GO:0023014

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Name signal transduction by phosphorylation
Categary Process
Go Slim No
Go Link GO:0023014
Unique Molecular Interactions 1584
Total Molecular Interactions 1981
Total Single Events 16909
Pain Genes Associated 38

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for signal transduction by phosphorylation. They are ordered first by their pain relevance and then by number of times they were reported for signal transduction by phosphorylation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
2 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
3 INT128293 Negative_regulation of Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.34
4 INT128292 Nts Positive_regulation of Insr 1 0.03 0.99 3.34
5 INT128291 Vom1r68 Positive_regulation of Insr 1 0.00 0.99 3.33
6 INT128294 Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.33
7 INT223866 Ltp Positive_regulation of Positive_regulation of Mapk1 2 0.46 0.75 2.61
8 INT314205 Ngf Positive_regulation of Phosphorylation of Mapk14 1 0.43 1.24 2.3
9 INT196586 Negative_regulation of Mapk14 Negative_regulation of TNF 2 0.04 2.02 2.08
10 INT281084 Prkaca Positive_regulation of Mapk1 2 0.25 0 2.06
11 INT314210 Ngf Regulation of Phosphorylation of Mapk14 1 0.34 0.85 1.84
12 INT169468 Binding of Egfr and Spink3 1 0.37 3.73 1.83
13 INT168715 Mapk8 Negative_regulation of Oprk1 1 0.18 0.26 1.75
14 INT168716 Mapk8 Negative_regulation of Insrr 1 0.01 0.25 1.75
15 INT346217 Braf Positive_regulation of Phosphorylation of Map2k1 1 0.22 3.23 1.72
16 INT169464 Akt1 Positive_regulation of Egfr 1 0.28 1.63 1.7
17 INT167427 Mapk8 Regulation of Regulation of Tnf 1 0.26 2.83 1.7
18 INT21570 Binding of Cck and Mapk8 1 0.06 0 1.6
19 INT158774 Mapk14 Regulation of Il6 1 0.11 0.08 1.57
20 INT89011 Lep Positive_regulation of Insr 1 0.19 2.41 1.57
21 INT314214 Mapk14 Positive_regulation of Ngf 1 0.43 1.97 1.56
22 INT169800 Negative_regulation of Adrbk1 Positive_regulation of Positive_regulation of Mapk1 1 0.39 1.04 1.45
23 INT261831 Mapk1 Negative_regulation of Hspg2 1 0.00 1.26 1.42
24 INT148450 Gene_expression of Inhbe Positive_regulation of Mapk1 1 0.07 1.35 1.41
25 INT161670 H2-M3 Positive_regulation of Positive_regulation of Mapk1 1 0.14 0.73 1.41
26 INT161511 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il1b 1 0.41 0.27 1.36
27 INT161513 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Tnf 1 0.33 0.27 1.35
28 INT106062 Positive_regulation of Oprl1 Positive_regulation of Mapk1 1 0.13 0.16 1.35
29 INT314213 Mapk14 Positive_regulation of Agtrap 1 0.04 1.15 1.34
30 INT300864 Ngf Positive_regulation of Mapk14 2 0.60 1.38 1.32
31 INT314209 Ngf Positive_regulation of Binding of Mapk14 1 0.43 1.48 1.27
32 INT161508 Tlr4 Positive_regulation of Mapk14 2 0.19 0.46 1.24
33 INT314198 Mapk14 Positive_regulation of Gene_expression of Trpv1 1 0.48 1.09 1.24
34 INT314212 Mapk14 Positive_regulation of Gene_expression of Agtrap 1 0.06 1.09 1.24
35 INT328743 TNF Positive_regulation of Mapk14 1 0.04 1.4 1.21
36 INT166388 Binding of Gnb2l1 and Mapk1 1 0.49 0.49 1.21
37 INT328742 Il1 Positive_regulation of Mapk14 1 0.01 1.4 1.2
38 INT139736 Htr1a Positive_regulation of Mapk3 1 0.54 0.13 1.19
39 INT169557 Cacna1h Positive_regulation of Mapk1 1 0.07 0.91 1.17
40 INT161509 Tlr4 Positive_regulation of Mapk8 1 0.15 0.3 1.16
41 INT161510 Tlr4 Positive_regulation of Mapk1 1 0.14 0.3 1.16
42 INT314206 Mapk14 Positive_regulation of Pax3 1 0.08 0.67 1.15
43 INT190771 Gene_expression of Il4 Negative_regulation of Gene_expression of Mapk14 1 0.15 1.14 1.13
