GO:0021631

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Name optic nerve morphogenesis
Categary Process
Go Slim No
Go Link GO:0021631
Unique Molecular Interactions 281
Total Molecular Interactions 333
Total Single Events 4078
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for optic nerve morphogenesis. They are ordered first by their pain relevance and then by number of times they were reported for optic nerve morphogenesis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT92738 Binding of Ephb1 and Tcas1 1 0.00 0.43 2.67
2 INT121742 Prkcg Positive_regulation of Ephb1 3 0.49 0.99 2.6
3 INT128044 Bdnf Positive_regulation of Ephb1 2 0.31 1.89 2.57
4 INT121746 Prkaca Positive_regulation of Ephb1 2 0.23 0.92 2.35
5 INT156623 Umod Regulation of Phosphorylation of Ephb1 1 0.05 0.33 2.27
6 INT344386 Efnb1 Positive_regulation of Phosphorylation of Ephb2 1 0.15 2.85 2.13
7 INT153533 NMS Regulation of Gene_expression of Ephb1 1 0.48 3.96 1.93
8 INT95405 Trib3 Positive_regulation of Phosphorylation of Ephb1 3 0.08 1.33 1.89
9 INT112517 Binding of Ephb1 and Prkaca 3 0.18 0.58 1.85
10 INT162992 Binding of Ephb1 and Ppm1e 1 0.03 0.25 1.77
11 INT249483 Binding of Ephb1 and Efnb2 1 0.02 2.35 1.66
12 INT131575 Grin1 Negative_regulation of Positive_regulation of Ephb1 1 0.28 0.31 1.58
13 INT131574 Negative_regulation of Ephb1 Negative_regulation of Gene_expression of Creb1 1 0.41 0.33 1.58
14 INT158778 Ptges3l1 Regulation of Ephb1 1 0.06 0.09 1.53
15 INT158775 Regulation of Tnf Regulation of Ephb1 1 0.18 0.09 1.52
16 INT158777 Tnf Regulation of Ephb1 1 0.18 0.09 1.51
17 INT158776 Il1b Regulation of Ephb1 1 0.15 0.09 1.46
18 INT256299 Binding of Efnb1 and Ephb1 1 0.02 1.22 1.42
19 INT249494 Binding of Ephb1 and Efnb1 1 0.01 1.34 1.4
20 INT261483 Binding of Ephb1 and Trpv1 1 0.39 1.37 1.37
21 INT95406 Trib3 Positive_regulation of Ephb1 2 0.08 0.96 1.29
22 INT249487 Binding of Ephb1 and Src 1 0.17 0.74 1.23
23 INT121729 Negative_regulation of Ngf Positive_regulation of Ephb1 1 0.24 0.69 1.22
24 INT256298 Binding of Creb1 and Ephb1 1 0.16 1.27 1.22
25 INT121724 Ngf Positive_regulation of Ephb1 1 0.40 0.68 1.21
26 INT334351 Bdnf Regulation of Positive_regulation of Ephb1 1 0.18 1.27 1.2
27 INT249481 Positive_regulation of Binding of Ephb1 and Efnb2 1 0.03 1.36 1.12
28 INT249488 Positive_regulation of Binding of Ephb1 and Src 1 0.23 0.68 1.12
29 INT269190 Positive_regulation of Ephb1 Positive_regulation of Ceacam3 1 0.03 0.66 1.12
30 INT256294 Binding of Grin2b and Ephb1 1 0.28 1.11 1.08
31 INT156462 Creb1 Regulation of Ephb1 1 0.29 0 1.07
32 INT269192 Ephb1 Regulation of Phosphorylation of Grin2a 1 0.02 0.63 1.06
33 INT121727 Pik3cb Positive_regulation of Ephb1 1 0.49 0.6 1.06
34 INT121743 Negative_regulation of Src Negative_regulation of Ephb1 1 0.27 0 1.02
35 INT240455 Ephb1 Positive_regulation of Positive_regulation of Prkaca 1 0.22 0.63 1.01
36 INT344389 Ephb2 Positive_regulation of Phosphorylation of Grin2b 1 0.16 1.46 0.98
