GO:0021983

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Name pituitary gland development
Categary Process
Go Slim No
Go Link GO:0021983
Unique Molecular Interactions 580
Total Molecular Interactions 793
Total Single Events 6897
Pain Genes Associated 33

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for pituitary gland development. They are ordered first by their pain relevance and then by number of times they were reported for pituitary gland development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT113080 Drd1a Positive_regulation of Phosphorylation of Creb1 2 0.27 0.43 3.88
2 INT161164 Prkcg Regulation of Phosphorylation of Creb1 3 0.41 0.62 3.11
3 INT309150 Edc4 Positive_regulation of Creb1 1 0.03 3.46 3.09
4 INT156622 Umod Regulation of Phosphorylation of Creb1 1 0.05 0.33 2.27
5 INT158964 FosB Negative_regulation of Creb1 1 0.21 0 2.07
6 INT114927 Positive_regulation of Binding of Oprm1 and Creb1 1 0.17 0.28 2.07
7 INT114923 Binding of Oprm1 and Creb1 1 0.16 0.28 2.06
8 INT124133 Camk2a Regulation of Phosphorylation of Creb1 1 0.46 0 2
9 INT186435 Prkcg Regulation of Creb1 1 0.44 0.45 1.9
10 INT186432 Prkaca Regulation of Creb1 1 0.14 0.45 1.9
11 INT186433 Trib3 Regulation of Phosphorylation of Creb1 1 0.03 0.32 1.71
12 INT131574 Negative_regulation of Ephb1 Negative_regulation of Gene_expression of Creb1 1 0.41 0.33 1.58
13 INT114926 Creb1 Negative_regulation of Positive_regulation of Oprm1 1 0.13 0.23 1.56
14 INT121747 Prkcg Negative_regulation of Positive_regulation of Creb1 1 0.16 0.2 1.5
15 INT121741 Prkaca Negative_regulation of Positive_regulation of Creb1 1 0.10 0.2 1.49
16 INT73650 Binding of Pim3 and Creb1 1 0.03 2.48 1.47
17 INT168724 Creb1 Negative_regulation of Gene_expression of Calca 1 0.46 1.09 1.38
18 INT168721 Positive_regulation of Creb1 Positive_regulation of Calca 1 0.53 1.07 1.37
19 INT106850 P2ry2 Positive_regulation of Phosphorylation of Creb1 2 0.49 0.73 1.36
20 INT168722 Creb1 Positive_regulation of Calca 1 0.73 1.05 1.35
21 INT131886 Creb1 Positive_regulation of Gene_expression of Prkcg 1 0.03 0 1.31
22 INT142207 Adcyap1 Positive_regulation of Localization of Gh 1 0.07 0 1.3
23 INT124767 Creb1 Regulation of Oprm1 1 0.45 0 1.26
24 INT74467 Adcyap1 Positive_regulation of Localization of Gh1 1 0.37 0 1.25
25 INT136250 Phosphorylation of Tff3 Regulation of Creb1 1 0.02 0.18 1.24
26 INT136256 Creb1 Regulation of SGCG 1 0.26 0.18 1.23
27 INT136258 Creb1 Regulation of GRIA1 1 0.26 0.18 1.23
28 INT131195 Creb1 Positive_regulation of Positive_regulation of Drd1a 2 0.27 0.61 1.22
29 INT256298 Binding of Creb1 and Ephb1 1 0.16 1.27 1.22
30 INT256297 Binding of Creb1 and Insrr 1 0.00 1.22 1.19
31 INT256295 Binding of Creb1 and Grin2b 1 0.11 1.21 1.19
32 INT124435 Gene_expression of Chrna9 Positive_regulation of Phosphorylation of Creb1 1 0.11 0.6 1.17
33 INT156462 Creb1 Regulation of Ephb1 1 0.29 0 1.07
34 INT119888 Binding of Creb1 and Usf1 1 0.18 0.15 1.05
35 INT48260 Binding of Adcyap1 and Calca 1 0.35 0 1.04
36 INT74027 Creb1 Regulation of Jun 4 0.27 1.04 1.02
37 INT210015 Binding of Adcyap1 and Crh 1 0.47 0.88 1
38 INT186431 Trib3 Regulation of Creb1 1 0.03 0.23 0.92
39 INT252879 Creb1 Positive_regulation of Gene_expression of Tacr1 1 0.03 0.24 0.91
40 INT219037 Creb1 Positive_regulation of Transcription of Bdnf 2 0.43 1.07 0.9
41 INT77253 Binding of gr and Creb1 1 0.03 0.4 0.9
42 INT309140 Dlat Positive_regulation of Creb1 1 0.06 1.1 0.9
43 INT142128 Nrgn Regulation of Creb1 1 0.38 0.25 0.89
