GO:0030010

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Name establishment of cell polarity
Categary Process
Go Slim No
Go Link GO:0030010
Unique Molecular Interactions 441
Total Molecular Interactions 565
Total Single Events 6145
Pain Genes Associated 20

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for establishment of cell polarity. They are ordered first by their pain relevance and then by number of times they were reported for establishment of cell polarity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT118158 Binding of Prkca and Prkcz 1 0.07 1.14 2.98
2 INT92738 Binding of Ephb1 and Tcas1 1 0.00 0.43 2.67
3 INT121742 Prkcg Positive_regulation of Ephb1 3 0.49 0.99 2.6
4 INT128044 Bdnf Positive_regulation of Ephb1 2 0.31 1.89 2.57
5 INT121746 Prkaca Positive_regulation of Ephb1 2 0.23 0.92 2.35
6 INT156623 Umod Regulation of Phosphorylation of Ephb1 1 0.05 0.33 2.27
7 INT153533 NMS Regulation of Gene_expression of Ephb1 1 0.48 3.96 1.93
8 INT95405 Trib3 Positive_regulation of Phosphorylation of Ephb1 3 0.08 1.33 1.89
9 INT112517 Binding of Ephb1 and Prkaca 3 0.18 0.58 1.85
10 INT162992 Binding of Ephb1 and Ppm1e 1 0.03 0.25 1.77
11 INT249483 Binding of Ephb1 and Efnb2 1 0.02 2.35 1.66
12 INT131575 Grin1 Negative_regulation of Positive_regulation of Ephb1 1 0.28 0.31 1.58
13 INT131574 Negative_regulation of Ephb1 Negative_regulation of Gene_expression of Creb1 1 0.41 0.33 1.58
14 INT158778 Ptges3l1 Regulation of Ephb1 1 0.06 0.09 1.53
15 INT158775 Regulation of Tnf Regulation of Ephb1 1 0.18 0.09 1.52
16 INT158777 Tnf Regulation of Ephb1 1 0.18 0.09 1.51
17 INT158776 Il1b Regulation of Ephb1 1 0.15 0.09 1.46
18 INT256299 Binding of Efnb1 and Ephb1 1 0.02 1.22 1.42
19 INT249494 Binding of Ephb1 and Efnb1 1 0.01 1.34 1.4
20 INT261483 Binding of Ephb1 and Trpv1 1 0.39 1.37 1.37
21 INT95406 Trib3 Positive_regulation of Ephb1 2 0.08 0.96 1.29
22 INT249487 Binding of Ephb1 and Src 1 0.17 0.74 1.23
23 INT121729 Negative_regulation of Ngf Positive_regulation of Ephb1 1 0.24 0.69 1.22
24 INT256298 Binding of Creb1 and Ephb1 1 0.16 1.27 1.22
25 INT121724 Ngf Positive_regulation of Ephb1 1 0.40 0.68 1.21
26 INT334351 Bdnf Regulation of Positive_regulation of Ephb1 1 0.18 1.27 1.2
27 INT249481 Positive_regulation of Binding of Ephb1 and Efnb2 1 0.03 1.36 1.12
28 INT249488 Positive_regulation of Binding of Ephb1 and Src 1 0.23 0.68 1.12
29 INT269190 Positive_regulation of Ephb1 Positive_regulation of Ceacam3 1 0.03 0.66 1.12
30 INT256294 Binding of Grin2b and Ephb1 1 0.28 1.11 1.08
31 INT156462 Creb1 Regulation of Ephb1 1 0.29 0 1.07
32 INT269192 Ephb1 Regulation of Phosphorylation of Grin2a 1 0.02 0.63 1.06
33 INT121727 Pik3cb Positive_regulation of Ephb1 1 0.49 0.6 1.06
34 INT121743 Negative_regulation of Src Negative_regulation of Ephb1 1 0.27 0 1.02
35 INT240455 Ephb1 Positive_regulation of Positive_regulation of Prkaca 1 0.22 0.63 1.01
36 INT121744 Src Positive_regulation of Positive_regulation of Ephb1 1 0.35 0 0.96
37 INT116930 OPRK1 Positive_regulation of Binding of PTK2 1 0.28 0.35 0.93
38 INT341371 CRX Positive_regulation of Gene_expression of Ephb1 1 0.02 0.99 0.9
39 INT167767 Prkcz Positive_regulation of Phosphorylation of Sigmar1 1 0.04 0.23 0.9
40 INT167766 Prkcz Positive_regulation of Positive_regulation of Sigmar1 1 0.04 0.23 0.9
41 INT121745 Tacr1 Negative_regulation of Positive_regulation of Ephb1 1 0.04 0 0.87
42 INT134993 P2rx6 Regulation of Ephb1 1 0.20 1.27 0.87
43 INT196578 Ephb1 Positive_regulation of Phosphorylation of Mapk9 1 0.13 0.5 0.85