44 INT190770 Il4 Negative_regulation of Gene_expression of Mapk14 1 0.20 1.14 1.13
45 INT223154 Negative_regulation of Mapk14 Negative_regulation of Localization of Il6 1 0.19 1.13 1.11
46 INT173059 Binding of KDR and VEGFA 43 0.43 29.63 1.1
47 INT139704 Tnf Positive_regulation of Mapk14 1 0.22 0.73 1.1
48 INT167429 Negative_regulation of Mapk8 Negative_regulation of RYBP 1 0.01 1.11 1.09
49 INT151825 Tnf Positive_regulation of Mapk14 1 0.22 1.72 1.09
50 INT283934 Phax Negative_regulation of Positive_regulation of Mapk14 1 0.03 2.06 1.09
51 INT139703 Tnf Positive_regulation of Mapk8 1 0.32 0.73 1.08
52 INT223875 Negative_regulation of Mapk8 Negative_regulation of Positive_regulation of Ltp 1 0.31 0 1.07
53 INT292531 Il10 Negative_regulation of Positive_regulation of Mapk14 1 0.15 1.13 1.06
54 INT154846 Negative_regulation of Mapk14 Negative_regulation of Positive_regulation of Trpv1 1 0.23 0.07 1.05
55 INT352456 Dusp1 Negative_regulation of Mapk14 1 0.03 1.31 1.03
56 INT229914 Egr1 Positive_regulation of Phosphorylation of Mapk3 1 0.46 1.03 1.02
57 INT75486 Binding of Tgfbr1 and Tgfbr2 1 0.10 1.94 1.02
58 INT283932 Positive_regulation of Mapk14 Regulation of Gene_expression of Trpv1 1 0.14 1.28 0.99
59 INT308169 Negative_regulation of Mapk14 Negative_regulation of Ltp 1 0.01 0.79 0.95
60 INT223871 Ltp Positive_regulation of Gene_expression of Mapk1 1 0.33 0 0.93
61 INT145853 Casp1 Positive_regulation of Mapk14 1 0.02 0.68 0.93
62 INT318461 Nnat Positive_regulation of Mapk14 1 0.05 0.97 0.92
63 INT352465 Dusp1 Negative_regulation of Gene_expression of Mapk14 1 0.03 1.09 0.92
64 INT302828 Mapkapk5 Positive_regulation of Mapk1 1 0.07 1.38 0.91
65 INT135446 Map2k1 Positive_regulation of Mapk3 1 0.54 0.25 0.91
66 INT352444 Dusp1 Negative_regulation of Phosphorylation of Mapk14 1 0.03 1.09 0.91
67 INT169469 Binding of Egfr and Tgfa 1 0.19 1.87 0.91
68 INT314207 Ngf Negative_regulation of Phosphorylation of Mapk14 1 0.33 0.4 0.88
69 INT97738 Mdk Positive_regulation of Mapk3 1 0.08 0.66 0.87
70 INT97735 Trib3 Positive_regulation of Mapk3 1 0.05 0.66 0.87
71 INT288201 Mapk14 Positive_regulation of Cish 1 0.03 0.06 0.82
72 INT128590 Mapk14 Regulation of Nav1 1 0.21 0.25 0.82
73 INT262572 Ngf Positive_regulation of Mapk1 2 0.04 0.52 0.81
74 INT168648 Positive_regulation of Cx3cr1 Positive_regulation of Phosphorylation of Mapk14 1 0.35 1.51 0.8
75 INT222024 Mapk8 Regulation of Mapk14 2 0.17 0.83 0.79
76 INT168647 Cx3cr1 Positive_regulation of Phosphorylation of Mapk14 1 0.52 1.51 0.79
77 INT161520 H2-M3 Regulation of Positive_regulation of Mapk1 1 0.09 0.47 0.79
78 INT132977 Tac1 Positive_regulation of Mapk1 1 0.06 0.17 0.79
79 INT117909 Mastl Positive_regulation of Mapk1 1 0.04 0 0.79
80 INT196577 Negative_regulation of Mapk14 Negative_regulation of Il6 1 0.13 0.45 0.78
81 INT152234 Mapk8 Positive_regulation of Localization of Nfkb1 1 0.33 0.26 0.78
82 INT152235 Mapk8 Positive_regulation of Localization of Tlr4 1 0.38 0.26 0.78
83 INT196574 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il6 1 0.13 0.45 0.78
84 INT196575 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il1a 1 0.04 0.44 0.77
85 INT136795 Spp1 Positive_regulation of Chuk 1 0.11 1.54 0.77
86 INT146780 Positive_regulation of Fgfr1 Positive_regulation of Mapk14 1 0.34 0.95 0.77
87 INT161945 TGFB2 Positive_regulation of TGFBR1 1 0.08 0.99 0.76
88 INT163830 ERBB2 Positive_regulation of MAPK1 1 0.06 1.63 0.76
89 INT76499 Binding of Insr and Adora2a 1 0.08 0 0.76
90 INT155096 Stat3 Regulation of Mapk3 1 0.36 0.45 0.76
91 INT262577 Localization of Ngf Positive_regulation of Positive_regulation of Mapk14 1 0.05 0.92 0.75