37 INT121744 Src Positive_regulation of Positive_regulation of Ephb1 1 0.35 0 0.96
38 INT137921 VEGFA Positive_regulation of Ephb2 1 0.03 0 0.93
39 INT341371 CRX Positive_regulation of Gene_expression of Ephb1 1 0.02 0.99 0.9
40 INT121745 Tacr1 Negative_regulation of Positive_regulation of Ephb1 1 0.04 0 0.87
41 INT134993 P2rx6 Regulation of Ephb1 1 0.20 1.27 0.87
42 INT196578 Ephb1 Positive_regulation of Phosphorylation of Mapk9 1 0.13 0.5 0.85
43 INT140985 Gli3 Regulation of Ihh 1 0.29 0.85 0.85
44 INT261480 Negative_regulation of Trib3 Positive_regulation of Ephb1 1 0.04 0.8 0.84
45 INT261479 Fig4 Positive_regulation of Ephb1 1 0.07 0.79 0.83
46 INT334358 Rvm Positive_regulation of Ephb1 1 0.17 0.98 0.82
47 INT334359 Negative_regulation of Rvm Positive_regulation of Ephb1 1 0.16 0.99 0.82
48 INT128042 Bdnf Positive_regulation of Phosphorylation of Ephb1 1 0.22 0.2 0.8
49 INT240456 Ephb1 Regulation of Prkcg 1 0.19 0.51 0.79
50 INT117971 Cd8a Negative_regulation of Positive_regulation of Ephb1 1 0.02 0.98 0.79
51 INT240454 Ephb1 Regulation of Prkaca 1 0.14 0.51 0.79
52 INT162995 Positive_regulation of Binding of Ephb1 and Ppm1e 1 0.04 0.06 0.74
53 INT314203 Nos2 Positive_regulation of Gli3 1 0.19 1.27 0.73
54 INT328625 NPL Regulation of Phosphorylation of Ephb1 1 0.04 0.42 0.7
55 INT154989 Phax Positive_regulation of Positive_regulation of Ephb1 1 0.22 0.92 0.69
56 INT68561 Binding of Gli3 and Ust 1 0.01 0.68 0.68
57 INT112515 Binding of Ephb1 and Trib3 1 0.06 0.41 0.65
58 INT128817 Ephb1 Negative_regulation of Gene_expression of Nos2 1 0.16 0.37 0.61
59 INT128814 Ephb1 Negative_regulation of Gene_expression of Il1b 1 0.02 0.37 0.61
60 INT261482 Pik3cb Positive_regulation of Phosphorylation of Ephb1 1 0.23 0.67 0.58
61 INT261485 Positive_regulation of Prkaca Positive_regulation of Phosphorylation of Ephb1 1 0.05 0.12 0.56
62 INT261478 Positive_regulation of Ephb1 Regulation of Gene_expression of Egr1 1 0.10 0.23 0.55
63 INT312746 Ephb1 Positive_regulation of Localization of Ltp 1 0.05 0.07 0.55
64 INT256296 Efnb1 Positive_regulation of Ephb1 1 0.03 0.66 0.54
65 INT132372 Lgals1 Positive_regulation of Ephb1 1 0.37 0.25 0.54
66 INT249499 Ephb1 Positive_regulation of Efnb2 1 0.04 0.95 0.54
67 INT249479 Binding of Ephb1 and Grin2b 1 0.29 0.37 0.54
68 INT193554 Ntrk2 Positive_regulation of Positive_regulation of Ephb1 1 0.01 0.73 0.52
69 INT274938 Ltp Positive_regulation of Localization of Ephb2 1 0.25 0 0.52
70 INT104960 Ephb1 Regulation of Positive_regulation of Mapk14 1 0.15 0.42 0.5
71 INT104961 Mapk14 Regulation of Positive_regulation of Ephb1 1 0.15 0.42 0.5
72 INT153534 Binding of Ephb1 and NMS 1 0.29 1.13 0.5
73 INT249486 Positive_regulation of Ephb1 Positive_regulation of Phosphorylation of Grin2b 1 0.33 0.4 0.46
74 INT95404 Map3k1 Positive_regulation of Phosphorylation of Ephb1 1 0.12 0.16 0.46
75 INT95408 Map3k1 Positive_regulation of Ephb1 1 0.12 0.16 0.46