44 INT261480 Negative_regulation of Trib3 Positive_regulation of Ephb1 1 0.04 0.8 0.84
45 INT116109 VEGFA Positive_regulation of PTK2 1 0.13 0.3 0.83
46 INT261479 Fig4 Positive_regulation of Ephb1 1 0.07 0.79 0.83
47 INT334358 Rvm Positive_regulation of Ephb1 1 0.17 0.98 0.82
48 INT334359 Negative_regulation of Rvm Positive_regulation of Ephb1 1 0.16 0.99 0.82
49 INT128042 Bdnf Positive_regulation of Phosphorylation of Ephb1 1 0.22 0.2 0.8
50 INT240456 Ephb1 Regulation of Prkcg 1 0.19 0.51 0.79
51 INT117971 Cd8a Negative_regulation of Positive_regulation of Ephb1 1 0.02 0.98 0.79
52 INT240454 Ephb1 Regulation of Prkaca 1 0.14 0.51 0.79
53 INT167770 Sigmar1 Positive_regulation of Prkcz 1 0.04 0.34 0.77
54 INT134049 Jak2 Positive_regulation of Gsk3b 1 0.37 0.22 0.77
55 INT167768 Regulation of Sigmar1 Positive_regulation of Prkcz 1 0.02 0.34 0.77
56 INT162995 Positive_regulation of Binding of Ephb1 and Ppm1e 1 0.04 0.06 0.74
57 INT328625 NPL Regulation of Phosphorylation of Ephb1 1 0.04 0.42 0.7
58 INT154989 Phax Positive_regulation of Positive_regulation of Ephb1 1 0.22 0.92 0.69
59 INT112515 Binding of Ephb1 and Trib3 1 0.06 0.41 0.65
60 INT111936 Binding of PIK3CA and PTK2 1 0.19 0.67 0.65
61 INT111937 Binding of PIK3CG and PTK2 1 0.08 0.67 0.64
62 INT128817 Ephb1 Negative_regulation of Gene_expression of Nos2 1 0.16 0.37 0.61
63 INT128814 Ephb1 Negative_regulation of Gene_expression of Il1b 1 0.02 0.37 0.61
64 INT261372 Gsk3b Regulation of Gene_expression of Ifi205 1 0.00 0.24 0.58
65 INT261482 Pik3cb Positive_regulation of Phosphorylation of Ephb1 1 0.23 0.67 0.58
66 INT261485 Positive_regulation of Prkaca Positive_regulation of Phosphorylation of Ephb1 1 0.05 0.12 0.56
67 INT261478 Positive_regulation of Ephb1 Regulation of Gene_expression of Egr1 1 0.10 0.23 0.55
68 INT312746 Ephb1 Positive_regulation of Localization of Ltp 1 0.05 0.07 0.55
69 INT256296 Efnb1 Positive_regulation of Ephb1 1 0.03 0.66 0.54
70 INT132372 Lgals1 Positive_regulation of Ephb1 1 0.37 0.25 0.54
71 INT249499 Ephb1 Positive_regulation of Efnb2 1 0.04 0.95 0.54
72 INT249479 Binding of Ephb1 and Grin2b 1 0.29 0.37 0.54
73 INT193554 Ntrk2 Positive_regulation of Positive_regulation of Ephb1 1 0.01 0.73 0.52
74 INT104960 Ephb1 Regulation of Positive_regulation of Mapk14 1 0.15 0.42 0.5
75 INT104961 Mapk14 Regulation of Positive_regulation of Ephb1 1 0.15 0.42 0.5
76 INT153534 Binding of Ephb1 and NMS 1 0.29 1.13 0.5
77 INT116932 PTK2 Negative_regulation of Positive_regulation of MAPK8 1 0.35 0.17 0.48
78 INT116935 Positive_regulation of OPRK1 Positive_regulation of Phosphorylation of PTK2 1 0.39 0.17 0.47
79 INT134046 Jak2 Regulation of Gsk3b 1 0.22 0.13 0.47
80 INT116939 OPRK1 Positive_regulation of Phosphorylation of PTK2 1 0.39 0.17 0.46
81 INT249486 Positive_regulation of Ephb1 Positive_regulation of Phosphorylation of Grin2b 1 0.33 0.4 0.46
82 INT95404 Map3k1 Positive_regulation of Phosphorylation of Ephb1 1 0.12 0.16 0.46
83 INT95408 Map3k1 Positive_regulation of Ephb1 1 0.12 0.16 0.46
84 INT110476 EDN1 Positive_regulation of Localization of PRKCZ 1 0.25 0.07 0.46
85 INT116928 PTK2 Positive_regulation of JUN 1 0.20 0.15 0.46
86 INT149006 RPL7AP5 Negative_regulation of Phosphorylation of Ephb1 1 0.00 0.22 0.45
87 INT127392 Negative_regulation of Ephb1 Negative_regulation of Gene_expression of Grin1 1 0.08 0.71 0.45
88 INT127393 Negative_regulation of Ephb1 Negative_regulation of Positive_regulation of Nfkb1 1 0.10 0.7 0.45
89 INT127394 Negative_regulation of Ephb1 Negative_regulation of Gene_expression of Grin2a 1 0.01 0.71 0.45
