GO:0030070

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Name insulin processing
Categary Process
Go Slim No
Go Link GO:0030070
Unique Molecular Interactions 223
Total Molecular Interactions 338
Total Single Events 1636
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for insulin processing. They are ordered first by their pain relevance and then by number of times they were reported for insulin processing. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT32444 Binding of Cpe and Pomc 2 0.22 0 4.47
2 INT73071 Binding of Cpe and Insrr 3 0.01 0.33 3.38
3 INT270949 Binding of Slc6a3 and Cpe 1 0.28 0.25 3.19
4 INT42728 Binding of PRLR and Cpe 1 0.00 0 2.91
5 INT56726 Cpe Negative_regulation of Pomc 1 0.07 0 2.41
6 INT45376 Binding of Cpe and Mme 1 0.07 0.32 2.13
7 INT69556 Slc7a11 Regulation of Cpe 2 0.06 0.46 1.95
8 INT73072 Negative_regulation of Binding of Cpe and Insrr 1 0.00 0 1.94
9 INT167319 Binding of OPRM1 and PCSK2 1 0.22 0.63 1.77
10 INT167320 Binding of CPE and OPRM1 1 0.14 0.63 1.77
11 INT26985 Cpe Negative_regulation of Localization of Ins1 1 0.02 0 1.57
12 INT76651 Cpe Positive_regulation of Gene_expression of Il6 1 0.08 0 1.56
13 INT111760 Dio1 Positive_regulation of Binding of Cpe 1 0.04 0.34 1.44
14 INT111761 Positive_regulation of Binding of Cpe and Insrr 1 0.01 0.33 1.43
15 INT111756 Dio1 Positive_regulation of Cpe 1 0.04 0.34 1.42
16 INT111759 Binding of Cpe and Drd2 1 0.01 0.32 1.42
17 INT111762 Positive_regulation of Binding of Cpe and Drd2 1 0.02 0.33 1.42
18 INT43814 Binding of Cpe and Oprm1 1 0.08 0 1.41
19 INT115985 Cpe Positive_regulation of Binding of Gnas 1 0.00 0.17 1.28
20 INT43446 Binding of Cpe and H3 1 0.02 0 1.25
21 INT33605 DFP Positive_regulation of Cpe 1 0.16 0 1.16
22 INT326665 Cpe Positive_regulation of Oprd1 1 0.01 1.24 1.15
23 INT84488 Negative_regulation of Binding of Cpe and Mif-ps1 1 0.06 0 1.13
24 INT84487 Binding of Cpe and Mif-ps1 1 0.05 0 1.13
25 INT161011 Binding of Cpe and St13 2 0.03 0.61 1.07
26 INT6415 Binding of Cpe and Oprd1 1 0.00 0 1.07
27 INT147232 Binding of tn and Cpe 1 0.03 1.55 0.95
28 INT42482 Binding of Cpe and Pebp1 1 0.02 0 0.95
29 INT12373 SCN5A Negative_regulation of Cpe 1 0.00 0 0.94
30 INT59482 Cpe Positive_regulation of Rbm39 1 0.02 0 0.89
31 INT26984 Cpe Regulation of Ins1 1 0.02 0 0.87
32 INT76652 Cpe Positive_regulation of Il6 1 0.08 0 0.87
33 INT41862 Agtr2 Regulation of Cpe 1 0.00 0 0.84
34 INT41865 Avp Regulation of Cpe 1 0.00 0 0.84
35 INT41864 Nts Regulation of Cpe 1 0.01 0 0.84
36 INT41867 GRP Regulation of Cpe 1 0.00 0 0.84
37 INT111744 Negative_regulation of Pcsk2 Positive_regulation of Sst 1 0.07 0 0.8
38 INT111745 Negative_regulation of Pcsk2 Positive_regulation of Npy 1 0.43 0 0.8
39 INT111743 Negative_regulation of Pcsk2 Positive_regulation of Cpe 1 0.06 0 0.8
40 INT111746 Negative_regulation of Pcsk2 Positive_regulation of Gene_expression of Sst 1 0.07 0 0.8
41 INT26982 Cpe Regulation of Localization of Pomc 1 0.01 0 0.75
42 INT26983 Cpe Regulation of Localization of Ins1 1 0.02 0 0.75
43 INT26986 Cpe Regulation of Pomc 1 0.01 0 0.73
44 INT26990 Pomc Regulation of Cpe 1 0.01 0 0.73
45 INT31243 Binding of Mme and Cpe 1 0.01 0 0.72
46 INT111747 Pcsk2 Regulation of Gene_expression of Npy 1 0.29 0 0.71
47 INT76654 Cpe Positive_regulation of Transcription of Il6 1 0.05 0 0.68
48 INT267891 Cpe Positive_regulation of Localization of Insrr 1 0.00 0 0.64
