GO:0022617

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Name extracellular matrix disassembly
Categary Process
Go Slim No
Go Link GO:0022617
Unique Molecular Interactions 124
Total Molecular Interactions 175
Total Single Events 1058
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for extracellular matrix disassembly. They are ordered first by their pain relevance and then by number of times they were reported for extracellular matrix disassembly. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT134215 CRH Positive_regulation of ENG 1 0.13 1.22 2.06
2 INT31445 ENG Positive_regulation of Localization of Prl 4 0.01 0 1.77
3 INT167321 Binding of ENG and OPRM1 1 0.27 0.63 1.76
4 INT199503 ENG Positive_regulation of Oprk1 1 0.01 0.87 1.69
5 INT45306 Pomc Positive_regulation of ENG 2 0.07 1.11 1.68
6 INT199504 ENG Positive_regulation of Oprm1 1 0.01 0.87 1.68
7 INT45307 ENG Positive_regulation of Localization of Avp 1 0.00 0 1.45
8 INT15846 Crh Positive_regulation of Localization of ENG 3 0.07 0.42 1.38
9 INT31444 ENG Positive_regulation of Prl 1 0.01 0 1.14
10 INT134213 CRH Positive_regulation of Gene_expression of ENG 1 0.13 0.61 1.03
11 INT32187 Binding of ENG and Negative_regulation of Localization of LH 1 0.01 0 0.91
12 INT291011 Pomc Regulation of Gene_expression of ENG 1 0.08 0.86 0.91
13 INT111924 Cpb2 Negative_regulation of Positive_regulation of Plg 1 0.02 1.29 0.9
14 INT153516 PLG Positive_regulation of Pas5a 1 0.57 0.05 0.83
15 INT32719 ENG Regulation of LH 2 0.00 0 0.64
16 INT99728 Binding of F13A1 and PLG 4 0.02 2.51 0.63
17 INT31443 ENG Positive_regulation of Localization of Pomc 1 0.00 0 0.63
18 INT99736 Binding of PLG and Serpinf2 1 0.01 0.73 0.55
19 INT134214 CRH Regulation of Localization of ENG 1 0.14 0.39 0.53
20 INT32151 ENG Positive_regulation of Gene_expression of IFNA1 1 0.37 0 0.53
21 INT32291 ENG Negative_regulation of LH 2 0.00 0 0.52
22 INT30618 Slc3a1 Regulation of ENG 1 0.00 0 0.5
23 INT30619 Pomc Regulation of ENG 1 0.00 0 0.5
24 INT102214 ENG Negative_regulation of HP 1 0.01 0 0.49
25 INT60872 Binding of ENG and Abat 1 0.00 0 0.49
26 INT60871 ENG Regulation of Localization of LH 1 0.00 0 0.49
27 INT43695 ENG Regulation of Regulation of Prl 1 0.00 0 0.47
28 INT60870 ENG Negative_regulation of Localization of LH 1 0.00 0 0.47
29 INT102213 Binding of ENG and HP 1 0.01 0 0.47
30 INT202516 Positive_regulation of Binding of ENG and Penk 1 0.03 0.58 0.42
31 INT202515 Binding of ENG and Penk 1 0.02 0.57 0.41
32 INT32720 Negative_regulation of ENG Regulation of LH 1 0.00 0 0.41
33 INT142286 Binding of PLG and Plat 2 0.52 0.7 0.31
34 INT55404 Binding of ENG and Th 1 0.02 0 0.3
35 INT29137 ENG Regulation of POMC 1 0.00 0 0.28
36 INT29139 ENG Regulation of Oprl1 1 0.00 0 0.28
37 INT171050 Negative_regulation of F13A1 Regulation of PLG 1 0.02 0.55 0.28
