GO:0022010

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Name central nervous system myelination
Categary Process
Go Slim No
Go Link GO:0022010
Unique Molecular Interactions 35
Total Molecular Interactions 37
Total Single Events 213
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for central nervous system myelination. They are ordered first by their pain relevance and then by number of times they were reported for central nervous system myelination. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT178576 CNTN2 Positive_regulation of DPYD 1 0.05 2.18 0.76
2 INT178581 CNTN2 Positive_regulation of PTHLH 1 0.24 2.16 0.75
3 INT178577 CNTN2 Positive_regulation of IL2RA 1 0.03 2.16 0.75
4 INT178579 CNTN2 Positive_regulation of IL6 1 0.07 2.17 0.75
5 INT329119 Binding of CNTN2 and CNTNAP2 1 0.08 2.41 0.73
6 INT48304 Positive_regulation of MBP Positive_regulation of PLP1 1 0.10 0.97 0.64
7 INT48303 MBP Positive_regulation of PLP1 1 0.10 0.97 0.64
8 INT69389 CNTN2 Positive_regulation of PENK 1 0.20 0.53 0.54
9 INT32761 Positive_regulation of Mrf Positive_regulation of Localization of Vip 1 0.08 0 0.38
10 INT180245 Binding of Plp1 and Uchl1 1 0.03 0.47 0.27
11 INT180248 Binding of Gad1 and Plp1 1 0.08 0.22 0.21
12 INT69387 Binding of PENK and CNTN2 1 0.14 0.22 0.21
13 INT69379 CNTN2 Positive_regulation of Gene_expression of PENK 1 0.18 0.19 0.18
14 INT2433 Mrf Positive_regulation of Mpo 1 0.33 0.65 0.18
15 INT329118 Binding of KCNA1 and CNTN2 1 0.02 0 0.14
16 INT69381 CNTN2 Positive_regulation of FOS 1 0.45 0 0.14
17 INT69380 CNTN2 Positive_regulation of Binding of FOS 1 0.49 0 0.14
18 INT69377 CNTN2 Positive_regulation of Binding of JUN 1 0.49 0 0.14
19 INT69388 CNTN2 Positive_regulation of Gene_expression of FOS 1 0.49 0 0.14
20 INT312841 Pou3f1 Regulation of Gene_expression of Plp1 1 0.24 0.16 0.09
21 INT312843 Egr2 Regulation of Gene_expression of Plp1 1 0.31 0.16 0.09
22 INT308749 Gene_expression of C11orf9 Positive_regulation of Gene_expression of MAG 1 0.13 0.08 0.09
23 INT166784 Binding of PSMD1 and Nkx6-2 1 0.21 0.5 0.08
24 INT334686 Olig1 Regulation of Plp1 1 0.17 0.55 0.06
25 INT334684 Eae1 Regulation of Plp1 1 0.05 0.5 0.06
26 INT334685 Olig1 Regulation of Gene_expression of Plp1 1 0.17 0.55 0.06
27 INT334688 Eae1 Regulation of Gene_expression of Plp1 1 0.05 0.5 0.06
28 INT206846 ESR1 Regulation of Gene_expression of PLP1 1 0.06 1.02 0.05
29 INT250865 Binding of Fgf8 and Fgfr3 1 0.18 0.3 0.05
30 INT206848 PLP1 Regulation of Gene_expression of ESR1 1 0.07 0.9 0.04
31 INT205862 CNTN2 Positive_regulation of TNF 1 0.01 0.08 0.04
32 INT197713 CNTN2 Positive_regulation of ABCB1 1 0.01 0.34 0
33 INT197315 Hes5 Regulation of Atoh1 1 0.00 0.14 0
34 INT197314 Hes5 Regulation of Ascl1 1 0.00 0.14 0
35 INT301366 Fgf18 Positive_regulation of Fgfr3 1 0.04 0.34 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for central nervous system myelination. They are ordered first by their pain relevance and then by number of times they were reported in central nervous system myelination. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT48308 Binding of PLP1 7 0.48 9.59 6.09
2 INT48307 Positive_regulation of PLP1 5 0.66 8.42 5.09