90 INT127391 Negative_regulation of Ephb1 Negative_regulation of Gene_expression of Elk1 1 0.08 0.71 0.45
91 INT127395 Negative_regulation of Ephb1 Negative_regulation of Gene_expression of Tacr1 1 0.07 0.71 0.45
92 INT127390 Negative_regulation of Ephb1 Negative_regulation of Phosphorylation of Elk1 1 0.08 0.7 0.44
93 INT149005 RPL7AP5 Negative_regulation of Ephb1 1 0.00 0.21 0.44
94 INT265647 Binding of Ephb1 and Mapk1 1 0.00 1.48 0.43
95 INT95403 Ephb1 Regulation of Positive_regulation of Trib3 1 0.07 0.19 0.41
96 INT285725 Binding of IGF1R and INS 1 0.27 0.07 0.4
97 INT288545 Gsk3b Negative_regulation of gr 1 0.25 0.38 0.38
98 INT304501 Binding of Ephb1 and Mapk1 1 0.18 0.69 0.36
99 INT224284 BDNF Positive_regulation of Ephb1 1 0.36 0.22 0.36
100 INT152453 Gsk3b Regulation of Nfkb1 1 0.02 1.68 0.36
101 INT270220 Negative_regulation of Ephb1 Negative_regulation of Positive_regulation of Pla2g4a 1 0.13 1 0.36
102 INT66369 Pomc Regulation of Positive_regulation of Gsk3b 1 0.07 0 0.35
103 INT309151 Dlat Positive_regulation of Positive_regulation of Ephb1 1 0.02 0.57 0.33
104 INT321366 Gsk3b Regulation of Gene_expression of CYP8B1 1 0.01 0.21 0.33
105 INT342882 Positive_regulation of Ephb1 Regulation of Gene_expression of Pdyn 1 0.01 0.36 0.33
106 INT309128 Edc4 Positive_regulation of Positive_regulation of Ephb1 1 0.01 0.58 0.33
107 INT249480 Positive_regulation of Ephb1 Positive_regulation of Phosphorylation of Src 1 0.22 0.23 0.31
108 INT342810 Binding of Adarb1 and Gsk3b 1 0.00 0.36 0.3
109 INT341777 SLC6A4 Regulation of EPHB1 1 0.02 0.96 0.3
110 INT135014 Binding of Ephb1 and Cabin1 1 0.09 0.32 0.3
111 INT218936 Dusp1 Negative_regulation of Ephb1 2 0.03 0.89 0.28
112 INT218934 Cyp3a23/3a1 Negative_regulation of Ephb1 1 0.01 0.95 0.28
113 INT309121 Positive_regulation of Gsdmc Positive_regulation of Positive_regulation of Ephb1 1 0.01 0.76 0.28
114 INT132373 Ephb1 Positive_regulation of Positive_regulation of Nfkb1 1 0.18 0.12 0.28
115 INT325530 Positive_regulation of Gsk3b Negative_regulation of Gene_expression of Wnt2 1 0.03 0.63 0.28
116 INT312894 Binding of Gsk3b and Positive_regulation of Gene_expression of Hdac6 1 0.08 1.3 0.27
117 INT132364 Ephb1 Positive_regulation of Nfkb1 1 0.07 0.11 0.27
118 INT309134 Edc4 Positive_regulation of Ephb1 1 0.01 0.54 0.27
119 INT316929 Pde5a Regulation of Ephb1 1 0.03 0.17 0.27
120 INT132370 Mapk8 Positive_regulation of Ephb1 1 0.15 0.12 0.27
121 INT309133 Dlat Positive_regulation of Ephb1 1 0.02 0.54 0.27
122 INT179928 Binding of Ephb1 and Mapk8 1 0.11 0.91 0.26
123 INT149947 Ephb1 Positive_regulation of Prkcg 1 0.27 0.07 0.26
124 INT149948 Ephb1 Negative_regulation of Phosphorylation of Map2 1 0.37 0.07 0.25
125 INT92581 IGF1R Positive_regulation of Gene_expression of PTGER2 1 0.09 0.79 0.24
126 INT187486 Binding of Prkag1 and Stk11 1 0.01 0.95 0.22
127 INT283858 Binding of PTK2 and APOA5 1 0.00 0.67 0.21
128 INT157692 Cck Positive_regulation of Ephb1 1 0.26 0 0.21
129 INT270433 PLAT Positive_regulation of Positive_regulation of Gsk3b 1 0.04 0.5 0.21
130 INT317394 Binding of Stk11 and Amp1 1 0.04 0.89 0.21
131 INT178086 Binding of EDNRA and PTK2 1 0.07 0.82 0.2
132 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19
133 INT334631 Igf1r Positive_regulation of Phosphorylation of Akt1 1 0.19 0.5 0.18
134 INT261401 Binding of Gsk3b and ADHD1 1 0.00 1.62 0.18
135 INT178092 EDN3 Positive_regulation of PTK2 1 0.01 1.02 0.17
136 INT333299 Zic2 Regulation of Transcription of Ephb1 1 0.50 0.09 0.17
