GO:0021915

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Name neural tube development
Categary Process
Go Slim No
Go Link GO:0021915
Unique Molecular Interactions 217
Total Molecular Interactions 309
Total Single Events 1737
Pain Genes Associated 32

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for neural tube development. They are ordered first by their pain relevance and then by number of times they were reported for neural tube development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT170447 Binding of Pax3 and Spr 1 0.01 0.1 5.37
2 INT126335 Binding of Pax3 and Tac1 6 0.07 6.22 5.27
3 INT113234 Binding of Pax3 and Tacr1 3 0.12 1.54 2.93
4 INT294909 Pax3 Positive_regulation of Gene_expression of Il6 1 0.09 5.43 2.51
5 INT213973 Binding of Pax3 and Mthfd1 1 0.00 0.16 1.99
6 INT93470 Notch1 Positive_regulation of Localization of Prkcg 2 0.09 0.31 1.65
7 INT191618 Binding of App and Nf1 1 0.35 3.77 1.65
8 INT48790 Negative_regulation of Rtcd1 Negative_regulation of Pax3 1 0.02 0 1.59
9 INT276687 Pax3 Positive_regulation of Nkx1-1 1 0.00 0.59 1.47
10 INT118784 Thop1 Positive_regulation of Protein_catabolism of Pax3 1 0.07 0.07 1.25
11 INT351715 Pax3 Negative_regulation of Adarb1 1 0.00 0 1.19
12 INT189017 Binding of Pax3 and Lmna 1 0.14 0.42 1.16
13 INT65373 Notch1 Regulation of Oprd1 1 0.09 0 1.16
14 INT48809 Pax3 Negative_regulation of Binding of Tac1 1 0.22 0 1.16
15 INT314206 Mapk14 Positive_regulation of Pax3 1 0.08 0.67 1.15
16 INT242625 Gdnf Positive_regulation of Pax3 1 0.01 0.34 1.15
17 INT294911 Pax3 Positive_regulation of Il6 1 0.06 1.78 1.14
18 INT168185 Binding of PLXNA2 and MRI1 1 0.25 0.78 1.08
19 INT117908 Em Regulation of Localization of Pax3 1 0.00 0.07 1.03
20 INT49164 Binding of Pax3 and Nka1 1 0.01 0.37 1.01
21 INT148327 Binding of Pkd1 and Trpv1 1 0.52 2.23 1.01
22 INT49162 Nka1 Negative_regulation of Binding of Pax3 1 0.02 0.37 1.01
23 INT170449 Pax3 Positive_regulation of Spr 1 0.01 0.26 0.99
24 INT49163 Binding of Pax3 and Calca 1 0.03 0.37 0.98
25 INT4916 Binding of Pax3 and Wdyhv1 1 0.00 0 0.98
26 INT107951 Pax3 Positive_regulation of Tac1 1 0.11 1.21 0.95
27 INT196591 Binding of Lpar1 and Pax3 1 0.05 1.1 0.92
28 INT334529 Pax3 Positive_regulation of Gene_expression of Ngf 1 0.03 0.31 0.91
29 INT14626 Binding of Dpep1 and Pax3 1 0.01 0 0.87
30 INT185329 Pax3 Positive_regulation of Gene_expression of Tg(CAG-EGFP)D4Nagy 1 0.00 0.22 0.87
31 INT213977 Pax3 Negative_regulation of Gene_expression of Il2 1 0.00 0.25 0.86
32 INT140985 Gli3 Regulation of Ihh 1 0.29 0.85 0.85
33 INT189018 Nka1 Regulation of Pax3 1 0.01 0.1 0.81
34 INT104831 Binding of GLI2 and NFKB1 1 0.08 0 0.8
35 INT262563 Negative_regulation of Pax3 Regulation of Calca 1 0.01 0.75 0.76
36 INT294908 Pax3 Positive_regulation of Gene_expression of Il1 1 0.03 0.45 0.76
37 INT262569 Pax3 Regulation of Calca 1 0.00 0.75 0.76
38 INT314203 Nos2 Positive_regulation of Gli3 1 0.19 1.27 0.73
39 INT294906 Binding of Pax3 and Tac4 1 0.01 1.15 0.71
40 INT68561 Binding of Gli3 and Ust 1 0.01 0.68 0.68
41 INT213971 Mthfd1 Positive_regulation of Gene_expression of Pax3 1 0.00 0.14 0.68
42 INT262570 Binding of Pax3 and Trpv1 1 0.02 1.05 0.67
