GO:0021953

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Name central nervous system neuron differentiation
Categary Process
Go Slim No
Go Link GO:0021953
Unique Molecular Interactions 90
Total Molecular Interactions 126
Total Single Events 838
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for central nervous system neuron differentiation. They are ordered first by their pain relevance and then by number of times they were reported for central nervous system neuron differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT140347 Binding of ATP1A2 and Cacna1a 1 0.11 2.88 2.73
2 INT74840 Binding of Cacna1a and Cacna1a 5 0.00 4.24 2.36
3 INT355251 Cacna1a Regulation of Gene_expression of Gabrg1 1 0.01 0.06 1.86
4 INT355249 Cacna1a Regulation of Gene_expression of Ltp 1 0.04 0.06 1.86
5 INT355254 Ltp Regulation of Cacna1a 1 0.04 0 1.58
6 INT74843 Binding of Cacna1a and Ea2 3 0.13 3.29 1.55
7 INT298283 Pou4f1 Positive_regulation of Gene_expression of Runx1 1 0.50 1.4 1.48
8 INT355250 Ltp Regulation of Positive_regulation of Cacna1a 1 0.04 0 1.39
9 INT355253 Ltp Positive_regulation of Cacna1a 1 0.05 0 1.34
10 INT355252 Binding of Cacna1a and Cnr1 1 0.04 0 1.31
11 INT74841 Binding of Cacna1a and Ea2 2 0.01 2.33 1.27
12 INT298260 Binding of Runx3 and Pou4f1 1 0.52 2.08 1.22
13 INT108729 Binding of CACNA1A and Cacna1a 3 0.13 1.21 0.95
14 INT298279 Pou4f1 Positive_regulation of Gene_expression of Runx3 1 0.50 1.31 0.81
15 INT31416 Cacna1a Positive_regulation of Gene_expression of Gcg 1 0.03 0 0.65
16 INT298262 Pou4f1 Positive_regulation of Positive_regulation of Ntrk3 1 0.36 0.79 0.63
17 INT297340 Apoe Regulation of Binding of Smo 1 0.10 1.1 0.6
18 INT148257 NR4A2 Regulation of Gene_expression of SLC6A3 1 0.60 0.4 0.59
19 INT354986 Cacna1a Regulation of Localization of Mpo 1 0.01 1.15 0.49
20 INT354981 Cacna1a Negative_regulation of Gene_expression of Nos2 1 0.01 0.99 0.45
21 INT298263 Pou4f1 Regulation of Gene_expression of Ntrk1 1 0.34 0.61 0.43
22 INT298259 Pou4f1 Negative_regulation of Gene_expression of Runx3 1 0.46 0.58 0.4
23 INT354984 Binding of Cacna1a and Tnf 1 0.01 0.83 0.4
24 INT298261 Pou4f1 Negative_regulation of Gene_expression of Runx1 1 0.45 0.58 0.4
25 INT158355 Cacna1a Regulation of Alox5 1 0.01 0.7 0.37
26 INT298281 Pou4f1 Regulation of Gene_expression of Runx3 1 0.66 0.61 0.37
27 INT90723 Nr4a2 Positive_regulation of Egr1 1 0.22 0.49 0.35
28 INT354985 Cacna1a Regulation of Nos2 1 0.01 0.73 0.34
29 INT354982 Cacna1a Regulation of Tnf 1 0.00 0.73 0.34
30 INT297342 Binding of Gnb5 and Smo 1 0.02 1.67 0.34
31 INT298285 Pou4f1 Positive_regulation of Runx3 1 0.50 0.56 0.32
32 INT298269 Positive_regulation of Pou4f1 Positive_regulation of Runx3 1 0.50 0.56 0.32
