GO:0030041

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Name actin filament polymerization
Categary Process
Go Slim No
Go Link GO:0030041
Unique Molecular Interactions 106
Total Molecular Interactions 129
Total Single Events 653
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for actin filament polymerization. They are ordered first by their pain relevance and then by number of times they were reported for actin filament polymerization. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT113337 EPO Positive_regulation of JAK2 1 0.76 2.8 1.55
2 INT105295 WAS Regulation of PTGS1 1 0.02 0.13 1.27
3 INT212815 WAS Positive_regulation of CNR1 1 0.01 0.62 1.16
4 INT212824 WAS Positive_regulation of Cnr1 1 0.21 0.62 1.16
5 INT34271 Positive_regulation of WAS Positive_regulation of Oprd1 1 0.01 0 0.91
6 INT34273 WAS Regulation of Oprd1 1 0.00 0 0.91
7 INT34272 WAS Positive_regulation of Oprd1 1 0.01 0 0.91
8 INT19299 ANG Regulation of AVP 1 0.25 0 0.82
9 INT121966 HRAS Positive_regulation of RAC1 1 0.75 0.41 0.67
10 INT121713 WAS Positive_regulation of Gene_expression of SELP 1 0.30 0.49 0.63
11 INT263977 PROC Negative_regulation of JAK2 1 0.00 0.93 0.47
12 INT109780 WAS Regulation of Localization of Acot1 1 0.01 0.26 0.46
13 INT19297 ANG Positive_regulation of AVP 1 0.28 0 0.46
14 INT19298 ANG Regulation of OXT 1 0.07 0 0.41
15 INT96833 Binding of WAS and Positive_regulation of Cnr1 1 0.02 0.69 0.39
16 INT345006 CSF2 Regulation of GSN 1 0.16 0.82 0.39
17 INT96834 Binding of WAS and Positive_regulation of Cnr2 1 0.03 0.69 0.39
18 INT96836 WAS Positive_regulation of Cnr1 1 0.02 0.69 0.39
19 INT96835 WAS Positive_regulation of Cnr2 1 0.03 0.69 0.39
20 INT303994 Il6 Positive_regulation of JAK2 1 0.03 0.41 0.37
21 INT345012 GSN Regulation of CCBE1 1 0.00 0.82 0.36
22 INT345010 GSN Regulation of DBP 1 0.26 0.81 0.36
23 INT231535 Binding of JAK2 and SOAT1 1 0.01 0.3 0.35
24 INT254391 Binding of F13A1 and GSN 1 0.00 1.08 0.34
25 INT254393 Binding of FN1 and GSN 1 0.01 1.08 0.34
26 INT295722 PTGER2 Positive_regulation of RAC1 1 0.02 2.14 0.32
27 INT337161 Binding of Diap1 and Iqgap1 1 0.29 0.78 0.28
28 INT118848 GNA14 Positive_regulation of RAC1 1 0.01 0.14 0.26
29 INT242215 Binding of ANG and OLR1 1 0.02 1.63 0.25
30 INT292561 MAP3K5 Positive_regulation of Positive_regulation of RAC1 1 0.03 0 0.23
31 INT323757 Negative_regulation of ACE2 Negative_regulation of ANG 1 0.18 1.73 0.17
32 INT323756 Negative_regulation of ACE2 Positive_regulation of ANG 1 0.19 1.73 0.17
33 INT326097 WAS Regulation of Gopc 1 0.01 0.55 0.16
34 INT254392 Binding of CRP and GSN 1 0.12 0.33 0.16
35 INT206070 ANG Positive_regulation of Transcription of IL6 1 0.05 1.5 0.15
36 INT104764 Binding of WAS and IL1RAPL1 1 0.00 0.17 0.15
37 INT337164 Binding of DIAPH1 and Iqgap1 1 0.53 0.37 0.14
