INT52690 Positive_regulation of Ptgs2 65 0.68 39.51 30.02
52 INT64113 Positive_regulation of Gene_expression of NOS1 110 0.60 71.03 29.72
53 INT651 Positive_regulation of PTGS1 93 0.69 37.27 29.18
54 INT2389 Regulation of PTGS1 86 0.61 31.23 28.95
55 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27
56 INT17825 Gene_expression of Flvcr2 44 0.68 12.58 28.08
57 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6
58 INT2393 Positive_regulation of Mb 174 0.69 93.59 26.79
59 INT5650 Gene_expression of Mpo 117 0.77 80.27 26.42
60 INT50490 Regulation of PTGS2 80 0.48 39.51 25.85
61 INT2040 Positive_regulation of CYP2B6 95 0.69 34.3 25.6
62 INT61953 Transcription of Nos2 101 0.72 46.64 25.49
63 INT9886 Gene_expression of Ptgs1 92 0.77 40.66 25.31
64 INT74688 Regulation of Nos1 55 0.62 22.16 25.3
65 INT48766 Regulation of NOS1 73 0.61 37.01 24.59
66 INT89854 Regulation of Nos2 49 0.61 42.58 24.1
67 INT70503 Regulation of Gene_expression of Nos2 71 0.62 44 24.01
68 INT58301 Positive_regulation of Mpo 87 0.70 80.19 23.99
69 INT79061 Positive_regulation of NOS2 92 0.65 58.89 23.96
70 INT49172 Regulation of Nos1 43 0.52 27.53 23.66
71 INT47741 Negative_regulation of Flvcr2 43 0.51 5.72 23.37
72 INT16721 Negative_regulation of Cat 56 0.59 44.44 22.84
73 INT21503 Binding of Ptgs1 45 0.48 15.6 22.29
74 INT71047 Gene_expression of CYP19A1 122 0.78 68.78 22.21
75 INT39914 Negative_regulation of Cyp1a2 44 0.58 10.04 22
76 INT47859 Negative_regulation of Cyp2e1 41 0.59 16.92 21.72
77 INT70504 Regulation of Gene_expression of NOS1 30 0.51 21.72 21.72
78 INT74059 Positive_regulation of Gene_expression of Nos1 55 0.70 11.5 21.39
79 INT52693 Positive_regulation of Gene_expression of Ptgs2 57 0.70 25.51 21.18
80 INT12951 Negative_regulation of Cat 126 0.57 64.39 20.61
81 INT17848 Binding of PTGS2 70 0.46 32.1 20.6
82 INT45840 Positive_regulation of Gene_expression of Ptgs1 35 0.50 16.07 20.49
83 INT8765 Positive_regulation of Cyp3a23/3a1 63 0.67 22.28 20.39
84 INT66281 Transcription of Nos2 81 0.71 39.49 20.37
85 INT20305 Gene_expression of Cyp2e1 53 0.78 19.75 19.54
86 INT6993 Negative_regulation of Mpo 72 0.59 61.83 19.51
87 INT68347 Negative_regulation of Cyp2d4 34 0.58 7.62 18.35
88 INT14724 Negative_regulation of CYP19A1 233 0.59 96.56 18.26
89 INT61519 Gene_expression of Mpo 112 0.78 89.29 18.22
90 INT9246 Positive_regulation of Cat 113 0.70 52.73 18.04
91 INT14111 Positive_regulation of Cyp2c22 41 0.67 7.24 17.88
92 INT50403 Negative_regulation of CYP2C19 55 0.59 8.97 17.79
93 INT83198 Positive_regulation of Nos3 78 0.64 35.69 17.71
94 INT80223 Positive_regulation of Hmox1 128 0.68 77.71 17.64
95 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45
96 INT50404 Negative_regulation of CYP1A2 49 0.59 8.61 17.35
97 INT76406 Gene_expression of Hmox1 140 0.78 85.86 17.15
98 INT61949 Regulation of Nos2 74 0.58 34.08 16.7
99 INT77433 Regulation of Gene_expression of Nos2 49 0.62 35.07 16.33
100 INT9197 Binding of PTGS1 44 0.48 18.48 16.26
101 INT170308 Gene_expression of Ido1 159 0.75 69.51 15.98
102 INT47742 Binding of Flvcr2 26 0.42 3.28 15.87
103 INT12950 Gene_expression of Cat 85 0.75 35.94 15.76