92 INT128815 Mapk14 Regulation of Gene_expression of Nos2 1 0.21 0.46 0.74
93 INT98179 Aap Positive_regulation of Mapk8 1 0.01 0.75 0.74
94 INT161949 TGFB2 Positive_regulation of Gene_expression of Ngf 1 0.21 0.97 0.74
95 INT168420 Positive_regulation of Mapk8 Positive_regulation of Phosphorylation of Jun 1 0.30 0.88 0.74
96 INT128813 Mapk8 Regulation of Gene_expression of Nos2 1 0.23 0.46 0.74
97 INT128404 Mapk1 Positive_regulation of Phosphorylation of Gja1 1 0.65 0.73 0.73
98 INT168911 Grm5 Regulation of Mapk3 1 0.17 0.78 0.71
99 INT223873 Mapk8 Regulation of Positive_regulation of Ltp 1 0.24 0 0.71
100 INT166386 Mapk1 Regulation of Gene_expression of Gnb2l1 1 0.46 0.25 0.7
101 INT148452 Inhbe Regulation of Acvrl1 1 0.01 0.69 0.69
102 INT223868 Mapk1 Positive_regulation of Creb1 2 0.17 0.34 0.68
103 INT223876 Mapk1 Positive_regulation of Atf6b 1 0.10 0 0.68
104 INT164783 Positive_regulation of Mapk14 Regulation of Gene_expression of Cx3cr1 1 0.19 0.81 0.68
105 INT223869 Mapk8 Negative_regulation of Positive_regulation of Ltp 1 0.20 0 0.68
106 INT155457 Tnfrsf1a Positive_regulation of Mapk14 1 0.20 1.17 0.67
107 INT314199 Mapk14 Regulation of Tnf 1 0.26 0.71 0.67
108 INT148139 Phosphorylation of Mapk14 Positive_regulation of Positive_regulation of Tnf 1 0.46 0.98 0.66
109 INT211915 Fig4 Positive_regulation of Mapk3 1 0.12 0.25 0.66
110 INT148138 Mapk14 Positive_regulation of Positive_regulation of Tnf 1 0.64 0.98 0.66
111 INT211916 Fig4 Positive_regulation of Mapk1 1 0.13 0.25 0.66
112 INT191332 AMPH Positive_regulation of Mapk1 1 0.76 0 0.66
113 INT110458 Binding of Atf2 and Mapk8 1 0.35 0 0.66
114 INT330046 Mapk8 Negative_regulation of Prkcg 1 0.13 0.4 0.66
115 INT166299 Binding of Mapk14 and Gpbar1 1 0.13 0.64 0.65
116 INT166302 Negative_regulation of Binding of Mapk14 and Gpbar1 1 0.12 0.64 0.65
117 INT148173 Positive_regulation of Grm5 Positive_regulation of Phosphorylation of Mapk1 1 0.01 0.45 0.65
118 INT288202 Negative_regulation of Cd14 Positive_regulation of Positive_regulation of Mapk14 1 0.09 1.08 0.64
119 INT165047 Mapk14 Positive_regulation of Gene_expression of Tnf 1 0.73 0.8 0.63
120 INT223155 Binding of Mapk14 and Stat4 1 0.36 0.84 0.63
121 INT148137 Tnf Positive_regulation of Positive_regulation of Mapk14 1 0.46 1 0.63
122 INT100030 TNF Positive_regulation of Mapk8 1 0.12 1.57 0.63
123 INT281092 Adcy1 Positive_regulation of Mapk1 1 0.21 0 0.63
124 INT281090 Prkacb Positive_regulation of Mapk1 1 0.06 0 0.62
125 INT46493 Binding of Insr and Oxt 1 0.14 0 0.62
126 INT128812 Mapk8 Negative_regulation of Gene_expression of Nos2 1 0.19 0.37 0.61
127 INT128811 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Casp1 1 0.06 0.35 0.61
128 INT219280 Mapk14 Positive_regulation of Pla2g2a 1 0.33 0.46 0.61
129 INT308175 Negative_regulation of Mapk14 Negative_regulation of Localization of TNF 1 0.03 0.89 0.61
130 INT314197 Mapk14 Positive_regulation of Positive_regulation of Tnf 1 0.48 1.16 0.61
131 INT219282 Mapk14 Positive_regulation of Pla2g1b 1 0.18 0.46 0.61
132 INT166385 Binding of Araf and Gnb2l1 1 0.23 0.24 0.6
133 INT276217 Pdk1 Positive_regulation of Positive_regulation of Insr 1 0.05 0.1 0.6
134 INT89010 Arc Positive_regulation of Insr 1 0.08 0.86 0.59
135 INT223158 Mapk3 Regulation of Gene_expression of Mapk14 1 0.48 1.33 0.59
136 INT89012 DST Positive_regulation of Insr 1 0.01 0.86 0.59
137 INT178437 Mapk8 Positive_regulation of Jun 3 0.40 2.69 0.58
138 INT291262 Positive_regulation of INS Positive_regulation of Mapk1 1 0.03 1.78 0.58
139 INT291258 INS Positive_regulation of Mapk1 1 0.04 1.77 0.58
140 INT148172 Mapk1 Positive_regulation of Phosphorylation of Kcnd2 1 0.49 0.55 0.57