33 INT156151 POU4F1 Positive_regulation of Gene_expression of NTRK1 1 0.46 0.37 0.31
34 INT156163 POU4F1 Positive_regulation of NTRK1 1 0.46 0.37 0.31
35 INT151258 Binding of Cacna1a and FCMTE1 1 0.00 0.57 0.3
36 INT203529 Pou4f1 Regulation of target gene 1 0.01 0.53 0.3
37 INT298264 Binding of Pou4f1 and Hist1h3f 1 0.12 0.49 0.3
38 INT99599 ZNF398 Negative_regulation of NR4A2 1 0.05 0.41 0.3
39 INT203526 Regulation of Pou4f1 Regulation of target gene 1 0.01 0.54 0.3
40 INT99600 ZNF398 Negative_regulation of Transcription of NR4A2 1 0.10 0.41 0.3
41 INT298282 Pou4f1 Regulation of Gene_expression of Runx1 1 0.48 0.36 0.29
42 INT156152 POU4F1 Positive_regulation of Positive_regulation of NTRK1 1 0.31 0.38 0.29
43 INT156149 Binding of HCFC1 and POU4F1 1 0.27 0.39 0.28
44 INT156154 POU4F1 Positive_regulation of HCFC1 1 0.36 0.38 0.28
45 INT298277 Pou4f1 Negative_regulation of Gene_expression of Neurod1 1 0.58 0.48 0.27
46 INT298280 Pou4f1 Negative_regulation of Gene_expression of Neurod4 1 0.38 0.48 0.27
47 INT156150 POU4F1 Regulation of Gene_expression of NTRK1 1 0.18 0.39 0.27
48 INT142003 Binding of Cacna1a and Etax2 1 0.00 1.02 0.26
49 INT142004 Binding of Cacna1a and TGM6 1 0.00 1.02 0.26
50 INT298297 Pou4f1 Positive_regulation of Gene_expression of Ntrk2 1 0.50 0.36 0.24
51 INT298290 Pou4f1 Regulation of Gene_expression of Ntrk2 1 0.29 0.48 0.23
52 INT149973 MC1R Positive_regulation of Gene_expression of NR4A2 1 0.44 0.32 0.23
53 INT203527 Pou4f1 Negative_regulation of Neurod1 1 0.32 0.54 0.2
54 INT203531 Pou4f1 Negative_regulation of Neurod4 1 0.46 0.54 0.2
55 INT203532 Negative_regulation of Pou4f1 Negative_regulation of Gene_expression of Pou4f2 1 0.34 0.44 0.19
56 INT298273 Binding of Pou4f1 and target gene site 1 0.01 0.53 0.18
57 INT203528 Binding of Pou4f1 and H3 1 0.17 0.42 0.18
58 INT71329 Cacna1a Regulation of Ea2 1 0.01 0.71 0.15
59 INT71328 Cacna1a Regulation of Atxn2 1 0.00 0.71 0.15
60 INT345343 PTCH1 Regulation of Negative_regulation of SMO 1 0.09 2.3 0.13
61 INT197317 Nr4a2 Regulation of Gene_expression of Th 1 0.03 0.07 0.12
62 INT262653 Binding of AICDA and Lmx1a 1 0.00 3.18 0.1
63 INT304813 Binding of MNX1 and RT1-CE1 1 0.00 0.34 0.1
64 INT262654 Binding of HLA-DQA1 and Lmx1a 1 0.01 3.15 0.1
65 INT120559 Binding of Cacna1a and FCMTE1 1 0.02 0.25 0.1
66 INT262751 Binding of PTCH1 and SMO 1 0.25 1.29 0.1
67 INT270464 Binding of Shh and Smo 1 0.07 1.3 0.08
68 INT243255 Binding of Cfp and Pou4f1 1 0.23 0.6 0.07
69 INT125208 Pou4f1 Negative_regulation of Gene_expression of Th 1 0.28 0.67 0.07
70 INT125209 Pou4f1 Positive_regulation of Gene_expression of Th 1 0.33 0.67 0.07
71 INT262652 Negative_regulation of Binding of HLA-DQA1 and Lmx1a 1 0.01 1.59 0.05