44 INT73653 Binding of Creb1 and Fos 1 0.40 1.49 0.87
45 INT304575 Creb1 Regulation of Gene_expression of Bdnf 1 0.04 1 0.84
46 INT271193 Creb1 Regulation of Bdnf 1 0.15 0.28 0.81
47 INT109142 Calca Positive_regulation of Transcription of Creb1 1 0.47 0.13 0.8
48 INT104831 Binding of GLI2 and NFKB1 1 0.08 0 0.8
49 INT182839 Camk4 Positive_regulation of Creb1 3 0.49 1.81 0.79
50 INT114924 Creb1 Regulation of Positive_regulation of Oprm1 1 0.09 0.13 0.79
51 INT186439 Prkaca Regulation of Phosphorylation of Creb1 1 0.06 0.08 0.79
52 INT131194 Creb1 Positive_regulation of Gene_expression of Pdyn 1 0.26 0.08 0.79
53 INT302831 Binding of Creb1 and Mapkapk5 1 0.07 1.3 0.79
54 INT224280 Bdnf Positive_regulation of Creb1 3 0.30 0.62 0.77
55 INT142208 Adcyap1 Positive_regulation of Transcription of Gh 1 0.05 0 0.77
56 INT261413 Positive_regulation of GRIN1 Positive_regulation of Positive_regulation of Creb1 1 0.00 0.81 0.77
57 INT142210 Adcyap1 Positive_regulation of Gh 1 0.05 0 0.77
58 INT106335 Olr1254 Positive_regulation of Phosphorylation of Creb1 1 0.03 0 0.76
59 INT109141 Calca Positive_regulation of Creb1 1 0.47 0.13 0.76
60 INT109143 Calca Positive_regulation of Phosphorylation of Creb1 1 0.47 0.13 0.76
61 INT186436 Phosphorylation of Creb1 Regulation of Transcription of Jun 1 0.21 0.44 0.73
62 INT186445 Creb1 Regulation of Transcription of FOS 1 0.49 0.44 0.73
63 INT186443 Phosphorylation of Creb1 Regulation of Transcription of FOS 1 0.49 0.44 0.73
64 INT186438 Creb1 Regulation of Transcription of Jun 1 0.21 0.44 0.73
65 INT186444 Creb1 Regulation of FOS 1 0.49 0.43 0.72
66 INT253828 Creb1 Positive_regulation of Gene_expression of Cartpt 1 0.19 0.15 0.72
67 INT186442 Phosphorylation of Creb1 Regulation of FOS 1 0.49 0.43 0.72
68 INT186440 Phosphorylation of Creb1 Regulation of Jun 1 0.21 0.43 0.72
69 INT123300 Mks1 Positive_regulation of Creb1 1 0.01 0.35 0.7
70 INT223868 Mapk1 Positive_regulation of Creb1 2 0.17 0.34 0.68
71 INT74468 Adcyap1 Positive_regulation of Localization of Gnrhr 1 0.27 0 0.67
72 INT111555 Negative_regulation of Npr1 Negative_regulation of Positive_regulation of Creb1 1 0.02 0.58 0.66
73 INT224823 CTBS Regulation of SALL1 1 0.14 0.53 0.66
74 INT266064 Binding of PAG1 and Creb1 1 0.04 1.52 0.65
75 INT266049 Binding of Ceacam3 and Creb1 1 0.14 1.53 0.65
76 INT235881 Prkaca Positive_regulation of Creb1 2 0.10 0.16 0.64
77 INT142209 Adcyap1 Positive_regulation of Gene_expression of Gh 1 0.05 0 0.63
78 INT266047 Creb1 Regulation of Ceacam3 1 0.20 1.15 0.62
79 INT186429 Camk2a Regulation of Regulation of Creb1 1 0.09 0.09 0.62
80 INT121873 Creb1 Regulation of Phosphorylation of Car2 1 0.10 0 0.62
81 INT123301 Car2 Positive_regulation of Creb1 1 0.21 0.28 0.61
82 INT113962 OPRM1 Regulation of CREB1 1 0.39 0.31 0.6
83 INT98725 Msr1 Positive_regulation of Gene_expression of Creb1 1 0.00 0.09 0.6
84 INT186434 Trib3 Positive_regulation of Phosphorylation of Creb1 1 0.05 0.26 0.58
85 INT317639 Igf1 Regulation of Creb1 1 0.23 0.16 0.57
86 INT317637 Ngf Regulation of Creb1 1 0.10 0.11 0.57
87 INT92974 Creb1 Regulation of Positive_regulation of Galr1 1 0.32 0 0.57
88 INT305744 Fst Positive_regulation of Creb1 1 0.12 0.33 0.57
89 INT305732 Tst Positive_regulation of Creb1 1 0.12 0.33 0.57
90 INT73656 Creb1 Positive_regulation of Transcription of Pdyn 1 0.42 0.97 0.56
91 INT296169 Binding of Htr4 and Creb1 1 0.49 0.1 0.56
92 INT59155 Binding of Adcyap1 and Vip 2 0.34 0.08 0.55
