GO:0021522

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Name spinal cord motor neuron differentiation
Categary Process
Go Slim No
Go Link GO:0021522
Unique Molecular Interactions 92
Total Molecular Interactions 118
Total Single Events 839
Pain Genes Associated 15

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for spinal cord motor neuron differentiation. They are ordered first by their pain relevance and then by number of times they were reported for spinal cord motor neuron differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT140347 Binding of ATP1A2 and Cacna1a 1 0.11 2.88 2.73
2 INT74840 Binding of Cacna1a and Cacna1a 5 0.00 4.24 2.36
3 INT122660 Binding of CACNA1A and DNAH8 2 0.28 2.68 2.08
4 INT355251 Cacna1a Regulation of Gene_expression of Gabrg1 1 0.01 0.06 1.86
5 INT355249 Cacna1a Regulation of Gene_expression of Ltp 1 0.04 0.06 1.86
6 INT355254 Ltp Regulation of Cacna1a 1 0.04 0 1.58
7 INT74843 Binding of Cacna1a and Ea2 3 0.13 3.29 1.55
8 INT355250 Ltp Regulation of Positive_regulation of Cacna1a 1 0.04 0 1.39
9 INT108727 Binding of ATP1A2 and CACNA1A 2 0.34 1.97 1.37
10 INT122659 Binding of CACNA1A and SAR1B 1 0.06 1.38 1.35
11 INT355253 Ltp Positive_regulation of Cacna1a 1 0.05 0 1.34
12 INT355252 Binding of Cacna1a and Cnr1 1 0.04 0 1.31
13 INT74841 Binding of Cacna1a and Ea2 2 0.01 2.33 1.27
14 INT52076 Binding of RYBP and Abt1 1 0.01 0.28 1.08
15 INT108729 Binding of CACNA1A and Cacna1a 3 0.13 1.21 0.95
16 INT214410 Binding of ATP1A4 and CACNA1A 1 0.26 0.95 0.7
17 INT31416 Cacna1a Positive_regulation of Gene_expression of Gcg 1 0.03 0 0.65
18 INT354986 Cacna1a Regulation of Localization of Mpo 1 0.01 1.15 0.49
19 INT173475 Bcar1 Regulation of Isl1 1 0.01 0 0.47
20 INT335850 Snrpc Negative_regulation of Gene_expression of Isl1 1 0.00 1.51 0.45
21 INT354981 Cacna1a Negative_regulation of Gene_expression of Nos2 1 0.01 0.99 0.45
22 INT155752 Binding of CACNA1A and ATCAY 1 0.04 0.86 0.42
23 INT354984 Binding of Cacna1a and Tnf 1 0.01 0.83 0.4
24 INT158355 Cacna1a Regulation of Alox5 1 0.01 0.7 0.37
25 INT354985 Cacna1a Regulation of Nos2 1 0.01 0.73 0.34
26 INT354982 Cacna1a Regulation of Tnf 1 0.00 0.73 0.34
27 INT101551 Binding of CACNA1A and CACNA1F 1 0.07 1.51 0.33
28 INT151258 Binding of Cacna1a and FCMTE1 1 0.00 0.57 0.3
29 INT142003 Binding of Cacna1a and Etax2 1 0.00 1.02 0.26
30 INT54460 Binding of Abt1 and Chrna9 1 0.03 0.31 0.26
31 INT142004 Binding of Cacna1a and TGM6 1 0.00 1.02 0.26
32 INT68298 Binding of Neurod1 and Abt1 1 0.24 0 0.26
33 INT70661 Binding of Hrasls and Nkx2-2 1 0.02 0 0.24
34 INT121807 CACNA1A Regulation of CAV2 1 0.01 0.25 0.2
35 INT76865 Lmo4 Positive_regulation of Sds 1 0.02 0.38 0.2
36 INT76866 Negative_regulation of Lmo4 Positive_regulation of Sds 1 0.02 0.38 0.2
37 INT71329 Cacna1a Regulation of Ea2 1 0.01 0.71 0.15
38 INT71328 Cacna1a Regulation of Atxn2 1 0.00 0.71 0.15
39 INT120559 Binding of Cacna1a and FCMTE1 1 0.02 0.25 0.1
40 INT196213 REST Regulation of Gene_expression of CACNA1A 1 0.46 0.08 0.08
41 INT333847 Binding of E2f5 and Mir17 1 0.03 0.52 0.05
42 INT333849 Binding of Mcm4 and Mir17 1 0.03 0.52 0.05
43 INT333846 Binding of Wee1 and Mir17 1 0.03 0.52 0.05
44 INT333840 Binding of Cables1 and Mir17 1 0.03 0.52 0.05