43 INT224823 CTBS Regulation of SALL1 1 0.14 0.53 0.66
44 INT170446 Pax3 Positive_regulation of Gene_expression of Spr 1 0.01 0 0.58
45 INT145431 Pax3 Positive_regulation of Positive_regulation of Ros1 1 0.02 0.07 0.57
46 INT126336 Negative_regulation of Binding of Pax3 and Tac1 1 0.01 0.66 0.49
47 INT165078 Binding of CTSB and Notch1 1 0.00 1.08 0.48
48 INT148377 PDP1 Positive_regulation of NOTCH1 1 0.44 0.64 0.44
49 INT148378 CP Positive_regulation of NOTCH1 1 0.11 0.64 0.44
50 INT126337 Pax3 Positive_regulation of Gene_expression of Ifng 1 0.05 0.56 0.44
51 INT126339 Pax3 Regulation of Insrr 1 0.00 0.56 0.44
52 INT126340 Pax3 Regulation of Gene_expression of Ifng 1 0.03 0.56 0.44
53 INT294910 Pax3 Regulation of Positive_regulation of Il1 1 0.02 2.03 0.42
54 INT116938 Positive_regulation of GLI2 Positive_regulation of MAPK8 1 0.10 0.07 0.41
55 INT116936 Positive_regulation of GLI2 Positive_regulation of JUN 1 0.12 0.07 0.41
56 INT15104 Binding of Pax3 and Penk 1 0.01 0 0.37
57 INT155058 Stat3 Negative_regulation of Akp3 1 0.01 3.7 0.33
58 INT191616 Binding of Cbln1 and Nf1 1 0.01 0.2 0.32
59 INT191620 Binding of Nf1 and Gopc 1 0.08 0.2 0.32
60 INT191611 Nf1 Regulation of ras 1 0.26 0.18 0.3
61 INT229635 SPINK5 Positive_regulation of NF1 1 0.01 2.17 0.3
62 INT208940 Pax3 Positive_regulation of Tacr1 1 0.07 0.55 0.29
63 INT208944 Pax3 Positive_regulation of Localization of Nfkb1 1 0.03 0.55 0.29
64 INT208941 Positive_regulation of Pax3 Positive_regulation of Tacr1 1 0.05 0.55 0.29
65 INT162599 Wnt5a Regulation of Gene_expression of IL4I1 1 0.00 0.1 0.28
66 INT126942 Binding of PKD2 and ZACN 1 0.00 1.38 0.28
67 INT218931 Cyp3a23/3a1 Regulation of Gene_expression of Akp3 1 0.00 0.55 0.27
68 INT294905 Binding of Hgf and Pax3 1 0.01 1.54 0.25
69 INT294912 Binding of Pax3 and Tacr3 1 0.01 1.54 0.25
70 INT283948 SALL1 Positive_regulation of Positive_regulation of Ptgfrn 1 0.00 0.21 0.22
71 INT104834 Binding of GLI2 and IGKV2OR2-1 1 0.00 0 0.22
72 INT297545 Pou3f3 Regulation of Hes1 1 0.05 0.41 0.2
73 INT297544 Pou3f3 Regulation of Notch1 1 0.06 0.41 0.2
74 INT294904 Binding of Pax3 and Slc12a3 1 0.02 1.9 0.2
75 INT126944 Binding of PKD2 and Pkd1 2 0.08 2.09 0.19
76 INT231622 Pax3 Positive_regulation of Il17a 1 0.03 1.01 0.19
77 INT303937 Positive_regulation of Binding of GLI2 and CCL5 1 0.01 0 0.18
78 INT303940 Regulation of Binding of GLI2 and CCL5 1 0.01 0 0.18
79 INT303938 Binding of GLI2 and CCL5 1 0.01 0 0.18
80 INT103197 Nf1 Negative_regulation of ras 1 0.04 1.19 0.17
81 INT155059 Csf2 Negative_regulation of Akp3 1 0.00 1.88 0.17
82 INT191615 Binding of Nf1 and Flna 1 0.08 0.53 0.17
83 INT191621 Binding of Drd3 and Nf1 1 0.32 0.53 0.17
84 INT303939 TRAP Positive_regulation of Protein_catabolism of GLI2 1 0.01 0 0.16
85 INT303941 CCL2 Positive_regulation of Protein_catabolism of GLI2 1 0.01 0 0.16
86 INT103198 NF1 Negative_regulation of ras 1 0.05 1.19 0.16
87 INT316052 Notch1 Regulation of Binding of Cd8a 1 0.01 0.86 0.15
88 INT316053 Notch1 Regulation of Binding of Cd4 1 0.02 0.86 0.15
89 INT104837 IGKV2OR2-1 Negative_regulation of GLI2 1 0.00 0 0.15
90 INT316050 Binding of Notch1 and Regulation of Binding of Cd8a 1 0.01 0.86 0.15