137 INT108663 Lrpap1 Negative_regulation of Positive_regulation of Ephb1 1 0.11 0.28 0.17
138 INT108667 ras Negative_regulation of Positive_regulation of Ephb1 1 0.02 0.28 0.17
139 INT178073 EDN1 Positive_regulation of PTK2 1 0.03 1.02 0.17
140 INT261477 Egf Positive_regulation of Positive_regulation of Ephb1 1 0.37 0.21 0.17
141 INT193546 Il1b Positive_regulation of Ephb1 1 0.12 0.35 0.16
142 INT168941 Irs2 Regulation of Gene_expression of Igf1r 1 0.39 0.91 0.16
143 INT334634 Binding of Igf1 and Igf1r 1 0.14 0.45 0.15
144 INT92582 IGF1R Positive_regulation of Transcription of PTGER2 1 0.09 0.43 0.15
145 INT179931 Ephb1 Regulation of Gene_expression of Mmp9 1 0.04 0.48 0.15
146 INT193550 Ephb1 Positive_regulation of Gene_expression of Bdnf 1 0.29 0.3 0.14
147 INT147727 Phosphorylation of PTK2 Regulation of Positive_regulation of RAC1 1 0.34 0.32 0.14
148 INT147726 Phosphorylation of PTK2 Regulation of Positive_regulation of PIK3CA 1 0.09 0.32 0.14
149 INT193553 Mtpn Positive_regulation of Ephb1 1 0.04 0.34 0.13
150 INT312893 Gsk3b Positive_regulation of Hdac6 1 0.07 0.65 0.13
151 INT263320 Gsk3b Regulation of Uts2r 1 0.02 0.68 0.13
152 INT263318 Akt1 Regulation of Gsk3b 1 0.02 0.75 0.13
153 INT354327 Gsk3b Positive_regulation of Gene_expression of Ide 1 0.17 0.33 0.13
154 INT193548 Gdnf Positive_regulation of Ephb1 1 0.40 0.34 0.13
155 INT351974 Agt Positive_regulation of Gene_expression of Stk11 1 0.51 11.1 0.12
156 INT189559 STK11 Positive_regulation of SNRK 1 0.03 0.36 0.11
157 INT268634 Ptpn2 Positive_regulation of Positive_regulation of Gsk3b 1 0.02 1.08 0.11
158 INT289768 Akt1 Regulation of Phosphorylation of Gsk3b 1 0.04 0.45 0.11
159 INT268626 Mpz Positive_regulation of Positive_regulation of Gsk3b 1 0.29 1.08 0.11
160 INT32546 Gsk3b Negative_regulation of Localization of Gnrh1 1 0.05 0 0.1
161 INT32547 Gsk3b Negative_regulation of Localization of LH 1 0.04 0 0.1
162 INT128696 Il1a Positive_regulation of Phosphorylation of Ephb1 1 0.26 0.82 0.1
163 INT317392 Negative_regulation of Binding of Stk11 and Amp1 1 0.05 0.34 0.1
164 INT178089 Binding of EDNRA and Positive_regulation of PTK2 1 0.09 0.74 0.09
165 INT270464 Binding of Shh and Smo 1 0.07 1.3 0.08
166 INT249126 Binding of Ephb1 and Mtor 1 0.02 0 0.08
167 INT268627 Ptpn2 Positive_regulation of Gsk3b 1 0.02 1.7 0.08
168 INT310564 Positive_regulation of Ephb1 Regulation of Stat3 1 0.03 0.17 0.08
169 INT109864 Negative_regulation of ras Positive_regulation of Ephb1 1 0.01 0.37 0.08
170 INT355582 VEGFA Regulation of Positive_regulation of PTK2 1 0.05 1.46 0.08
171 INT290906 Shh Positive_regulation of Egfr 1 0.23 0 0.08
172 INT109865 ras Positive_regulation of Ephb1 1 0.01 0.37 0.08
173 INT317398 Amp1 Positive_regulation of Phosphorylation of Stk11 1 0.05 0.22 0.07
174 INT268630 Mpz Positive_regulation of Regulation of Gsk3b 1 0.18 0.57 0.07
175 INT354328 Gsk3b Regulation of Gs 1 0.16 0.84 0.07
176 INT354329 Gsk3b Regulation of Gene_expression of Gs 1 0.16 0.84 0.07
177 INT317391 Amp1 Positive_regulation of Stk11 1 0.05 0.22 0.07
178 INT298349 HES3 Positive_regulation of Shh 1 0.12 0.14 0.07
179 INT309112 Edc4 Regulation of Positive_regulation of Ephb1 1 0.01 0.15 0.07
180 INT253139 Il6 Positive_regulation of Phosphorylation of Stk11 1 0.26 0.34 0.07
181 INT290905 Gene_expression of Shh Positive_regulation of Gene_expression of Angpt1 1 0.14 0 0.06
182 INT221235 Akt1 Negative_regulation of Gsk3b 1 0.06 0.14 0.06
183 INT184924 Ephb1 Positive_regulation of Agtrap 1 0.01 0.08 0.06
184 INT317389 Binding of Prkag1 and Stk11 1 0.16 0.2 0.06