45 INT333851 Binding of Ccna1 and Mir17 1 0.04 0.52 0.05
46 INT352623 Tpt1 Regulation of Olig2 1 0.02 0.54 0.05
47 INT352622 Olig2 Negative_regulation of Tpt1 1 0.06 0.54 0.05
48 INT333841 Binding of Rad51 and Mir17 1 0.02 0.52 0.05
49 INT354983 Cacna1a Regulation of Mpo 1 0.02 0.41 0.04
50 INT249898 Binding of Neurod1 and Olig2 1 0.09 0.14 0.03
51 INT354987 Cacna1a Regulation of Localization of LDHA 1 0.00 0.23 0.03
52 INT249889 Binding of Neurog3 and Olig2 1 0.09 0.14 0.03
53 INT249891 Binding of Atoh1 and Olig2 1 0.08 0.14 0.03
54 INT249899 Binding of Neurog2 and Olig2 1 0.09 0.14 0.03
55 INT249901 Binding of Neurod4 and Olig2 1 0.09 0.14 0.03
56 INT249896 Binding of Neurog1 and Olig2 1 0.09 0.14 0.03
57 INT249902 Binding of Neurod6 and Olig2 1 0.09 0.14 0.03
58 INT249900 Binding of Neurod2 and Olig2 1 0.09 0.14 0.03
59 INT244856 Lbx1 Regulation of Isl1 1 0.60 0 0
60 INT196208 REST Regulation of CACNA1A 1 0.46 0.06 0
61 INT196216 Binding of CACNA1A and REST 1 0.28 0 0
62 INT261963 Binding of Cacna1a and Tgm2 1 0.08 1.19 0
63 INT172838 Binding of ISL1 and T2dm2 1 0.00 2.41 0
64 INT259095 Binding of RBBP8 and LMO4 1 0.15 0.73 0
65 INT336780 Ighmbp2 Regulation of ERAP2 1 0.02 0.15 0
66 INT250496 Gopc Regulation of Positive_regulation of Cacna1a 1 0.37 0 0
67 INT259093 Binding of TSC1 and LMO4 1 0.02 0.74 0
68 INT323254 Binding of Ptprv and Isl1 1 0.00 0.6 0
69 INT244860 Lbx1 Negative_regulation of Isl1 1 0.16 0 0
70 INT323253 Binding of Ins1 and Isl1 1 0.00 0.59 0
71 INT243233 Positive_regulation of Ighmbp2 Negative_regulation of Rs1 1 0.11 0.31 0
72 INT259091 Binding of BRCA1 and LMO4 1 0.24 0.74 0
73 INT240011 Ass1 Positive_regulation of Gene_expression of Nkx2-2 1 0.00 0 0
74 INT243235 Ighmbp2 Negative_regulation of Rs1 1 0.11 0.31 0
75 INT323251 Binding of Isl1 and Uchl1 1 0.00 0.6 0
76 INT243232 Ighmbp2 Negative_regulation of Ptch1 1 0.02 0.22 0
77 INT323252 Binding of H2-Ab1 and Isl1 1 0.00 0.6 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for spinal cord motor neuron differentiation. They are ordered first by their pain relevance and then by number of times they were reported in spinal cord motor neuron differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT66331 Gene_expression of Cacna1a 101 0.78 49.58 46.32
2 INT26698 Positive_regulation of Cacna1a 37 0.67 26.33 39.1
3 INT41487 Negative_regulation of Cacna1a 16 0.57 9.42 25.2
4 INT31136 Binding of Cacna1a 28 0.45 30.76 17.35
5 INT30101 Regulation of Cacna1a 25 0.45 14.38 12.43
6 INT75765 Positive_regulation of Gene_expression of Cacna1a 17 0.70 17.51 10.91
7 INT68267 Gene_expression of CACNA1A 22 0.75 11.39 8.65
8 INT91821 Binding of Cacna1a 16 0.48 13.1 6.37
9 INT48840 Gene_expression of Nkx2-2 8 0.23 1.55 5.44
10 INT129508 Localization of Cacna1a 7 0.74 6.47 5.13
11 INT110796 Positive_regulation of Positive_regulation of Cacna1a 1 0.49 0.51 4.84
12 INT203443 Gene_expression of Isl1 27 0.67 11.12 4.65
13 INT82731 Transcription of Cacna1a 5 0.56 3.41 4.27
14 INT15257 Positive_regulation of Nkx2-2 10 0.21 1.75 4.2
15 INT51180 Regulation of Nkx2-2 5 0.26 2.16 4.14
16 INT8600 Binding of Nkx2-2 6 0.10 0.87 3.82
17 INT287526 Negative_regulation of Gene_expression of CACNA1A 1 0.42 4.25 3.81