38 INT171048 F13A1 Regulation of PLG 1 0.02 0.55 0.27
39 INT32156 Binding of ENG and Oprd1 1 0.00 0 0.26
40 INT32149 Binding of ENG and LLGL1 1 0.11 0 0.26
41 INT76081 Plg Positive_regulation of Gene_expression of IL6 1 0.03 0.18 0.26
42 INT76082 Plg Regulation of Gene_expression of IL6 1 0.01 0.19 0.26
43 INT180964 PLG Positive_regulation of MMP13 1 0.24 0.45 0.25
44 INT31097 Binding of Penk and Plg 1 0.29 0.07 0.24
45 INT43713 ENG Regulation of Prl 1 0.00 0 0.23
46 INT216911 Positive_regulation of P2rx7 Positive_regulation of Localization of Plg 1 0.02 0.13 0.23
47 INT255259 Binding of Plg and Tsp1 1 0.05 0.84 0.2
48 INT27675 Plg Positive_regulation of Protein_catabolism of F13A1 1 0.00 0.75 0.2
49 INT99735 Binding of PLG and Ppp1r1a 1 0.00 0.24 0.19
50 INT99727 Binding of SERPINE1 and PLG 1 0.02 0.24 0.19
51 INT212084 NOXO1 Positive_regulation of CDKN1A 1 0.06 0.53 0.19
52 INT46306 Asrgl1 Positive_regulation of Negative_regulation of Plg 1 0.01 1.07 0.19
53 INT270416 PLAT Negative_regulation of Positive_regulation of PLG 1 0.00 0.48 0.15
54 INT319119 SERPINE1 Negative_regulation of Positive_regulation of PLG 1 0.11 1.56 0.15
55 INT188249 PLAT Positive_regulation of PLG 2 0.10 0.86 0.14
56 INT174917 Negative_regulation of PLG Negative_regulation of Positive_regulation of FUT1 1 0.01 0.68 0.13
57 INT32294 ENG Positive_regulation of Trh 1 0.01 0 0.13
58 INT99732 Serpinf2 Negative_regulation of PLG 1 0.01 0.24 0.12
59 INT307075 Tbxas1 Negative_regulation of Negative_regulation of PLG 1 0.01 1.22 0.11
60 INT232017 F12 Positive_regulation of PLG 1 0.03 0.52 0.11
61 INT60399 ENG Regulation of Localization of Prl 1 0.04 0.57 0.1
62 INT158011 KLRF1 Positive_regulation of ENG 1 0.03 0.39 0.09
63 INT348686 Plg Positive_regulation of Protein_catabolism of Ecm1 1 0.02 0.17 0.09
64 INT158012 Binding of ENG and FLT1 1 0.21 0.39 0.09
65 INT232010 PLG Positive_regulation of TRGC1 1 0.08 0.51 0.09
66 INT32290 ENG Regulation of Positive_regulation of Trh 1 0.01 0 0.09
67 INT247079 Gene_expression of PLAT Positive_regulation of Gene_expression of PLG 1 0.36 0.3 0.07
68 INT25491 TFPI Regulation of Localization of ENG 1 0.27 0.31 0.06
69 INT259635 Plau Positive_regulation of PLG 1 0.13 0.22 0.06
70 INT25490 Binding of ENG and TFPI 1 0.27 0.4 0.06
71 INT58586 IFNG Positive_regulation of Gene_expression of PLG 1 0.41 0.38 0.06
72 INT245833 Plg Negative_regulation of VEGFA 1 0.05 2.21 0.04
73 INT240769 Positive_regulation of Binding of F13A1 and PLG 1 0.02 0.9 0.04
74 INT245826 Plg Regulation of Gene_expression of Serpinf1 1 0.09 1.57 0.04
75 INT32293 ENG Regulation of Positive_regulation of Gnrh1 1 0.00 0 0.04
76 INT328498 Sumo1 Positive_regulation of Plg 1 0.07 0.61 0.04
77 INT180955 PLG Regulation of Positive_regulation of TIMP1 1 0.21 0.38 0.04
78 INT180956 PLG Regulation of Positive_regulation of MMP13 1 0.32 0.38 0.04
