GO:0030032

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Name lamellipodium assembly
Categary Process
Go Slim No
Go Link GO:0030032
Unique Molecular Interactions 108
Total Molecular Interactions 136
Total Single Events 1384
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for lamellipodium assembly. They are ordered first by their pain relevance and then by number of times they were reported for lamellipodium assembly. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT324926 Ptpro Positive_regulation of Bdkrb2 1 0.01 2.25 1.5
2 INT116730 Rac1 Regulation of Localization of Calca 1 0.13 1.32 1.19
3 INT53152 Rac1 Regulation of Scg2 1 0.03 0 0.9
4 INT53155 Rac1 Positive_regulation of Gene_expression of Calca 1 0.06 0 0.89
5 INT43662 Negative_regulation of Binding of Chrna7 and Rac1 1 0.01 0 0.73
6 INT43661 Binding of Chrna7 and Rac1 1 0.01 0 0.72
7 INT121966 HRAS Positive_regulation of RAC1 1 0.75 0.41 0.67
8 INT330104 Binding of Sh3rf1 and Rac1 1 0.13 2.41 0.62
9 INT330101 Binding of Map3k11 and Rac1 1 0.16 2.43 0.62
10 INT5544 Ptpro Regulation of Syt17 1 0.05 0 0.6
11 INT131508 Gene_expression of Rac1 Positive_regulation of Trpv1 1 0.42 0.21 0.48
12 INT131503 Gene_expression of Rac1 Positive_regulation of Ngf 1 0.38 0.21 0.48
13 INT148930 Rac1 Regulation of Chrna7 1 0.13 0.6 0.44
14 INT131506 Rac1 Regulation of Positive_regulation of Mapk14 1 0.19 0.39 0.42
15 INT131505 Rac1 Regulation of Gene_expression of Trpv1 1 0.55 0.39 0.42
16 INT275156 Agt Positive_regulation of Rac1 1 0.03 2.89 0.4
17 INT353392 Binding of DRD4 and NCK1 1 0.37 0.62 0.37
18 INT330105 Rac1 Positive_regulation of Mapk8 1 0.15 1.47 0.34
19 INT330103 Rac1 Positive_regulation of Positive_regulation of Mapk8 1 0.14 1.24 0.32
20 INT295722 PTGER2 Positive_regulation of RAC1 1 0.02 2.14 0.32
21 INT330109 Binding of Racgap1 and Rac1 1 0.03 1.22 0.32
22 INT118848 GNA14 Positive_regulation of RAC1 1 0.01 0.14 0.26
23 INT292561 MAP3K5 Positive_regulation of Positive_regulation of RAC1 1 0.03 0 0.23
24 INT178074 EDN1 Positive_regulation of Phosphorylation of PXN 1 0.05 0.82 0.2
25 INT143973 Rac1 Positive_regulation of Vti1b 1 0.00 0.16 0.2
26 INT147727 Phosphorylation of PTK2 Regulation of Positive_regulation of RAC1 1 0.34 0.32 0.14
27 INT177980 CSF1R Regulation of PXN 1 0.07 0.48 0.11
28 INT275157 Binding of Stat3 and Rac1 1 0.05 0.71 0.1
29 INT275158 Rac1 Positive_regulation of Stat3 1 0.07 0.72 0.1
30 INT206054 RAC1 Positive_regulation of STAT3 1 0.07 0.11 0.09
31 INT141257 Binding of S100A8 and VCL 1 0.36 0.97 0.09
32 INT348167 Thbs1 Positive_regulation of RAC1 1 0.04 0.71 0.08
33 INT171709 Rac1 Negative_regulation of Localization of Chrna7 1 0.04 0.75 0.08
34 INT333247 Gene_expression of Cxcl12 Negative_regulation of Pxn 1 0.09 1 0.07
35 INT141256 S100A8 Positive_regulation of VCL 1 0.50 0.99 0.06
36 INT141258 S100A8 Negative_regulation of VCL 1 0.43 0.99 0.06
37 INT302632 Rac1 Positive_regulation of Gene_expression of Rhog 1 0.37 0.21 0.05
38 INT206087 RAC1 Positive_regulation of Gene_expression of STAT3 1 0.08 0.05 0.05
39 INT206073 Negative_regulation of RAC1 Positive_regulation of IL6 1 0.14 0.06 0.04
40 INT206067 Gene_expression of RAC1 Positive_regulation of Positive_regulation of IL6 1 0.16 0.07 0.04
41 INT290312 Binding of CASP1 and NCK1 1 0.00 0.29 0.04
42 INT206068 RAC1 Positive_regulation of IL6 1 0.16 0.06 0.04