18 INT233640 Negative_regulation of Olig2 5 0.54 2.02 3.47
19 INT53516 Binding of CACNA1A 9 0.47 6.86 3.36
20 INT94045 Regulation of Cacna1a 5 0.42 3.56 3.33
21 INT78317 Regulation of CACNA1A 8 0.62 7.68 3.08
22 INT85572 Gene_expression of Cacna1a 11 0.66 5.72 3.02
23 INT142940 Positive_regulation of Negative_regulation of Cacna1a 3 0.50 1.65 2.97
24 INT355244 Negative_regulation of Negative_regulation of Cacna1a 1 0.04 0 2.67
25 INT161575 Localization of CACNA1A 4 0.75 5.28 2.26
26 INT132383 Gene_expression of Olig2 16 0.75 5.46 2.07
27 INT110795 Regulation of Positive_regulation of Cacna1a 2 0.26 0.65 2.07
28 INT354979 Positive_regulation of Localization of Cacna1a 2 0.05 0.86 1.79
29 INT355239 Negative_regulation of Positive_regulation of Cacna1a 1 0.04 0 1.79
30 INT71327 Localization of Cacna1a 3 0.60 2.51 1.7
31 INT112845 Negative_regulation of Binding of Nkx2-2 2 0.12 0.14 1.47
32 INT355242 Negative_regulation of Binding of Cacna1a 1 0.04 0.17 1.47
33 INT120340 Negative_regulation of Abt1 2 0.10 1.27 1.45
34 INT132081 Regulation of Gene_expression of Nkx2-2 2 0.10 0.24 1.43
35 INT355245 Regulation of Localization of Cacna1a 1 0.04 0 1.43
36 INT90740 Negative_regulation of Cacna1a 3 0.23 1.43 1.38
37 INT82727 Positive_regulation of Transcription of Cacna1a 1 0.01 1.07 1.25
38 INT200838 Positive_regulation of Isl1 6 0.60 0.73 1.19
39 INT85571 Positive_regulation of Cacna1a 3 0.50 2.06 1.18
40 INT355243 Negative_regulation of Regulation of Cacna1a 1 0.04 0 1.16
41 INT172809 Gene_expression of ISL1 33 0.40 21.63 1.12
42 INT179583 Gene_expression of Lmo4 5 0.41 1.97 1.03
43 INT321650 Negative_regulation of Gene_expression of Cacna1a 2 0.04 0.13 0.95
44 INT94046 Protein_catabolism of Cacna1a 1 0.70 0.83 0.9
45 INT60930 Binding of Abt1 1 0.41 0.64 0.9
46 INT131964 Positive_regulation of CACNA1A 5 0.61 0.73 0.85
47 INT173472 Positive_regulation of Isl1 1 0.03 0.2 0.83
48 INT259113 Gene_expression of LMO4 1 0.78 71.49 0.76
49 INT138396 Transcription of Nkx2-2 1 0.26 0.05 0.75
50 INT138395 Positive_regulation of Transcription of Nkx2-2 1 0.19 0.05 0.75
51 INT248470 Gene_expression of Ighmbp2 5 0.75 3.32 0.68
52 INT103336 Transcription of Cacna1a 2 0.69 1.17 0.68
53 INT243779 Negative_regulation of Gene_expression of Isl1 2 0.30 2.62 0.68
54 INT141227 Phosphorylation of CACNA1A 1 0.55 0.78 0.66
55 INT106974 Regulation of Abt1 1 0.01 0.49 0.65
56 INT226838 Transcription of Isl1 2 0.28 0.36 0.6
57 INT189813 Negative_regulation of CACNA1A 4 0.57 3.07 0.55
58 INT122930 Positive_regulation of Gene_expression of CACNA1A 2 0.49 0.91 0.54
59 INT48503 Positive_regulation of Positive_regulation of Nkx2-2 1 0.15 0 0.42
60 INT17937 Gene_expression of Isl1 4 0.27 0.48 0.36
61 INT99962 Positive_regulation of Gene_expression of Cacna1a 1 0.01 1.1 0.34
62 INT155753 Regulation of Gene_expression of CACNA1A 1 0.27 0.66 0.32
63 INT122619 Gene_expression of Nkx2-2 6 0.36 0.15 0.31
64 INT172806 Localization of ISL1 4 0.26 2.64 0.29
65 INT78132 Binding of Isl1 1 0.16 0 0.27
66 INT25465 Positive_regulation of ISL1 6 0.15 3.59 0.26
67 INT173797 Negative_regulation of Isl1 3 0.37 0.15 0.26
68 INT208497 Localization of Nkx2-2 1 0.01 0 0.26
69 INT173792 Negative_regulation of Negative_regulation of Isl1 1 0.08 0.15 0.26
