GO:0021542

From wiki-pain
Jump to: navigation, search
Name dentate gyrus development
Categary Process
Go Slim No
Go Link GO:0021542
Unique Molecular Interactions 183
Total Molecular Interactions 241
Total Single Events 1480
Pain Genes Associated 14

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for dentate gyrus development. They are ordered first by their pain relevance and then by number of times they were reported for dentate gyrus development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT7022 Drd1a Positive_regulation of Npr1 6 0.05 0.26 4.32
2 INT113080 Drd1a Positive_regulation of Phosphorylation of Creb1 2 0.27 0.43 3.88
3 INT7023 Negative_regulation of Drd1a Positive_regulation of Npr1 2 0.05 0.1 1.81
4 INT70148 Drd1a Positive_regulation of Localization of Acot1 1 0.14 0 1.7
5 INT261463 Binding of Drd1a and Sftpd 1 0.12 0.13 1.35
6 INT136249 Drd1a Positive_regulation of Phosphorylation of Tff3 1 0.01 0.18 1.23
7 INT131195 Creb1 Positive_regulation of Positive_regulation of Drd1a 2 0.27 0.61 1.22
8 INT7024 Regulation of Drd1a Positive_regulation of Npr1 1 0.04 0.07 1.13
9 INT74185 Cck Negative_regulation of Drd1a 1 0.30 0.1 1.1
10 INT265070 Reln Positive_regulation of Gene_expression of Fos 1 0.02 0.51 1.01
11 INT7025 Positive_regulation of Drd1a Positive_regulation of Npr1 1 0.04 0.08 1.01
12 INT87854 Binding of Drd1a and Positive_regulation of Localization of Abat 1 0.08 0 0.96
13 INT74184 Cck Regulation of Localization of Drd1a 1 0.32 0.06 0.95
14 INT215650 Binding of Adora1 and Drd1a 2 0.39 0.54 0.92
15 INT136172 NPY Negative_regulation of Positive_regulation of Drd1a 1 0.21 0 0.91
16 INT7292 Binding of Drd1a and Penk 1 0.14 0 0.9
17 INT52760 Oprd1 Regulation of Drd1a 1 0.02 0 0.9
18 INT52762 Dll1 Regulation of Drd1a 1 0.10 0 0.89
19 INT29279 Binding of Drd1a and Htr1a 1 0.35 0.2 0.84
20 INT344101 Positive_regulation of Drd1a Positive_regulation of Localization of Abat 1 0.01 0 0.84
21 INT278690 LEF1 Negative_regulation of Gene_expression of IK 1 0.00 0.66 0.83
22 INT56499 Neurod1 Positive_regulation of Maoa 1 0.47 0 0.8
23 INT278697 LEF1 Negative_regulation of STAT6 1 0.00 0.44 0.78
24 INT353721 Negative_regulation of Binding of Drd1a and Ghsr 1 0.16 0 0.76
25 INT353720 Binding of Drd1a and Ghsr 1 0.18 0 0.76
26 INT21260 Positive_regulation of Drd1a Positive_regulation of Npr1 1 0.05 0 0.76
27 INT111194 Binding of NEUROD1 and Pck1 1 0.39 0 0.75
28 INT327707 Binding of Comt and Drd1a 1 0.18 0.27 0.74
29 INT99938 Drd1a Regulation of Transcription of Qrfp 1 0.03 0 0.69
30 INT81769 Binding of Chrna4 and Neurod1 1 0.35 0.07 0.69
31 INT71988 Drd1a Regulation of Npr1 1 0.10 0 0.68
32 INT99939 Drd1a Regulation of Qrfp 1 0.03 0 0.68
33 INT154263 NEUROD1 Positive_regulation of Gene_expression of GAL 1 0.50 0.06 0.63
34 INT317638 Ins1 Positive_regulation of Gene_expression of Drd1a 1 0.14 0.86 0.59