38 INT147727 Phosphorylation of PTK2 Regulation of Positive_regulation of RAC1 1 0.34 0.32 0.14
39 INT102885 Binding of ANG and ACE 2 0.17 0.37 0.13
40 INT281911 Binding of ANG and MAS1 1 0.05 0.39 0.13
41 INT345011 Binding of GSN and PTAFR 1 0.09 0.83 0.12
42 INT281912 Binding of AGTR2 and ANG 1 0.13 0.37 0.1
43 INT281899 Binding of ANG and NOS3 1 0.12 0.37 0.1
44 INT206054 RAC1 Positive_regulation of STAT3 1 0.07 0.11 0.09
45 INT185644 Binding of STATH and WASF1 1 0.00 0 0.09
46 INT348167 Thbs1 Positive_regulation of RAC1 1 0.04 0.71 0.08
47 INT206072 ANG Positive_regulation of IL6 1 0.05 0.5 0.08
48 INT273374 Binding of JAK2 and STAT3 1 0.24 0 0.07
49 INT273368 Negative_regulation of Binding of JAK2 and STAT3 1 0.28 0 0.07
50 INT21649 ANG Regulation of Alb 1 0.04 0.64 0.07
51 INT206080 ANG Regulation of Gene_expression of IL6 1 0.03 0.4 0.07
52 INT206063 ANG Positive_regulation of Gene_expression of KRT20 1 0.00 1.01 0.07
53 INT273371 JAK2 Regulation of Protein_catabolism of SOCS1 1 0.01 0 0.06
54 INT325769 Binding of EPOR and Positive_regulation of Phosphorylation of JAK2 1 0.66 0 0.06
55 INT273365 JAK2 Regulation of SOCS1 1 0.01 0 0.06
56 INT238117 Positive_regulation of STAT3 Positive_regulation of Gene_expression of JAK2 1 0.11 0 0.05
57 INT281906 BDKRB2 Positive_regulation of ANG 1 0.11 0.51 0.05
58 INT206087 RAC1 Positive_regulation of Gene_expression of STAT3 1 0.08 0.05 0.05
59 INT336132 Binding of AGTR1 and ANG 1 0.00 0.38 0.05
60 INT238116 STAT3 Positive_regulation of Gene_expression of JAK2 1 0.16 0 0.05
61 INT206073 Negative_regulation of RAC1 Positive_regulation of IL6 1 0.14 0.06 0.04
62 INT206067 Gene_expression of RAC1 Positive_regulation of Positive_regulation of IL6 1 0.16 0.07 0.04
63 INT206068 RAC1 Positive_regulation of IL6 1 0.16 0.06 0.04
64 INT345182 Binding of Lpar1 and Gsn 1 0.04 0 0.04
65 INT102887 Binding of ANG and SGCG 1 0.37 0 0.03
66 INT206061 RAC1 Positive_regulation of Positive_regulation of STAT3 1 0.07 0.43 0.03
67 INT194707 RAC1 Positive_regulation of PAK1 1 0.01 0 0.03
68 INT194738 Binding of PAK1 and RAC1 1 0.01 0 0.03
69 INT254511 RAC1 Positive_regulation of Positive_regulation of CYBB 1 0.14 0.39 0.03
70 INT225898 Positive_regulation of RAC1 Positive_regulation of PAK1 1 0.01 0.08 0
71 INT295710 PTGER2 Regulation of Positive_regulation of RAC1 1 0.01 1.62 0
72 INT295701 Positive_regulation of Binding of RAC1 and Racgap1 1 0.28 0.16 0
73 INT206079 ANG Regulation of KRT20 1 0.00 0.54 0
74 INT235011 Ctnnd1 Positive_regulation of RAC1 1 0.00 0.07 0
75 INT206069 ANG Positive_regulation of Gene_expression of IL6 1 0.05 0.51 0
76 INT249151 Binding of Cfl1 and Was 1 0.01 0.18 0
77 INT321783 Binding of Pi4kb and Gsn 1 0.03 0 0
78 INT349987 Per1 Positive_regulation of Gene_expression of Diap1 1 0.08 0 0
79 INT306269 Binding of MAPK8 and RAC1 1 0.25 0 0
80 INT101591 Binding of RAC1 and RAC3 1 0.13 0.52 0