91 INT316051 Binding of Notch1 and Regulation of Binding of Cd4 1 0.02 0.86 0.15
92 INT65267 Igf1 Regulation of Gene_expression of Plod3 1 0.07 0 0.13
93 INT65271 Igf1 Positive_regulation of Gene_expression of Plod3 1 0.12 0 0.13
94 INT287884 WNT5A Positive_regulation of THEMIS 1 0.00 0.08 0.13
95 INT148329 Pkd1 Positive_regulation of Trpv1 1 0.55 0.39 0.13
96 INT191612 Nf1 Positive_regulation of ras 1 0.25 2.6 0.11
97 INT297546 Neurod1 Regulation of Notch1 1 0.05 0.2 0.1
98 INT297548 Neurod1 Regulation of Hes1 1 0.05 0.2 0.1
99 INT233510 Wnt5a Positive_regulation of Gene_expression of Il12a 1 0.03 0.33 0.1
100 INT278217 Binding of Ciita and Notch1 1 0.41 0.22 0.09
101 INT211960 Wnt5a Positive_regulation of Car2 1 0.13 0.38 0.08
102 INT191617 Binding of Nf1 and Rtcd1 1 0.01 0.95 0.08
103 INT234222 PSEN1 Regulation of Gene_expression of NOTCH1 1 0.03 0 0.08
104 INT287879 Binding of WNT5A and FZD5 1 0.06 1.16 0.08
105 INT131130 Binding of PKD1 and Krt16 1 0.01 1 0.08
106 INT297246 Binding of Notch1 and Ncstn 1 0.04 0.32 0.07
107 INT298349 HES3 Positive_regulation of Shh 1 0.12 0.14 0.07
108 INT327871 Binding of Notch1 and Postn 1 0.38 1.42 0.07
109 INT297244 Regulation of Binding of Notch1 and Ncstn 1 0.05 0.32 0.07
110 INT286592 Binding of PKD1 and P1Ehs1 1 0.00 0.16 0.06
111 INT189557 Binding of NOTCH1 and ROBO4 1 0.01 0.22 0.06
112 INT286591 Binding of PKD1 and Id2 1 0.07 0.17 0.06
113 INT343538 TGFB1 Positive_regulation of Gene_expression of GLI2 1 0.08 0.2 0.05
114 INT349314 Binding of Notch1 and Notch3 1 0.11 0.67 0.04
115 INT312943 ANTXR1 Regulation of Gene_expression of Hes3 1 0.00 0.67 0.03
116 INT343545 Binding of GLI2 and ROCK1 1 0.07 0.65 0.03
117 INT347165 Binding of NOTCH1 and PAX5 1 0.05 0.86 0.03
118 INT327876 Postn Regulation of Gene_expression of Notch1 1 0.56 0.92 0.03
119 INT347163 NOTCH1 Positive_regulation of MSC 1 0.03 0.85 0.03
120 INT312942 ANTXR1 Regulation of Localization of Hes3 1 0.00 0.67 0.03
121 INT343544 Negative_regulation of GLI2 Negative_regulation of Gene_expression of PTHLH 1 0.24 0.53 0.03
122 INT347164 NOTCH1 Negative_regulation of Gene_expression of EBF1 1 0.03 0.85 0.03
123 INT191613 Binding of Nf1 and Rasa1 1 0.06 0.88 0.03
124 INT258529 Binding of JAG1 and NOTCH1 3 0.06 2.44 0
125 INT258528 Binding of NOTCH1 and DLL1 2 0.07 1.6 0
126 INT291330 Binding of ENO1 and NOTCH1 1 0.03 1.33 0
127 INT193946 Binding of Notch1 and Positive_regulation of Psen1 1 0.03 0.06 0
128 INT327870 Postn Positive_regulation of Gene_expression of Notch1 1 0.37 0.57 0
129 INT297245 Prnp Positive_regulation of Notch1 1 0.21 0.73 0
130 INT245158 AD5 Regulation of PKD1 1 0.00 0.44 0
131 INT264735 Binding of Hes1 and Mir199b 1 0.08 0.93 0
132 INT293982 MYC Negative_regulation of SFRP1 1 0.21 0.62 0
133 INT327873 Postn Regulation of Notch1 1 0.41 0 0
134 INT302321 Negative_regulation of Binding of Lrp6 and SOST 1 0.16 0.26 0
135 INT264738 Mir199b Regulation of Gene_expression of Hes1 1 0.08 0.89 0
136 INT335884 Akt1 Regulation of Positive_regulation of Wnt5a 1 0.03 0.15 0
137 INT235645 TP53 Regulation of EPHA2 1 0.10 0.97 0
138 INT291329 Binding of NOTCH1 and CERS1 1 0.06 1.42 0
139 INT356083 Binding of App and Notch1 1 0.02 0.2 0