185 INT317397 Negative_regulation of Binding of Prkag1 and Stk11 1 0.19 0.2 0.06
186 INT234619 IGF1 Regulation of IGF1R 1 0.11 0.39 0.05
187 INT234624 Binding of IGF1 and IGF1R 1 0.09 0.39 0.05
188 INT333846 Binding of Wee1 and Mir17 1 0.03 0.52 0.05
189 INT282140 Ephb1 Regulation of Grip2 1 0.00 0 0.05
190 INT193966 AKT1 Negative_regulation of Gsk3b 1 0.05 0.75 0.05
191 INT193969 AKT1 Negative_regulation of Phosphorylation of Gsk3b 1 0.05 0.75 0.05
192 INT234620 Regulation of Binding of IGF1 and IGF1R 1 0.07 0.39 0.05
193 INT346280 Binding of COL5A2 and PTK2 1 0.01 0.1 0.05
194 INT181814 Gsk3b Regulation of Gata4 1 0.06 0.37 0.05
195 INT193964 Mapk1 Negative_regulation of Gsk3b 1 0.00 0.74 0.05
196 INT179930 Litaf Positive_regulation of Ephb1 1 0.01 0.4 0.04
197 INT213563 Binding of Ctnnd2 and Shh 1 0.27 0.09 0.04
198 INT270459 Binding of Shh and Gli1 1 0.02 0.65 0.04
199 INT290810 Gsk3b Regulation of Arntl 1 0.15 0 0.04
200 INT303092 Gsk3b Positive_regulation of NEUROG2 1 0.01 0.16 0.03

Single Events

The table below shows the top 100 pain related interactions that have been reported for establishment of cell polarity. They are ordered first by their pain relevance and then by number of times they were reported in establishment of cell polarity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT63932 Positive_regulation of Ephb1 537 0.70 259.67 296.14
2 INT63934 Phosphorylation of Ephb1 377 0.82 150.52 188.66
3 INT48923 Gene_expression of Ephb1 211 0.77 106.23 109.9
4 INT63936 Positive_regulation of Phosphorylation of Ephb1 131 0.70 49.38 73.16
5 INT84495 Positive_regulation of Positive_regulation of Ephb1 85 0.70 46.12 54.11
6 INT48920 Negative_regulation of Ephb1 107 0.57 43.6 51.02
7 INT48929 Regulation of Ephb1 71 0.62 24.42 42.11
8 INT63933 Negative_regulation of Positive_regulation of Ephb1 53 0.58 22.83 33.43
9 INT63935 Positive_regulation of Gene_expression of Ephb1 52 0.61 24.3 33.05
10 INT84494 Negative_regulation of Phosphorylation of Ephb1 44 0.59 22.34 28.68
11 INT123035 Gene_expression of Ephb1 38 0.78 28.84 27.32
12 INT109379 Regulation of Phosphorylation of Ephb1 22 0.59 12.58 18.84
13 INT92733 Negative_regulation of Ephb1 19 0.51 8.56 17.72
14 INT124371 Negative_regulation of Gsk3b 170 0.55 87.92 15.51
15 INT128921 Negative_regulation of Gene_expression of Ephb1 18 0.49 9.54 14.93
16 INT124372 Gene_expression of Gsk3b 164 0.75 95.64 14.35
17 INT84496 Regulation of Positive_regulation of Ephb1 18 0.61 10.16 13.92
18 INT135909 Positive_regulation of Ephb1 11 0.70 8.94 11.78
19 INT135372 Positive_regulation of Gsk3b 72 0.70 50.03 9.28
20 INT127853 Localization of Ephb1 20 0.74 5.47 7.96
21 INT147715 Regulation of Gene_expression of Ephb1 6 0.62 5.26 7.49
22 INT92734 Binding of Ephb1 5 0.37 3.86 7.02
23 INT48922 Regulation of Gene_expression of Ephb1 14 0.50 5.73 6.47
24 INT118151 Positive_regulation of Prkcz 5 0.12 2.35 6.41
25 INT181053 Regulation of Ephb1 6 0.45 6.17 5.77
26 INT9325 Gene_expression of Igf1r 14 0.77 8.74 5.48
27 INT124370 Positive_regulation of Gene_expression of Gsk3b 47 0.67 24.56 5.4
28 INT126847 Binding of Ephb1 15 0.46 6.47 5.17
29 INT135374 Binding of Gsk3b 46 0.48 24.36 4.75
30 INT87345 Phosphorylation of PTK2 110 0.82 59.39 4.28
31 INT66366 Positive_regulation of Gsk3b 15 0.68 6.56 4.27
32 INT167284 Phosphorylation of Gsk3b 88 0.82 36.03 4.21
33 INT116642 Negative_regulation of Gsk3b 13 0.57 7.16 3.83
34 INT135373 Regulation of Gsk3b 35 0.62 18.11 3.53
35 INT66367 Gene_expression of Gsk3b 16 0.45 9.75 3.07