93 INT296293 Prkaca Regulation of Positive_regulation of Creb1 1 0.16 0.62 0.55
94 INT105424 Creb1 Positive_regulation of Gene_expression of Penk 1 0.49 0 0.55
95 INT114928 Positive_regulation of Creb1 Positive_regulation of Positive_regulation of Oprm1 1 0.16 0.05 0.54
96 INT142206 Negative_regulation of Adcyap1 Positive_regulation of Gh 1 0.04 0 0.54
97 INT305738 Binding of Creb1 and Atf6b 1 0.08 0.34 0.53
98 INT106662 Adcyap1 Regulation of Penk 1 0.00 0 0.49
99 INT106664 Adcyap1 Regulation of Gene_expression of Vip 1 0.00 0 0.49
100 INT219038 Creb1 Regulation of Gene_expression of Bdnf 1 0.25 0.25 0.49
101 INT106663 Adcyap1 Regulation of Vip 1 0.00 0 0.49
102 INT319718 Binding of Crebbp and Creb1 1 0.10 1.68 0.48
103 INT173475 Bcar1 Regulation of Isl1 1 0.01 0 0.47
104 INT305735 Binding of Bdnf and Creb1 1 0.08 0.49 0.47
105 INT305746 Positive_regulation of Creb1 Positive_regulation of BDNF 1 0.32 0.41 0.47
106 INT305743 Binding of Bdnf and Positive_regulation of Positive_regulation of Creb1 1 0.11 0.49 0.47
107 INT235882 Creb1 Positive_regulation of Positive_regulation of Bdnf 1 0.11 0.17 0.47
108 INT142826 UPF1 Positive_regulation of CREB1 1 0.11 0 0.46
109 INT305736 Positive_regulation of Creb1 Positive_regulation of Bdnf 1 0.10 0.41 0.46
110 INT317640 Slc3a1 Positive_regulation of Creb1 1 0.12 0.58 0.46
111 INT161162 Creb1 Regulation of Nts 1 0.19 0.15 0.45
112 INT335850 Snrpc Negative_regulation of Gene_expression of Isl1 1 0.00 1.51 0.45
113 INT259208 Ca2 Positive_regulation of Phosphorylation of Creb1 1 0.04 0 0.45
114 INT317636 Creb1 Positive_regulation of Phosphorylation of Hmmr 1 0.04 0.55 0.45
115 INT283731 Trib3 Positive_regulation of Creb1 2 0.01 0.16 0.44
116 INT151782 Phosphorylation of Creb1 Positive_regulation of Gene_expression of P2rx1 1 0.41 0.07 0.44
117 INT309113 Edc4 Positive_regulation of Gene_expression of Creb1 1 0.03 0.45 0.43
118 INT106333 Olr1254 Positive_regulation of Creb1 1 0.02 0 0.43
119 INT309145 Positive_regulation of Edc4 Positive_regulation of Creb1 1 0.02 0.35 0.42
120 INT116938 Positive_regulation of GLI2 Positive_regulation of MAPK8 1 0.10 0.07 0.41
121 INT116936 Positive_regulation of GLI2 Positive_regulation of JUN 1 0.12 0.07 0.41
122 INT186148 Camk4 Positive_regulation of Phosphorylation of Creb1 2 0.50 1.11 0.4
123 INT235868 Creb1 Negative_regulation of Atf6b 1 0.02 0.21 0.4
124 INT302825 Binding of Creb1 and Xpnpep1 1 0.00 0.64 0.39
125 INT13077 Tac2 Positive_regulation of NKX2-1 1 0.00 0 0.39
126 INT354820 Creb1 Negative_regulation of Transcription of Cpox 1 0.03 0.59 0.38
127 INT235878 Creb1 Positive_regulation of Gene_expression of Bcl2 1 0.05 0.17 0.38
128 INT207211 Binding of Creb1 and Crem 2 0.30 1.35 0.36
129 INT340607 Bdnf Regulation of Gene_expression of Creb1 1 0.36 0.31 0.36
130 INT274937 Ephb2 Regulation of Phosphorylation of Creb1 1 0.21 0 0.36
131 INT273955 Creb1 Positive_regulation of Transcription of Crh 1 0.14 0.96 0.33
132 INT207212 Creb1 Regulation of Bdnf 1 0.17 0.92 0.32
133 INT315385 Adcyap1 Positive_regulation of Phosphorylation of Bad 1 0.05 0.44 0.32
134 INT126851 Prkcg Positive_regulation of Creb1 1 0.46 0.09 0.32
135 INT182837 Binding of Creb1 and Crebbp 1 0.12 0.57 0.32
136 INT315387 Adcyap1 Positive_regulation of Phosphorylation of Gopc 1 0.03 0.44 0.32
137 INT126852 Prkaca Positive_regulation of Creb1 1 0.27 0.09 0.32
138 INT124258 Creb1 Regulation of Gene_expression of Cpox 1 0.17 0.44 0.32
139 INT188288 Ghrl Regulation of Gene_expression of Pou1f1 1 0.07 0 0.3
