GO:0021559

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Name trigeminal nerve development
Categary Process
Go Slim No
Go Link GO:0021559
Unique Molecular Interactions 73
Total Molecular Interactions 87
Total Single Events 372
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for trigeminal nerve development. They are ordered first by their pain relevance and then by number of times they were reported for trigeminal nerve development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT298283 Pou4f1 Positive_regulation of Gene_expression of Runx1 1 0.50 1.4 1.48
2 INT298260 Binding of Runx3 and Pou4f1 1 0.52 2.08 1.22
3 INT298279 Pou4f1 Positive_regulation of Gene_expression of Runx3 1 0.50 1.31 0.81
4 INT207540 Tfap2a Regulation of Oprm1 1 0.13 0.06 0.7
5 INT135207 Gmeb1 Regulation of Gene_expression of Tfap2a 1 0.07 0.48 0.69
6 INT135206 Ighen Regulation of Gene_expression of Tfap2a 1 0.06 0.48 0.69
7 INT135202 Tfap2a Regulation of Gene_expression of Ighen 1 0.06 0.48 0.69
8 INT135213 Tfap2a Regulation of Gene_expression of Nfkb1 1 0.02 0.48 0.69
9 INT135211 Nfkb1 Regulation of Gene_expression of Tfap2a 1 0.02 0.48 0.69
10 INT135204 Tfap2a Regulation of Gene_expression of Gmeb1 1 0.10 0.48 0.69
11 INT207543 Tfap2a Regulation of Qsox1 1 0.04 0.06 0.67
12 INT298262 Pou4f1 Positive_regulation of Positive_regulation of Ntrk3 1 0.36 0.79 0.63
13 INT244028 Positive_regulation of Binding of Cacnb3 and Tfap2a 1 0.01 0.24 0.49
14 INT244037 Positive_regulation of Binding of Prkaca and Tfap2a 1 0.01 0.24 0.49
15 INT244000 Positive_regulation of Binding of Tfap2a and Dnm1 1 0.04 0.24 0.49
16 INT244035 Binding of Prkaca and Tfap2a 1 0.01 0.24 0.49
17 INT243997 Binding of Tfap2a and Dnm1 1 0.03 0.24 0.49
18 INT244060 Binding of Cacnb3 and Tfap2a 1 0.00 0.24 0.49
19 INT173475 Bcar1 Regulation of Isl1 1 0.01 0 0.47
20 INT335850 Snrpc Negative_regulation of Gene_expression of Isl1 1 0.00 1.51 0.45
21 INT298263 Pou4f1 Regulation of Gene_expression of Ntrk1 1 0.34 0.61 0.43
22 INT298259 Pou4f1 Negative_regulation of Gene_expression of Runx3 1 0.46 0.58 0.4
23 INT298261 Pou4f1 Negative_regulation of Gene_expression of Runx1 1 0.45 0.58 0.4
24 INT298281 Pou4f1 Regulation of Gene_expression of Runx3 1 0.66 0.61 0.37
25 INT301054 Tfap2a Regulation of Gene_expression of Faslg 1 0.00 1.23 0.34
26 INT298285 Pou4f1 Positive_regulation of Runx3 1 0.50 0.56 0.32
27 INT298269 Positive_regulation of Pou4f1 Positive_regulation of Runx3 1 0.50 0.56 0.32
28 INT156151 POU4F1 Positive_regulation of Gene_expression of NTRK1 1 0.46 0.37 0.31
29 INT156163 POU4F1 Positive_regulation of NTRK1 1 0.46 0.37 0.31
30 INT203529 Pou4f1 Regulation of target gene 1 0.01 0.53 0.3
31 INT298264 Binding of Pou4f1 and Hist1h3f 1 0.12 0.49 0.3
32 INT203526 Regulation of Pou4f1 Regulation of target gene 1 0.01 0.54 0.3
33 INT298282 Pou4f1 Regulation of Gene_expression of Runx1 1 0.48 0.36 0.29
34 INT156152 POU4F1 Positive_regulation of Positive_regulation of NTRK1 1 0.31 0.38 0.29
35 INT156149 Binding of HCFC1 and POU4F1 1 0.27 0.39 0.28
36 INT156154 POU4F1 Positive_regulation of HCFC1 1 0.36 0.38 0.28
37 INT298277 Pou4f1 Negative_regulation of Gene_expression of Neurod1 1 0.58 0.48 0.27