36 INT118156 Binding of Prkcz 2 0.08 2.68 2.89
37 INT256286 Negative_regulation of Gene_expression of Ephb1 1 0.43 3.36 2.78
38 INT55090 Positive_regulation of Wnt7a 13 0.37 2.25 2.2
39 INT147417 Positive_regulation of Gene_expression of Igf1r 3 0.46 1.69 2.2
40 INT144973 Gene_expression of Shh 9 0.77 4.32 1.96
41 INT9336 Negative_regulation of Gene_expression of Igf1r 4 0.42 3.53 1.92
42 INT204018 Localization of Gsk3b 27 0.71 13.67 1.87
43 INT109059 Gene_expression of PRKCZ 2 0.65 0.64 1.87
44 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77
45 INT116110 Positive_regulation of PTK2 20 0.66 10.53 1.64
46 INT98788 Negative_regulation of EPHB1 11 0.37 3.65 1.64
47 INT158773 Positive_regulation of Localization of Ephb1 1 0.34 0.08 1.64
48 INT117717 Negative_regulation of Regulation of Ephb1 3 0.41 0.61 1.61
49 INT147713 Localization of Ephb1 1 0.70 0 1.54
50 INT118149 Positive_regulation of Binding of Prkcz 1 0.09 0.58 1.54
51 INT111946 Positive_regulation of Phosphorylation of PTK2 8 0.66 11.5 1.53
52 INT135907 Negative_regulation of Positive_regulation of Ephb1 1 0.38 0.42 1.51
53 INT135908 Regulation of Negative_regulation of Ephb1 1 0.24 0.4 1.49
54 INT135906 Positive_regulation of Positive_regulation of Ephb1 1 0.44 0.38 1.45
55 INT212466 Regulation of EPHB1 7 0.37 5.72 1.42
56 INT118150 Positive_regulation of Positive_regulation of Prkcz 1 0.08 0.49 1.42
57 INT49128 Gene_expression of IGF1R 35 0.63 23.48 1.39
58 INT228036 Negative_regulation of Cfl1 1 0.09 1.1 1.34
59 INT117719 Transcription of Ephb1 2 0.44 0.06 1.25
60 INT9323 Transcription of Igf1r 2 0.63 1.08 1.23
61 INT87343 Negative_regulation of Phosphorylation of PTK2 34 0.59 18.38 1.19
62 INT166274 Gene_expression of EPHB1 14 0.55 8.2 1.19
63 INT87346 Binding of PTK2 6 0.37 4.03 1.18
64 INT167283 Negative_regulation of Phosphorylation of Gsk3b 12 0.59 7.94 1.16
65 INT134036 Regulation of Gsk3b 4 0.60 1.42 1.15
66 INT253191 Positive_regulation of Gene_expression of Shh 2 0.66 2.57 1.14
67 INT32545 Localization of Gsk3b 9 0.07 2.88 1.11
68 INT208536 Positive_regulation of Positive_regulation of Gsk3b 6 0.30 4.83 1.11
69 INT147416 Positive_regulation of Transcription of Igf1r 1 0.46 0.72 1.1
70 INT147415 Positive_regulation of Igf1r 2 0.43 0.97 1.09
71 INT165530 Positive_regulation of Shh 4 0.69 1.21 1.05
72 INT87342 Regulation of Phosphorylation of PTK2 3 0.59 5.7 1.05
73 INT127647 Regulation of Wnt7a 3 0.07 1.28 1.01
74 INT116646 Regulation of Negative_regulation of Gsk3b 2 0.44 0.39 0.99
75 INT240461 Regulation of Negative_regulation of Ephb1 4 0.37 1.66 0.96
76 INT261360 Binding of Gsk3b 5 0.36 2.85 0.9
77 INT167763 Negative_regulation of Prkcz 1 0.04 0.32 0.88
78 INT87344 Gene_expression of PTK2 90 0.78 59.03 0.87
79 INT147716 Negative_regulation of Localization of Ephb1 1 0.51 0 0.84
80 INT109060 Regulation of Gene_expression of PRKCZ 1 0.03 0 0.83
81 INT167285 Positive_regulation of Phosphorylation of Gsk3b 17 0.50 5.92 0.82
82 INT156945 Positive_regulation of Negative_regulation of Gsk3b 6 0.38 4.58 0.82
83 INT66365 Positive_regulation of Gene_expression of Gsk3b 2 0.07 0.95 0.81
84 INT114714 Binding of IGF1R 8 0.36 5.26 0.78
85 INT116644 Phosphorylation of Gsk3b 4 0.61 0.68 0.78
86 INT204002 Negative_regulation of Gene_expression of Gsk3b 15 0.55 8.57 0.77
87 INT87341 Regulation of Gene_expression of PTK2 2 0.62 8.34 0.77
88 INT97782 Protein_catabolism of Ephb1 5 0.86 1.27 0.76
89 INT242137 Negative_regulation of Positive_regulation of Gsk3b 7 0.39 2.99 0.67
90 INT28958 Negative_regulation of Wnt7a 3 0.45 0.49 0.65
