GO:0030056

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Name hemidesmosome
Categary Component
Go Slim No
Go Link GO:0030056
Unique Molecular Interactions 85
Total Molecular Interactions 100
Total Single Events 675
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for hemidesmosome. They are ordered first by their pain relevance and then by number of times they were reported for hemidesmosome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT168609 Binding of Itgb1 and Mmp9 1 0.02 0.41 1.58
2 INT12327 Igh-Dex Positive_regulation of Plec 1 0.03 0.73 1.57
3 INT81582 Plec Positive_regulation of st 1 0.02 0 1.07
4 INT81581 Plec Positive_regulation of Nudt14 1 0.01 0 1.07
5 INT253836 Cck Regulation of DST 1 0.03 0.42 0.95
6 INT89012 DST Positive_regulation of Insr 1 0.01 0.86 0.59
7 INT253835 Binding of DST and Fos 1 0.02 0 0.55
8 INT244421 Binding of DST and Ctss 1 0.02 0.42 0.41
9 INT67633 Binding of DST and Gabrd 1 0.03 0 0.41
10 INT25526 Dst Regulation of Gh 1 0.00 0.26 0.34
11 INT244422 Binding of DST and Fig4 1 0.01 0.42 0.29
12 INT291641 Binding of DST and ESRRG 1 0.16 1.8 0.28
13 INT291642 Binding of DST and GGT1 1 0.00 1.4 0.19
14 INT214170 Binding of DST and Lep 1 0.02 0.17 0.18
15 INT210795 Ihh Negative_regulation of Itgb1 1 0.30 0 0.17
16 INT274353 DST Regulation of Gopc 1 0.00 0 0.17
17 INT327879 Binding of Itgb1 and Postn 1 0.02 1.05 0.14
18 INT291644 Binding of DST and ESR1 1 0.05 0.84 0.14
19 INT254133 PLEC Regulation of MCRS1 1 0.03 0.33 0.13
20 INT201762 JUP Regulation of Gene_expression of Ccnd1 1 0.03 0.8 0.13
21 INT201791 JUP Regulation of Gene_expression of Myc 1 0.49 0.8 0.13
22 INT327877 Itgb1 Negative_regulation of Gene_expression of Dlk1 1 0.02 0.99 0.13
23 INT311727 Plat Regulation of Protein_catabolism of Col17a1 1 0.31 0.71 0.13
24 INT271525 ITGB1 Positive_regulation of Gopc 1 0.02 0.57 0.11
25 INT214168 Msx1 Positive_regulation of Gene_expression of DST 1 0.00 0.13 0.09
26 INT262163 Positive_regulation of Binding of Nr1i2 and Plec 1 0.04 0.31 0.09
27 INT214166 DST Negative_regulation of Gene_expression of Npy 1 0.02 0.07 0.09
28 INT262157 Binding of Nr1i2 and Plec 1 0.03 0.3 0.09
29 INT311083 DST Regulation of FOS 1 0.03 0.15 0.08
30 INT339111 Binding of ERBB2 and JUP 1 0.38 0.62 0.07
31 INT339108 Binding of ESR1 and JUP 1 0.38 0.62 0.07
32 INT135641 Binding of Dst and Ina 1 0.35 0.34 0.06
33 INT317416 Binding of FN1 and ITGB1 1 0.47 0.69 0.05
34 INT311082 DST Regulation of MAPK8 1 0.02 0.07 0.04
35 INT214167 Binding of DST and Pomc 1 0.03 0.22 0.03
36 INT214171 Binding of DST and Cartpt 1 0.01 0.21 0.03
37 INT205046 MUC13 Negative_regulation of Localization of COL17A1 1 0.31 0.62 0
38 INT311211 Binding of Plec and Postn 1 0.00 0.6 0
39 INT199367 DST Regulation of Igf2 1 0.03 1.03 0
40 INT282331 Binding of DST and Gopc 1 0.01 0.61 0
41 INT315069 ITGB4 Regulation of MT1X 1 0.27 0.52 0
42 INT199368 DST Positive_regulation of Gene_expression of Igf2 1 0.04 1.51 0
43 INT262213 Plec Positive_regulation of Cyp3a11 1 0.02 0 0
44 INT199371 DST Regulation of Transcription of Igf2 1 0.05 1.47 0
45 INT221650 Binding of Plec and Fer 1 0.08 0 0