76 INT149006 RPL7AP5 Negative_regulation of Phosphorylation of Ephb1 1 0.00 0.22 0.45
77 INT127392 Negative_regulation of Ephb1 Negative_regulation of Gene_expression of Grin1 1 0.08 0.71 0.45
78 INT127393 Negative_regulation of Ephb1 Negative_regulation of Positive_regulation of Nfkb1 1 0.10 0.7 0.45
79 INT127394 Negative_regulation of Ephb1 Negative_regulation of Gene_expression of Grin2a 1 0.01 0.71 0.45
80 INT127391 Negative_regulation of Ephb1 Negative_regulation of Gene_expression of Elk1 1 0.08 0.71 0.45
81 INT127395 Negative_regulation of Ephb1 Negative_regulation of Gene_expression of Tacr1 1 0.07 0.71 0.45
82 INT127390 Negative_regulation of Ephb1 Negative_regulation of Phosphorylation of Elk1 1 0.08 0.7 0.44
83 INT149005 RPL7AP5 Negative_regulation of Ephb1 1 0.00 0.21 0.44
84 INT265647 Binding of Ephb1 and Mapk1 1 0.00 1.48 0.43
85 INT95403 Ephb1 Regulation of Positive_regulation of Trib3 1 0.07 0.19 0.41
86 INT304501 Binding of Ephb1 and Mapk1 1 0.18 0.69 0.36
87 INT274936 Ephb2 Regulation of Gene_expression of Fos 1 0.15 0 0.36
88 INT274941 Ephb2 Regulation of Phosphorylation of Mapk1 1 0.19 0 0.36
89 INT224284 BDNF Positive_regulation of Ephb1 1 0.36 0.22 0.36
90 INT274937 Ephb2 Regulation of Phosphorylation of Creb1 1 0.21 0 0.36
91 INT274933 Ephb2 Regulation of Phosphorylation of Camk2a 1 0.29 0 0.36
92 INT270220 Negative_regulation of Ephb1 Negative_regulation of Positive_regulation of Pla2g4a 1 0.13 1 0.36
93 INT309151 Dlat Positive_regulation of Positive_regulation of Ephb1 1 0.02 0.57 0.33
94 INT342882 Positive_regulation of Ephb1 Regulation of Gene_expression of Pdyn 1 0.01 0.36 0.33
95 INT249490 Phosphorylation of Ephb2 Positive_regulation of Src 1 0.17 0.15 0.33
96 INT309128 Edc4 Positive_regulation of Positive_regulation of Ephb1 1 0.01 0.58 0.33
97 INT249480 Positive_regulation of Ephb1 Positive_regulation of Phosphorylation of Src 1 0.22 0.23 0.31
98 INT309366 Pax2 Negative_regulation of Transcription of Slc6a5 1 0.03 0 0.31
99 INT309369 Ptf1a Positive_regulation of Pax2 1 0.10 0 0.3
100 INT341777 SLC6A4 Regulation of EPHB1 1 0.02 0.96 0.3
101 INT135014 Binding of Ephb1 and Cabin1 1 0.09 0.32 0.3
102 INT218936 Dusp1 Negative_regulation of Ephb1 2 0.03 0.89 0.28
103 INT218934 Cyp3a23/3a1 Negative_regulation of Ephb1 1 0.01 0.95 0.28
104 INT309121 Positive_regulation of Gsdmc Positive_regulation of Positive_regulation of Ephb1 1 0.01 0.76 0.28
105 INT132373 Ephb1 Positive_regulation of Positive_regulation of Nfkb1 1 0.18 0.12 0.28
106 INT132364 Ephb1 Positive_regulation of Nfkb1 1 0.07 0.11 0.27
107 INT309134 Edc4 Positive_regulation of Ephb1 1 0.01 0.54 0.27
108 INT316929 Pde5a Regulation of Ephb1 1 0.03 0.17 0.27
109 INT132370 Mapk8 Positive_regulation of Ephb1 1 0.15 0.12 0.27
110 INT309133 Dlat Positive_regulation of Ephb1 1 0.02 0.54 0.27
111 INT274940 Ephb2 Negative_regulation of Gene_expression of Fos 1 0.15 0.07 0.27
112 INT179928 Binding of Ephb1 and Mapk8 1 0.11 0.91 0.26