35 INT317634 Ins1 Positive_regulation of Drd1a 1 0.14 0.86 0.59
36 INT5111 DIO2 Positive_regulation of Drd1a 1 0.04 0 0.53
37 INT119745 NEUROD1 Regulation of Gene_expression of BHLHE22 1 0.11 0.26 0.53
38 INT95042 Binding of NEUROD1 and Olr1246 1 0.02 0.23 0.51
39 INT223925 Drd1a Positive_regulation of Gene_expression of Serpina1 1 0.01 0 0.51
40 INT184874 Drd1a Regulation of Gene_expression of Drd2 1 0.13 0.97 0.51
41 INT162499 Binding of AHR and NEUROD1 3 0.25 0.19 0.49
42 INT281982 Cyp3a23/3a1 Negative_regulation of Gene_expression of MDK 1 0.00 0.67 0.47
43 INT317635 Positive_regulation of Drd1a Positive_regulation of Phosphorylation of Gtf3a 1 0.01 0.53 0.43
44 INT171185 Binding of NEUROD1 and ACOT1 1 0.01 0.37 0.42
45 INT331675 Binding of Drd1a and Sptan1 1 0.03 0.33 0.4
46 INT32244 Slc3a1 Positive_regulation of Localization of Drd1a 1 0.15 0 0.39
47 INT32243 Drd1a Positive_regulation of Localization of Slc3a1 1 0.15 0 0.39
48 INT344103 Positive_regulation of Drd1a Positive_regulation of Obfc1 1 0.00 0 0.38
49 INT70010 Binding of Neurod1 and Insrr 1 0.01 0.11 0.37
50 INT37247 Binding of Drd1a and Drd2 1 0.20 0 0.37
51 INT327708 Binding of Drd1a and Drd2 1 0.12 0.12 0.37
52 INT281981 Binding of MDK and Gtf3a 1 0.00 0.76 0.31
53 INT36571 MDK Positive_regulation of Localization of PRL 1 0.04 0.19 0.29
54 INT97595 Penk Regulation of Gene_expression of Drd1a 1 0.25 0.1 0.28
55 INT298277 Pou4f1 Negative_regulation of Gene_expression of Neurod1 1 0.58 0.48 0.27
56 INT167488 Binding of NEUROD1 and GGNBP2 1 0.08 0 0.27
57 INT281980 Scn9a Positive_regulation of MDK 1 0.06 0.24 0.26
58 INT281963 SCN11A Positive_regulation of MDK 1 0.12 0.24 0.26
59 INT68298 Binding of Neurod1 and Abt1 1 0.24 0 0.26
60 INT162502 NEUROD1 Regulation of CYP1A1 2 0.07 0.09 0.25
61 INT162501 NEUROD1 Regulation of CYP1A2 2 0.22 0.09 0.25
62 INT73385 Cfp Regulation of Drd1a 1 0.10 0 0.25
63 INT73384 Positive_regulation of Cfp Regulation of Drd1a 1 0.18 0 0.25
64 INT261465 Binding of Drd1a and Ptgdr 1 0.03 0.1 0.23
65 INT149791 Binding of Lrp8 and Reln 4 0.36 0.38 0.22
66 INT203527 Pou4f1 Negative_regulation of Neurod1 1 0.32 0.54 0.2
67 INT18966 TNF Positive_regulation of NEUROD1 1 0.53 0.83 0.2
68 INT244054 Prkaca Regulation of Neurod1 1 0.02 0.06 0.19
69 INT241070 Klf16 Positive_regulation of Drd1a 1 0.05 0.13 0.12
70 INT10731 NEUROD1 Regulation of CD4 1 0.42 1.3 0.12
71 INT10732 NEUROD1 Regulation of CD9 1 0.49 1.29 0.12
72 INT297543 Neurod1 Regulation of Psen1 1 0.00 0.2 0.12
73 INT149792 Binding of Reln and Vldlr 3 0.51 0.35 0.11
74 INT328067 IL4 Positive_regulation of BTG2 1 0.03 0.8 0.11
75 INT262653 Binding of AICDA and Lmx1a 1 0.00 3.18 0.1
76 INT139558 Chrna4 Regulation of Neurod1 1 0.17 0 0.1
77 INT297546 Neurod1 Regulation of Notch1 1 0.05 0.2 0.1
78 INT297548 Neurod1 Regulation of Hes1 1 0.05 0.2 0.1
79 INT171188 Positive_regulation of Binding of NEUROD1 and TNIP1 1 0.08 0 0.1