79 INT245825 Plg Positive_regulation of Gene_expression of Serpinf1 1 0.21 1.01 0.04
80 INT32297 ENG Regulation of Positive_regulation of LH 1 0.00 0 0.04
81 INT207997 Bel Regulation of Gene_expression of Plg 1 0.00 0 0.04
82 INT180957 Binding of PLG and Regulation of Positive_regulation of MMP13 1 0.14 0.38 0.04
83 INT294217 Binding of PLG and Ldlr 1 0.33 0.06 0.04
84 INT320786 Binding of Eng and Kdr 1 0.04 1.17 0.04
85 INT57787 Binding of PLG and SGCG 1 0.02 0.13 0.03
86 INT79163 Binding of PLG and CLEC3B 2 0.29 3.18 0
87 INT79164 CLEC3B Positive_regulation of Positive_regulation of PLG 2 0.78 2.67 0
88 INT340614 Binding of ENG and MMP9 1 0.16 0.14 0
89 INT245834 Plg Regulation of Gene_expression of VEGFA 1 0.04 1.11 0
90 INT120661 Positive_regulation of Plg Positive_regulation of Serpine1 1 0.00 0 0
91 INT314373 Binding of Cd34 and Eng 1 0.08 0.9 0
92 INT294202 Binding of Plat and Plg 1 0.11 0 0
93 INT272300 Binding of LPA and PLG 1 0.09 0.66 0
94 INT272301 Negative_regulation of Binding of LPA and PLG 1 0.08 0.68 0
95 INT32148 POMC Regulation of ENG 1 0.24 0 0
96 INT245823 Binding of Plg and Plg 1 0.03 1.41 0
97 INT337630 Binding of PLAT and PLG 1 0.07 0.69 0
98 INT15847 Avp Positive_regulation of Localization of ENG 1 0.07 0 0
99 INT57794 Binding of PLAT and Plg 1 0.00 0.15 0
100 INT337627 Binding of CLEC3B and Positive_regulation of Positive_regulation of PLG 1 0.52 1.22 0
101 INT340613 Binding of COL4A4 and ENG 1 0.07 0.14 0
102 INT294219 PLG Positive_regulation of Grin1 1 0.44 0 0
103 INT337628 Binding of HGF and PLG 1 0.17 0.69 0
104 INT329746 ENG Positive_regulation of SMAD1 1 0.15 0.44 0
105 INT342910 LPA Negative_regulation of PLG 1 0.15 0.44 0
106 INT57792 Binding of Plg and Plat 1 0.00 0.07 0
107 INT245822 Plg Negative_regulation of Phosphorylation of Mapk3 1 0.10 2.09 0
108 INT228288 Binding of ENG and Ptprc 1 0.06 0.25 0
109 INT79162 Binding of TNC and PLG 1 0.28 0.23 0
110 INT245827 Plg Negative_regulation of Vegfa 1 0.14 1.3 0
111 INT228287 Binding of ENG and Cd14 1 0.20 0.25 0
112 INT251891 Serpine1 Negative_regulation of Plg 1 0.12 3.13 0
113 INT160761 Cma1 Regulation of Positive_regulation of ENG 1 0.01 0.07 0
114 INT337632 PLAU Positive_regulation of PLG 1 0.07 0.36 0
115 INT307074 Binding of Plg and Tbxas1 1 0.00 0.14 0
116 INT35139 SPANXC Regulation of PLG 1 0.01 0 0
117 INT120660 Plg Positive_regulation of Serpine1 1 0.00 0 0
118 INT212083 Binding of SSRP1 and NOXO1 1 0.02 0.67 0
119 INT245835 Plg Negative_regulation of Gene_expression of VEGFA 1 0.05 3.51 0
120 INT57795 Binding of F13A1 and Plg 1 0.00 0.07 0
121 INT245824 Plg Regulation of Negative_regulation of Ocln 1 0.06 0.57 0
122 INT314372 Binding of Eng and Ptprc 1 0.04 0.84 0