43 INT238212 Binding of STAT3 and Pxn 1 0.02 0 0.03
44 INT206061 RAC1 Positive_regulation of Positive_regulation of STAT3 1 0.07 0.43 0.03
45 INT194707 RAC1 Positive_regulation of PAK1 1 0.01 0 0.03
46 INT194738 Binding of PAK1 and RAC1 1 0.01 0 0.03
47 INT254511 RAC1 Positive_regulation of Positive_regulation of CYBB 1 0.14 0.39 0.03
48 INT288829 Binding of Rhoa and Rac1 2 0.21 1.88 0
49 INT225898 Positive_regulation of RAC1 Positive_regulation of PAK1 1 0.01 0.08 0
50 INT295710 PTGER2 Regulation of Positive_regulation of RAC1 1 0.01 1.62 0
51 INT295701 Positive_regulation of Binding of RAC1 and Racgap1 1 0.28 0.16 0
52 INT302640 Rac1 Regulation of Gene_expression of VEGFA 1 0.03 0 0
53 INT235011 Ctnnd1 Positive_regulation of RAC1 1 0.00 0.07 0
54 INT302641 Rac1 Regulation of TIE1 1 0.25 0.47 0
55 INT306269 Binding of MAPK8 and RAC1 1 0.25 0 0
56 INT101591 Binding of RAC1 and RAC3 1 0.13 0.52 0
57 INT225908 Binding of RAC1 and IQGAP1 1 0.00 0.09 0
58 INT225890 Binding of RAC1 and STAT3 1 0.01 0 0
59 INT257663 Binding of Nck1 and Nphs1 1 0.09 0 0
60 INT338194 Regulation of VAV3 Regulation of AR 1 0.31 0.49 0
61 INT284914 Binding of HDAC1 and NCK1 1 0.00 0.13 0
62 INT294412 Binding of Vav2 and Vav3 1 0.41 0.65 0
63 INT254847 Rac1 Positive_regulation of Fbrs 1 0.09 0.81 0
64 INT228112 Gene_expression of Chrm2 Positive_regulation of Positive_regulation of Rac1 1 0.14 0.26 0
65 INT288826 Binding of Rac1 and Vav1 1 0.25 0.68 0
66 INT295700 Binding of RAC1 and Racgap1 1 0.21 0.16 0
67 INT334474 PGGT1B Regulation of Localization of Rac1 1 0.03 0.47 0
68 INT302634 Rac1 Regulation of Gene_expression of Kdr 1 0.36 0 0
69 INT206077 RAC1 Positive_regulation of Phosphorylation of STAT3 1 0.07 0.35 0
70 INT338187 VAV3 Regulation of CDCP1 1 0.00 1.47 0
71 INT302633 Rac1 Regulation of Cdc42ep2 1 0.01 0 0
72 INT194695 RAC1 Positive_regulation of PAK4 1 0.00 0 0
73 INT334468 Rhoa Regulation of Localization of Rac1 1 0.25 0.18 0
74 INT348534 ELMO1 Positive_regulation of RAC1 1 0.02 0.7 0
75 INT225891 DOCK1 Positive_regulation of RAC1 1 0.01 0 0
76 INT254853 Rhoa Positive_regulation of Rac1 1 0.10 0.81 0
77 INT257340 Binding of Cyba and Rac1 1 0.09 0.29 0
78 INT225899 Binding of DOCK1 and RAC1 1 0.01 0 0
79 INT254850 Setd1a Negative_regulation of Rac1 1 0.00 0 0
80 INT338185 VAV3 Regulation of Positive_regulation of AR 1 0.19 0.49 0
81 INT338193 VAV3 Regulation of AR 1 0.31 0.49 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for lamellipodium assembly. They are ordered first by their pain relevance and then by number of times they were reported in lamellipodium assembly. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT19396 Regulation of Rac1 66 0.53 37.41 30.01
2 INT47459 Gene_expression of Rac1 101 0.68 45.27 24.33
3 INT23212 Positive_regulation of Rac1 46 0.55 32.85 15.1
4 INT27627 Binding of Rac1 41 0.41 22.88 13.68
5 INT50055 Negative_regulation of Rac1 36 0.50 19.74 8.98
6 INT69350 Gene_expression of RAC1 23 0.77 12.16 5.54
7 INT78619 Positive_regulation of RAC1 27 0.65 10.43 3.75
8 INT121967 Regulation of RAC1 9 0.45 6.14 3.41
9 INT106422 Negative_regulation of Gene_expression of Rac1 4 0.43 3.97 3.41
10 INT58475 Localization of Rac1 12 0.75 5.94 3.2
11 INT65928 Positive_regulation of Gene_expression of Rac1 12 0.42 3.34 2.33
12 INT70987 Binding of RAC1 14 0.37 12.14 2.13