91 INT127854 Regulation of Localization of Ephb1 1 0.25 0.69 0.62
92 INT204006 Negative_regulation of Localization of Gsk3b 6 0.40 1.66 0.6
93 INT230679 Positive_regulation of Binding of Gsk3b 3 0.42 1.42 0.58
94 INT127648 Gene_expression of Wnt7a 2 0.13 1.11 0.56
95 INT145859 Regulation of Gene_expression of Igf1r 1 0.59 1.58 0.55
96 INT249507 Regulation of Binding of Ephb1 1 0.38 0.58 0.55
97 INT253108 Phosphorylation of Stk11 4 0.65 2.13 0.52
98 INT208537 Regulation of Gene_expression of Gsk3b 4 0.36 2.15 0.52
99 INT126849 Positive_regulation of Binding of Ephb1 3 0.49 0.24 0.5
100 INT333283 Positive_regulation of Gene_expression of Ephb1 3 0.32 1.17 0.47
101 INT206484 Localization of Shh 2 0.75 1.14 0.46
102 INT110477 Positive_regulation of Localization of PRKCZ 1 0.20 0.07 0.45
103 INT232798 Positive_regulation of Gene_expression of Shh 7 0.70 1.49 0.44
104 INT274928 Negative_regulation of Binding of Ephb1 1 0.40 0 0.44
105 INT288540 Negative_regulation of Binding of Gsk3b 4 0.53 2.12 0.43
106 INT208552 Negative_regulation of Negative_regulation of Gsk3b 3 0.31 1.8 0.43
107 INT110479 Localization of PRKCZ 1 0.35 0.07 0.43
108 INT235064 Regulation of Positive_regulation of Gsk3b 3 0.41 1.5 0.42
109 INT204012 Regulation of Negative_regulation of Gsk3b 4 0.42 4.51 0.39
110 INT208559 Negative_regulation of Gene_expression of Shh 8 0.43 1.58 0.38
111 INT208538 Regulation of Phosphorylation of Gsk3b 3 0.49 4.49 0.38
112 INT193542 Regulation of Regulation of Ephb1 2 0.25 0.79 0.38
113 INT168940 Phosphorylation of Igf1r 1 0.77 2.18 0.38
114 INT110478 Regulation of PRKCZ 1 0.20 0.1 0.37
115 INT351970 Gene_expression of Stk11 1 0.75 33.89 0.35
116 INT66364 Regulation of Positive_regulation of Gsk3b 1 0.07 0 0.35
117 INT207078 Gene_expression of Cfl1 1 0.16 0.85 0.34
118 INT207066 Localization of Cfl1 1 0.18 0.83 0.33
119 INT210766 Gene_expression of Igf1r 6 0.65 2.15 0.31
120 INT268620 Regulation of Localization of Gsk3b 3 0.35 2.12 0.28
121 INT179917 Negative_regulation of Negative_regulation of Ephb1 2 0.25 1.17 0.28
122 INT163893 Positive_regulation of Phosphorylation of EPHB1 1 0.49 0.43 0.27
123 INT163892 Phosphorylation of EPHB1 1 0.80 0.42 0.27
124 INT232795 Positive_regulation of Shh 2 0.70 3.68 0.26
125 INT345254 Positive_regulation of Localization of Gsk3b 2 0.01 0.91 0.24
126 INT119080 Negative_regulation of PTK2 15 0.56 8.88 0.23
127 INT204021 Transcription of Gsk3b 8 0.57 2.75 0.23
128 INT268621 Positive_regulation of Localization of Gsk3b 4 0.40 1.54 0.22
129 INT116647 Positive_regulation of Phosphorylation of Gsk3b 1 0.37 0.18 0.22
130 INT183062 Gene_expression of SHH 12 0.65 5.28 0.21
131 INT87338 Regulation of PTK2 10 0.62 4.75 0.21
132 INT192958 Negative_regulation of IGF1R 8 0.30 6.35 0.21
133 INT250517 Phosphorylation of Igf1r 5 0.79 1.21 0.21
134 INT213792 Positive_regulation of Igf1r 3 0.45 1 0.2
135 INT274731 Binding of EPHB1 3 0.22 0.76 0.2
136 INT134477 Negative_regulation of SHH 2 0.37 1.13 0.2
137 INT157288 Positive_regulation of Cfl1 2 0.45 1.49 0.19
138 INT351969 Positive_regulation of Gene_expression of Stk11 1 0.67 21.03 0.19
139 INT168938 Negative_regulation of Phosphorylation of Igf1r 1 0.40 1.1 0.19
140 INT292483 Negative_regulation of Positive_regulation of PTK2 2 0.41 3.51 0.18
141 INT181029 Transcription of Ephb1 2 0.51 0.51 0.17
142 INT232799 Regulation of Gene_expression of Shh 3 0.27 1.04 0.16
143 INT253177 Negative_regulation of Gene_expression of Shh 2 0.55 0.63 0.16
144 INT55089 Positive_regulation of Positive_regulation of Wnt7a 2 0.27 0.06 0.16