46 INT282330 Binding of DST and Arc 1 0.04 1.1 0
47 INT199366 DST Positive_regulation of Macf1 1 0.01 1.14 0
48 INT266555 Mapk8 Regulation of JUP 1 0.08 0.1 0
49 INT199370 DST Regulation of Gene_expression of Igf2 1 0.02 1.07 0
50 INT199369 DST Regulation of Igf1 1 0.02 0.8 0
51 INT282329 Regulation of Binding of DST and Arc 1 0.03 0.35 0
52 INT315071 ITGB4 Regulation of Gene_expression of PAR4 1 0.35 0.53 0
53 INT205056 LGALS4 Negative_regulation of Localization of COL17A1 1 0.32 0.62 0
54 INT291643 Binding of DST and INS 1 0.07 0.38 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for hemidesmosome. They are ordered first by their pain relevance and then by number of times they were reported in hemidesmosome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT12325 Gene_expression of Plec 47 0.72 11.92 13.35
2 INT67101 Gene_expression of DST 47 0.54 25.92 9.59
3 INT38644 Positive_regulation of DST 30 0.53 12.48 6.59
4 INT94453 Gene_expression of ITGB1 50 0.75 18.41 4.72
5 INT205272 Positive_regulation of Gene_expression of Plec 11 0.43 1.5 4.49
6 INT11761 Negative_regulation of DST 13 0.42 7.66 3.65
7 INT102076 Regulation of DST 15 0.22 10 3.5
8 INT205266 Regulation of Gene_expression of Plec 3 0.57 1.45 1.74
9 INT168602 Negative_regulation of Itgb1 3 0.21 1.29 1.73
10 INT135640 Negative_regulation of Dst 5 0.57 2.25 1.56
11 INT205269 Positive_regulation of Plec 8 0.43 1.78 1.55
12 INT57973 Positive_regulation of ITGB1 5 0.67 1.23 1.44
13 INT38645 Negative_regulation of Positive_regulation of DST 3 0.29 1.05 1.29
14 INT101027 Binding of DST 20 0.41 10.9 1.17
15 INT227925 Negative_regulation of Gene_expression of ITGB1 1 0.02 2.19 1.12
16 INT5986 Negative_regulation of Plec 1 0.18 1.56 1.08
17 INT242171 Protein_catabolism of JUP 4 0.96 0.91 1.01
18 INT113672 Positive_regulation of Gene_expression of ITGB1 3 0.49 1.4 0.86
19 INT205275 Regulation of Plec 4 0.42 2.93 0.8
20 INT205270 Regulation of Regulation of Plec 1 0.01 0.2 0.71
21 INT244420 Positive_regulation of Gene_expression of DST 4 0.41 2.05 0.59
22 INT341563 Positive_regulation of ITGB4 1 0.38 2.58 0.59
23 INT145225 Transcription of ITGB1 1 0.10 0.1 0.52
24 INT266535 Phosphorylation of JUP 3 0.79 0.63 0.49
25 INT200851 Binding of Plec 8 0.44 4.77 0.46
26 INT242168 Transcription of JUP 4 0.67 1.17 0.46
27 INT214136 Localization of DST 7 0.65 2.59 0.42
28 INT135638 Binding of Dst 4 0.36 2.76 0.38
29 INT200744 Regulation of Gene_expression of DST 5 0.20 2.64 0.36
30 INT229679 Localization of Plec 4 0.65 1.64 0.35
31 INT242169 Positive_regulation of Protein_catabolism of JUP 1 0.49 0.23 0.34
32 INT119073 Negative_regulation of ITGB1 1 0.01 0.1 0.33
33 INT185886 Gene_expression of JUP 20 0.75 15.41 0.32
34 INT68338 Gene_expression of PLEC 4 0.75 0.44 0.32
35 INT75628 Gene_expression of Dst 4 0.60 0.78 0.31
36 INT229681 Negative_regulation of Plec 2 0.39 1.71 0.3
37 INT82066 Gene_expression of COL17A1 1 0.74 1.83 0.3
38 INT221546 Transcription of Plec 2 0.17 0.61 0.29
39 INT75626 Positive_regulation of Dst 2 0.50 0.52 0.23
40 INT282322 Regulation of Binding of DST 1 0.04 0.35 0.22