81 INT225908 Binding of RAC1 and IQGAP1 1 0.00 0.09 0
82 INT225890 Binding of RAC1 and STAT3 1 0.01 0 0
83 INT336129 Binding of ANG and EXTL3 1 0.01 0.38 0
84 INT249148 Binding of Was and Racgap1 1 0.03 0.18 0
85 INT300081 Binding of JAK2 and TYK2 1 0.09 1.13 0
86 INT345154 Lpar1 Positive_regulation of Phosphorylation of Gsn 1 0.05 0 0
87 INT295700 Binding of RAC1 and Racgap1 1 0.21 0.16 0
88 INT336131 Binding of ANG and ATP6AP2 1 0.00 0.38 0
89 INT321771 Binding of P4hb and Gsn 1 0.31 0.38 0
90 INT321776 Whrn Regulation of Localization of Gsn 1 0.23 0.07 0
91 INT350503 Binding of HSP90AA1 and JAK2 1 0.06 1.39 0
92 INT249149 Binding of Cdc42 and Was 1 0.08 0.18 0
93 INT206077 RAC1 Positive_regulation of Phosphorylation of STAT3 1 0.07 0.35 0
94 INT321780 Binding of Guk1 and Gsn 1 0.06 0 0
95 INT312304 Binding of JAK2 and VEGFA 1 0.30 0.82 0
96 INT281904 ANG Positive_regulation of PTGIS 1 0.04 0 0
97 INT194695 RAC1 Positive_regulation of PAK4 1 0.00 0 0
98 INT321775 Binding of Whrn and Gsn 1 0.46 0.42 0
99 INT348534 ELMO1 Positive_regulation of RAC1 1 0.02 0.7 0
100 INT193343 Binding of STAR and WASF1 1 0.04 0 0
101 INT225891 DOCK1 Positive_regulation of RAC1 1 0.01 0 0
102 INT336130 Binding of ANG and REN 1 0.06 0.38 0
103 INT225899 Binding of DOCK1 and RAC1 1 0.01 0 0
104 INT198026 JAK2 Positive_regulation of HCC 1 0.19 1.35 0
105 INT350505 Negative_regulation of Binding of HSP90AA1 and JAK2 1 0.07 1.5 0
106 INT350504 ABL1 Negative_regulation of JAK2 1 0.20 2.18 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for actin filament polymerization. They are ordered first by their pain relevance and then by number of times they were reported in actin filament polymerization. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT87698 Gene_expression of WAS 25 0.58 8.75 11.83
2 INT29740 Gene_expression of ANG 55 0.78 24.53 9.86
3 INT34268 Binding of WAS 14 0.47 4.41 8.67
4 INT87699 Positive_regulation of WAS 16 0.45 5.84 8.03
5 INT189230 Gene_expression of GSN 12 0.75 25.04 7.6
6 INT33105 Regulation of WAS 11 0.60 3.61 7.18
7 INT254400 Negative_regulation of GSN 22 0.57 18.15 5.89
8 INT69350 Gene_expression of RAC1 23 0.77 12.16 5.54
9 INT48456 Localization of WAS 6 0.56 1.63 3.95
10 INT78619 Positive_regulation of RAC1 27 0.65 10.43 3.75
11 INT121967 Regulation of RAC1 9 0.45 6.14 3.41
12 INT105297 Negative_regulation of Regulation of WAS 3 0.28 0.98 3.07
13 INT113339 Binding of JAK2 6 0.40 5.31 2.4
14 INT118871 Negative_regulation of JAK2 15 0.57 11.4 2.16
15 INT70987 Binding of RAC1 14 0.37 12.14 2.13
16 INT189239 Binding of GSN 11 0.36 9.34 1.93
17 INT8787 Negative_regulation of WAS 4 0.42 2.42 1.81
18 INT29739 Positive_regulation of ANG 11 0.69 4.37 1.75
19 INT102893 Positive_regulation of Gene_expression of ANG 10 0.69 5.62 1.71
20 INT189226 Protein_catabolism of GSN 3 0.54 7.1 1.7