140 INT186430 Creb1 Positive_regulation of Trib3 1 0.04 0.17 0.3
141 INT118655 Bdnf Positive_regulation of Phosphorylation of Creb1 1 0.44 0.16 0.3
142 INT118653 Binding of Bdnf and Creb1 1 0.39 0.19 0.3
143 INT186152 Camk4 Regulation of Phosphorylation of Creb1 3 0.27 0.44 0.29
144 INT73657 Binding of Jun and Creb1 1 0.25 0.5 0.29
145 INT286699 Positive_regulation of Mapk1 Positive_regulation of Phosphorylation of Creb1 1 0.22 0.18 0.28
146 INT58898 Adcyap1 Regulation of Localization of Acot1 1 0.17 0 0.28
147 INT296284 Calm3 Regulation of Positive_regulation of Creb1 1 0.09 0.31 0.28
148 INT286704 Mapk1 Positive_regulation of Phosphorylation of Creb1 1 0.32 0.18 0.28
149 INT179425 Fig4 Regulation of Creb1 1 0.02 0.32 0.28
150 INT286701 Rps6ka5 Positive_regulation of Phosphorylation of Creb1 1 0.20 0.18 0.28
151 INT283732 Prkaca Positive_regulation of Creb1 1 0.03 0 0.28
152 INT283733 Trib3 Positive_regulation of Creb1 1 0.00 0 0.28
153 INT51858 Akr1d1 Positive_regulation of Phosphorylation of Creb1 1 0.01 0 0.27
154 INT296287 Camk4 Regulation of Positive_regulation of Creb1 1 0.27 0.31 0.27
155 INT342164 Binding of Csf2 and Nkx2-1 1 0.01 0.52 0.26
156 INT74118 Adcyap1 Positive_regulation of Localization of Avp 1 0.33 0 0.26
157 INT186151 Camk4 Regulation of Creb1 2 0.27 1.06 0.25
158 INT194670 CREB1 Regulation of Gene_expression of CD4 1 0.05 0.07 0.25
159 INT194714 CREB1 Regulation of Gene_expression of IK 1 0.00 0.07 0.25
160 INT169049 Positive_regulation of Binding of Creb1 and Sult4a1 1 0.47 0.11 0.24
161 INT169051 Binding of Creb1 and Sult4a1 1 0.32 0.11 0.24
162 INT95741 Creb1 Regulation of Mapk8 1 0.39 0 0.23
163 INT69073 Adcyap1 Regulation of Localization of Gnrh1 2 0.66 0 0.22
164 INT255842 CREB1 Regulation of Binding of ATF2 1 0.03 0.12 0.22
165 INT283948 SALL1 Positive_regulation of Positive_regulation of Ptgfrn 1 0.00 0.21 0.22
166 INT255837 ATF2 Regulation of Binding of CREB1 1 0.03 0.12 0.22
167 INT104834 Binding of GLI2 and IGKV2OR2-1 1 0.00 0 0.22
168 INT255940 Elk1 Regulation of Transcription of CREB1 1 0.03 0.12 0.22
169 INT255835 ATF2 Regulation of Transcription of CREB1 1 0.03 0.12 0.22
170 INT150582 Creb1 Positive_regulation of Gene_expression of Homer1 1 0.00 0 0.22
171 INT255839 CREB1 Regulation of Transcription of ATF2 1 0.03 0.12 0.22
172 INT255947 CREB1 Regulation of Transcription of Elk1 1 0.03 0.12 0.22
173 INT255943 Elk1 Regulation of Binding of CREB1 1 0.03 0.12 0.22
174 INT255938 CREB1 Regulation of Binding of Elk1 1 0.03 0.12 0.22
175 INT149900 Gli1 Regulation of Localization of Mmp14 1 0.02 1.17 0.22
176 INT87169 Creb1 Positive_regulation of Gene_expression of Nkx1-1 1 0.11 0.17 0.21
177 INT5874 Pitx1 Positive_regulation of Ina 1 0.17 0 0.21
178 INT5873 Pitx1 Negative_regulation of Ina 1 0.15 0 0.21
179 INT137228 MAPK1 Positive_regulation of Phosphorylation of Creb1 1 0.46 0 0.2
180 INT297545 Pou3f3 Regulation of Hes1 1 0.05 0.41 0.2
181 INT315384 Adcyap1 Negative_regulation of Positive_regulation of Casp3 1 0.02 0.53 0.2
182 INT315386 Adcyap1 Positive_regulation of Bad 1 0.03 0.52 0.2
183 INT342163 Nkx2-1 Regulation of Gene_expression of Aqp1 1 0.06 0.51 0.2
184 INT80049 Adcyap1 Positive_regulation of Positive_regulation of Slc4a4 1 0.19 0 0.2
185 INT257233 PRKG1 Positive_regulation of Phosphorylation of Creb1 1 0.01 0.09 0.2
186 INT257224 Pde5a Positive_regulation of Phosphorylation of Creb1 1 0.03 0.09 0.2
187 INT57383 Binding of Creb1 and Penk 1 0.05 0.67 0.2
188 INT236338 Negative_regulation of Binding of PCSK1 and GOPC 1 0.06 0.19 0.2