123 INT151902 PLG Positive_regulation of Protein_catabolism of F13A1 1 0.00 0.16 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for extracellular matrix disassembly. They are ordered first by their pain relevance and then by number of times they were reported in extracellular matrix disassembly. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT7675 Gene_expression of ENG 146 0.77 45.35 34.6
2 INT11764 Positive_regulation of ENG 78 0.61 27.65 33.69
3 INT10799 Localization of ENG 63 0.78 18.67 27.28
4 INT7674 Regulation of ENG 42 0.30 11.41 14.44
5 INT7673 Negative_regulation of ENG 31 0.42 7.9 8.61
6 INT10145 Gene_expression of Plg 28 0.62 12.68 7.46
7 INT16389 Gene_expression of Plg 80 0.67 36.88 6.74
8 INT10610 Negative_regulation of Plg 22 0.40 11.81 6.74
9 INT23375 Binding of ENG 17 0.47 6.02 6.46
10 INT4561 Gene_expression of PLG 32 0.75 17.59 6.21
11 INT12104 Positive_regulation of PLG 45 0.68 28.94 4.81
12 INT16478 Positive_regulation of Plg 29 0.45 18.07 4.07
13 INT17324 Negative_regulation of Plg 26 0.38 13.5 4.05
14 INT16644 Positive_regulation of Plg 16 0.60 6.38 3.62
15 INT15844 Positive_regulation of Localization of ENG 7 0.67 4.2 3.47
16 INT25344 Localization of Plg 10 0.57 5 3.27
17 INT16390 Regulation of Plg 13 0.48 6.72 3.2
18 INT32222 Negative_regulation of Gene_expression of ENG 9 0.37 2.23 2.89
19 INT22071 Positive_regulation of Gene_expression of ENG 13 0.50 5.44 2.62
20 INT4560 Protein_catabolism of PLG 18 0.96 11.64 2.32
21 INT13997 Regulation of Gene_expression of ENG 11 0.36 3.31 2.31
22 INT12133 Regulation of Localization of ENG 3 0.03 0.57 2.24
23 INT17268 Localization of PLG 9 0.78 11.71 2.06
24 INT32135 Positive_regulation of Positive_regulation of ENG 2 0.02 0.98 1.99
25 INT35146 Negative_regulation of PLG 27 0.57 17.63 1.98
26 INT59283 Positive_regulation of Gene_expression of Plg 6 0.25 2.36 1.97
27 INT17326 Binding of Plg 14 0.43 11.72 1.94
28 INT15845 Negative_regulation of Localization of ENG 3 0.05 0.76 1.71
29 INT16388 Protein_catabolism of Plg 6 0.79 3.46 1.4
30 INT17325 Negative_regulation of Protein_catabolism of Plg 1 0.32 0 1.37
31 INT41381 Positive_regulation of Gene_expression of Plg 8 0.44 3.29 1.3
32 INT32717 Negative_regulation of Regulation of ENG 3 0.00 0.43 1.25
33 INT90938 Gene_expression of Eng 48 0.72 15.76 1.24
34 INT18422 Regulation of Plg 6 0.45 1.71 1.22
35 INT51863 Negative_regulation of Negative_regulation of ENG 2 0.04 0.51 1.13
36 INT97768 Positive_regulation of Gene_expression of PLG 5 0.49 2.49 0.89
37 INT35141 Regulation of PLG 6 0.44 2.64 0.85
38 INT30926 Regulation of Gene_expression of Plg 11 0.45 2.14 0.78
39 INT79169 Binding of PLG 10 0.47 5.88 0.72
40 INT13702 Protein_catabolism of Plg 4 0.12 0.88 0.69
41 INT11763 Positive_regulation of Regulation of ENG 1 0.01 0.97 0.64
42 INT90939 Positive_regulation of Eng 9 0.64 4.62 0.57
43 INT46340 Positive_regulation of Negative_regulation of Plg 2 0.15 1.71 0.54