140 INT193949 Alph1 Positive_regulation of Notch1 1 0.01 0.08 0
141 INT308352 Binding of Ctnnd2 and Tcf7l2 1 0.15 0.74 0
142 INT235648 Binding of EFNA1 and EPHA2 1 0.23 1.3 0
143 INT149115 Cat Negative_regulation of Pax3 1 0.02 0.05 0
144 INT261883 PKD2 Positive_regulation of Localization of Ca2 1 0.02 0.67 0
145 INT264736 Hes1 Regulation of Notch2 1 0.20 0.13 0
146 INT235647 TP63 Regulation of EPHA2 1 0.15 0.97 0
147 INT287885 Binding of DVL1 and AXIN1 1 0.02 0 0
148 INT193950 Alph1 Positive_regulation of Positive_regulation of Notch1 1 0.01 0.07 0
149 INT197316 Hes1 Regulation of Atoh1 1 0.01 0.14 0
150 INT281814 Negative_regulation of Akt1 Positive_regulation of Phgdh 1 0.00 1.7 0
151 INT207374 Gene_expression of GLI2 Negative_regulation of Gene_expression of Chol1 1 0.04 0 0
152 INT302320 Binding of Lrp6 and SOST 1 0.18 0.26 0
153 INT193948 Binding of Psen1 and Notch1 1 0.02 0 0
154 INT340919 Binding of Fkbp8 and Ptplad1 1 0.14 0.17 0
155 INT335887 Akt1 Regulation of Lrp6 1 0.06 0.15 0
156 INT264727 Binding of Notch1 and Mir199b 1 0.00 0.86 0
157 INT312944 ANTXR1 Positive_regulation of Localization of Hes3 1 0.01 0.36 0
158 INT314866 Binding of Six1 and Sall1 1 0.39 0.76 0
159 INT343548 GLI2 Positive_regulation of Gene_expression of PTHLH 1 0.28 0.94 0
160 INT337491 Binding of E2F1 and Tcf7 1 0.19 0 0
161 INT197304 Ahr Regulation of Hes1 1 0.06 0.17 0
162 INT214919 Pkd1 Positive_regulation of CDKN1A 1 0.51 2.6 0
163 INT335883 Binding of Lrp6 and Wnt5a 1 0.27 0.08 0
164 INT264731 Gene_expression of Hes1 Negative_regulation of Positive_regulation of Musd1 1 0.00 0.18 0
165 INT235651 TP73 Regulation of EPHA2 1 0.15 0.98 0
166 INT286501 Binding of PKD1 and LILRB1 1 0.01 1.07 0
167 INT312939 Binding of Hes3 and Setd1a 1 0.01 0.66 0
168 INT343549 GLI2 Positive_regulation of GYPA 1 0.05 0.95 0
169 INT197315 Hes5 Regulation of Atoh1 1 0.00 0.14 0
170 INT351675 Efna1 Positive_regulation of Epha2 1 0.05 0.68 0
171 INT264728 Mir199b Regulation of Notch1 1 0.01 0.85 0
172 INT214917 Pkd1 Positive_regulation of Negative_regulation of CDKN1A 1 0.37 1.46 0
173 INT315194 Binding of SFRP1 and Slc10a1 1 0.02 8.85 0
174 INT207336 Gene_expression of GLI2 Negative_regulation of Gene_expression of CYP27A1 1 0.00 0 0
175 INT285770 Binding of NOTCH1 and Das 1 0.00 1.14 0
176 INT197314 Hes5 Regulation of Ascl1 1 0.00 0.14 0
177 INT264726 Binding of Notch1 and Gtf3a 1 0.00 1.68 0
178 INT356084 Binding of Notch1 and Ncstn 1 0.01 0.07 0
179 INT264729 Mir199b Regulation of Hes1 1 0.05 0.25 0
180 INT285769 Das Regulation of NOTCH1 1 0.00 0.78 0
181 INT197310 Hes1 Regulation of Ascl1 1 0.01 0.14 0
182 INT193947 Notch1 Positive_regulation of Alph1 1 0.01 0.07 0
183 INT291333 Binding of CSHL1 and NOTCH1 1 0.05 1.16 0
184 INT299456 Binding of Gabpa and Notch1 1 0.21 0.09 0
185 INT264725 Binding of Hes1 and Notch1 1 0.03 0.84 0
186 INT180836 Binding of CTD and NF1 1 0.15 0.2 0
187 INT304023 SFRP1 Regulation of Binding of MSI1 1 0.04 1.78 0
188 INT264734 Mir199b Negative_regulation of Negative_regulation of Hes1 1 0.07 0.1 0
189 INT315187 Binding of SFRP1 and COPD 1 0.01 4.47 0
190 INT343539 GLI2 Regulation of PTHLH 1 0.15 0.25 0
191 INT258564 Binding of NOTCH1 and Crlf2 1 0.27 0.67 0