21 INT113340 Phosphorylation of JAK2 17 0.78 5.69 1.6
22 INT345015 Positive_regulation of Gene_expression of GSN 1 0.49 3.58 1.5
23 INT58930 Negative_regulation of RAC1 14 0.55 7.55 1.4
24 INT251834 Negative_regulation of Gene_expression of ANG 5 0.59 3.95 1.38
25 INT254397 Negative_regulation of Gene_expression of GSN 2 0.41 3.56 1.28
26 INT345013 Regulation of GSN 4 0.51 3.49 1.11
27 INT19303 Regulation of ANG 3 0.62 1.08 1.09
28 INT198049 Positive_regulation of JAK2 16 0.58 5.35 0.96
29 INT118538 Binding of ANG 5 0.47 3.02 0.92
30 INT261882 Positive_regulation of Protein_catabolism of WAS 1 0.03 0.14 0.92
31 INT261876 Protein_catabolism of WAS 1 0.05 0.14 0.92
32 INT175904 Localization of RAC1 7 0.41 5.05 0.86
33 INT111943 Negative_regulation of Positive_regulation of RAC1 2 0.46 1.33 0.86
34 INT187376 Regulation of Localization of WAS 1 0.08 0.38 0.86
35 INT187380 Negative_regulation of Localization of WAS 1 0.07 0.38 0.85
36 INT238201 Gene_expression of JAK2 9 0.70 7.09 0.81
37 INT109079 Negative_regulation of ANG 4 0.57 2.2 0.8
38 INT254401 Positive_regulation of GSN 4 0.38 2 0.79
39 INT111945 Protein_catabolism of RAC1 1 0.31 0.67 0.79
40 INT113342 Positive_regulation of Phosphorylation of JAK2 2 0.66 2.58 0.72
41 INT74484 Negative_regulation of WASF1 5 0.57 2.01 0.71
42 INT107156 Regulation of WASF1 3 0.23 1.61 0.7
43 INT185647 Binding of WASF1 5 0.05 2.46 0.67
44 INT87701 Negative_regulation of Positive_regulation of WAS 2 0.36 0.58 0.64
45 INT254402 Localization of GSN 2 0.78 2.73 0.63
46 INT22391 Positive_regulation of WASF1 2 0.45 1.52 0.63
47 INT143278 Regulation of Gene_expression of ANG 2 0.62 1.13 0.59
48 INT147734 Phosphorylation of RAC1 3 0.64 1.33 0.58
49 INT127736 Regulation of Gene_expression of RAC1 2 0.27 2 0.53
50 INT164267 Negative_regulation of Phosphorylation of RAC1 1 0.33 0.96 0.46
51 INT164266 Positive_regulation of Phosphorylation of RAC1 1 0.39 0.95 0.45
52 INT87700 Positive_regulation of Gene_expression of WAS 1 0.42 0 0.44
53 INT345016 Regulation of Gene_expression of GSN 1 0.38 0.78 0.35
54 INT102890 Localization of ANG 9 0.72 0.41 0.26
55 INT303972 Positive_regulation of Gene_expression of JAK2 2 0.63 1.3 0.24
56 INT321755 Regulation of Gsn 1 0.54 0.88 0.23
57 INT337145 Localization of Diap1 1 0.37 0.7 0.22
58 INT193376 Gene_expression of WASF1 7 0.75 1.6 0.2
59 INT254396 Negative_regulation of Transcription of GSN 1 0.36 0.78 0.19
60 INT254398 Transcription of GSN 1 0.44 0.78 0.19
61 INT337163 Localization of DIAPH1 1 0.68 0.41 0.14
62 INT282160 Regulation of Binding of RAC1 1 0.18 0.45 0.13
63 INT243073 Gene_expression of Gsn 5 0.68 1.47 0.12
64 INT321743 Binding of Gsn 1 0.42 1.41 0.12
65 INT337144 Positive_regulation of Localization of Diap1 1 0.24 0.36 0.11
66 INT312354 Regulation of Gene_expression of JAK2 1 0.25 1.17 0.1
67 INT176593 Positive_regulation of Gene_expression of RAC1 2 0.17 0.97 0.08