44 INT58591 Negative_regulation of Positive_regulation of PLG 4 0.42 2.46 0.51
45 INT96864 Localization of Plg 7 0.67 2.07 0.48
46 INT151903 Positive_regulation of Positive_regulation of PLG 3 0.45 1.53 0.48
47 INT17269 Negative_regulation of Localization of PLG 1 0.03 0.54 0.45
48 INT158577 Negative_regulation of Gene_expression of Plg 7 0.17 3.36 0.43
49 INT39640 Negative_regulation of Gene_expression of Plg 2 0.25 1.13 0.39
50 INT92242 Binding of Plg 2 0.32 1.09 0.37
51 INT96865 Regulation of Positive_regulation of Plg 1 0.01 0.05 0.36
52 INT152276 Regulation of Positive_regulation of PLG 2 0.44 1.53 0.32
53 INT180969 Positive_regulation of Protein_catabolism of PLG 1 0.36 0.47 0.27
54 INT200522 Negative_regulation of Negative_regulation of PLG 2 0.41 1.53 0.24
55 INT153877 Positive_regulation of Binding of Plg 1 0.44 0.41 0.23
56 INT216887 Positive_regulation of Localization of Plg 1 0.04 0.13 0.22
57 INT212089 Gene_expression of NOXO1 4 0.10 2.05 0.21
58 INT25345 Negative_regulation of Localization of Plg 1 0.08 0.81 0.19
59 INT45721 Transcription of Plg 1 0.20 0.16 0.18
60 INT131558 Protein_catabolism of ENG 1 0.01 0 0.18
61 INT39633 Negative_regulation of Positive_regulation of Plg 2 0.22 0.4 0.14
62 INT90940 Binding of Eng 5 0.35 1.92 0.13
63 INT216835 Positive_regulation of Localization of Plg 1 0.03 0.27 0.11
64 INT200599 Positive_regulation of Positive_regulation of Plg 3 0.07 2.11 0.1
65 INT26064 Regulation of Positive_regulation of ENG 1 0.01 0.1 0.09
66 INT90941 Negative_regulation of Eng 1 0.31 0.25 0.09
67 INT39641 Regulation of Gene_expression of Plg 1 0.26 0 0.08
68 INT35144 Negative_regulation of Gene_expression of PLG 3 0.29 0.98 0.06
69 INT265338 Regulation of Eng 2 0.42 0.94 0.05
70 INT328495 Positive_regulation of Binding of Plg 1 0.13 0.62 0.04
71 INT328496 Positive_regulation of Protein_catabolism of Plg 1 0.14 0.68 0.03
72 INT245858 Positive_regulation of Gene_expression of Eng 1 0.12 0 0.03
73 INT289876 Localization of Eng 3 0.44 0.59 0
74 INT190471 Transcription of ENG 3 0.21 1.76 0
75 INT265314 Regulation of Gene_expression of Eng 2 0.42 0.68 0
76 INT265324 Negative_regulation of Gene_expression of Eng 2 0.40 0.9 0
77 INT331173 Negative_regulation of Localization of Plg 1 0.02 0.67 0
78 INT212098 Positive_regulation of NOXO1 1 0.06 0.88 0
79 INT212099 Negative_regulation of Gene_expression of NOXO1 1 0.05 0.76 0
80 INT197394 Protein_catabolism of Eng 1 0.07 0.13 0
81 INT245808 Phosphorylation of Plg 1 0.25 0.68 0
82 INT212087 Negative_regulation of NOXO1 1 0.05 0.47 0
83 INT310171 Phosphorylation of Eng 1 0.24 0.5 0
84 INT283545 Regulation of Binding of Plg 1 0.13 0 0
85 INT212097 Regulation of Gene_expression of NOXO1 1 0.06 0.71 0
86 INT256230 Positive_regulation of Gene_expression of NOXO1 1 0.09 0.75 0
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