80 INT139557 Chrna4 Regulation of Gene_expression of Neurod1 1 0.17 0 0.1
81 INT262654 Binding of HLA-DQA1 and Lmx1a 1 0.01 3.15 0.1
82 INT171184 Binding of NEUROD1 and TNIP1 1 0.06 0 0.1
83 INT185278 Binding of CCND1 and CDK6 3 0.13 1.62 0.08
84 INT341004 Reln Positive_regulation of Fabp7 1 0.03 0.12 0.08
85 INT261454 Akr1d1 Regulation of Drd1a 1 0.00 0.71 0.06
86 INT262652 Negative_regulation of Binding of HLA-DQA1 and Lmx1a 1 0.01 1.59 0.05
87 INT341019 Binding of VLDLR and Reln 1 0.01 0.1 0.05
88 INT341011 Reln Positive_regulation of Cp 1 0.00 0.15 0.04
89 INT198917 Lrp8 Negative_regulation of Binding of Reln 1 0.15 0 0.04
90 INT341002 Reln Positive_regulation of Gene_expression of Fabp7 1 0.04 0.32 0.04
91 INT244018 Binding of Neurod1 and Trak2 1 0.01 0 0.04
92 INT341016 Reln Positive_regulation of Positive_regulation of PIK3CB 1 0.01 0.15 0.04
93 INT149793 Binding of LRP8 and Reln 1 0.03 0.17 0.04
94 INT249898 Binding of Neurod1 and Olig2 1 0.09 0.14 0.03
95 INT289101 Binding of KCNA1 and LEF1 1 0.00 2.58 0.03
96 INT249902 Binding of Neurod6 and Olig2 1 0.09 0.14 0.03
97 INT341003 Reln Positive_regulation of Positive_regulation of Lrp8 1 0.03 0.11 0
98 INT233280 Binding of PBX1 and Emx2 1 0.19 0.68 0
99 INT233273 Binding of Emx2 and Tbca 1 0.01 0.34 0
100 INT314863 Binding of Neurod1 and Atoh7 1 0.18 0.27 0
101 INT337402 LEF1 Positive_regulation of E2F1 1 0.11 0 0
102 INT330958 Binding of VDR and BTG2 1 0.07 0.51 0
103 INT341006 Reln Regulation of Gene_expression of Fabp7 1 0.03 0 0
104 INT89016 Oprd1 Negative_regulation of Drd1a 1 0.06 0 0
105 INT185281 Binding of CDK6 and CDKN2A 1 0.29 0.87 0
106 INT183648 Binding of Lef1 and Ctnnd2 1 0.07 1.05 0
107 INT337415 Negative_regulation of MIR203 Positive_regulation of Positive_regulation of LEF1 1 0.03 0.25 0
108 INT197309 Ascl1 Regulation of Neurod1 1 0.01 0.13 0
109 INT197313 Atoh1 Regulation of Neurod1 1 0.01 0.13 0
110 INT337405 MIR203 Regulation of LEF1 1 0.02 0.31 0
111 INT302364 Binding of Arx and Reln 1 0.32 1.25 0
112 INT337411 Negative_regulation of MIR203 Positive_regulation of Gene_expression of LEF1 1 0.04 0.25 0
113 INT314851 Positive_regulation of Binding of Neurod1 and Atoh7 1 0.23 0.27 0
114 INT185280 Binding of CDK4 and CDK6 1 0.20 0.87 0
115 INT289102 KCNA1 Negative_regulation of Gene_expression of LEF1 1 0.00 0.44 0
116 INT289098 KCNA1 Regulation of LEF1 1 0.00 0.67 0
117 INT233271 Binding of Emx2 and Hoxa10 1 0.13 0.36 0
118 INT337417 MIR203 Negative_regulation of LEF1 1 0.04 0.57 0
119 INT220822 Binding of Myc and LEF1 1 0.26 0.08 0
120 INT341001 Binding of Reln and Vim 1 0.02 0.14 0
121 INT220766 Binding of MAX and LEF1 1 0.40 0.08 0
122 INT197306 Atoh1 Regulation of Neurod6 1 0.00 0.13 0
123 INT341024 VLDLR Positive_regulation of Reln 1 0.02 0 0
124 INT197307 Ascl1 Regulation of Neurod6 1 0.00 0.13 0
125 INT314864 Binding of Neurod1 and Positive_regulation of Gene_expression of Atoh7 1 0.25 0.27 0