189 INT99797 Jun Positive_regulation of Creb1 1 0.15 0.19 0.2
190 INT308669 CREB1 Regulation of Gene_expression of Ins1 1 0.01 0 0.19
191 INT308657 Creb1 Regulation of Gene_expression of Ins1 1 0.01 0 0.19
192 INT182929 Binding of CREB1 and KCNIP3 1 0.18 0.37 0.19
193 INT303937 Positive_regulation of Binding of GLI2 and CCL5 1 0.01 0 0.18
194 INT303940 Regulation of Binding of GLI2 and CCL5 1 0.01 0 0.18
195 INT303938 Binding of GLI2 and CCL5 1 0.01 0 0.18
196 INT198382 Binding of AR and SRD5A1 2 0.06 0.84 0.17
197 INT320260 Binding of Atf4 and Creb1 1 0.15 0.36 0.17
198 INT114936 Myoz1 Positive_regulation of Creb1 1 0.00 0 0.17
199 INT156970 Negative_regulation of Kcnip3 Positive_regulation of Transcription of Creb1 1 0.47 0.45 0.17
200 INT315396 Adcyap1 Regulation of IFNA1 1 0.02 0.14 0.17

Single Events

The table below shows the top 100 pain related interactions that have been reported for pituitary gland development. They are ordered first by their pain relevance and then by number of times they were reported in pituitary gland development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT11009 Phosphorylation of Creb1 458 0.82 111.34 221.97
2 INT11012 Positive_regulation of Creb1 258 0.70 84.4 132
3 INT11011 Positive_regulation of Phosphorylation of Creb1 190 0.70 49.25 112.01
4 INT49651 Gene_expression of Creb1 276 0.78 114.77 111.96
5 INT57380 Phosphorylation of Creb1 213 0.82 66.8 71.26
6 INT102020 Gene_expression of Creb1 190 0.78 57.31 59.77
7 INT82055 Positive_regulation of Creb1 176 0.70 60.2 58.39
8 INT88617 Positive_regulation of Gene_expression of Creb1 90 0.69 51.69 44.29
9 INT11013 Negative_regulation of Phosphorylation of Creb1 55 0.59 18.74 34.66
10 INT16714 Regulation of Creb1 64 0.62 22.23 33.56
11 INT57379 Positive_regulation of Phosphorylation of Creb1 79 0.69 28.24 30.25
12 INT11010 Regulation of Phosphorylation of Creb1 52 0.62 7.26 29.04
13 INT11014 Phosphorylation of CREB1 72 0.81 26.35 25.64
14 INT102021 Positive_regulation of Gene_expression of Creb1 66 0.70 24.04 23.28
15 INT61160 Negative_regulation of Gene_expression of Creb1 37 0.59 17.95 23.17
16 INT106175 Positive_regulation of Positive_regulation of Creb1 37 0.70 13.89 22.46
17 INT61159 Regulation of Gene_expression of Creb1 46 0.62 24.07 20.52
18 INT62577 Negative_regulation of Creb1 55 0.59 19.68 18.1
19 INT61158 Negative_regulation of Creb1 33 0.59 11.54 18.06
20 INT54077 Gene_expression of Adcyap1 62 0.78 23.17 16.75
21 INT102023 Regulation of Creb1 51 0.62 16.29 16.71
22 INT58896 Localization of Adcyap1 35 0.81 4.57 14.77
23 INT48259 Positive_regulation of Adcyap1 33 0.67 10.94 14.39
24 INT107248 Negative_regulation of Gene_expression of Creb1 26 0.58 9.24 13.41
25 INT16713 Binding of Creb1 53 0.48 20.24 13.06
26 INT62576 Transcription of Creb1 34 0.69 16.97 10.6
27 INT109280 Negative_regulation of Phosphorylation of Creb1 29 0.59 11.81 10.37
28 INT99495 Gene_expression of SRD5A1 14 0.77 5 9.21
29 INT54588 Positive_regulation of CREB1 38 0.67 12.01 9.18
30 INT109279 Regulation of Phosphorylation of Creb1 14 0.62 4.06 8.96
31 INT93673 Transcription of Creb1 19 0.66 9.27 8.26
32 INT52116 Regulation of Adcyap1 20 0.53 6.1 8.14
33 INT87271 Positive_regulation of Phosphorylation of CREB1 27 0.66 12.87 7.91
34 INT111607 Gene_expression of CDH1 103 0.75 90.45 7.77
35 INT116619 Positive_regulation of Positive_regulation of Creb1 25 0.69 8.32 7.3
36 INT86867 Regulation of CREB1 15 0.46 4.95 7.28
37 INT106330 Regulation of Positive_regulation of Creb1 11 0.56 5.57 7.06
38 INT114642 Negative_regulation of Positive_regulation of Creb1 12 0.57 2.32 6.75
39 INT92971 Binding of Creb1 31 0.47 11.3 6.22
40 INT43224 Negative_regulation of Adcyap1 17 0.54 3.69 6.19
41 INT6667 Gene_expression of CREB1 27 0.77 6.29 5.84
42 INT61986 Localization of Creb1 16 0.69 2.12 5.66
43 INT102019 Regulation of Gene_expression of Creb1 14 0.61 5.27 5.08
44 INT102202 Negative_regulation of Positive_regulation of Creb1 11 0.58 4.55 4.99
45 INT203443 Gene_expression of Isl1 27 0.67 11.12 4.65
46 INT66048 Positive_regulation of Gene_expression of Adcyap1 5 0.49 8.21 4.52
47 INT121866 Localization of Creb1 13 0.73 1.95 4.48
48 INT57642 Gene_expression of PCSK1 26 0.76 5.09 4.28
49 INT138209 Positive_regulation of Localization of Adcyap1 2 0.41 2.07 4.08
50 INT64170 Gene_expression of GLI2 31 0.46 14.96 3.99
51 INT99889 Transcription of SRD5A1 5 0.71 1.45 3.74
52 INT59154 Binding of Adcyap1 12 0.48 4.16 3.71
53 INT58897 Regulation of Localization of Adcyap1 4 0.45 1.82 3.48
54 INT11015 Regulation of Phosphorylation of CREB1 4 0.46 1.45 3.17
55 INT34977 Gene_expression of Hmga2 11 0.76 12.39 3.07
56 INT16616 Negative_regulation of SRD5A1 44 0.57 34.81 2.96
57 INT111554 Positive_regulation of Regulation of Creb1 4 0.50 2.12 2.85
58 INT156021 Positive_regulation of Transcription of Creb1 8 0.57 3.36 2.83
59 INT98919 Negative_regulation of Phosphorylation of CREB1 8 0.58 2.4 2.63
60 INT224826 Gene_expression of SALL1 1 0.55 1.94 2.57
61 INT158666 Regulation of Transcription of Creb1 6 0.45 2.41 2.44
62 INT121543 Positive_regulation of Gene_expression of PCSK1 4 0.29 1.63 2.21
63 INT87168 Positive_regulation of Binding of Creb1 4 0.48 4.6 2.21
64 INT159118 Protein_catabolism of Creb1 3 0.61 0.37 2.17
65 INT106718 Regulation of Positive_regulation of Creb1 9 0.45 3.7 2.16
66 INT13075 Binding of NKX2-1 6 0.05 0.12 2.08
67 INT342815 Positive_regulation of Transcription of SRD5A1 1 0.49 0.33 2.04
68 INT158442 Gene_expression of Nkx2-1 21 0.59 8.47 1.99
69 INT54076 Transcription of Adcyap1 4 0.67 1.65 1.98
70 INT77300 Negative_regulation of Positive_regulation of Adcyap1 3 0.35 0 1.88
71 INT66047 Regulation of Gene_expression of Adcyap1 2 0.58 3.36 1.84
72 INT90926 Positive_regulation of GLI2 12 0.45 4.99 1.74
73 INT120088 Gene_expression of Bmp4 37 0.73 13.89 1.73
74 INT111603 Positive_regulation of Gene_expression of CDH1 14 0.49 11.17 1.72
75 INT69917 Negative_regulation of CREB1 8 0.58 2.28 1.59
76 INT59153 Positive_regulation of Binding of Adcyap1 3 0.43 0.56 1.37
77 INT139237 Negative_regulation of Gene_expression of CDH1 23 0.57 24.31 1.28
78 INT98923 Negative_regulation of Localization of Creb1 3 0.50 0.66 1.26
79 INT198387 Regulation of SRD5A1 2 0.60 1.29 1.26
80 INT143759 Gene_expression of SOX2 46 0.55 11.12 1.24
81 INT104839 Negative_regulation of GLI2 8 0.35 2.7 1.24
82 INT169721 Negative_regulation of Negative_regulation of Creb1 1 0.43 0.09 1.22
83 INT121867 Positive_regulation of Localization of Creb1 2 0.60 0.43 1.2
84 INT200838 Positive_regulation of Isl1 6 0.60 0.73 1.19
85 INT122103 Negative_regulation of Cdh1 5 0.49 2.05 1.18
86 INT157765 Negative_regulation of CDH1 32 0.53 35.72 1.15
87 INT111605 Positive_regulation of CDH1 12 0.50 7.95 1.15
88 INT172809 Gene_expression of ISL1 33 0.40 21.63 1.12
89 INT78266 Localization of NKX2-1 2 0.73 0.16 1.12
90 INT142831 Positive_regulation of Gene_expression of CREB1 3 0.69 0.08 1.1
91 INT207201 Positive_regulation of Transcription of Creb1 4 0.50 0.69 1.09
92 INT71476 Negative_regulation of Regulation of Creb1 1 0.18 0.17 1.06
93 INT142829 Transcription of CREB1 9 0.46 3.37 1.03
94 INT154493 Regulation of Gene_expression of SRD5A1 3 0.45 0.58 1.03
95 INT15040 Gene_expression of NKX2-1 8 0.65 3.95 1.02
96 INT119674 Localization of GLI2 6 0.52 2.84 0.99
97 INT182322 Negative_regulation of Gene_expression of GLI2 6 0.11 2.37 0.98
98 INT34978 Negative_regulation of Gene_expression of Hmga2 2 0.42 1.53 0.95
99 INT88032 Negative_regulation of PCSK1 4 0.32 1.27 0.92
100 INT72944 Positive_regulation of PCSK1 3 0.49 0 0.89
101 INT64173 Regulation of Gene_expression of GLI2 4 0.37 2.89 0.88
102 INT13074 Positive_regulation of NKX2-1 4 0.19 0.86 0.87
103 INT165345 Localization of PCSK1 2 0.48 0.39 0.87
104 INT289474 Regulation of GLI2 2 0.06 1.08 0.87
105 INT142122 Regulation of Gene_expression of Bmp4 5 0.43 2.69 0.86
106 INT43221 Negative_regulation of Negative_regulation of Adcyap1 1 0.18 0 0.85
107 INT250509 Gene_expression of Pou1f1 65 0.76 11.8 0.84
108 INT115494 Negative_regulation of Positive_regulation of CREB1 2 0.05 1.25 0.83
109 INT173472 Positive_regulation of Isl1 1 0.03 0.2 0.83
110 INT224830 Positive_regulation of Gene_expression of SALL1 1 0.41 0.64 0.81
111 INT210247 Positive_regulation of Bmp4 6 0.65 4.36 0.8
112 INT188286 Gene_expression of Pou1f1 3 0.19 0.64 0.79
113 INT208142 Gene_expression of PITX1 3 0.65 9.36 0.73
114 INT210014 Regulation of Binding of Adcyap1 1 0.38 0.25 0.73
115 INT54546 Binding of CREB1 9 0.41 3.44 0.72
116 INT104840 Binding of GLI2 6 0.08 1.89 0.72
117 INT15039 Negative_regulation of NKX2-1 3 0.21 0 0.72
118 INT114536 Regulation of Negative_regulation of Creb1 1 0.45 0 0.72
119 INT86370 Regulation of CDH1 10 0.54 13.89 0.7
120 INT126376 Gene_expression of Gli1 8 0.68 4.52 0.7
121 INT210012 Regulation of Transcription of Adcyap1 1 0.44 0.48 0.7
122 INT210011 Negative_regulation of Gene_expression of Adcyap1 1 0.36 1.22 0.69
123 INT243779 Negative_regulation of Gene_expression of Isl1 2 0.30 2.62 0.68
124 INT271162 Positive_regulation of Regulation of Creb1 1 0.20 0.3 0.67
125 INT189877 Gene_expression of Cdh1 55 0.58 9.36 0.66
126 INT121868 Regulation of Localization of Creb1 1 0.23 0 0.66
127 INT88987 Gene_expression of HMGA2 8 0.77 10.46 0.64
128 INT264709 Gene_expression of Hes1 24 0.76 7.04 0.63
129 INT96422 Gene_expression of Bmp4 18 0.69 3.26 0.63
130 INT224827 Regulation of SALL1 2 0.37 3.36 0.62
131 INT93674 Regulation of Binding of Creb1 1 0.38 0.1 0.62
132 INT142827 Regulation of Gene_expression of CREB1 3 0.61 0.39 0.61
133 INT226838 Transcription of Isl1 2 0.28 0.36 0.6
134 INT133974 Binding of Pou1f1 3 0.37 0.52 0.59
135 INT296583 Gene_expression of Fgf10 3 0.59 2.64 0.57
136 INT303595 Negative_regulation of Localization of Creb1 1 0.19 0.86 0.57
137 INT296594 Regulation of Fgf10 1 0.15 1.53 0.56
138 INT342811 Positive_regulation of Gene_expression of SRD5A1 1 0.45 0.22 0.5
139 INT68358 Regulation of Positive_regulation of Adcyap1 1 0.44 0 0.5
140 INT88170 Positive_regulation of HMGA2 2 0.69 2 0.48
141 INT24317 Gene_expression of Gli1 4 0.54 1.46 0.47
142 INT207194 Regulation of Regulation of Creb1 2 0.45 1.09 0.46
143 INT317620 Negative_regulation of Binding of Creb1 1 0.40 0.81 0.46
144 INT116134 Positive_regulation of Positive_regulation of CREB1 2 0.28 0.59 0.45
145 INT142828 Regulation of Transcription of CREB1 1 0.24 0 0.45
146 INT142124 Binding of Bmp4 1 0.35 0.46 0.45
147 INT216457 Negative_regulation of Pou1f1 16 0.57 2.69 0.44
148 INT85854 Binding of SALL1 5 0.36 1.4 0.41
149 INT180688 Transcription of Bmp4 3 0.58 0.35 0.41
150 INT180702 Positive_regulation of Transcription of Bmp4 3 0.42 0.35 0.41
151 INT149890 Positive_regulation of Gene_expression of Gli1 1 0.48 1.56 0.41
152 INT124256 Positive_regulation of Binding of Creb1 2 0.40 1.27 0.39
153 INT274924 Positive_regulation of Protein_catabolism of Creb1 1 0.30 0 0.39
154 INT156860 Gene_expression of ETS1 2 0.30 0.84 0.37
155 INT17937 Gene_expression of Isl1 4 0.27 0.48 0.36
156 INT163489 Binding of CDH1 13 0.19 8.63 0.35
157 INT88167 Negative_regulation of Positive_regulation of HMGA2 1 0.41 0.16 0.35
158 INT127871 Regulation of Gene_expression of CDH1 4 0.44 2.34 0.34
159 INT198170 Positive_regulation of SALL1 4 0.49 1.5 0.32
160 INT124253 Negative_regulation of Binding of Creb1 3 0.42 0.75 0.32
161 INT119675 Positive_regulation of Localization of GLI2 1 0.32 0.43 0.3
162 INT24320 Localization of Gli1 6 0.77 0.63 0.29
163 INT172806 Localization of ISL1 4 0.26 2.64 0.29
164 INT102992 Regulation of Negative_regulation of SRD5A1 4 0.60 3.59 0.29
165 INT326154 Regulation of ETS1 1 0.07 1.69 0.29
166 INT88988 Positive_regulation of Gene_expression of HMGA2 1 0.69 4.05 0.29
167 INT196937 Positive_regulation of Hmga2 3 0.68 2.47 0.28
168 INT234407 Positive_regulation of Binding of GLI2 2 0.05 1.33 0.28
169 INT126059 Positive_regulation of Gata2 1 0.02 0.87 0.28
170 INT176492 Positive_regulation of Gene_expression of ETS1 1 0.09 0.84 0.28
171 INT78132 Binding of Isl1 1 0.16 0 0.27
172 INT25465 Positive_regulation of ISL1 6 0.15 3.59 0.26
173 INT173797 Negative_regulation of Isl1 3 0.37 0.15 0.26
174 INT250514 Regulation of Gene_expression of Pou1f1 2 0.60 0.85 0.26
175 INT173792 Negative_regulation of Negative_regulation of Isl1 1 0.08 0.15 0.26
176 INT165153 Positive_regulation of Gli1 4 0.59 1.17 0.25
177 INT229206 Regulation of Positive_regulation of CREB1 2 0.11 0.25 0.25
178 INT69072 Positive_regulation of Negative_regulation of Adcyap1 1 0.50 0 0.25
179 INT244742 Gene_expression of Gata2 2 0.54 0.18 0.23
180 INT353967 Positive_regulation of Gene_expression of Gata2 1 0.42 0.18 0.23
181 INT126794 Binding of SRD5A1 2 0.36 3.26 0.22
182 INT303943 Protein_catabolism of GLI2 2 0.11 0 0.22
183 INT142121 Positive_regulation of Gene_expression of Bmp4 3 0.47 7 0.21
184 INT114371 Negative_regulation of Tcf7l2 1 0.05 0.7 0.2
185 INT205087 Positive_regulation of Gene_expression of ISL1 4 0.26 3.86 0.19
186 INT123265 Negative_regulation of SALL1 3 0.18 0.78 0.19
187 INT24316 Regulation of Localization of Gli1 1 0.51 0 0.19
188 INT243778 Binding of Isl1 1 0.26 0 0.19
189 INT264701 Negative_regulation of Gene_expression of Hes1 1 0.42 0.73 0.18
190 INT254701 Transcription of CDH1 6 0.67 2.5 0.17
191 INT120085 Negative_regulation of Gene_expression of Bmp4 5 0.55 0.61 0.17
192 INT266053 Positive_regulation of Protein_catabolism of Creb1 1 0.50 0.96 0.17
193 INT185254 Gene_expression of Pax6 14 0.72 1.77 0.16
194 INT273921 Regulation of Binding of Creb1 2 0.35 0.28 0.16
195 INT98772 Localization of Isl1 2 0.65 0 0.16
196 INT182321 Positive_regulation of Gene_expression of GLI2 2 0.28 1.32 0.16
197 INT201210 Negative_regulation of ISL1 2 0.02 0.4 0.16
198 INT266056 Protein_catabolism of Creb1 1 0.88 0.95 0.16
199 INT338872 Regulation of Regulation of Creb1 1 0.21 0.28 0.15
200 INT164160 Localization of CDH1 8 0.66 3.39 0.14
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