13 INT117980 Regulation of Rac1 10 0.45 3.72 1.88
14 INT111944 Phosphorylation of VCL 3 0.73 5.23 1.72
15 INT58930 Negative_regulation of RAC1 14 0.55 7.55 1.4
16 INT271464 Transcription of Ptpro 1 0.02 0.95 1.4
17 INT65121 Negative_regulation of Ptpro 1 0.02 0.97 1.36
18 INT16013 Gene_expression of Rac1 52 0.75 23.79 1.21
19 INT98062 Regulation of Gene_expression of Rac1 4 0.39 1.41 1.21
20 INT98061 Negative_regulation of Binding of Rac1 3 0.43 2.28 1.13
21 INT67174 Negative_regulation of Rac1 22 0.56 10.72 0.99
22 INT81211 Transcription of Rac1 4 0.54 1.05 0.89
23 INT175904 Localization of RAC1 7 0.41 5.05 0.86
24 INT111943 Negative_regulation of Positive_regulation of RAC1 2 0.46 1.33 0.86
25 INT330097 Positive_regulation of Positive_regulation of Rac1 1 0.37 2.47 0.86
26 INT111941 Regulation of Phosphorylation of VCL 1 0.27 0.66 0.8
27 INT111942 Positive_regulation of Phosphorylation of VCL 1 0.30 0.67 0.8
28 INT264629 Localization of Rac1 8 0.72 5.7 0.79
29 INT111945 Protein_catabolism of RAC1 1 0.31 0.67 0.79
30 INT115596 Regulation of Regulation of Rac1 1 0.36 0.29 0.7
31 INT147734 Phosphorylation of RAC1 3 0.64 1.33 0.58
32 INT228103 Positive_regulation of Rac1 25 0.67 18.92 0.57
33 INT16012 Binding of Rac1 17 0.37 6.9 0.53
34 INT127736 Regulation of Gene_expression of RAC1 2 0.27 2 0.53
35 INT164267 Negative_regulation of Phosphorylation of RAC1 1 0.33 0.96 0.46
36 INT81212 Negative_regulation of Transcription of Rac1 1 0.01 0 0.46
37 INT164266 Positive_regulation of Phosphorylation of RAC1 1 0.39 0.95 0.45
38 INT87847 Regulation of Positive_regulation of Rac1 2 0.36 1.49 0.43
39 INT134738 Gene_expression of NCK1 2 0.01 0.14 0.34
40 INT124986 Positive_regulation of Localization of Rac1 3 0.50 1.22 0.33
41 INT112551 Protein_catabolism of Rac1 2 0.66 0.29 0.3
42 INT116729 Regulation of Localization of Rac1 1 0.01 0.07 0.29
43 INT99682 Phosphorylation of Rac1 1 0.54 0.72 0.28
44 INT271459 Positive_regulation of Ptpro 1 0.01 1.09 0.27
45 INT162873 Negative_regulation of Negative_regulation of Rac1 1 0.34 0.35 0.26
46 INT178106 Phosphorylation of PXN 2 0.12 1.14 0.25
47 INT330090 Regulation of Negative_regulation of Rac1 1 0.36 0.53 0.25
48 INT330093 Negative_regulation of Positive_regulation of Rac1 1 0.34 0.88 0.23
49 INT321550 Gene_expression of Pxn 5 0.18 2.08 0.21
50 INT168055 Regulation of Transcription of Rac1 1 0.36 0.34 0.16
51 INT133599 Positive_regulation of Binding of Rac1 2 0.40 0.4 0.15
52 INT330085 Regulation of Binding of Rac1 1 0.36 0.28 0.15
53 INT282160 Regulation of Binding of RAC1 1 0.18 0.45 0.13
54 INT321546 Negative_regulation of Pxn 3 0.10 0.72 0.11
55 INT333240 Negative_regulation of Gene_expression of Pxn 1 0.08 0.27 0.11
56 INT177991 Regulation of PXN 2 0.04 0.56 0.1
57 INT302613 Positive_regulation of Gene_expression of Rac1 14 0.67 3.7 0.08
58 INT176593 Positive_regulation of Gene_expression of RAC1 2 0.17 0.97 0.08
59 INT294408 Positive_regulation of Vav2 1 0.50 0.7 0.08
60 INT181030 Regulation of Pxn 1 0.09 1.11 0.08
61 INT334443 Positive_regulation of Positive_regulation of Rac1 1 0.33 1.1 0.08
62 INT159858 Negative_regulation of Negative_regulation of RAC1 1 0.40 0.17 0.07
63 INT141261 Negative_regulation of VCL 1 0.45 0.95 0.07
64 INT270629 Gene_expression of Vav3 3 0.78 9.71 0.06
65 INT294400 Transcription of Vav2 1 0.53 0 0.06
66 INT294404 Transcription of Vav3 1 0.53 0 0.06