126 INT289100 KCNA1 Regulation of Gene_expression of LEF1 1 0.00 0.68 0
127 INT283716 Neurod1 Positive_regulation of Pax6 1 0.23 0.46 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for dentate gyrus development. They are ordered first by their pain relevance and then by number of times they were reported in dentate gyrus development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5858 Positive_regulation of Drd1a 66 0.69 4.51 51.73
2 INT13334 Gene_expression of Drd1a 43 0.62 7.73 24.43
3 INT13838 Positive_regulation of Drd1a 48 0.70 9.83 23.42
4 INT7680 Regulation of Drd1a 27 0.45 4.52 18.86
5 INT51779 Gene_expression of Drd1a 46 0.66 11.18 17.51
6 INT7020 Negative_regulation of Drd1a 25 0.57 1.84 17.1
7 INT5859 Positive_regulation of Positive_regulation of Drd1a 20 0.55 2.05 15.61
8 INT13409 Gene_expression of NEUROD1 52 0.75 14.17 12.23
9 INT7682 Binding of Drd1a 22 0.48 1.8 11.83
10 INT6019 Positive_regulation of NEUROD1 37 0.67 17.3 8.89
11 INT16735 Localization of Drd1a 11 0.61 0.35 8.42
12 INT64370 Gene_expression of Neurod1 22 0.75 5.19 7.1
13 INT22369 Negative_regulation of Drd1a 15 0.47 6.13 6.87
14 INT245173 Gene_expression of MDK 81 0.49 51.08 6.78
15 INT6097 Negative_regulation of NEUROD1 30 0.57 9.71 6.24
16 INT21552 Regulation of Drd1a 10 0.57 3.7 6.05
17 INT6098 Binding of NEUROD1 17 0.47 3.4 5.99
18 INT18366 Negative_regulation of Positive_regulation of Drd1a 6 0.42 0.49 5.54
19 INT101925 Binding of Drd1a 9 0.43 1.82 4.97
20 INT48567 Transcription of Drd1a 7 0.51 2.44 4.54
21 INT113078 Phosphorylation of Drd1a 4 0.30 0.77 4.45
22 INT28734 Gene_expression of Reln 7 0.74 5.76 4.33
23 INT13333 Regulation of Gene_expression of Drd1a 8 0.36 3.37 4.28
24 INT20011 Regulation of NEUROD1 10 0.44 3.83 3.53
25 INT62901 Positive_regulation of Gene_expression of Drd1a 2 0.57 0.66 3.35
26 INT13335 Negative_regulation of Gene_expression of Drd1a 6 0.34 0.8 3.16
27 INT18365 Positive_regulation of Regulation of Drd1a 4 0.50 1.74 3.04
28 INT39856 Binding of Neurod1 8 0.47 1.44 2.88
29 INT113077 Positive_regulation of Phosphorylation of Drd1a 1 0.11 0.15 2.87
30 INT281978 Regulation of MDK 1 0.30 5.9 2.66
31 INT64248 Positive_regulation of Positive_regulation of Drd1a 6 0.45 1.97 2.62
32 INT89992 Positive_regulation of Gene_expression of Drd1a 5 0.39 2.11 2.54
33 INT86462 Transcription of Drd1a 3 0.44 1.86 2.36
34 INT24407 Negative_regulation of Binding of Drd1a 3 0.25 0.81 2.18
35 INT82048 Positive_regulation of Neurod1 7 0.49 2.39 2.13
36 INT21046 Regulation of Positive_regulation of Drd1a 3 0.44 0.09 2.06
37 INT13837 Negative_regulation of Positive_regulation of Drd1a 2 0.43 1.43 2.01
38 INT100046 Gene_expression of BTG2 16 0.20 10.81 1.95
39 INT13999 Positive_regulation of Positive_regulation of NEUROD1 5 0.67 4.07 1.86
40 INT265064 Binding of Reln 1 0.02 2.7 1.83
41 INT265066 Positive_regulation of Reln 1 0.02 1.59 1.72