141 INT314208 Trap1 Positive_regulation of Mapk14 1 0.10 0.66 0.57
142 INT110032 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il12a 1 0.36 0 0.57
143 INT196585 Mapk14 Regulation of TNF 1 0.02 0.36 0.55
144 INT328744 TNF Regulation of Positive_regulation of Mapk14 1 0.02 0.81 0.55
145 INT161251 Ptgs2 Regulation of Mapk14 1 0.16 0.82 0.54
146 INT161250 Trib3 Regulation of Mapk14 1 0.04 0.81 0.54
147 INT200913 Dio1 Positive_regulation of Mapk8 1 0.00 0 0.53
148 INT313376 Cnr1 Positive_regulation of Phosphorylation of Mapk14 1 0.20 0.38 0.5
149 INT356286 Ngf Regulation of Positive_regulation of Mapk1 1 0.03 0.76 0.5
150 INT104960 Ephb1 Regulation of Positive_regulation of Mapk14 1 0.15 0.42 0.5
151 INT313375 Cnr2 Positive_regulation of Phosphorylation of Mapk14 1 0.18 0.39 0.5
152 INT356279 Gdnf Regulation of Positive_regulation of Mapk1 1 0.03 0.76 0.5
153 INT104961 Mapk14 Regulation of Positive_regulation of Ephb1 1 0.15 0.42 0.5
154 INT110031 Positive_regulation of Adra2c Positive_regulation of Mapk14 1 0.25 0 0.48
155 INT110030 Adra2c Positive_regulation of Mapk14 1 0.25 0 0.48
156 INT110034 Negative_regulation of Adra2c Positive_regulation of Mapk14 1 0.23 0 0.48
157 INT237154 LGALS4 Positive_regulation of KIT 1 0.10 1.99 0.47
158 INT131504 Ngf Positive_regulation of Positive_regulation of Mapk14 1 0.14 0.2 0.47
159 INT131507 Ngf Positive_regulation of Mapk14 1 0.13 0.2 0.47
160 INT265646 Binding of Mapk1 and Mapk14 1 0.01 1.53 0.46
161 INT254225 Mapk14 Positive_regulation of Mapk8 1 0.02 0.87 0.46
162 INT37599 Ace Regulation of Localization of Insr 1 0.18 0 0.46
163 INT254198 Mapk1 Positive_regulation of Mapk8 1 0.01 0.87 0.46
164 INT254216 Mapk14 Positive_regulation of Mapk1 1 0.02 0.87 0.46
165 INT72089 TGFB2 Positive_regulation of POMC 1 0.11 0 0.46
166 INT254222 Mapk1 Positive_regulation of Mapk14 1 0.02 0.86 0.46
167 INT190870 BDNF Positive_regulation of Phosphorylation of Mapk1 1 0.12 0.54 0.44
168 INT313378 Trib3 Regulation of Phosphorylation of Mapk14 1 0.01 0.37 0.44
169 INT223863 Positive_regulation of Mapk1 Positive_regulation of Positive_regulation of Ltp 1 0.31 0 0.43
170 INT264473 Il1a Positive_regulation of Mapk1 1 0.00 0 0.43
171 INT264476 Il1a Positive_regulation of Gene_expression of Mapk8 1 0.04 0 0.43
172 INT265647 Binding of Ephb1 and Mapk1 1 0.00 1.48 0.43
173 INT264471 Il1a Positive_regulation of Gene_expression of Mapk1 1 0.01 0 0.43
174 INT264475 Il1a Positive_regulation of Mapk8 1 0.04 0 0.43
175 INT264479 Il1a Positive_regulation of Gene_expression of Mapk14 1 0.02 0 0.43
176 INT124088 Rab38 Negative_regulation of Mapk14 1 0.00 0.89 0.42
177 INT331799 IL8 Negative_regulation of Mapk14 1 0.01 1.6 0.42
178 INT201610 Binding of Mc1r and Braf 1 0.31 0.75 0.42
179 INT161521 Negative_regulation of H2-M3 Positive_regulation of Mapk1 1 0.14 0.41 0.42
180 INT131506 Rac1 Regulation of Positive_regulation of Mapk14 1 0.19 0.39 0.42
181 INT274864 Negative_regulation of Mapk1 Negative_regulation of Gene_expression of TNF 1 0.05 1.15 0.41
182 INT161522 H2-M3 Positive_regulation of Mapk1 1 0.15 0.41 0.41
183 INT274867 Negative_regulation of Mapk1 Negative_regulation of TNF 1 0.03 1.15 0.41
184 INT319312 Socs4 Positive_regulation of Mapk8 1 0.05 0.68 0.41
185 INT124260 Plat Positive_regulation of Mapk1 1 0.14 0.81 0.41
186 INT319313 Socs4 Positive_regulation of Mapk14 1 0.02 0.68 0.41
187 INT95402 Mapk14 Regulation of Positive_regulation of Trib3 1 0.06 0.19 0.41
188 INT75489 Binding of SGCG and Tgfbr2 1 0.23 0.83 0.41
189 INT75487 Binding of TGFB1 and Tgfbr2 1 0.31 0.83 0.41