113 INT149947 Ephb1 Positive_regulation of Prkcg 1 0.27 0.07 0.26
114 INT149948 Ephb1 Negative_regulation of Phosphorylation of Map2 1 0.37 0.07 0.25
115 INT157692 Cck Positive_regulation of Ephb1 1 0.26 0 0.21
116 INT333299 Zic2 Regulation of Transcription of Ephb1 1 0.50 0.09 0.17
117 INT108663 Lrpap1 Negative_regulation of Positive_regulation of Ephb1 1 0.11 0.28 0.17
118 INT108667 ras Negative_regulation of Positive_regulation of Ephb1 1 0.02 0.28 0.17
119 INT261477 Egf Positive_regulation of Positive_regulation of Ephb1 1 0.37 0.21 0.17
120 INT193546 Il1b Positive_regulation of Ephb1 1 0.12 0.35 0.16
121 INT179931 Ephb1 Regulation of Gene_expression of Mmp9 1 0.04 0.48 0.15
122 INT193550 Ephb1 Positive_regulation of Gene_expression of Bdnf 1 0.29 0.3 0.14
123 INT193553 Mtpn Positive_regulation of Ephb1 1 0.04 0.34 0.13
124 INT193548 Gdnf Positive_regulation of Ephb1 1 0.40 0.34 0.13
125 INT309371 Lhx1 Positive_regulation of Gene_expression of Pax2 1 0.08 0.07 0.11
126 INT309372 Lhx5 Positive_regulation of Gene_expression of Pax2 1 0.09 0.07 0.11
127 INT128696 Il1a Positive_regulation of Phosphorylation of Ephb1 1 0.26 0.82 0.1
128 INT249126 Binding of Ephb1 and Mtor 1 0.02 0 0.08
129 INT310564 Positive_regulation of Ephb1 Regulation of Stat3 1 0.03 0.17 0.08
130 INT109864 Negative_regulation of ras Positive_regulation of Ephb1 1 0.01 0.37 0.08
131 INT109865 ras Positive_regulation of Ephb1 1 0.01 0.37 0.08
132 INT309112 Edc4 Regulation of Positive_regulation of Ephb1 1 0.01 0.15 0.07
133 INT184924 Ephb1 Positive_regulation of Agtrap 1 0.01 0.08 0.06
134 INT282140 Ephb1 Regulation of Grip2 1 0.00 0 0.05
135 INT179930 Litaf Positive_regulation of Ephb1 1 0.01 0.4 0.04
136 INT218929 Pts Negative_regulation of Ephb1 1 0.05 0.69 0.03
137 INT317959 Negative_regulation of Ephb1 Negative_regulation of Cldn4 1 0.10 0.27 0.03
138 INT352381 Mir21 Regulation of Ephb1 1 0.02 0 0.03
139 INT218927 Pts Positive_regulation of Ephb1 1 0.06 0.69 0.03
140 INT317961 Negative_regulation of Ephb1 Negative_regulation of Negative_regulation of Cldn4 1 0.10 0.27 0.03
141 INT317955 Negative_regulation of Ephb1 Negative_regulation of Tecr 1 0.08 0.28 0.03
142 INT244839 Lbx1 Positive_regulation of Pax2 1 0.39 0 0
143 INT317960 Negative_regulation of Ephb1 Positive_regulation of Gene_expression of Tecr 1 0.15 0.08 0
144 INT216283 Bdnf Negative_regulation of Positive_regulation of Ephb1 1 0.04 0.99 0
145 INT294880 DPYD Positive_regulation of Ephb1 1 0.00 0.53 0
146 INT84499 Chrm3 Positive_regulation of Ephb1 1 0.40 0 0
147 INT267015 Ephb1 Regulation of Bdnf 1 0.05 0.07 0
148 INT262413 Binding of EPHB1 and ADHD1 1 0.17 0.1 0
149 INT317962 Negative_regulation of Ephb1 Positive_regulation of Tecr 1 0.11 0.08 0
150 INT297691 Binding of Fut1 and Pax2 1 0.03 0 0
151 INT84498 Negative_regulation of Chrm3 Positive_regulation of Ephb1 1 0.34 0 0
152 INT333306 Ephb1 Regulation of Gene_expression of Slc6a4 1 0.19 0.21 0
