GO:0021776

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Name smoothened signaling pathway involved in spinal cord motor neuron cell fate specification
Categary Process
Go Slim No
Go Link GO:0021776
Unique Molecular Interactions 21
Total Molecular Interactions 26
Total Single Events 138
Pain Genes Associated 2

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for smoothened signaling pathway involved in spinal cord motor neuron cell fate specification. They are ordered first by their pain relevance and then by number of times they were reported for smoothened signaling pathway involved in spinal cord motor neuron cell fate specification. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT140985 Gli3 Regulation of Ihh 1 0.29 0.85 0.85
2 INT104831 Binding of GLI2 and NFKB1 1 0.08 0 0.8
3 INT314203 Nos2 Positive_regulation of Gli3 1 0.19 1.27 0.73
4 INT68561 Binding of Gli3 and Ust 1 0.01 0.68 0.68
5 INT116938 Positive_regulation of GLI2 Positive_regulation of MAPK8 1 0.10 0.07 0.41
6 INT116936 Positive_regulation of GLI2 Positive_regulation of JUN 1 0.12 0.07 0.41
7 INT104834 Binding of GLI2 and IGKV2OR2-1 1 0.00 0 0.22
8 INT303937 Positive_regulation of Binding of GLI2 and CCL5 1 0.01 0 0.18
9 INT303940 Regulation of Binding of GLI2 and CCL5 1 0.01 0 0.18
10 INT303938 Binding of GLI2 and CCL5 1 0.01 0 0.18
11 INT303939 TRAP Positive_regulation of Protein_catabolism of GLI2 1 0.01 0 0.16
12 INT303941 CCL2 Positive_regulation of Protein_catabolism of GLI2 1 0.01 0 0.16
13 INT104837 IGKV2OR2-1 Negative_regulation of GLI2 1 0.00 0 0.15
14 INT343538 TGFB1 Positive_regulation of Gene_expression of GLI2 1 0.08 0.2 0.05
15 INT343545 Binding of GLI2 and ROCK1 1 0.07 0.65 0.03
16 INT343544 Negative_regulation of GLI2 Negative_regulation of Gene_expression of PTHLH 1 0.24 0.53 0.03
17 INT207374 Gene_expression of GLI2 Negative_regulation of Gene_expression of Chol1 1 0.04 0 0
18 INT343548 GLI2 Positive_regulation of Gene_expression of PTHLH 1 0.28 0.94 0
19 INT343549 GLI2 Positive_regulation of GYPA 1 0.05 0.95 0
20 INT207336 Gene_expression of GLI2 Negative_regulation of Gene_expression of CYP27A1 1 0.00 0 0
21 INT343539 GLI2 Regulation of PTHLH 1 0.15 0.25 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for smoothened signaling pathway involved in spinal cord motor neuron cell fate specification. They are ordered first by their pain relevance and then by number of times they were reported in smoothened signaling pathway involved in spinal cord motor neuron cell fate specification. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT68559 Negative_regulation of Gli3 5 0.37 4.56 4.93
2 INT64170 Gene_expression of GLI2 31 0.46 14.96 3.99
3 INT126581 Positive_regulation of Gli3 6 0.35 1.59 2.48
4 INT126374 Gene_expression of Gli3 6 0.77 3.67 2.02
5 INT90926 Positive_regulation of GLI2 12 0.45 4.99 1.74
6 INT140245 Binding of Gli3 3 0.36 2.65 1.46
7 INT104839 Negative_regulation of GLI2 8 0.35 2.7 1.24
8 INT119674 Localization of GLI2 6 0.52 2.84 0.99
9 INT182322 Negative_regulation of Gene_expression of GLI2 6 0.11 2.37 0.98
10 INT64173 Regulation of Gene_expression of GLI2 4 0.37 2.89 0.88
11 INT289474 Regulation of GLI2 2 0.06 1.08 0.87
12 INT104840 Binding of GLI2 6 0.08 1.89 0.72
13 INT68560 Regulation of Gli3 3 0.18 1.51 0.68
14 INT135062 Transcription of Gli3 1 0.05 0 0.52
15 INT119675 Positive_regulation of Localization of GLI2 1 0.32 0.43 0.3
16 INT234407 Positive_regulation of Binding of GLI2 2 0.05 1.33 0.28
17 INT135061 Protein_catabolism of Gli3 1 0.04 0 0.25
18 INT303943 Protein_catabolism of GLI2 2 0.11 0 0.22
19 INT135060 Negative_regulation of Transcription of Gli3 1 0.03 0 0.19
20 INT182321 Positive_regulation of Gene_expression of GLI2 2 0.28 1.32 0.16
21 INT270451 Localization of Gli3 1 0.26 0.63 0.11
22 INT135063 Regulation of Gene_expression of Gli3 1 0.04 0 0.09
23 INT126375 Negative_regulation of Gene_expression of Gli3 1 0.58 0.79 0.08
24 INT207371 Positive_regulation of Transcription of GLI2 1 0.03 0.08 0
25 INT307407 Regulation of Localization of GLI2 1 0.01 0.67 0
26 INT207369 Transcription of GLI2 1 0.05 0.08 0
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