192 INT264739 Mir199b Negative_regulation of Gene_expression of Hes1 1 0.07 0.82 0
193 INT264737 Hes1 Regulation of Shh 1 0.19 0.13 0
194 INT264733 Hes1 Regulation of Mir199b 1 0.05 0.43 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for neural tube development. They are ordered first by their pain relevance and then by number of times they were reported in neural tube development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT8534 Localization of Pax3 85 0.59 28.71 82.82
2 INT14624 Gene_expression of Pax3 100 0.38 33.22 69.47
3 INT4913 Binding of Pax3 52 0.28 9.57 42.67
4 INT6584 Negative_regulation of Pax3 31 0.39 14.64 27.97
5 INT28336 Positive_regulation of Pax3 37 0.33 20.94 25.66
6 INT70557 Negative_regulation of Localization of Pax3 1 0.36 1.15 17.32
7 INT70556 Positive_regulation of Localization of Pax3 9 0.34 3.13 12.11
8 INT121223 Positive_regulation of Gene_expression of Pax3 17 0.16 4.52 12.06
9 INT70555 Regulation of Pax3 13 0.35 3.62 12.05
10 INT118782 Protein_catabolism of Pax3 7 0.94 0.46 6.95
11 INT4911 Negative_regulation of Binding of Pax3 7 0.22 1.89 6.17
12 INT123726 Positive_regulation of Notch1 23 0.70 7.2 5.65
13 INT68559 Negative_regulation of Gli3 5 0.37 4.56 4.93
14 INT68216 Binding of NF1 40 0.48 51.24 4.59
15 INT69217 Gene_expression of Notch1 20 0.78 7.8 4.41
16 INT64170 Gene_expression of GLI2 31 0.46 14.96 3.99
17 INT100161 Positive_regulation of Phgdh 6 0.49 0.77 3.81
18 INT122323 Positive_regulation of NOTCH1 36 0.70 35.63 3.7
19 INT76815 Regulation of Gene_expression of Pax3 4 0.12 3.81 3.65
20 INT67726 Gene_expression of Notch1 36 0.75 9.77 3.54
21 INT170438 Negative_regulation of Gene_expression of Pax3 4 0.04 1.03 3.42
22 INT139872 Regulation of Notch1 14 0.45 7.69 2.82
23 INT168188 Gene_expression of PLXNA2 13 0.58 9 2.73
24 INT119025 Gene_expression of NOTCH1 46 0.75 31.32 2.64
25 INT48807 Regulation of Binding of Pax3 2 0.13 0 2.59
26 INT224826 Gene_expression of SALL1 1 0.55 1.94 2.57
27 INT126581 Positive_regulation of Gli3 6 0.35 1.59 2.48
28 INT121224 Positive_regulation of Positive_regulation of Pax3 5 0.14 2.32 2.4
29 INT61434 Regulation of Nf1 3 0.26 1.39 2.4
30 INT64700 Binding of Nf1 14 0.45 15.24 2.29
31 INT70558 Regulation of Localization of Pax3 1 0.20 0.07 2.29
32 INT50057 Regulation of Notch1 3 0.39 0.87 2.14
33 INT126374 Gene_expression of Gli3 6 0.77 3.67 2.02
34 INT84510 Positive_regulation of Nf1 8 0.69 9.52 1.93
35 INT68181 Binding of Nf1 6 0.48 8.14 1.88
36 INT140036 Positive_regulation of Gene_expression of Notch1 6 0.61 2 1.86
37 INT148326 Gene_expression of Pkd1 7 0.76 5.38 1.85
38 INT52633 Negative_regulation of Notch1 4 0.42 2.99 1.84
39 INT90926 Positive_regulation of GLI2 12 0.45 4.99 1.74
40 INT6830 Positive_regulation of Notch1 20 0.55 7.91 1.57
41 INT213959 Transcription of Pax3 2 0.03 0.68 1.54
42 INT163381 Transcription of Notch1 2 0.69 0.41 1.52
43 INT108273 Gene_expression of Phgdh 7 0.65 2.29 1.48
44 INT140245 Binding of Gli3 3 0.36 2.65 1.46
45 INT130098 Negative_regulation of NOTCH1 11 0.42 5.45 1.33
46 INT110784 Protein_catabolism of Notch1 8 0.21 2.32 1.31
47 INT189015 Negative_regulation of Positive_regulation of Pax3 1 0.12 0.31 1.31