153 INT216285 Bdnf Negative_regulation of Phosphorylation of Ephb1 1 0.04 1.31 0
154 INT283899 Binding of Ephb2 and APOA5 1 0.00 0.67 0
155 INT258713 Camk1g Positive_regulation of Ephb1 1 0.48 0.08 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for optic nerve morphogenesis. They are ordered first by their pain relevance and then by number of times they were reported in optic nerve morphogenesis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT63932 Positive_regulation of Ephb1 537 0.70 259.67 296.14
2 INT63934 Phosphorylation of Ephb1 377 0.82 150.52 188.66
3 INT48923 Gene_expression of Ephb1 211 0.77 106.23 109.9
4 INT63936 Positive_regulation of Phosphorylation of Ephb1 131 0.70 49.38 73.16
5 INT84495 Positive_regulation of Positive_regulation of Ephb1 85 0.70 46.12 54.11
6 INT48920 Negative_regulation of Ephb1 107 0.57 43.6 51.02
7 INT48929 Regulation of Ephb1 71 0.62 24.42 42.11
8 INT63933 Negative_regulation of Positive_regulation of Ephb1 53 0.58 22.83 33.43
9 INT63935 Positive_regulation of Gene_expression of Ephb1 52 0.61 24.3 33.05
10 INT84494 Negative_regulation of Phosphorylation of Ephb1 44 0.59 22.34 28.68
11 INT123035 Gene_expression of Ephb1 38 0.78 28.84 27.32
12 INT109379 Regulation of Phosphorylation of Ephb1 22 0.59 12.58 18.84
13 INT92733 Negative_regulation of Ephb1 19 0.51 8.56 17.72
14 INT128921 Negative_regulation of Gene_expression of Ephb1 18 0.49 9.54 14.93
15 INT84496 Regulation of Positive_regulation of Ephb1 18 0.61 10.16 13.92
16 INT135909 Positive_regulation of Ephb1 11 0.70 8.94 11.78
17 INT127853 Localization of Ephb1 20 0.74 5.47 7.96
18 INT147715 Regulation of Gene_expression of Ephb1 6 0.62 5.26 7.49
19 INT92734 Binding of Ephb1 5 0.37 3.86 7.02
20 INT150287 Positive_regulation of Ephb2 5 0.33 5.54 6.9
21 INT48922 Regulation of Gene_expression of Ephb1 14 0.50 5.73 6.47
22 INT181053 Regulation of Ephb1 6 0.45 6.17 5.77
23 INT126847 Binding of Ephb1 15 0.46 6.47 5.17
24 INT68559 Negative_regulation of Gli3 5 0.37 4.56 4.93
25 INT137907 Phosphorylation of Ephb2 2 0.61 2.78 2.96
26 INT256286 Negative_regulation of Gene_expression of Ephb1 1 0.43 3.36 2.78
27 INT150286 Gene_expression of Ephb2 3 0.39 2.57 2.74
28 INT126581 Positive_regulation of Gli3 6 0.35 1.59 2.48
29 INT126374 Gene_expression of Gli3 6 0.77 3.67 2.02
30 INT154515 Localization of Ephb2 2 0.73 0.17 1.77
31 INT98788 Negative_regulation of EPHB1 11 0.37 3.65 1.64
32 INT158773 Positive_regulation of Localization of Ephb1 1 0.34 0.08 1.64
33 INT117717 Negative_regulation of Regulation of Ephb1 3 0.41 0.61 1.61
34 INT147713 Localization of Ephb1 1 0.70 0 1.54
35 INT135907 Negative_regulation of Positive_regulation of Ephb1 1 0.38 0.42 1.51
36 INT135908 Regulation of Negative_regulation of Ephb1 1 0.24 0.4 1.49
37 INT140245 Binding of Gli3 3 0.36 2.65 1.46
38 INT135906 Positive_regulation of Positive_regulation of Ephb1 1 0.44 0.38 1.45
39 INT212466 Regulation of EPHB1 7 0.37 5.72 1.42