104 INT20336 Positive_regulation of CYP2E1 48 0.70 19.26 15.66
105 INT114025 Transcription of Nos1 20 0.70 16.48 15.63
106 INT59929 Negative_regulation of CYP2C9 60 0.59 16.33 15.39
107 INT32706 Gene_expression of Cyp3a23/3a1 51 0.65 19.48 15.06
108 INT74098 Negative_regulation of Gene_expression of Nos1 36 0.59 16.25 14.82
109 INT64112 Regulation of Gene_expression of Nos1 22 0.62 21.45 14.76
110 INT9904 Gene_expression of CYP2E1 64 0.78 13.11 14.65
111 INT5904 Localization of MPO 62 0.81 36.37 14.64
112 INT52696 Positive_regulation of Ptgs2 48 0.70 27.65 14.44
113 INT53080 Positive_regulation of Ptgs1 42 0.42 23.58 14.37
114 INT19408 Negative_regulation of Cyp2c22 37 0.59 6.23 14.22
115 INT80228 Positive_regulation of Gene_expression of Hmox1 68 0.70 62.88 14.01
116 INT53747 Positive_regulation of Cyp2e1 34 0.70 29.03 13.39
117 INT18191 Negative_regulation of Cyp3a23/3a1 48 0.57 10.21 13.38
118 INT89842 Phosphorylation of Src 34 0.69 9.57 13.08
119 INT83200 Positive_regulation of Gene_expression of Nos3 48 0.70 24.75 12.99
120 INT28014 Localization of Cyp3a23/3a1 34 0.77 9.8 12.96
121 INT116528 Gene_expression of HMOX1 106 0.78 86.13 12.8
122 INT121242 Positive_regulation of Gene_expression of Nos3 37 0.69 31.96 12.71
123 INT83201 Gene_expression of NOS3 93 0.78 47.16 12.48
124 INT90909 Negative_regulation of Gene_expression of NOS1 44 0.55 23.83 12.47
125 INT59080 Negative_regulation of Gene_expression of PTGS2 55 0.58 22.92 12.39
126 INT80790 Positive_regulation of Flvcr2 22 0.45 4.92 12.35
127 INT4460 Regulation of Mpo 44 0.62 31.16 12.11
128 INT5649 Negative_regulation of Positive_regulation of Mpo 31 0.59 26.62 11.92
129 INT116433 Gene_expression of CYBB 93 0.70 50.44 11.91
130 INT16772 Gene_expression of MPO 81 0.78 90.98 11.9
131 INT12992 Negative_regulation of Gene_expression of Ptgs1 33 0.42 20.47 11.77
132 INT73431 Positive_regulation of Nos3 82 0.65 53.22 11.61
133 INT97381 Negative_regulation of Positive_regulation of Nos2 34 0.59 16.66 11.6
134 INT20457 Regulation of Ptgs1 23 0.48 11.63 11.56
135 INT787 Localization of Ptgs1 31 0.80 12.36 11.55
136 INT53082 Positive_regulation of Gene_expression of Ptgs2 47 0.64 25.39 11.39
137 INT95369 Positive_regulation of Gene_expression of NOS2 36 0.55 25.09 11.37
138 INT10798 Positive_regulation of CYP2D6 24 0.56 5.82 11.31
139 INT80251 Binding of Nos1 21 0.30 8.24 11.31
140 INT48956 Negative_regulation of Positive_regulation of Nos2 34 0.46 13.15 11.15
141 INT71189 Gene_expression of Cyp1a2 24 0.78 11.39 11.12
142 INT62580 Gene_expression of Cyp2e1 31 0.78 15.4 11.08
143 INT48912 Localization of NOS1 52 0.77 24.14 10.92
144 INT111223 Positive_regulation of HMOX1 47 0.70 39.14 10.92
145 INT2791 Regulation of Mb 53 0.61 23.03 10.73
146 INT22132 Positive_regulation of CAT 41 0.67 18.64 10.67
147 INT22210 Gene_expression of CYP1A2 45 0.78 4.95 10.66
148 INT52689 Regulation of Ptgs2 27 0.60 12.76 10.6
149 INT90114 Regulation of Gene_expression of Nos1 18 0.62 6.38 10.52
150 INT86361 Positive_regulation of Positive_regulation of NOS1 39 0.53 18.93 10.42
151 INT53081 Negative_regulation of Gene_expression of Ptgs2 29 0.59 15.83 10.39