72 INT262757 SMO Positive_regulation of Regulation of GLI1 1 0.34 0.6 0.04
73 INT354983 Cacna1a Regulation of Mpo 1 0.02 0.41 0.04
74 INT270458 Binding of Gli1 and Smo 1 0.00 0.65 0.04
75 INT354987 Cacna1a Regulation of Localization of LDHA 1 0.00 0.23 0.03
76 INT298257 Pou4f1 Negative_regulation of Proc 1 0.01 0.54 0.03
77 INT205975 Binding of PTCH1 and Smo 1 0.02 0.72 0
78 INT261963 Binding of Cacna1a and Tgm2 1 0.08 1.19 0
79 INT205974 Smo Positive_regulation of GLI1 1 0.04 0.66 0
80 INT267257 BCL11B Regulation of Transcription of BMI1 1 0.28 0.74 0
81 INT352525 SLC25A16 Negative_regulation of SMO 1 0.00 1.1 0
82 INT250496 Gopc Regulation of Positive_regulation of Cacna1a 1 0.37 0 0
83 INT298268 Regulation of Pou4f1 Regulation of Gene_expression of Avp 1 0.00 0.09 0
84 INT267258 Binding of TP53 and BCL11B 1 0.09 0.42 0
85 INT244851 Lbx1 Negative_regulation of Pou4f1 1 0.38 0 0
86 INT205965 Binding of Ptch1 and Smo 1 0.03 0.72 0
87 INT267259 BCL11B Regulation of BMI1 1 0.65 1.48 0
88 INT299445 Lhb Positive_regulation of Gene_expression of Nr4a2 1 0.22 0.13 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for central nervous system neuron differentiation. They are ordered first by their pain relevance and then by number of times they were reported in central nervous system neuron differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT66331 Gene_expression of Cacna1a 101 0.78 49.58 46.32
2 INT26698 Positive_regulation of Cacna1a 37 0.67 26.33 39.1
3 INT41487 Negative_regulation of Cacna1a 16 0.57 9.42 25.2
4 INT31136 Binding of Cacna1a 28 0.45 30.76 17.35
5 INT30101 Regulation of Cacna1a 25 0.45 14.38 12.43
6 INT203473 Gene_expression of Pou4f1 69 0.76 25.94 11.36
7 INT75765 Positive_regulation of Gene_expression of Cacna1a 17 0.70 17.51 10.91
8 INT91821 Binding of Cacna1a 16 0.48 13.1 6.37
9 INT105215 Negative_regulation of Pou4f1 16 0.53 9.42 5.97
10 INT129508 Localization of Cacna1a 7 0.74 6.47 5.13
11 INT25831 Gene_expression of NR4A2 20 0.74 2.73 4.92
12 INT203506 Positive_regulation of Pou4f1 3 0.49 6.17 4.85
13 INT110796 Positive_regulation of Positive_regulation of Cacna1a 1 0.49 0.51 4.84
14 INT82731 Transcription of Cacna1a 5 0.56 3.41 4.27
15 INT105217 Regulation of Pou4f1 8 0.60 6.15 3.88
16 INT94045 Regulation of Cacna1a 5 0.42 3.56 3.33
17 INT85572 Gene_expression of Cacna1a 11 0.66 5.72 3.02
18 INT142940 Positive_regulation of Negative_regulation of Cacna1a 3 0.50 1.65 2.97
19 INT355244 Negative_regulation of Negative_regulation of Cacna1a 1 0.04 0 2.67
20 INT50723 Positive_regulation of Nr4a2 7 0.53 0.47 2.46
21 INT99607 Transcription of NR4A2 2 0.68 1.61 2.41
22 INT110795 Regulation of Positive_regulation of Cacna1a 2 0.26 0.65 2.07