190 INT346222 Positive_regulation of Braf Positive_regulation of Map2k1 1 0.15 0.67 0.39
191 INT152238 Mapk14 Positive_regulation of Localization of Tlr4 1 0.29 0.13 0.39
192 INT346221 Positive_regulation of Braf Positive_regulation of Positive_regulation of Map2k2 1 0.11 0.67 0.39
193 INT152237 Mapk1 Positive_regulation of Localization of Tlr4 1 0.33 0.13 0.39
194 INT346219 Positive_regulation of Braf Positive_regulation of Map2k2 1 0.11 0.67 0.39
195 INT152239 Mapk1 Positive_regulation of Localization of Nfkb1 1 0.29 0.13 0.39
196 INT152241 Mapk14 Positive_regulation of Localization of Nfkb1 1 0.25 0.13 0.39
197 INT163831 ERBB2 Positive_regulation of CCND1 1 0.03 0.82 0.38
198 INT179938 Negative_regulation of Mapk8 Negative_regulation of TNF 1 0.02 1.09 0.37
199 INT264482 Il1a Positive_regulation of Phosphorylation of Mapk14 1 0.02 0 0.37
200 INT187233 Positive_regulation of Mapk8 Positive_regulation of Jun 1 0.12 0.92 0.37

Single Events

The table below shows the top 100 pain related interactions that have been reported for signal transduction by phosphorylation. They are ordered first by their pain relevance and then by number of times they were reported in signal transduction by phosphorylation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94
2 INT94952 Positive_regulation of Mapk14 305 0.70 197.83 186.61
3 INT97701 Phosphorylation of Mapk14 191 0.82 115.33 100.46
4 INT94953 Negative_regulation of Mapk14 156 0.59 104.77 91.51
5 INT96917 Positive_regulation of Mapk14 261 0.70 173.29 88.79
6 INT5610 Positive_regulation of Insr 140 0.69 37.26 86.24
7 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46
8 INT99070 Gene_expression of Mapk14 147 0.78 103.99 79.59
9 INT48934 Positive_regulation of Mapk1 157 0.70 60.61 61.72
10 INT5034 Negative_regulation of Insr 100 0.55 28.08 54.5
11 INT96914 Phosphorylation of Mapk14 168 0.82 108.46 53.32
12 INT17915 Gene_expression of Insr 141 0.75 47.45 48.59
13 INT110023 Negative_regulation of Mapk14 127 0.59 84.27 45.42
14 INT92437 Positive_regulation of Phosphorylation of Mapk1 113 0.70 32.19 40.29
15 INT114751 Gene_expression of Mapk1 137 0.76 60.14 39.98
16 INT102611 Negative_regulation of Positive_regulation of Mapk1 74 0.58 35.57 39.37
17 INT48933 Gene_expression of Mapk3 93 0.75 44.39 37.92
18 INT97702 Positive_regulation of Phosphorylation of Mapk14 69 0.69 49.21 36.81
19 INT84260 Positive_regulation of Mapk8 124 0.69 72.84 35.98
20 INT109434 Phosphorylation of Mapk1 110 0.82 61.64 34.05
21 INT48924 Positive_regulation of Mapk3 107 0.67 50.53 34.05
22 INT95734 Phosphorylation of Mapk8 108 0.82 49.92 33.52
23 INT48925 Gene_expression of Mapk1 95 0.74 42.21 32.91
24 INT96913 Positive_regulation of Mapk8 179 0.69 130.44 32.2
25 INT117112 Negative_regulation of Mapk1 87 0.56 40.34 31.18
26 INT8691 Localization of Insr 85 0.80 9.27 30.32
27 INT72375 Phosphorylation of Mapk3 87 0.80 43.66 30.27
28 INT110020 Gene_expression of Mapk14 142 0.77 72.33 30.08
29 INT5300 Regulation of Insr 54 0.60 11.33 29.26
30 INT95788 Positive_regulation of Positive_regulation of Mapk1 83 0.69 24.75 25.84
31 INT106272 Positive_regulation of Positive_regulation of Mapk14 39 0.70 32.08 24.71
32 INT99069 Positive_regulation of Gene_expression of Mapk14 42 0.53 29.84 23.16
33 INT99068 Gene_expression of Mapk8 62 0.78 33.57 21.25
34 INT125411 Negative_regulation of Phosphorylation of Mapk14 31 0.57 18.55 19.98
35 INT111531 Negative_regulation of Phosphorylation of Mapk14 37 0.50 20 17.68
36 INT109316 Negative_regulation of Mapk8 72 0.59 50.59 17.24
37 INT104493 Negative_regulation of Mapk8 56 0.53 27.76 16.86
38 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79