38 INT298280 Pou4f1 Negative_regulation of Gene_expression of Neurod4 1 0.38 0.48 0.27
39 INT156150 POU4F1 Regulation of Gene_expression of NTRK1 1 0.18 0.39 0.27
40 INT298297 Pou4f1 Positive_regulation of Gene_expression of Ntrk2 1 0.50 0.36 0.24
41 INT298290 Pou4f1 Regulation of Gene_expression of Ntrk2 1 0.29 0.48 0.23
42 INT203527 Pou4f1 Negative_regulation of Neurod1 1 0.32 0.54 0.2
43 INT203531 Pou4f1 Negative_regulation of Neurod4 1 0.46 0.54 0.2
44 INT203532 Negative_regulation of Pou4f1 Negative_regulation of Gene_expression of Pou4f2 1 0.34 0.44 0.19
45 INT298273 Binding of Pou4f1 and target gene site 1 0.01 0.53 0.18
46 INT203528 Binding of Pou4f1 and H3 1 0.17 0.42 0.18
47 INT191758 ROS1 Positive_regulation of TFAP2A 1 0.01 0.54 0.08
48 INT243255 Binding of Cfp and Pou4f1 1 0.23 0.6 0.07
49 INT125208 Pou4f1 Negative_regulation of Gene_expression of Th 1 0.28 0.67 0.07
50 INT125209 Pou4f1 Positive_regulation of Gene_expression of Th 1 0.33 0.67 0.07
51 INT298257 Pou4f1 Negative_regulation of Proc 1 0.01 0.54 0.03
52 INT244856 Lbx1 Regulation of Isl1 1 0.60 0 0
53 INT245820 Binding of Sp1 and Tfap2a 1 0.03 0.64 0
54 INT172838 Binding of ISL1 and T2dm2 1 0.00 2.41 0
55 INT298268 Regulation of Pou4f1 Regulation of Gene_expression of Avp 1 0.00 0.09 0
56 INT323254 Binding of Ptprv and Isl1 1 0.00 0.6 0
57 INT244860 Lbx1 Negative_regulation of Isl1 1 0.16 0 0
58 INT296999 Binding of EPS15 and TFAP2A 1 0.06 0.2 0
59 INT244851 Lbx1 Negative_regulation of Pou4f1 1 0.38 0 0
60 INT323253 Binding of Ins1 and Isl1 1 0.00 0.59 0
61 INT245828 Binding of VEGFA and Tfap2a 1 0.01 0.64 0
62 INT323251 Binding of Isl1 and Uchl1 1 0.00 0.6 0
63 INT323252 Binding of H2-Ab1 and Isl1 1 0.00 0.6 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for trigeminal nerve development. They are ordered first by their pain relevance and then by number of times they were reported in trigeminal nerve development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT203473 Gene_expression of Pou4f1 69 0.76 25.94 11.36
2 INT105215 Negative_regulation of Pou4f1 16 0.53 9.42 5.97
3 INT203506 Positive_regulation of Pou4f1 3 0.49 6.17 4.85
4 INT203443 Gene_expression of Isl1 27 0.67 11.12 4.65
5 INT105217 Regulation of Pou4f1 8 0.60 6.15 3.88
6 INT207521 Gene_expression of Tfap2a 7 0.48 1.89 1.45
7 INT200838 Positive_regulation of Isl1 6 0.60 0.73 1.19
8 INT203436 Negative_regulation of Gene_expression of Pou4f1 4 0.57 2.88 1.14
9 INT172809 Gene_expression of ISL1 33 0.40 21.63 1.12
10 INT298235 Binding of Pou4f1 1 0.47 2.95 1.11
11 INT203498 Localization of Pou4f1 5 0.73 3.29 1.07
12 INT84511 Positive_regulation of Tfap2a 3 0.27 0.72 1.04
13 INT243240 Transcription of Pou4f1 2 0.68 1.91 0.94
14 INT243974 Binding of Tfap2a 7 0.18 1.36 0.93
15 INT203489 Positive_regulation of Gene_expression of Pou4f1 3 0.49 2.33 0.84
16 INT221796 Positive_regulation of Gene_expression of Tfap2a 2 0.10 1.19 0.83
17 INT173472 Positive_regulation of Isl1 1 0.03 0.2 0.83
18 INT207535 Transcription of Tfap2a 3 0.31 0.98 0.74
19 INT135197 Gene_expression of Tfap2a 1 0.45 0.48 0.69
20 INT243779 Negative_regulation of Gene_expression of Isl1 2 0.30 2.62 0.68
21 INT226838 Transcription of Isl1 2 0.28 0.36 0.6
22 INT207529 Localization of Tfap2a 2 0.34 0.13 0.6