48 INT131645 Negative_regulation of Nf1 10 0.58 8.12 1.24
49 INT104839 Negative_regulation of GLI2 8 0.35 2.7 1.24
50 INT170442 Positive_regulation of Binding of Pax3 2 0.17 2.05 1.24
51 INT61993 Gene_expression of NF1 29 0.78 34.47 1.23
52 INT149295 Regulation of NOTCH1 10 0.13 4.26 1.22
53 INT148321 Positive_regulation of Gene_expression of Pkd1 5 0.68 2.93 1.21
54 INT118779 Positive_regulation of Protein_catabolism of Pax3 1 0.47 0.05 1.2
55 INT108519 Binding of Lrp6 8 0.44 1.47 1.19
56 INT110780 Localization of Notch1 2 0.06 0.47 1.19
57 INT100162 Regulation of Positive_regulation of Phgdh 1 0.08 0 1.18
58 INT150074 Gene_expression of WNT5A 8 0.75 6.3 1.17
59 INT149292 Localization of NOTCH1 7 0.54 6.11 1.14
60 INT123727 Negative_regulation of Notch1 6 0.21 1.22 1.11
61 INT152404 Regulation of PKD1 2 0.45 2.02 1.04
62 INT119674 Localization of GLI2 6 0.52 2.84 0.99
63 INT182322 Negative_regulation of Gene_expression of GLI2 6 0.11 2.37 0.98
64 INT6833 Binding of Notch1 4 0.36 0.05 0.94
65 INT108274 Positive_regulation of Gene_expression of Phgdh 1 0.15 0.38 0.93
66 INT47039 Regulation of SFRP1 14 0.62 7.44 0.92
67 INT118783 Negative_regulation of Protein_catabolism of Pax3 1 0.35 0.09 0.89
68 INT64173 Regulation of Gene_expression of GLI2 4 0.37 2.89 0.88
69 INT289474 Regulation of GLI2 2 0.06 1.08 0.87
70 INT15247 Negative_regulation of Negative_regulation of Pax3 1 0.16 0 0.86
71 INT287954 Gene_expression of DVL1 8 0.24 2.48 0.83
72 INT224830 Positive_regulation of Gene_expression of SALL1 1 0.41 0.64 0.81
73 INT168189 Positive_regulation of PLXNA2 1 0.20 0.49 0.75
74 INT129174 Gene_expression of PKD1 24 0.67 14.91 0.74
75 INT104840 Binding of GLI2 6 0.08 1.89 0.72
76 INT140037 Positive_regulation of Positive_regulation of Notch1 2 0.22 1.34 0.69
77 INT68179 Gene_expression of Nf1 9 0.78 8.87 0.68
78 INT68560 Regulation of Gli3 3 0.18 1.51 0.68
79 INT179133 Localization of Nf1 2 0.80 2.18 0.68
80 INT49650 Gene_expression of Nf1 4 0.76 3.38 0.67
81 INT342318 Localization of PLXNA2 1 0.25 0.75 0.67
82 INT264709 Gene_expression of Hes1 24 0.76 7.04 0.63
83 INT47038 Gene_expression of SFRP1 14 0.67 9.6 0.63
84 INT137850 Gene_expression of PKD2 9 0.65 6.68 0.63
85 INT298346 Gene_expression of HES3 1 0.53 1.17 0.63
86 INT224827 Regulation of SALL1 2 0.37 3.36 0.62
87 INT6831 Negative_regulation of Binding of Notch1 1 0.27 0 0.6
88 INT136920 Positive_regulation of Gene_expression of NOTCH1 12 0.49 8.25 0.59
89 INT150075 Positive_regulation of Gene_expression of WNT5A 2 0.67 2.53 0.59
90 INT175294 Binding of Phgdh 2 0.06 1.37 0.57
91 INT110782 Negative_regulation of Localization of Notch1 1 0.03 0.33 0.56
92 INT149294 Regulation of Localization of NOTCH1 1 0.10 0.9 0.55
93 INT110785 Positive_regulation of Protein_catabolism of Notch1 1 0.05 0.33 0.55
94 INT218908 Gene_expression of Akp3 1 0.11 1.45 0.53
95 INT312933 Localization of Hes3 1 0.63 7.94 0.53
96 INT135062 Transcription of Gli3 1 0.05 0 0.52
97 INT61992 Positive_regulation of Gene_expression of NF1 3 0.50 4.47 0.51
98 INT149297 Protein_catabolism of NOTCH1 2 0.15 0.87 0.51
99 INT108275 Positive_regulation of Positive_regulation of Phgdh 1 0.15 0 0.5
100 INT242004 Binding of Tcf7 4 0.36 2.66 0.49