152 INT110017 Phosphorylation of Nos1 12 0.60 1.64 10.3
153 INT2792 Gene_expression of Mb 91 0.76 41.56 10.25
154 INT17824 Positive_regulation of Gene_expression of Flvcr2 15 0.41 6.66 10.23
155 INT55418 Regulation of CYP2D6 29 0.61 1.83 10.21
156 INT19132 Gene_expression of CYP27A1 83 0.75 34.31 10.17
157 INT79720 Positive_regulation of Cat 57 0.70 31.81 10.11
158 INT85535 Negative_regulation of Gene_expression of Ptgs2 27 0.51 16.04 10.01
159 INT47860 Negative_regulation of Cyp1a2 20 0.57 6.06 10
160 INT120509 Gene_expression of Cat 65 0.77 50.9 9.75
161 INT95271 Negative_regulation of Nos3 46 0.53 24.1 9.71
162 INT70850 Positive_regulation of Transcription of Nos2 30 0.70 18.95 9.68
163 INT12563 Localization of Mpo 33 0.81 20.99 9.58
164 INT68372 Regulation of CYP2C9 28 0.62 5.64 9.53
165 INT69321 Regulation of Gene_expression of PTGS2 27 0.61 13.27 9.53
166 INT53746 Regulation of Cyp2e1 11 0.62 3.82 9.52
167 INT12398 Regulation of Flvcr2 11 0.39 1.8 9.47
168 INT130497 Gene_expression of Cbs 5 0.77 16.93 9.34
169 INT57665 Negative_regulation of Cyp2e1 35 0.59 8.05 9.29
170 INT37896 Positive_regulation of Gene_expression of PTGS1 37 0.67 17.28 9.27
171 INT181307 Gene_expression of NGB 1 0.76 11.15 9.18
172 INT10597 Gene_expression of Cyp19a1 27 0.78 7.48 9.11
173 INT107087 Positive_regulation of Gene_expression of Cyp2e1 20 0.70 8.89 9.04
174 INT89845 Positive_regulation of Src 19 0.44 7.5 9.01
175 INT12991 Negative_regulation of Gene_expression of PTGS1 28 0.41 13.39 8.9
176 INT23264 Negative_regulation of Positive_regulation of Ptgs1 16 0.39 8.47 8.9
177 INT52442 Binding of Ptgs1 16 0.35 9.05 8.78
178 INT66819 Binding of CYP2C9 41 0.48 8.23 8.76
179 INT6573 Regulation of Negative_regulation of Ptgs1 19 0.45 6.16 8.71
180 INT28521 Gene_expression of HBG2 56 0.77 16.62 8.64
181 INT4046 Positive_regulation of HBG2 42 0.69 13.66 8.51
182 INT48908 Transcription of NOS1 27 0.55 13.46 8.39
183 INT5194 Positive_regulation of Lpo 63 0.70 26.44 8.37
184 INT119904 Regulation of CYP19A1 25 0.62 9.36 8.34
185 INT61599 Positive_regulation of CYP2C9 43 0.69 11.1 8.33
186 INT127378 Localization of Mpo 21 0.78 26.36 8.28
187 INT84672 Negative_regulation of Positive_regulation of Nos1 12 0.48 3.76 8.27
188 INT56223 Positive_regulation of MPO 35 0.70 43 8.2
189 INT116605 Binding of Nos2 28 0.37 16.88 8.18
190 INT82450 Negative_regulation of Hmox1 33 0.55 19.07 8.12
191 INT72337 Positive_regulation of Positive_regulation of Nos2 37 0.65 17.02 8.11
192 INT5114 Gene_expression of Ptgis 41 0.50 21.43 8.1
193 INT114023 Positive_regulation of Transcription of Nos1 7 0.60 5.35 8.06
194 INT71381 Localization of Nos1 33 0.79 11.46 8.05
195 INT22056 Positive_regulation of CYBB 88 0.68 32.13 7.95
196 INT76091 Positive_regulation of NOS3 48 0.61 18.4 7.92
197 INT173808 Positive_regulation of CYP27A1 35 0.68 23.7 7.87
198 INT172789 Regulation of Gene_expression of Nos3 15 0.53 16.23 7.86
199 INT96724 Gene_expression of Cyp3a11 10 0.77 4.82 7.76
200 INT112191 Positive_regulation of Transcription of Nos2 22 0.66 12.4 7.74
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