68 INT159858 Negative_regulation of Negative_regulation of RAC1 1 0.40 0.17 0.07
69 INT242229 Negative_regulation of Positive_regulation of ANG 1 0.08 0.63 0.06
70 INT310747 Regulation of JAK2 2 0.33 1.58 0.05
71 INT124020 Negative_regulation of Gene_expression of WAS 2 0.06 0.25 0.05
72 INT238202 Negative_regulation of Localization of JAK2 1 0.09 0 0.05
73 INT238200 Localization of JAK2 1 0.16 0 0.05
74 INT249134 Localization of Was 1 0.64 0.06 0.05
75 INT336137 Negative_regulation of Binding of ANG 1 0.08 0.38 0.05
76 INT254550 Negative_regulation of Gene_expression of RAC1 1 0.13 0.63 0.04
77 INT249135 Gene_expression of Was 1 0.76 4.18 0.04
78 INT254537 Negative_regulation of Binding of RAC1 1 0.13 0.64 0.04
79 INT238199 Positive_regulation of Positive_regulation of JAK2 1 0.10 0 0.03
80 INT249136 Regulation of Was 1 0.38 0.55 0.03
81 INT206165 Positive_regulation of Localization of RAC1 1 0.16 0.07 0.03
82 INT321733 Transcription of Gsn 1 0.61 0.63 0.03
83 INT193373 Localization of WASF1 1 0.42 0 0
84 INT249143 Binding of Was 1 0.32 0.16 0
85 INT321742 Positive_regulation of Gsn 1 0.36 0.19 0
86 INT323760 Protein_catabolism of ANG 1 0.24 0.44 0
87 INT345130 Phosphorylation of Gsn 1 0.09 0 0
88 INT257362 Negative_regulation of Localization of RAC1 1 0.24 0.58 0
89 INT246980 Binding of DIAPH1 1 0.04 0.11 0
90 INT238196 Negative_regulation of Binding of JAK2 1 0.09 0 0
91 INT321728 Negative_regulation of Gsn 1 0.38 0 0
92 INT321734 Regulation of Localization of Gsn 1 0.40 0.07 0
93 INT249133 Negative_regulation of Was 1 0.42 0.24 0
94 INT297037 Regulation of DIAPH1 1 0.27 0.1 0
95 INT349986 Positive_regulation of Diap1 1 0.08 0 0
96 INT249141 Positive_regulation of Gene_expression of Was 1 0.43 0.08 0
97 INT249138 Protein_catabolism of Was 1 0.75 0.08 0
98 INT350506 Protein_catabolism of JAK2 1 0.48 1.55 0
99 INT320539 Negative_regulation of Phosphorylation of JAK2 1 0.26 0.46 0
100 INT295687 Positive_regulation of Binding of RAC1 1 0.25 0 0
101 INT281924 Transcription of ANG 1 0.39 0.1 0
102 INT321756 Negative_regulation of Gene_expression of Gsn 1 0.52 0.13 0
103 INT249142 Negative_regulation of Gene_expression of Was 1 0.41 0.05 0
104 INT342314 Regulation of Gene_expression of WASF1 1 0.02 1.1 0
105 INT349985 Gene_expression of Diap1 1 0.11 0 0
106 INT295678 Regulation of Positive_regulation of RAC1 1 0.23 1.55 0
107 INT321747 Positive_regulation of Gene_expression of Gsn 1 0.44 0.32 0
108 INT269630 Positive_regulation of DIAPH1 1 0.01 0 0
109 INT321741 Localization of Gsn 1 0.71 0.53 0
110 INT281916 Negative_regulation of Transcription of ANG 1 0.23 0.1 0
111 INT249140 Transcription of Was 1 0.67 0 0
112 INT249139 Positive_regulation of Was 1 0.43 0.13 0
113 INT249137 Positive_regulation of Negative_regulation of Was 1 0.49 0.05 0
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