39 INT95790 Regulation of Mapk1 55 0.61 21.17 16.31
40 INT111462 Negative_regulation of Phosphorylation of Mapk1 45 0.57 19.49 15.59
41 INT128401 Positive_regulation of Positive_regulation of Mapk1 39 0.70 10.88 15.38
42 INT96911 Positive_regulation of Phosphorylation of Mapk14 46 0.70 43.03 15.15
43 INT95738 Positive_regulation of Phosphorylation of Mapk8 40 0.70 23.46 13.88
44 INT111529 Phosphorylation of Mapk3 41 0.80 21.14 13.72
45 INT14768 Negative_regulation of Positive_regulation of Insr 16 0.56 5.51 13.59
46 INT104954 Negative_regulation of Positive_regulation of Mapk14 29 0.58 17.71 13.31
47 INT48927 Regulation of Mapk3 25 0.60 14.06 12.82
48 INT110025 Positive_regulation of Positive_regulation of Mapk14 39 0.63 20.67 12.71
49 INT150676 Positive_regulation of Gene_expression of Mapk1 30 0.45 10.06 12.37
50 INT119396 Regulation of Positive_regulation of Mapk1 22 0.61 7.88 12.25
51 INT117113 Regulation of Mapk14 28 0.45 16.71 11.99
52 INT109315 Gene_expression of Mapk8 70 0.78 45.46 11.65
53 INT118906 Regulation of Mapk14 21 0.44 17.95 11.63
54 INT96915 Phosphorylation of Mapk8 73 0.81 40.69 11.44
55 INT103923 Negative_regulation of Positive_regulation of Mapk14 23 0.53 13.95 10.64
56 INT48921 Regulation of Mapk1 25 0.49 19.51 10.41
57 INT87451 Positive_regulation of Mapk3 34 0.67 12.82 10.38
58 INT145695 Regulation of Mapk8 26 0.62 14.67 9.83
59 INT109432 Negative_regulation of Phosphorylation of Mapk1 19 0.54 7.01 8.98
60 INT111998 Positive_regulation of Positive_regulation of Mapk8 23 0.69 9.33 8.97
61 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95
62 INT111133 Negative_regulation of Mapk3 31 0.57 10.89 8.9
63 INT144430 Gene_expression of Erbb2 137 0.77 103.87 8.66
64 INT104481 Regulation of Mapk8 21 0.50 13.87 8.41
65 INT126848 Positive_regulation of Phosphorylation of Mapk1 30 0.50 15.94 8.34
66 INT96912 Positive_regulation of Phosphorylation of Mapk8 29 0.69 18.33 8.14
67 INT82762 Positive_regulation of Positive_regulation of Mapk3 23 0.67 7.72 7.91
68 INT159750 Negative_regulation of Gene_expression of Mapk14 15 0.40 10.88 7.81
69 INT72372 Positive_regulation of Phosphorylation of Mapk3 30 0.67 13.6 7.69
70 INT113705 Gene_expression of Egfr 228 0.78 149.05 7.59
71 INT99071 Positive_regulation of Gene_expression of Mapk8 16 0.55 9.87 7.58
72 INT30920 Positive_regulation of Gene_expression of Insr 14 0.66 2.91 7.32
73 INT128695 Regulation of Gene_expression of Mapk14 14 0.44 11.49 7.14
74 INT24622 Positive_regulation of Localization of Insr 15 0.69 0.32 6.85
75 INT48928 Positive_regulation of Gene_expression of Mapk1 19 0.48 9.38 6.59
76 INT48926 Positive_regulation of Gene_expression of Mapk3 12 0.46 6.02 6.13
77 INT128587 Localization of Mapk14 15 0.81 8.41 6.1
78 INT139964 Regulation of Phosphorylation of Mapk1 12 0.58 10.04 6.1
79 INT32611 Phosphorylation of Insr 13 0.80 4.18 5.77
80 INT113700 Positive_regulation of Chuk 30 0.41 21.17 5.69
81 INT112124 Positive_regulation of Egfr 71 0.70 47.82 5.61
82 INT14769 Positive_regulation of Positive_regulation of Insr 10 0.43 2.66 5.55
83 INT128922 Negative_regulation of Gene_expression of Mapk8 6 0.34 3.93 5.36
84 INT15376 Positive_regulation of Gene_expression of ERBB2 215 0.70 168.54 5.23
85 INT176524 Binding of Mapk14 19 0.43 12.54 5.21
86 INT135291 Positive_regulation of Positive_regulation of Mapk8 24 0.64 19.37 5.16
87 INT126047 Regulation of Phosphorylation of Mapk14 7 0.60 5.05 5.03
88 INT131717 Positive_regulation of Gene_expression of Mapk8 18 0.55 14.25 5.02
89 INT162365 Gene_expression of Map3k8 33 0.58 22.75 4.95
90 INT10115 Gene_expression of INSR 31 0.75 11.98 4.86