23 INT80300 Gene_expression of TFAP2A 5 0.54 2.76 0.59
24 INT243970 Phosphorylation of Tfap2a 2 0.25 0.56 0.56
25 INT125207 Positive_regulation of Negative_regulation of Pou4f1 1 0.21 0.69 0.5
26 INT203518 Regulation of Localization of Pou4f1 1 0.44 1.15 0.42
27 INT80302 Binding of TFAP2A 7 0.39 1.67 0.38
28 INT17937 Gene_expression of Isl1 4 0.27 0.48 0.36
29 INT131415 Gene_expression of POU4F1 1 0.60 1.87 0.36
30 INT106402 Positive_regulation of TFAP2A 2 0.13 0.35 0.35
31 INT173635 Negative_regulation of TFAP2A 3 0.34 2.93 0.33
32 INT172806 Localization of ISL1 4 0.26 2.64 0.29
33 INT292207 Negative_regulation of Gene_expression of TFAP2A 1 0.05 1.2 0.27
34 INT78132 Binding of Isl1 1 0.16 0 0.27
35 INT25465 Positive_regulation of ISL1 6 0.15 3.59 0.26
36 INT173797 Negative_regulation of Isl1 3 0.37 0.15 0.26
37 INT173792 Negative_regulation of Negative_regulation of Isl1 1 0.08 0.15 0.26
38 INT205087 Positive_regulation of Gene_expression of ISL1 4 0.26 3.86 0.19
39 INT243778 Binding of Isl1 1 0.26 0 0.19
40 INT162939 Binding of Tfap2a 1 0.26 0.34 0.17
41 INT162940 Negative_regulation of Tfap2a 1 0.32 0.34 0.17
42 INT162941 Negative_regulation of Binding of Tfap2a 1 0.32 0.34 0.17
43 INT98772 Localization of Isl1 2 0.65 0 0.16
44 INT201210 Negative_regulation of ISL1 2 0.02 0.4 0.16
45 INT203450 Negative_regulation of Localization of Pou4f1 1 0.42 0.4 0.14
46 INT131412 Regulation of POU4F1 1 0.21 0.69 0.14
47 INT131409 Positive_regulation of Gene_expression of POU4F1 1 0.54 0.63 0.13
48 INT98774 Regulation of Localization of Isl1 1 0.08 0 0.13
49 INT203492 Negative_regulation of Positive_regulation of Pou4f1 1 0.36 0.68 0.11
50 INT207829 Positive_regulation of Localization of ISL1 1 0.02 0.1 0.1
51 INT173473 Positive_regulation of Positive_regulation of Isl1 1 0.02 0.06 0.09
52 INT173470 Positive_regulation of Phosphorylation of Isl1 1 0.02 0 0.09
53 INT173471 Phosphorylation of Isl1 1 0.04 0 0.09
54 INT298237 Regulation of Isl1 1 0.03 0.24 0.06
55 INT97754 Regulation of Gene_expression of TFAP2A 1 0.36 0.13 0.06
56 INT289490 Negative_regulation of Negative_regulation of Pou4f1 1 0.32 0.09 0.06
57 INT352541 Transcription of ISL1 1 0.36 0.2 0.03
58 INT180121 Phosphorylation of Isl1 1 0.27 0 0
59 INT180097 Positive_regulation of Phosphorylation of Isl1 1 0.17 0 0
60 INT173648 Regulation of Binding of TFAP2A 1 0.03 0.32 0
61 INT227625 Regulation of ISL1 1 0.05 0.35 0
62 INT173631 Negative_regulation of Positive_regulation of TFAP2A 1 0.05 0.27 0
63 INT243237 Regulation of Gene_expression of Pou4f1 1 0.25 0.27 0
64 INT173627 Negative_regulation of Binding of TFAP2A 1 0.08 0.28 0
65 INT173642 Transcription of TFAP2A 1 0.09 0.27 0
66 INT243780 Positive_regulation of Gene_expression of Isl1 1 0.35 0 0
67 INT183071 Negative_regulation of Gene_expression of ISL1 1 0.20 0.34 0
68 INT173645 Regulation of TFAP2A 1 0.02 0.33 0
69 INT298239 Positive_regulation of Binding of Pou4f1 1 0.46 0.09 0
70 INT173630 Positive_regulation of Transcription of TFAP2A 1 0.06 0.54 0
71 INT311630 Negative_regulation of Tfap2a 1 0.34 0.23 0
72 INT319128 Positive_regulation of Binding of Tfap2a 1 0.23 0.5 0
73 INT311626 Negative_regulation of Gene_expression of Tfap2a 1 0.34 0.29 0
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