101 INT135366 Localization of SFRP1 4 0.75 1.82 0.47
102 INT316933 Transcription of Nf1 1 0.18 0.49 0.47
103 INT316939 Positive_regulation of Transcription of Nf1 1 0.16 0.49 0.47
104 INT248346 Binding of PLXNA2 4 0.29 1.38 0.46
105 INT155057 Transcription of Akp3 2 0.11 1.91 0.46
106 INT158426 Binding of NOTCH1 10 0.36 7.95 0.45
107 INT170437 Regulation of Positive_regulation of Pax3 1 0.03 0 0.45
108 INT85854 Binding of SALL1 5 0.36 1.4 0.41
109 INT148322 Localization of Pkd1 1 0.79 1.07 0.41
110 INT235660 Gene_expression of EPHA2 27 0.75 23.46 0.4
111 INT175295 Negative_regulation of Gene_expression of Phgdh 1 0.08 1.04 0.39
112 INT235655 Positive_regulation of Gene_expression of EPHA2 14 0.67 13.48 0.35
113 INT112334 Regulation of NF1 18 0.52 15.85 0.34
114 INT298347 Positive_regulation of Gene_expression of HES3 1 0.34 0.72 0.34
115 INT198170 Positive_regulation of SALL1 4 0.49 1.5 0.32
116 INT235658 Positive_regulation of EPHA2 4 0.67 3.42 0.32
117 INT258685 Regulation of Gene_expression of Notch1 2 0.40 1.45 0.3
118 INT65266 Gene_expression of Plod3 1 0.17 0 0.3
119 INT119675 Positive_regulation of Localization of GLI2 1 0.32 0.43 0.3
120 INT287931 Positive_regulation of Gene_expression of DVL1 2 0.09 0.08 0.29
121 INT234407 Positive_regulation of Binding of GLI2 2 0.05 1.33 0.28
122 INT218912 Positive_regulation of Transcription of Akp3 1 0.07 0.52 0.28
123 INT335875 Regulation of Lrp6 1 0.57 0.43 0.27
124 INT218907 Regulation of Gene_expression of Akp3 1 0.07 0.55 0.27
125 INT274104 Regulation of PLXNA2 2 0.33 2.66 0.25
126 INT135061 Protein_catabolism of Gli3 1 0.04 0 0.25
127 INT129342 Positive_regulation of Positive_regulation of Nf1 1 0.50 0.79 0.23
128 INT316049 Regulation of Regulation of Notch1 1 0.03 0.92 0.23
129 INT68180 Regulation of Nf1 2 0.27 2.02 0.22
130 INT303943 Protein_catabolism of GLI2 2 0.11 0 0.22
131 INT336864 Negative_regulation of Tcf7 1 0.41 0.44 0.22
132 INT248347 Negative_regulation of PLXNA2 1 0.38 0.24 0.22
133 INT130099 Negative_regulation of Positive_regulation of NOTCH1 4 0.43 2.56 0.21
134 INT177938 Negative_regulation of NF1 9 0.43 10.3 0.2
135 INT297241 Positive_regulation of Positive_regulation of Notch1 2 0.40 1.02 0.2
136 INT129341 Negative_regulation of Gene_expression of Nf1 2 0.43 1.67 0.2
137 INT352913 Regulation of EPHA2 1 0.05 0.74 0.2
138 INT312932 Gene_expression of Hes3 1 0.61 3.2 0.2
139 INT114371 Negative_regulation of Tcf7l2 1 0.05 0.7 0.2
140 INT193945 Binding of Notch1 7 0.15 1.28 0.19
141 INT123265 Negative_regulation of SALL1 3 0.18 0.78 0.19
142 INT135060 Negative_regulation of Transcription of Gli3 1 0.03 0 0.19
143 INT130096 Positive_regulation of Positive_regulation of NOTCH1 2 0.50 1.15 0.18
144 INT264701 Negative_regulation of Gene_expression of Hes1 1 0.42 0.73 0.18
145 INT65264 Positive_regulation of Gene_expression of Plod3 1 0.11 0 0.18
146 INT311446 Negative_regulation of Gene_expression of PLXNA2 1 0.12 1.1 0.18
147 INT155285 Positive_regulation of Nf1 1 0.16 0.55 0.17
148 INT218909 Regulation of Akp3 1 0.07 1.15 0.17
149 INT289128 Negative_regulation of Gene_expression of DVL1 1 0.07 0.31 0.17
150 INT184344 Transcription of Phgdh 1 0.67 0.75 0.17