23 INT354979 Positive_regulation of Localization of Cacna1a 2 0.05 0.86 1.79
24 INT355239 Negative_regulation of Positive_regulation of Cacna1a 1 0.04 0 1.79
25 INT81169 Localization of Nr4a2 1 0.68 0 1.71
26 INT71327 Localization of Cacna1a 3 0.60 2.51 1.7
27 INT50724 Positive_regulation of Positive_regulation of Nr4a2 2 0.49 0.17 1.58
28 INT53008 Gene_expression of Nr4a2 25 0.74 4.89 1.5
29 INT355242 Negative_regulation of Binding of Cacna1a 1 0.04 0.17 1.47
30 INT355245 Regulation of Localization of Cacna1a 1 0.04 0 1.43
31 INT90740 Negative_regulation of Cacna1a 3 0.23 1.43 1.38
32 INT102200 Gene_expression of Nr4a2 9 0.72 3.69 1.28
33 INT82727 Positive_regulation of Transcription of Cacna1a 1 0.01 1.07 1.25
34 INT183068 Gene_expression of SMO 2 0.17 0.27 1.2
35 INT85571 Positive_regulation of Cacna1a 3 0.50 2.06 1.18
36 INT355243 Negative_regulation of Regulation of Cacna1a 1 0.04 0 1.16
37 INT203436 Negative_regulation of Gene_expression of Pou4f1 4 0.57 2.88 1.14
38 INT298235 Binding of Pou4f1 1 0.47 2.95 1.11
39 INT203498 Localization of Pou4f1 5 0.73 3.29 1.07
40 INT230633 Positive_regulation of MNX1 3 0.30 1.4 0.97
41 INT321650 Negative_regulation of Gene_expression of Cacna1a 2 0.04 0.13 0.95
42 INT243240 Transcription of Pou4f1 2 0.68 1.91 0.94
43 INT148259 Negative_regulation of Gene_expression of NR4A2 2 0.55 0.71 0.91
44 INT94046 Protein_catabolism of Cacna1a 1 0.70 0.83 0.9
45 INT203489 Positive_regulation of Gene_expression of Pou4f1 3 0.49 2.33 0.84
46 INT305483 Negative_regulation of MNX1 1 0.04 0.73 0.82
47 INT270447 Binding of Smo 2 0.07 2.61 0.78
48 INT148261 Negative_regulation of Transcription of NR4A2 1 0.41 0.31 0.72
49 INT90714 Positive_regulation of Nr4a2 1 0.67 0.97 0.71
50 INT183037 Gene_expression of MNX1 12 0.53 4.27 0.69
51 INT140874 Binding of MNX1 4 0.36 0.85 0.69
52 INT103336 Transcription of Cacna1a 2 0.69 1.17 0.68
53 INT193196 Regulation of MNX1 2 0.19 2.53 0.64
54 INT205957 Negative_regulation of Smo 4 0.08 2.57 0.6
55 INT149974 Positive_regulation of Gene_expression of NR4A2 4 0.41 0.52 0.58
56 INT148260 Negative_regulation of NR4A2 2 0.36 0.68 0.56
57 INT148258 Regulation of Gene_expression of NR4A2 1 0.26 0.39 0.56
58 INT148265 Regulation of Transcription of NR4A2 1 0.58 0.39 0.56
59 INT267269 Gene_expression of BCL11B 62 0.78 48.75 0.55
60 INT125207 Positive_regulation of Negative_regulation of Pou4f1 1 0.21 0.69 0.5
61 INT203518 Regulation of Localization of Pou4f1 1 0.44 1.15 0.42
62 INT131415 Gene_expression of POU4F1 1 0.60 1.87 0.36
63 INT99962 Positive_regulation of Gene_expression of Cacna1a 1 0.01 1.1 0.34
64 INT90716 Regulation of Gene_expression of Nr4a2 2 0.43 0.41 0.32
65 INT99609 Localization of NR4A2 2 0.73 0.6 0.3