3 INT48246 Gene_expression of PLP1 18 0.64 10.33 4.73
4 INT69395 Gene_expression of CNTN2 28 0.68 13.29 4.37
5 INT12785 Positive_regulation of Mrf 9 0.44 1.08 3.02
6 INT15555 Localization of PLP1 6 0.60 3.35 2.75
7 INT8466 Binding of Plp1 5 0.48 5.07 2.29
8 INT48687 Gene_expression of Plp1 7 0.54 3.51 1.03
9 INT120485 Positive_regulation of Plp1 1 0.33 2.2 0.9
10 INT107970 Positive_regulation of Protein_catabolism of CNTN2 1 0.20 1.22 0.88
11 INT14632 Gene_expression of Mrf 4 0.14 0.75 0.87
12 INT204825 Negative_regulation of Plp1 3 0.33 2.96 0.87
13 INT118469 Gene_expression of Fgfr3 5 0.72 6.98 0.75
14 INT178590 Regulation of CNTN2 7 0.24 2.91 0.68
15 INT48306 Positive_regulation of Positive_regulation of PLP1 1 0.42 0.97 0.64
16 INT1072 Gene_expression of Nkx6-2 2 0.65 0.36 0.62
17 INT69392 Positive_regulation of Gene_expression of CNTN2 3 0.44 2.43 0.58
18 INT19281 Gene_expression of C11orf9 2 0.50 0.18 0.55
19 INT69393 Positive_regulation of CNTN2 4 0.45 0.8 0.5
20 INT34707 Binding of Nkx6-2 2 0.42 0.45 0.5
21 INT178591 Binding of CNTN2 4 0.23 1.56 0.44
22 INT107967 Protein_catabolism of CNTN2 1 0.28 0.61 0.44
23 INT204851 Transcription of Plp1 1 0.40 1.38 0.42
24 INT180234 Negative_regulation of Gene_expression of Plp1 1 0.08 1.54 0.42
25 INT23724 Regulation of Nkx6-2 3 0.45 0.48 0.41
26 INT135835 Positive_regulation of Gene_expression of PLP1 1 0.21 2.44 0.41
27 INT245361 Regulation of Plp1 1 0.35 1.15 0.38
28 INT94304 Negative_regulation of Gene_expression of PLP1 2 0.20 1.02 0.36
29 INT94305 Negative_regulation of PLP1 1 0.03 4.28 0.35
30 INT165328 Positive_regulation of Nkx6-2 1 0.21 0.09 0.31
31 INT178585 Regulation of Binding of CNTN2 1 0.21 0.71 0.3
32 INT1073 Negative_regulation of Nkx6-2 2 0.35 0 0.27
33 INT14633 Negative_regulation of Gene_expression of Mrf 1 0.08 0.53 0.27
34 INT178584 Regulation of Gene_expression of CNTN2 1 0.21 1.39 0.24
35 INT308771 Positive_regulation of Gene_expression of C11orf9 1 0.39 0.18 0.18
36 INT50844 Positive_regulation of Positive_regulation of Mrf 1 0.32 0 0.17
37 INT94712 Binding of Mrf 1 0.31 1.03 0.15
38 INT308772 Positive_regulation of C11orf9 1 0.39 0.1 0.11
39 INT48686 Localization of Plp1 7 0.07 0.71 0.09
40 INT308769 Negative_regulation of C11orf9 1 0.36 0.15 0.08
41 INT250839 Binding of Fgfr3 1 0.16 0.19 0.08
42 INT308785 Regulation of C11orf9 1 0.23 0.2 0.07
43 INT298251 Gene_expression of Hes5 2 0.45 0.39 0.06
44 INT206882 Regulation of PLP1 1 0.13 0.84 0.04
45 INT276327 Positive_regulation of Gene_expression of Fgfr3 2 0.43 1.83 0
46 INT205791 Transcription of CNTN2 1 0.25 0.7 0
47 INT252396 Transcription of PLP1 1 0.03 0.05 0
48 INT243057 Positive_regulation of Fgfr3 1 0.46 0.79 0
49 INT303553 Regulation of Gene_expression of Fgfr3 1 0.25 0.3 0
50 INT243058 Positive_regulation of Positive_regulation of Fgfr3 1 0.46 0.8 0
51 INT298236 Localization of Hes5 1 0.51 0.39 0
52 INT301359 Positive_regulation of Fgfr3 1 0.19 0.64 0
53 INT205792 Negative_regulation of CNTN2 1 0.15 0.07 0
54 INT301357 Negative_regulation of Positive_regulation of Fgfr3 1 0.16 0.35 0
55 INT308764 Binding of C11orf9 1 0.34 0 0
56 INT205798 Localization of CNTN2 1 0.24 0.27 0
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