70 INT179581 Negative_regulation of Gene_expression of Lmo4 1 0.18 0.06 0.26
71 INT259120 Regulation of Gene_expression of LMO4 1 0.45 5.61 0.23
72 INT205087 Positive_regulation of Gene_expression of ISL1 4 0.26 3.86 0.19
73 INT243778 Binding of Isl1 1 0.26 0 0.19
74 INT234156 Negative_regulation of Gene_expression of Olig2 1 0.40 0.79 0.18
75 INT98772 Localization of Isl1 2 0.65 0 0.16
76 INT201210 Negative_regulation of ISL1 2 0.02 0.4 0.16
77 INT259111 Transcription of LMO4 1 0.72 12.56 0.16
78 INT323420 Positive_regulation of Gene_expression of Lmo4 1 0.01 0.71 0.16
79 INT259110 Negative_regulation of Gene_expression of LMO4 1 0.43 3.47 0.16
80 INT249876 Binding of Olig2 2 0.30 0 0.13
81 INT259117 Positive_regulation of Gene_expression of LMO4 1 0.70 16.1 0.13
82 INT98774 Regulation of Localization of Isl1 1 0.08 0 0.13
83 INT243228 Protein_catabolism of Ighmbp2 3 0.16 0.83 0.1
84 INT234159 Regulation of Gene_expression of Olig2 1 0.56 0.61 0.1
85 INT207829 Positive_regulation of Localization of ISL1 1 0.02 0.1 0.1
86 INT173473 Positive_regulation of Positive_regulation of Isl1 1 0.02 0.06 0.09
87 INT80893 Localization of Abt1 1 0.61 0 0.09
88 INT173470 Positive_regulation of Phosphorylation of Isl1 1 0.02 0 0.09
89 INT173471 Phosphorylation of Isl1 1 0.04 0 0.09
90 INT196235 Negative_regulation of Transcription of CACNA1A 1 0.36 0.1 0.07
91 INT196229 Transcription of CACNA1A 1 0.60 0.24 0.07
92 INT190034 Transcription of Ighmbp2 3 0.07 0.95 0.06
93 INT213690 Regulation of Olig2 2 0.28 0.06 0.06
94 INT259118 Positive_regulation of LMO4 1 0.70 9.69 0.06
95 INT298237 Regulation of Isl1 1 0.03 0.24 0.06
96 INT309389 Phosphorylation of Cacna1a 1 0.01 0.54 0.05
97 INT309386 Positive_regulation of Phosphorylation of Cacna1a 1 0.01 0.54 0.05
98 INT234158 Positive_regulation of Olig2 2 0.40 0.31 0.04
99 INT122620 Negative_regulation of Gene_expression of Nkx2-2 1 0.20 0 0.04
100 INT248475 Regulation of Ighmbp2 2 0.05 0.96 0.03
101 INT333799 Gene_expression of Mir17 1 0.12 0.32 0.03
102 INT352541 Transcription of ISL1 1 0.36 0.2 0.03
103 INT180121 Phosphorylation of Isl1 1 0.27 0 0
104 INT336756 Regulation of Transcription of Ighmbp2 1 0.03 0 0
105 INT180097 Positive_regulation of Phosphorylation of Isl1 1 0.17 0 0
106 INT352836 Transcription of Mir17 1 0.04 0 0
107 INT259107 Regulation of LMO4 1 0.45 2.68 0
108 INT227625 Regulation of ISL1 1 0.05 0.35 0
109 INT248485 Positive_regulation of Gene_expression of Ighmbp2 1 0.05 0.1 0
110 INT259108 Negative_regulation of LMO4 1 0.59 0.74 0
111 INT143655 Transcription of Nkx2-2 1 0.58 0 0
112 INT236702 Positive_regulation of Mir17 1 0.06 0.52 0
113 INT243780 Positive_regulation of Gene_expression of Isl1 1 0.35 0 0
114 INT336755 Positive_regulation of Ighmbp2 1 0.03 0.09 0
115 INT183071 Negative_regulation of Gene_expression of ISL1 1 0.20 0.34 0
116 INT196237 Positive_regulation of Transcription of CACNA1A 1 0.39 0.14 0
117 INT336753 Positive_regulation of Negative_regulation of Ighmbp2 1 0.03 0.14 0
118 INT259114 Binding of LMO4 1 0.37 4.39 0
119 INT143654 Positive_regulation of Transcription of Nkx2-2 1 0.56 0 0
120 INT337913 Binding of Ighmbp2 1 0.36 0.26 0
121 INT336757 Negative_regulation of Ighmbp2 1 0.03 0.27 0
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