91 INT171472 Binding of Mapk14 10 0.36 6.79 4.83
92 INT199560 Binding of Braf 4 0.30 8.83 4.8
93 INT108919 Positive_regulation of Mapk9 9 0.34 3.55 4.74
94 INT24620 Negative_regulation of Gene_expression of Insr 14 0.39 6.98 4.61
95 INT103155 Gene_expression of KDR 78 0.66 50.53 4.38
96 INT103914 Phosphorylation of Egfr 35 0.82 16.98 4.31
97 INT111535 Negative_regulation of Phosphorylation of Mapk3 9 0.57 6.39 4.31
98 INT51084 Binding of Insr 13 0.30 4.25 4.23
99 INT110024 Negative_regulation of Gene_expression of Mapk14 19 0.42 7.83 4.21
100 INT155512 Positive_regulation of Braf 2 0.49 7.88 4.2
101 INT158416 Localization of Mapk1 19 0.67 5.32 4.18
102 INT144428 Positive_regulation of Gene_expression of Erbb2 41 0.69 41.4 4.13
103 INT83035 Binding of INSR 16 0.47 9.29 4.11
104 INT133244 Regulation of Positive_regulation of Mapk1 11 0.43 3.52 4.03
105 INT131782 Regulation of Positive_regulation of Mapk14 7 0.43 2.68 4.02
106 INT112782 Localization of Mapk3 8 0.78 1.87 3.98
107 INT110021 Positive_regulation of Gene_expression of Mapk14 29 0.46 19.06 3.86
108 INT113924 Binding of Mapk1 27 0.38 8.64 3.84
109 INT123827 Positive_regulation of Phosphorylation of Mapk3 10 0.67 5.22 3.82
110 INT94291 Regulation of Gene_expression of Mapk3 4 0.40 3.05 3.8
111 INT75485 Gene_expression of Tgfbr2 10 0.57 10.98 3.76
112 INT162366 Positive_regulation of Map3k8 24 0.50 15.69 3.71
113 INT10116 Localization of INSR 11 0.57 5.43 3.48
114 INT21569 Binding of Mapk8 8 0.48 5.55 3.44
115 INT14060 Negative_regulation of Negative_regulation of Insr 6 0.53 3.53 3.44
116 INT129751 Regulation of Phosphorylation of Mapk3 11 0.55 3.91 3.35
117 INT162368 Negative_regulation of Map3k8 17 0.42 7.96 3.34
118 INT139807 Gene_expression of Braf 7 0.51 8.78 3.34
119 INT97737 Negative_regulation of Phosphorylation of Mapk3 9 0.57 5.64 3.3
120 INT163529 Negative_regulation of Positive_regulation of Mapk8 14 0.43 8.37 3.2
121 INT171368 Regulation of Phosphorylation of Mapk1 14 0.61 4.77 3.14
122 INT120562 Negative_regulation of Egfr 108 0.59 79.38 3.11
123 INT110755 Negative_regulation of Positive_regulation of Mapk8 15 0.46 9.91 2.98
124 INT174958 Negative_regulation of Chuk 21 0.25 8.73 2.96
125 INT132773 Negative_regulation of Acvr2b 3 0.41 1.55 2.87
126 INT155453 Protein_catabolism of Mapk14 6 0.36 4.24 2.85
127 INT200895 Localization of Mapk1 6 0.67 2.08 2.82
128 INT96901 Regulation of Negative_regulation of Mapk14 3 0.45 4.07 2.79
129 INT169112 Negative_regulation of Positive_regulation of Mapk1 9 0.59 1.84 2.78
130 INT145821 Negative_regulation of Gene_expression of Mapk1 16 0.41 8.05 2.77
131 INT346210 Phosphorylation of Braf 1 0.44 5.3 2.77
132 INT152927 Negative_regulation of Mapk1 16 0.41 5.85 2.73
133 INT95735 Regulation of Phosphorylation of Mapk8 7 0.50 1.88 2.69
134 INT222845 Gene_expression of Chuk 27 0.52 25.15 2.67
135 INT95739 Negative_regulation of Phosphorylation of Mapk8 11 0.42 6.77 2.61
136 INT196919 Regulation of Braf 3 0.32 6.14 2.55
137 INT23527 Negative_regulation of Localization of Insr 10 0.39 2.58 2.5
138 INT103917 Positive_regulation of Phosphorylation of Egfr 12 0.68 7.23 2.18
139 INT24621 Regulation of Gene_expression of Insr 9 0.42 2.68 2.18
140 INT85085 Positive_regulation of KIT 36 0.53 30.08 2.17
141 INT109327 Negative_regulation of KIT 42 0.57 43.2 2.15
142 INT170482 Regulation of Gene_expression of Mapk1 5 0.43 5.73 2.1
143 INT156270 Regulation of Positive_regulation of Mapk8 3 0.41 2.31 2.08
144 INT31006 Regulation of Localization of Insr 7 0.50 0.2 2.05
145 INT152696 Negative_regulation of Negative_regulation of Mapk8 1 0.32 0.35 2
146 INT108921 Negative_regulation of Positive_regulation of Mapk9 3 0.25 1.8 1.99