42 INT28735 Localization of Reln 2 0.12 1.49 1.7
43 INT245172 Positive_regulation of Gene_expression of MDK 19 0.43 12.97 1.65
44 INT65602 Negative_regulation of Neurod1 7 0.42 2.52 1.55
45 INT278715 Gene_expression of LEF1 10 0.33 5.43 1.54
46 INT278727 Negative_regulation of Gene_expression of LEF1 3 0.11 1.59 1.47
47 INT140305 Negative_regulation of Binding of Drd1a 2 0.21 0.54 1.46
48 INT64371 Positive_regulation of Gene_expression of Neurod1 4 0.64 1.56 1.45
49 INT113079 Regulation of Phosphorylation of Drd1a 1 0.06 0.07 1.43
50 INT159312 Regulation of Reln 4 0.43 1.79 1.4
51 INT27356 Localization of NEUROD1 8 0.78 3.44 1.39
52 INT152951 Negative_regulation of LEF1 5 0.41 3.22 1.31
53 INT18971 Positive_regulation of Gene_expression of NEUROD1 8 0.67 1.91 1.23
54 INT100044 Regulation of BTG2 3 0.23 1.78 1.2
55 INT245174 Positive_regulation of MDK 4 0.30 5.05 1.17
56 INT123643 Gene_expression of Reln 19 0.75 1.85 1.13
57 INT97369 Regulation of Gene_expression of NEUROD1 1 0.26 0.25 1.12
58 INT281973 Regulation of Gene_expression of MDK 1 0.30 2.52 1.11
59 INT94210 Regulation of Neurod1 2 0.33 0.07 1.04
60 INT184839 Localization of Drd1a 4 0.73 0.84 1.03
61 INT250699 Binding of CDK6 3 0.33 2.54 0.97
62 INT140720 Negative_regulation of Reln 5 0.57 2.43 0.95
63 INT64690 Negative_regulation of Localization of Drd1a 2 0.09 0 0.95
64 INT74183 Positive_regulation of Localization of Drd1a 1 0.32 0.06 0.95
65 INT51906 Negative_regulation of Gene_expression of NEUROD1 4 0.57 1.56 0.91
66 INT281977 Negative_regulation of Gene_expression of MDK 1 0.29 3.05 0.91
67 INT99668 Positive_regulation of Binding of Drd1a 2 0.43 0.89 0.87
68 INT278710 Phosphorylation of LEF1 1 0.05 0.76 0.82
69 INT245171 Transcription of MDK 4 0.35 2.61 0.78
70 INT52187 Regulation of Binding of NEUROD1 1 0.44 0 0.77
71 INT153157 Regulation of Regulation of Drd1a 2 0.25 0.2 0.66
72 INT184848 Positive_regulation of Transcription of Drd1a 1 0.26 0.93 0.65
73 INT140306 Regulation of Binding of Drd1a 1 0.20 0.36 0.64
74 INT72516 Regulation of Binding of Drd1a 2 0.44 0.4 0.63
75 INT149788 Binding of Reln 4 0.37 1.41 0.6
76 INT182677 Gene_expression of Emx2 11 0.78 2.14 0.59
77 INT281979 Negative_regulation of MDK 1 0.21 1.4 0.5
78 INT76845 Regulation of Gene_expression of Neurod1 2 0.44 0.28 0.44
79 INT154042 Localization of Neurod1 1 0.02 0.08 0.44
80 INT60952 Negative_regulation of Regulation of NEUROD1 1 0.42 0.3 0.41
81 INT60953 Negative_regulation of Negative_regulation of NEUROD1 1 0.41 0.3 0.41
82 INT48566 Regulation of Transcription of Drd1a 1 0.32 0 0.37
83 INT156490 Protein_catabolism of Neurod1 1 0.34 0.16 0.37
84 INT51266 Transcription of Neurod1 2 0.69 0.19 0.35
85 INT47995 Positive_regulation of Regulation of NEUROD1 1 0.45 0.68 0.34
86 INT111230 Transcription of LEF1 3 0.30 1.72 0.33
87 INT24861 Regulation of Positive_regulation of NEUROD1 2 0.44 0.39 0.33