151 INT289117 Negative_regulation of DVL1 1 0.07 0.31 0.17
152 INT335861 Localization of Lrp6 1 0.69 0.54 0.17
153 INT182321 Positive_regulation of Gene_expression of GLI2 2 0.28 1.32 0.16
154 INT218921 Negative_regulation of Akp3 1 0.09 1.13 0.16
155 INT103196 Negative_regulation of Gene_expression of Nf1 1 0.57 1.21 0.16
156 INT199521 Protein_catabolism of PKD1 2 0.96 0.39 0.15
157 INT336865 Regulation of Binding of Tcf7 1 0.44 0.33 0.15
158 INT148323 Binding of Pkd1 1 0.37 0.5 0.15
159 INT148324 Phosphorylation of Pkd1 1 0.81 0.52 0.14
160 INT297239 Positive_regulation of Gene_expression of Notch1 2 0.40 1.31 0.13
161 INT338718 Positive_regulation of Localization of NOTCH1 1 0.04 0.6 0.13
162 INT287922 Phosphorylation of DVL1 4 0.20 1.21 0.12
163 INT316042 Negative_regulation of Gene_expression of Notch1 1 0.27 1.7 0.12
164 INT312930 Positive_regulation of Gene_expression of Hes3 1 0.54 0.22 0.12
165 INT312929 Regulation of Phosphorylation of Hes3 1 0.21 0.36 0.11
166 INT312935 Regulation of Hes3 1 0.35 0.59 0.11
167 INT312938 Phosphorylation of Hes3 1 0.49 0.36 0.11
168 INT312926 Positive_regulation of Hes3 1 0.54 0.35 0.11
169 INT312936 Regulation of Positive_regulation of Hes3 1 0.48 0.36 0.11
170 INT270451 Localization of Gli3 1 0.26 0.63 0.11
171 INT162574 Gene_expression of Wnt5a 7 0.47 0.92 0.1
172 INT282594 Localization of WNT5A 2 0.18 0.89 0.1
173 INT233483 Regulation of Gene_expression of Wnt5a 1 0.19 0.33 0.1
174 INT329940 Gene_expression of Sall1 1 0.02 0 0.1
175 INT312937 Positive_regulation of Localization of Hes3 1 0.54 0.55 0.09
176 INT135063 Regulation of Gene_expression of Gli3 1 0.04 0 0.09
177 INT162576 Positive_regulation of Wnt5a 3 0.48 0.71 0.08
178 INT141999 Regulation of Gene_expression of NOTCH1 2 0.04 0.97 0.08
179 INT61991 Negative_regulation of Gene_expression of NF1 1 0.59 1.67 0.08
180 INT298343 Binding of HES3 1 0.33 0.33 0.08
181 INT312927 Negative_regulation of Hes3 1 0.29 0.07 0.08
182 INT126375 Negative_regulation of Gene_expression of Gli3 1 0.58 0.79 0.08
183 INT190026 Positive_regulation of Gene_expression of Nf1 3 0.53 2.45 0.07
184 INT327728 Regulation of Gene_expression of Notch1 2 0.27 0.73 0.07
185 INT290078 Regulation of WNT5A 1 0.07 2.3 0.07
186 INT354592 Positive_regulation of Gene_expression of PLXNA2 1 0.04 0.37 0.07
187 INT224825 Regulation of Gene_expression of SALL1 1 0.37 0.07 0.07
188 INT287947 Binding of DVL1 3 0.10 0.95 0.06
189 INT298251 Gene_expression of Hes5 2 0.45 0.39 0.06
190 INT298344 Negative_regulation of Gene_expression of HES3 1 0.40 0 0.06
191 INT298339 Negative_regulation of HES3 1 0.29 0 0.06
192 INT286583 Localization of PKD2 1 0.35 0.17 0.06
193 INT312934 Regulation of Gene_expression of Hes3 1 0.48 0.76 0.06
194 INT206866 Positive_regulation of SFRP1 7 0.51 3.97 0.05
195 INT211006 Binding of PKD1 6 0.22 2.69 0.05
196 INT261879 Binding of PKD2 3 0.13 2.59 0.05
197 INT193845 Localization of Notch1 2 0.78 0.32 0.05
198 INT287913 Positive_regulation of Gene_expression of SFRP1 2 0.25 2.12 0.05
199 INT335865 Positive_regulation of Phosphorylation of Lrp6 1 0.64 0.46 0.05
200 INT335862 Phosphorylation of Lrp6 1 0.76 0.37 0.05
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