67 INT333229 Negative_regulation of Phosphorylation of Pxn 1 0.08 0.96 0.06
68 INT294398 Gene_expression of Vav2 1 0.78 10.67 0.06
69 INT333237 Phosphorylation of Pxn 1 0.12 0.95 0.06
70 INT302624 Negative_regulation of Gene_expression of Rac1 1 0.56 3.67 0.06
71 INT225726 Positive_regulation of PXN 1 0.05 0.34 0.06
72 INT263798 Gene_expression of VCL 1 0.18 1.14 0.05
73 INT323949 Negative_regulation of Positive_regulation of Rac1 1 0.23 0.53 0.05
74 INT338241 Positive_regulation of VAV3 1 0.56 1.28 0.04
75 INT334445 Regulation of Positive_regulation of Rac1 1 0.40 1.73 0.04
76 INT352009 Positive_regulation of Gene_expression of Pxn 1 0.07 0.1 0.04
77 INT254550 Negative_regulation of Gene_expression of RAC1 1 0.13 0.63 0.04
78 INT254537 Negative_regulation of Binding of RAC1 1 0.13 0.64 0.04
79 INT191746 Gene_expression of Ptpro 1 0.28 0.85 0.04
80 INT302611 Regulation of Gene_expression of Rac1 1 0.43 4.5 0.03
81 INT338258 Binding of VAV3 1 0.39 0.86 0.03
82 INT198711 Binding of NCK1 1 0.05 1.08 0.03
83 INT206165 Positive_regulation of Localization of RAC1 1 0.16 0.07 0.03
84 INT302615 Transcription of Rac1 5 0.66 1.1 0
85 INT294394 Negative_regulation of Gene_expression of Vav2 1 0.43 0.77 0
86 INT294407 Positive_regulation of Negative_regulation of Vav3 1 0.50 0.73 0
87 INT286551 Binding of Pxn 1 0.08 0.94 0
88 INT287053 Phosphorylation of Vav2 1 0.43 0 0
89 INT334450 Regulation of Localization of Rac1 1 0.30 0.65 0
90 INT338234 Localization of VAV3 1 0.61 0.38 0
91 INT228095 Phosphorylation of Rac1 1 0.34 0.21 0
92 INT302609 Positive_regulation of Transcription of Rac1 1 0.48 0.27 0
93 INT338248 Negative_regulation of Gene_expression of VAV3 1 0.48 2.92 0
94 INT302631 Regulation of Transcription of Rac1 1 0.43 0.47 0
95 INT294396 Regulation of Vav2 1 0.45 1.43 0
96 INT257362 Negative_regulation of Localization of RAC1 1 0.24 0.58 0
97 INT309323 Positive_regulation of NCK1 1 0.01 0.06 0
98 INT302621 Regulation of Negative_regulation of Rac1 1 0.43 0 0
99 INT294409 Regulation of Vav3 1 0.45 1.42 0
100 INT338235 Negative_regulation of VAV3 1 0.48 0.38 0
101 INT294397 Regulation of Binding of Vav3 1 0.45 0.87 0
102 INT302627 Negative_regulation of Localization of Rac1 1 0.41 0.28 0
103 INT338236 Gene_expression of VAV3 1 0.63 8.45 0
104 INT302620 Negative_regulation of Transcription of Rac1 1 0.41 0 0
105 INT294403 Localization of Vav3 1 0.80 0.96 0
106 INT334438 Positive_regulation of Localization of Rac1 1 0.33 2.37 0
107 INT295687 Positive_regulation of Binding of RAC1 1 0.25 0 0
108 INT294401 Localization of Vav2 1 0.80 0.97 0
109 INT338243 Positive_regulation of Gene_expression of VAV3 1 0.41 1.9 0
110 INT295678 Regulation of Positive_regulation of RAC1 1 0.23 1.55 0
111 INT283878 Localization of VCL 1 0.19 1.12 0
112 INT191744 Binding of Ptpro 1 0.15 0.79 0
113 INT294406 Positive_regulation of Negative_regulation of Vav2 1 0.50 0.73 0
114 INT294395 Binding of Vav2 1 0.48 0.82 0
115 INT254786 Positive_regulation of Negative_regulation of Rac1 1 0.26 0.95 0
116 INT302614 Positive_regulation of Binding of Rac1 1 0.48 0.31 0
117 INT294402 Binding of Vav3 1 0.48 2.43 0
118 INT294399 Negative_regulation of Vav3 1 0.59 1.59 0
119 INT307737 Binding of VCL 1 0.13 0.36 0
120 INT294405 Negative_regulation of Vav2 1 0.59 1.58 0
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