88 INT275045 Binding of MDK 2 0.15 1.32 0.31
89 INT149790 Localization of Reln 2 0.79 1.38 0.29
90 INT104311 Positive_regulation of Transcription of NEUROD1 1 0.49 0.28 0.29
91 INT104309 Transcription of NEUROD1 1 0.69 0.28 0.29
92 INT136052 Negative_regulation of Negative_regulation of Drd1a 1 0.13 0.66 0.27
93 INT281976 Regulation of Transcription of MDK 1 0.13 0.29 0.26
94 INT27461 Gene_expression of Lmx1a 2 0.52 0.18 0.23
95 INT302239 Positive_regulation of Gene_expression of BTG2 2 0.12 1.18 0.23
96 INT281971 Negative_regulation of Negative_regulation of MDK 1 0.18 0.27 0.23
97 INT159314 Positive_regulation of Gene_expression of Reln 1 0.44 0.47 0.2
98 INT82049 Negative_regulation of Positive_regulation of Neurod1 1 0.41 0.61 0.18
99 INT207718 Positive_regulation of BTG2 2 0.33 1.77 0.17
100 INT262634 Binding of Lmx1a 1 0.02 0.74 0.17
101 INT48771 Positive_regulation of Localization of NEUROD1 2 0.49 1.5 0.16
102 INT340963 Positive_regulation of Positive_regulation of Reln 1 0.08 0.75 0.13
103 INT155189 Regulation of Reln 2 0.44 0.94 0.12
104 INT197449 Negative_regulation of Emx2 1 0.51 0.2 0.12
105 INT340975 Positive_regulation of Reln 1 0.08 0.78 0.12
106 INT351552 Localization of MDK 1 0.47 0 0.11
107 INT265068 Transcription of Reln 1 0.03 0.07 0.09
108 INT36311 Protein_catabolism of NEUROD1 1 0.86 0.51 0.09
109 INT197443 Positive_regulation of Gene_expression of Emx2 1 0.47 0.1 0.08
110 INT123644 Negative_regulation of Gene_expression of Reln 2 0.41 0.95 0.07
111 INT117620 Regulation of Localization of NEUROD1 1 0.60 0.24 0.07
112 INT123646 Transcription of Reln 1 0.52 0.66 0.07
113 INT220802 Binding of LEF1 7 0.36 3.86 0.04
114 INT289116 Positive_regulation of Localization of LEF1 2 0.22 1.19 0.04
115 INT289110 Localization of LEF1 2 0.32 1.19 0.04
116 INT340952 Positive_regulation of Localization of Reln 1 0.09 0.24 0.04
117 INT248201 Phosphorylation of Neurod1 1 0.28 0.07 0.04
118 INT310486 Transcription of Emx2 1 0.32 0 0.03
119 INT325167 Gene_expression of CDK6 2 0.43 0 0
120 INT289127 Positive_regulation of LEF1 2 0.22 0.76 0
121 INT330970 Phosphorylation of BTG2 1 0.16 1.28 0
122 INT203486 Positive_regulation of Neurod6 1 0.48 0.18 0
123 INT337456 Positive_regulation of Binding of LEF1 1 0.22 0 0
124 INT234916 Gene_expression of Lef1 1 0.04 0.25 0
125 INT233225 Regulation of Gene_expression of Emx2 1 0.23 0.09 0
126 INT289129 Positive_regulation of Gene_expression of LEF1 1 0.13 0.76 0
127 INT337461 Positive_regulation of Transcription of LEF1 1 0.22 0.26 0
128 INT302260 Negative_regulation of CDK6 1 0.19 0.29 0
129 INT289108 Negative_regulation of Transcription of LEF1 1 0.11 0.32 0
130 INT325171 Regulation of Gene_expression of CDK6 1 0.25 0 0
131 INT220775 Binding of Lef1 1 0.20 0.06 0
132 INT289124 Negative_regulation of Positive_regulation of LEF1 1 0.11 0.34 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox