GO:0021986

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Name habenula development
Categary Process
Go Slim No
Go Link GO:0021986
Unique Molecular Interactions 43
Total Molecular Interactions 57
Total Single Events 316
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for habenula development. They are ordered first by their pain relevance and then by number of times they were reported for habenula development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT298283 Pou4f1 Positive_regulation of Gene_expression of Runx1 1 0.50 1.4 1.48
2 INT298260 Binding of Runx3 and Pou4f1 1 0.52 2.08 1.22
3 INT298279 Pou4f1 Positive_regulation of Gene_expression of Runx3 1 0.50 1.31 0.81
4 INT298262 Pou4f1 Positive_regulation of Positive_regulation of Ntrk3 1 0.36 0.79 0.63
5 INT148257 NR4A2 Regulation of Gene_expression of SLC6A3 1 0.60 0.4 0.59
6 INT298263 Pou4f1 Regulation of Gene_expression of Ntrk1 1 0.34 0.61 0.43
7 INT298259 Pou4f1 Negative_regulation of Gene_expression of Runx3 1 0.46 0.58 0.4
8 INT298261 Pou4f1 Negative_regulation of Gene_expression of Runx1 1 0.45 0.58 0.4
9 INT298281 Pou4f1 Regulation of Gene_expression of Runx3 1 0.66 0.61 0.37
10 INT90723 Nr4a2 Positive_regulation of Egr1 1 0.22 0.49 0.35
11 INT298285 Pou4f1 Positive_regulation of Runx3 1 0.50 0.56 0.32
12 INT298269 Positive_regulation of Pou4f1 Positive_regulation of Runx3 1 0.50 0.56 0.32
13 INT156151 POU4F1 Positive_regulation of Gene_expression of NTRK1 1 0.46 0.37 0.31
14 INT156163 POU4F1 Positive_regulation of NTRK1 1 0.46 0.37 0.31
15 INT203529 Pou4f1 Regulation of target gene 1 0.01 0.53 0.3
16 INT298264 Binding of Pou4f1 and Hist1h3f 1 0.12 0.49 0.3
17 INT99599 ZNF398 Negative_regulation of NR4A2 1 0.05 0.41 0.3
18 INT203526 Regulation of Pou4f1 Regulation of target gene 1 0.01 0.54 0.3
19 INT99600 ZNF398 Negative_regulation of Transcription of NR4A2 1 0.10 0.41 0.3
20 INT298282 Pou4f1 Regulation of Gene_expression of Runx1 1 0.48 0.36 0.29
21 INT156152 POU4F1 Positive_regulation of Positive_regulation of NTRK1 1 0.31 0.38 0.29
22 INT156149 Binding of HCFC1 and POU4F1 1 0.27 0.39 0.28
23 INT156154 POU4F1 Positive_regulation of HCFC1 1 0.36 0.38 0.28
24 INT298277 Pou4f1 Negative_regulation of Gene_expression of Neurod1 1 0.58 0.48 0.27
25 INT298280 Pou4f1 Negative_regulation of Gene_expression of Neurod4 1 0.38 0.48 0.27
26 INT156150 POU4F1 Regulation of Gene_expression of NTRK1 1 0.18 0.39 0.27
27 INT298297 Pou4f1 Positive_regulation of Gene_expression of Ntrk2 1 0.50 0.36 0.24
28 INT298290 Pou4f1 Regulation of Gene_expression of Ntrk2 1 0.29 0.48 0.23
29 INT149973 MC1R Positive_regulation of Gene_expression of NR4A2 1 0.44 0.32 0.23
30 INT203527 Pou4f1 Negative_regulation of Neurod1 1 0.32 0.54 0.2
31 INT203531 Pou4f1 Negative_regulation of Neurod4 1 0.46 0.54 0.2
32 INT203532 Negative_regulation of Pou4f1 Negative_regulation of Gene_expression of Pou4f2 1 0.34 0.44 0.19
33 INT298273 Binding of Pou4f1 and target gene site 1 0.01 0.53 0.18
34 INT203528 Binding of Pou4f1 and H3 1 0.17 0.42 0.18
35 INT197317 Nr4a2 Regulation of Gene_expression of Th 1 0.03 0.07 0.12
36 INT243255 Binding of Cfp and Pou4f1 1 0.23 0.6 0.07
37 INT125208 Pou4f1 Negative_regulation of Gene_expression of Th 1 0.28 0.67 0.07
38 INT125209 Pou4f1 Positive_regulation of Gene_expression of Th 1 0.33 0.67 0.07
39 INT298257 Pou4f1 Negative_regulation of Proc 1 0.01 0.54 0.03
40 INT298268 Regulation of Pou4f1 Regulation of Gene_expression of Avp 1 0.00 0.09 0
41 INT244851 Lbx1 Negative_regulation of Pou4f1 1 0.38 0 0
42 INT299445 Lhb Positive_regulation of Gene_expression of Nr4a2 1 0.22 0.13 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for habenula development. They are ordered first by their pain relevance and then by number of times they were reported in habenula development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT203473 Gene_expression of Pou4f1 69 0.76 25.94 11.36
2 INT105215 Negative_regulation of Pou4f1 16 0.53 9.42 5.97
3 INT25831 Gene_expression of NR4A2 20 0.74 2.73 4.92
4 INT203506 Positive_regulation of Pou4f1 3 0.49 6.17 4.85
5 INT105217 Regulation of Pou4f1 8 0.60 6.15 3.88
6 INT50723 Positive_regulation of Nr4a2 7 0.53 0.47 2.46
7 INT99607 Transcription of NR4A2 2 0.68 1.61 2.41
8 INT81169 Localization of Nr4a2 1 0.68 0 1.71
9 INT50724 Positive_regulation of Positive_regulation of Nr4a2 2 0.49 0.17 1.58
10 INT53008 Gene_expression of Nr4a2 25 0.74 4.89 1.5
11 INT102200 Gene_expression of Nr4a2 9 0.72 3.69 1.28
12 INT203436 Negative_regulation of Gene_expression of Pou4f1 4 0.57 2.88 1.14
13 INT298235 Binding of Pou4f1 1 0.47 2.95 1.11
14 INT203498 Localization of Pou4f1 5 0.73 3.29 1.07
15 INT243240 Transcription of Pou4f1 2 0.68 1.91 0.94
16 INT148259 Negative_regulation of Gene_expression of NR4A2 2 0.55 0.71 0.91
17 INT203489 Positive_regulation of Gene_expression of Pou4f1 3 0.49 2.33 0.84
18 INT148261 Negative_regulation of Transcription of NR4A2 1 0.41 0.31 0.72
19 INT90714 Positive_regulation of Nr4a2 1 0.67 0.97 0.71
20 INT149974 Positive_regulation of Gene_expression of NR4A2 4 0.41 0.52 0.58
21 INT148260 Negative_regulation of NR4A2 2 0.36 0.68 0.56
22 INT148258 Regulation of Gene_expression of NR4A2 1 0.26 0.39 0.56
23 INT148265 Regulation of Transcription of NR4A2 1 0.58 0.39 0.56
24 INT125207 Positive_regulation of Negative_regulation of Pou4f1 1 0.21 0.69 0.5
25 INT203518 Regulation of Localization of Pou4f1 1 0.44 1.15 0.42
26 INT131415 Gene_expression of POU4F1 1 0.60 1.87 0.36
27 INT90716 Regulation of Gene_expression of Nr4a2 2 0.43 0.41 0.32
28 INT99609 Localization of NR4A2 2 0.73 0.6 0.3
29 INT99611 Negative_regulation of Localization of NR4A2 1 0.42 0.41 0.3
30 INT246013 Transcription of Nr4a2 4 0.46 1.29 0.27
31 INT148898 Negative_regulation of Gene_expression of Nr4a2 3 0.54 1.13 0.26
32 INT276798 Positive_regulation of NR4A2 2 0.16 0.08 0.25
33 INT203450 Negative_regulation of Localization of Pou4f1 1 0.42 0.4 0.14
34 INT131412 Regulation of POU4F1 1 0.21 0.69 0.14
35 INT131409 Positive_regulation of Gene_expression of POU4F1 1 0.54 0.63 0.13
36 INT159223 Binding of NR4A2 2 0.47 0.38 0.12
37 INT197289 Transcription of Nr4a2 1 0.06 0.06 0.12
38 INT203492 Negative_regulation of Positive_regulation of Pou4f1 1 0.36 0.68 0.11
39 INT84940 Binding of Nr4a2 1 0.35 0.09 0.08
40 INT289490 Negative_regulation of Negative_regulation of Pou4f1 1 0.32 0.09 0.06
41 INT246012 Negative_regulation of Gene_expression of Nr4a2 1 0.29 0.06 0.05
42 INT246014 Negative_regulation of Nr4a2 1 0.29 0 0.05
43 INT246015 Localization of Nr4a2 1 0.50 0 0.03
44 INT206868 Regulation of NR4A2 1 0.02 0.28 0
45 INT243237 Regulation of Gene_expression of Pou4f1 1 0.25 0.27 0
46 INT298239 Positive_regulation of Binding of Pou4f1 1 0.46 0.09 0
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