66 INT356400 Transcription of Smo 1 0.02 0.05 0.3
67 INT99611 Negative_regulation of Localization of NR4A2 1 0.42 0.41 0.3
68 INT277474 Positive_regulation of Gene_expression of SMO 1 0.11 0 0.29
69 INT246013 Transcription of Nr4a2 4 0.46 1.29 0.27
70 INT216120 Negative_regulation of SMO 2 0.49 3.05 0.27
71 INT148898 Negative_regulation of Gene_expression of Nr4a2 3 0.54 1.13 0.26
72 INT276798 Positive_regulation of NR4A2 2 0.16 0.08 0.25
73 INT27461 Gene_expression of Lmx1a 2 0.52 0.18 0.23
74 INT230622 Negative_regulation of Gene_expression of MNX1 3 0.26 0.61 0.22
75 INT262634 Binding of Lmx1a 1 0.02 0.74 0.17
76 INT203450 Negative_regulation of Localization of Pou4f1 1 0.42 0.4 0.14
77 INT131412 Regulation of POU4F1 1 0.21 0.69 0.14
78 INT131409 Positive_regulation of Gene_expression of POU4F1 1 0.54 0.63 0.13
79 INT159223 Binding of NR4A2 2 0.47 0.38 0.12
80 INT197289 Transcription of Nr4a2 1 0.06 0.06 0.12
81 INT149063 Regulation of BCL11B 1 0.11 0.06 0.12
82 INT203492 Negative_regulation of Positive_regulation of Pou4f1 1 0.36 0.68 0.11
83 INT183057 Positive_regulation of Gene_expression of MNX1 2 0.38 0.75 0.1
84 INT84940 Binding of Nr4a2 1 0.35 0.09 0.08
85 INT345344 Regulation of SMO 1 0.23 1.07 0.06
86 INT289490 Negative_regulation of Negative_regulation of Pou4f1 1 0.32 0.09 0.06
87 INT246012 Negative_regulation of Gene_expression of Nr4a2 1 0.29 0.06 0.05
88 INT309389 Phosphorylation of Cacna1a 1 0.01 0.54 0.05
89 INT246014 Negative_regulation of Nr4a2 1 0.29 0 0.05
90 INT309386 Positive_regulation of Phosphorylation of Cacna1a 1 0.01 0.54 0.05
91 INT262772 Binding of SMO 1 0.27 0.59 0.05
92 INT262777 Localization of SMO 1 0.59 0.6 0.04
93 INT193195 Localization of MNX1 1 0.59 1.01 0.03
94 INT246015 Localization of Nr4a2 1 0.50 0 0.03
95 INT267282 Negative_regulation of BCL11B 1 0.38 1.19 0
96 INT267268 Positive_regulation of BCL11B 1 0.70 6.43 0
97 INT267280 Transcription of BCL11B 1 0.69 1.37 0
98 INT252242 Gene_expression of Smo 1 0.01 0.23 0
99 INT267278 Negative_regulation of Gene_expression of BCL11B 1 0.51 2.67 0
100 INT206868 Regulation of NR4A2 1 0.02 0.28 0
101 INT267281 Localization of BCL11B 1 0.75 3.21 0
102 INT267275 Regulation of Transcription of BCL11B 1 0.45 0.64 0
103 INT243237 Regulation of Gene_expression of Pou4f1 1 0.25 0.27 0
104 INT267279 Positive_regulation of Gene_expression of BCL11B 1 0.70 14.02 0
105 INT267283 Regulation of Gene_expression of BCL11B 1 0.45 0.67 0
106 INT205956 Localization of Smo 1 0.06 0.71 0
107 INT267277 Binding of BCL11B 1 0.37 0.96 0
108 INT298239 Positive_regulation of Binding of Pou4f1 1 0.46 0.09 0
109 INT267273 Negative_regulation of Positive_regulation of BCL11B 1 0.43 1.38 0
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