40 INT117719 Transcription of Ephb1 2 0.44 0.06 1.25
41 INT166274 Gene_expression of EPHB1 14 0.55 8.2 1.19
42 INT240461 Regulation of Negative_regulation of Ephb1 4 0.37 1.66 0.96
43 INT147716 Negative_regulation of Localization of Ephb1 1 0.51 0 0.84
44 INT97782 Protein_catabolism of Ephb1 5 0.86 1.27 0.76
45 INT68560 Regulation of Gli3 3 0.18 1.51 0.68
46 INT127854 Regulation of Localization of Ephb1 1 0.25 0.69 0.62
47 INT249507 Regulation of Binding of Ephb1 1 0.38 0.58 0.55
48 INT274916 Negative_regulation of Localization of Ephb2 1 0.29 0 0.52
49 INT135062 Transcription of Gli3 1 0.05 0 0.52
50 INT126849 Positive_regulation of Binding of Ephb1 3 0.49 0.24 0.5
51 INT333283 Positive_regulation of Gene_expression of Ephb1 3 0.32 1.17 0.47
52 INT274928 Negative_regulation of Binding of Ephb1 1 0.40 0 0.44
53 INT193542 Regulation of Regulation of Ephb1 2 0.25 0.79 0.38
54 INT274927 Negative_regulation of Ephb2 1 0.29 0 0.35
55 INT213507 Gene_expression of Pax2 10 0.67 1.41 0.34
56 INT249513 Positive_regulation of Positive_regulation of Ephb2 1 0.33 0.15 0.34
57 INT249528 Phosphorylation of Ephb2 1 0.41 0.15 0.33
58 INT145185 Binding of Ephb2 2 0.28 0.31 0.31
59 INT309354 Regulation of Pax2 1 0.10 0 0.29
60 INT179917 Negative_regulation of Negative_regulation of Ephb1 2 0.25 1.17 0.28
61 INT309339 Negative_regulation of Localization of Pax2 1 0.15 0 0.28
62 INT163893 Positive_regulation of Phosphorylation of EPHB1 1 0.49 0.43 0.27
63 INT163892 Phosphorylation of EPHB1 1 0.80 0.42 0.27
64 INT135061 Protein_catabolism of Gli3 1 0.04 0 0.25
65 INT316046 Gene_expression of Ephb2 1 0.47 0.57 0.23
66 INT274731 Binding of EPHB1 3 0.22 0.76 0.2
67 INT135060 Negative_regulation of Transcription of Gli3 1 0.03 0 0.19
68 INT181029 Transcription of Ephb1 2 0.51 0.51 0.17
69 INT309352 Localization of Pax2 1 0.27 0 0.14
70 INT270451 Localization of Gli3 1 0.26 0.63 0.11
71 INT135063 Regulation of Gene_expression of Gli3 1 0.04 0 0.09
72 INT173212 Positive_regulation of Gene_expression of EPHB1 1 0.04 1.22 0.08
73 INT126375 Negative_regulation of Gene_expression of Gli3 1 0.58 0.79 0.08
74 INT244741 Positive_regulation of Gene_expression of Pax2 1 0.38 0 0.06
75 INT217725 Localization of EPHB1 4 0.45 0.21 0.03
76 INT258547 Binding of Ephb2 2 0.35 1.61 0
77 INT212465 Positive_regulation of EPHB1 2 0.08 1.93 0
78 INT134692 Positive_regulation of Negative_regulation of Ephb1 1 0.23 0.07 0
79 INT283854 Positive_regulation of Binding of Ephb2 1 0.45 0.34 0
80 INT244782 Negative_regulation of Pax2 1 0.44 0 0
81 INT283856 Positive_regulation of Positive_regulation of Ephb2 1 0.49 0.33 0
82 INT274732 Regulation of Localization of EPHB1 1 0.23 0 0
83 INT181058 Regulation of Transcription of Ephb1 1 0.18 0.42 0
84 INT283855 Positive_regulation of Ephb2 1 0.49 0.66 0
85 INT213529 Negative_regulation of Gene_expression of Pax2 1 0.37 0.23 0
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