41 INT262098 Negative_regulation of Positive_regulation of Plec 1 0.03 0.41 0.21
42 INT135637 Regulation of Dst 3 0.44 1.03 0.2
43 INT225973 Binding of Itgb1 2 0.08 1.1 0.2
44 INT245860 Gene_expression of Itgb1 8 0.42 5.37 0.19
45 INT3891 Regulation of Plec 1 0.24 0.17 0.18
46 INT151742 Positive_regulation of PLEC 3 0.41 0.89 0.17
47 INT200745 Negative_regulation of Gene_expression of DST 3 0.10 2.75 0.17
48 INT189311 Gene_expression of ITGB4 2 0.41 0.53 0.16
49 INT82067 Positive_regulation of Gene_expression of COL17A1 1 0.66 0.91 0.15
50 INT205083 Positive_regulation of JUP 6 0.49 5.51 0.13
51 INT311708 Positive_regulation of Protein_catabolism of Col17a1 1 0.30 0.69 0.13
52 INT75625 Localization of Dst 1 0.75 0.15 0.13
53 INT254136 Regulation of PLEC 1 0.23 0.33 0.13
54 INT230645 Binding of PLEC 3 0.47 0.8 0.12
55 INT222042 Localization of ITGB1 3 0.29 0.72 0.12
56 INT311721 Protein_catabolism of Col17a1 1 0.53 0.63 0.12
57 INT242173 Positive_regulation of Gene_expression of JUP 2 0.49 2.37 0.09
58 INT309877 Localization of JUP 2 0.73 1.38 0.08
59 INT339206 Negative_regulation of Localization of JUP 1 0.41 1.1 0.08
60 INT82068 Negative_regulation of Gene_expression of COL17A1 1 0.41 0.41 0.07
61 INT229678 Regulation of Localization of Plec 1 0.25 0.78 0.07
62 INT214135 Transcription of DST 1 0.05 0.41 0.06
63 INT244419 Positive_regulation of Binding of DST 1 0.02 0.15 0.06
64 INT134674 Transcription of PLEC 1 0.49 0.41 0.06
65 INT326581 Positive_regulation of Gene_expression of Dst 1 0.36 0.17 0.05
66 INT341556 Binding of ITGB4 1 0.18 0 0.04
67 INT317004 Regulation of Phosphorylation of PLEC 1 0.37 0.06 0.03
68 INT317003 Phosphorylation of PLEC 1 0.67 0.06 0.03
69 INT266537 Positive_regulation of Phosphorylation of JUP 2 0.49 0.29 0
70 INT268299 Positive_regulation of Gene_expression of Itgb1 2 0.38 1.37 0
71 INT266534 Negative_regulation of Phosphorylation of JUP 2 0.41 0.15 0
72 INT242174 Negative_regulation of Gene_expression of JUP 2 0.41 2.58 0
73 INT221864 Binding of JUP 2 0.36 1.05 0
74 INT282119 Negative_regulation of Negative_regulation of Plec 1 0.20 0.45 0
75 INT309874 Positive_regulation of Binding of JUP 1 0.49 0.32 0
76 INT225977 Regulation of Binding of Itgb1 1 0.07 0.41 0
77 INT205090 Localization of COL17A1 1 0.57 0.61 0
78 INT242170 Negative_regulation of JUP 1 0.42 0.85 0
79 INT245366 Regulation of Itgb1 1 0.03 0 0
80 INT355317 Negative_regulation of Gene_expression of Itgb1 1 0.20 0.14 0
81 INT291604 Binding of ITGB1 1 0.05 0.16 0
82 INT291645 Positive_regulation of Localization of DST 1 0.41 0.49 0
83 INT205097 Binding of COL17A1 1 0.28 0.63 0
84 INT309876 Regulation of JUP 1 0.60 0.67 0
85 INT315097 Localization of ITGB4 1 0.51 0.26 0
86 INT229680 Negative_regulation of Gene_expression of Plec 1 0.39 0.41 0
87 INT280923 Localization of Itgb1 1 0.40 0.72 0
88 INT309875 Regulation of Gene_expression of JUP 1 0.44 0.39 0
89 INT311719 Regulation of Col17a1 1 0.16 0.33 0
90 INT175647 Regulation of Gene_expression of ITGB1 1 0.01 0.4 0
91 INT355092 Positive_regulation of Transcription of JUP 1 0.49 0.05 0
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