145 INT196603 Gene_expression of STK11 5 0.55 6.75 0.15
146 INT157287 Positive_regulation of Phosphorylation of Cfl1 1 0.11 0.41 0.15
147 INT168939 Negative_regulation of Igf1r 1 0.40 1.01 0.15
148 INT157285 Phosphorylation of Cfl1 1 0.18 0.41 0.15
149 INT147730 Regulation of Positive_regulation of PTK2 1 0.35 0.33 0.15
150 INT189633 Regulation of STK11 3 0.41 3.57 0.14
151 INT106227 Binding of STK11 3 0.42 3.13 0.13
152 INT253190 Localization of Shh 2 0.77 1.06 0.13
153 INT189583 Transcription of STK11 2 0.49 4.43 0.13
154 INT330233 Positive_regulation of Stk11 2 0.67 8.15 0.13
155 INT9320 Regulation of Transcription of Igf1r 1 0.04 0.36 0.13
156 INT9333 Regulation of Igf1r 1 0.07 0.36 0.13
157 INT253183 Negative_regulation of Shh 8 0.55 2.13 0.12
158 INT92590 Positive_regulation of Gene_expression of IGF1R 3 0.57 2.31 0.12
159 INT151587 Positive_regulation of Stk11 2 0.38 0.44 0.12
160 INT92589 Positive_regulation of IGF1R 4 0.38 0.98 0.11
161 INT268617 Negative_regulation of Regulation of Gsk3b 3 0.28 1.84 0.11
162 INT312954 Regulation of Binding of IGF1R 1 0.13 0 0.1
163 INT309869 Regulation of Binding of Gsk3b 1 0.12 0.66 0.1
164 INT250519 Negative_regulation of Igf1r 5 0.42 2.7 0.09
165 INT312871 Positive_regulation of Transcription of Gsk3b 2 0.29 0.15 0.09
166 INT270442 Transcription of Shh 1 0.53 0.25 0.09
167 INT213515 Binding of Shh 8 0.37 1.92 0.08
168 INT234926 Protein_catabolism of Gsk3b 2 0.58 1.33 0.08
169 INT234906 Positive_regulation of Protein_catabolism of Gsk3b 2 0.33 1.33 0.08
170 INT173212 Positive_regulation of Gene_expression of EPHB1 1 0.04 1.22 0.08
171 INT270453 Regulation of Shh 1 0.27 0.83 0.08
172 INT92587 Positive_regulation of Positive_regulation of IGF1R 1 0.38 0.38 0.08
173 INT147735 Regulation of Binding of PTK2 1 0.35 0.23 0.08
174 INT349623 Negative_regulation of Binding of Igf1r 1 0.39 0.51 0.08
175 INT250508 Negative_regulation of Gene_expression of Igf1r 1 0.42 2.01 0.08
176 INT349620 Binding of Igf1r 1 0.34 0.51 0.08
177 INT205973 Binding of SHH 3 0.35 1.03 0.07
178 INT253107 Regulation of Stk11 2 0.33 0.3 0.07
179 INT253102 Negative_regulation of Stk11 1 0.31 0.22 0.07
180 INT256862 Regulation of Shh 1 0.25 0 0.07
181 INT144400 Positive_regulation of Gene_expression of PTK2 33 0.70 21.24 0.06
182 INT234462 Phosphorylation of IGF1R 2 0.42 0.99 0.06
183 INT270445 Positive_regulation of Localization of Shh 1 0.44 0.13 0.05
184 INT159426 Positive_regulation of Gene_expression of Wnt7a 1 0.10 0.51 0.05
185 INT329775 Regulation of Regulation of PTK2 1 0.11 0.49 0.05
186 INT330228 Phosphorylation of Stk11 1 0.18 0.27 0.05
187 INT330227 Positive_regulation of Positive_regulation of Stk11 1 0.11 0.06 0.05
188 INT333798 Localization of Wee1 1 0.40 0.51 0.05
189 INT181793 Positive_regulation of SHH 3 0.67 2.59 0.04
190 INT315099 Localization of IGF1R 2 0.55 0.36 0.04
191 INT208560 Negative_regulation of Shh 2 0.59 2.22 0.04
192 INT333822 Negative_regulation of Wee1 1 0.31 0.48 0.04
193 INT336062 Regulation of Localization of Gsk3b 1 0.03 0.48 0.04
194 INT351967 Negative_regulation of Gene_expression of Stk11 1 0.57 0.89 0.04
195 INT333803 Negative_regulation of Positive_regulation of Wee1 1 0.20 0.48 0.04
196 INT333814 Positive_regulation of Wee1 1 0.32 0.48 0.04
197 INT351966 Binding of Stk11 1 0.36 2.15 0.04
198 INT217725 Localization of EPHB1 4 0.45 0.21 0.03
199 INT253104 Gene_expression of Stk11 2 0.53 0.07 0.03
200 INT234471 Negative_regulation of Phosphorylation of IGF1R 1 0.04 0.76 0.03
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