147 INT109313 Binding of Mapk8 6 0.48 1.78 1.98
148 INT121781 Regulation of Mapk3 5 0.44 1.96 1.98
149 INT96916 Negative_regulation of Phosphorylation of Mapk8 16 0.52 9.68 1.97
150 INT136503 Negative_regulation of KDR 46 0.48 43.1 1.86
151 INT112131 Positive_regulation of Positive_regulation of Egfr 10 0.49 9.95 1.85
152 INT120563 Positive_regulation of Gene_expression of Egfr 56 0.70 46.19 1.82
153 INT164864 Positive_regulation of Negative_regulation of Mapk8 1 0.31 1.33 1.82
154 INT48792 Regulation of ERBB2 48 0.57 36.56 1.8
155 INT82760 Negative_regulation of Positive_regulation of Mapk3 7 0.57 3.18 1.78
156 INT118907 Negative_regulation of Negative_regulation of Mapk14 2 0.57 2.09 1.77
157 INT299365 Transcription of Mapk8 9 0.72 5.91 1.75
158 INT152894 Regulation of Positive_regulation of Mapk14 9 0.45 6.01 1.74
159 INT218303 Protein_catabolism of INSR 3 0.29 0.67 1.73
160 INT226868 Transcription of Map3k8 2 0.52 17.13 1.73
161 INT232645 Transcription of INSR 2 0.09 1.19 1.71
162 INT21788 Positive_regulation of ERBB2 49 0.66 28.88 1.68
163 INT168686 Transcription of Mapk14 6 0.52 2.96 1.67
164 INT149994 Gene_expression of Mapk3 16 0.65 3.45 1.62
165 INT168714 Negative_regulation of Binding of Mapk8 1 0.36 0.18 1.62
166 INT169461 Regulation of Gene_expression of Mapk1 7 0.44 1.64 1.61
167 INT142678 Positive_regulation of Phosphorylation of Mapk9 4 0.51 2.1 1.6
168 INT291207 Positive_regulation of Transcription of Map3k8 1 0.50 11.36 1.53
169 INT82761 Regulation of Positive_regulation of Mapk3 3 0.40 1.34 1.52
170 INT52962 Binding of ERBB2 77 0.47 50.03 1.49
171 INT132886 Negative_regulation of Positive_regulation of Mapk3 2 0.30 1.27 1.49
172 INT167085 Negative_regulation of ERBB2 67 0.57 44.6 1.48
173 INT142676 Phosphorylation of Mapk9 5 0.61 1.48 1.48
174 INT190646 Regulation of Regulation of Mapk1 1 0.30 1.16 1.43
175 INT237409 Localization of Erbb4 3 0.57 1.31 1.41
176 INT153627 Binding of Mapk1 5 0.36 2.88 1.4
177 INT310167 Gene_expression of Acvrl1 2 0.40 5.47 1.4
178 INT159784 Gene_expression of Mapk9 8 0.61 6.28 1.37
179 INT142679 Negative_regulation of Phosphorylation of Mapk9 1 0.17 0.51 1.37
180 INT143716 Phosphorylation of Chuk 16 0.41 5.25 1.35
181 INT96838 Negative_regulation of Gene_expression of ERBB2 25 0.57 15.83 1.34
182 INT217438 Binding of Chuk 24 0.25 7.29 1.29
183 INT202365 Regulation of Gene_expression of Mapk14 6 0.45 4.89 1.26
184 INT10117 Positive_regulation of INSR 10 0.43 4.71 1.22
185 INT154048 Negative_regulation of Gene_expression of Mapk8 5 0.43 4.43 1.22
186 INT105270 Positive_regulation of KDR 25 0.49 11.49 1.2
187 INT148491 Negative_regulation of Map3k3 3 0.02 1.71 1.18
188 INT268662 Regulation of Araf 4 0.17 2.5 1.13
189 INT106339 Positive_regulation of Phosphorylation of Insr 1 0.49 0 1.12
190 INT126525 Regulation of Negative_regulation of Mapk14 2 0.41 0.81 1.11
191 INT32354 Negative_regulation of Regulation of Insr 3 0.33 0.13 1.08
192 INT293487 Regulation of Gene_expression of Erbb2 4 0.61 3.4 1.06
193 INT140054 Negative_regulation of Mapk9 3 0.25 1.9 1.05
194 INT291221 Regulation of Gene_expression of Map3k8 1 0.44 5.59 1
195 INT178391 Localization of Mapk14 9 0.68 5.27 0.97
196 INT81878 Gene_expression of TGFB2 3 0.42 2.02 0.97
197 INT145028 Positive_regulation of Localization of Mapk14 2 0.20 0.85 0.96
198 INT151946 Positive_regulation of Regulation of Mapk3 1 0.16 1.31 0.96
199 INT231494 Regulation of Phosphorylation of Mapk14 2 0.24 2.59 0.93
200 INT213917 Negative_regulation of Phosphorylation of ERBB2 9 0.54 8.68 0.91
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