49 INT2700 Binding of App and Cpe 1 0.00 0 0.63
50 INT103000 Cpe Regulation of Penk 1 0.07 0.19 0.62
51 INT63525 Cpe Positive_regulation of Gpi1 1 0.03 0 0.59
52 INT270943 Binding of Prkcg and Cpe 1 0.05 0 0.58
53 INT270935 Cpe Regulation of Phosphorylation of Slc6a3 1 0.31 0 0.57
54 INT84489 Cpe Negative_regulation of Binding of Mif-ps1 1 0.06 0 0.56
55 INT28925 Cpe Regulation of Sh2b3 1 0.04 0.14 0.55
56 INT165045 Drd2 Regulation of Cpe 1 0.07 0 0.52
57 INT270937 Cpe Regulation of Slc6a3 1 0.36 0 0.5
58 INT47225 Asap1 Regulation of Cpe 1 0.04 0.18 0.49
59 INT6280 Cpe Regulation of Gene_expression of Mc2r 1 0.09 0 0.46
60 INT6279 Cpe Regulation of Gene_expression of Pomc 1 0.27 0 0.46
61 INT90642 Cpe Negative_regulation of Negative_regulation of Slc6a3 1 0.04 0 0.44
62 INT90765 Pcsk2 Positive_regulation of Gene_expression of Pdyn 1 0.41 0 0.39
63 INT42847 Binding of Cpe and SLTM 1 0.00 0 0.38
64 INT161009 Binding of Cpe and Itgam 1 0.03 0.53 0.37
65 INT80694 Cpe Negative_regulation of Positive_regulation of Fos 1 0.08 0 0.37
66 INT161004 Binding of Cpe and Cpb2 1 0.03 0.53 0.37
67 INT161000 Binding of Cpe and Gfap 1 0.05 0.53 0.37
68 INT270939 Gene_expression of Cpe Positive_regulation of Slc6a3 1 0.20 0 0.36
69 INT75941 Negative_regulation of Binding of Cpe and Frk 1 0.01 1.28 0.34
70 INT75946 Binding of Cpe and Frk 1 0.01 1.28 0.34
71 INT92444 Cpe Negative_regulation of Phosphorylation of Cd3eap 1 0.01 0 0.34
72 INT75942 Positive_regulation of Binding of Cpe and Frk 1 0.02 1.28 0.34
73 INT75949 Negative_regulation of Binding of Cpe and Ptafr 1 0.03 1.27 0.33
74 INT75953 Binding of Cpe and Ptafr 1 0.03 1.27 0.33
75 INT33581 Thop1 Positive_regulation of Cpe 1 0.01 0 0.33
76 INT75940 Positive_regulation of Binding of Cpe and Ptafr 1 0.04 1.27 0.33
77 INT115161 Adora2a Regulation of Gene_expression of Cpe 1 0.04 0.36 0.33
78 INT110464 Cpe Regulation of Phosphorylation of Atf2 1 0.02 0 0.32
79 INT110462 Cpe Regulation of Phosphorylation of Gtf3a 1 0.00 0 0.32
80 INT31276 Oxt Negative_regulation of Cpe 1 0.01 0 0.31
81 INT31275 Avp Negative_regulation of Cpe 1 0.00 0 0.31
82 INT31277 Penk Negative_regulation of Cpe 1 0.12 0 0.29
83 INT270954 Gene_expression of Cpe Positive_regulation of Gene_expression of Slc6a3 1 0.23 0 0.28
84 INT33584 Enpep Positive_regulation of Cpe 1 0.03 0 0.27
85 INT118928 Csf2 Regulation of Cpe 1 0.04 0.27 0.27
86 INT33583 Enpep Regulation of Positive_regulation of Cpe 1 0.03 0 0.27
87 INT33582 Thop1 Regulation of Positive_regulation of Cpe 1 0.01 0 0.26
88 INT74433 Binding of INS and Cpe 2 0.03 0 0.25
89 INT270955 Cpe Regulation of Gene_expression of Slc6a3 1 0.14 0 0.25
90 INT270951 Regulation of Binding of Slc6a3 and Cpe 1 0.23 0 0.25
91 INT270940 Negative_regulation of Binding of Slc6a3 and Cpe 1 0.25 0 0.23
92 INT77046 Binding of Pcsk2 and Olfr714 1 0.09 0.07 0.23
93 INT270948 Cpe Regulation of Regulation of Slc6a3 1 0.14 0.28 0.23
94 INT74437 Negative_regulation of Cpe Positive_regulation of Localization of INS 1 0.06 0 0.2
95 INT74431 Negative_regulation of Cpe Positive_regulation of Localization of PENK 1 0.44 0 0.2
96 INT74439 Negative_regulation of Cpe Positive_regulation of INS 1 0.06 0 0.2
97 INT74436 Negative_regulation of Cpe Positive_regulation of CHGA 1 0.44 0 0.2
98 INT74434 Negative_regulation of Cpe Positive_regulation of PENK 1 0.44 0 0.2
99 INT270947 Cpe Negative_regulation of Phosphorylation of Slc6a3 1 0.25 0 0.2
100 INT72117 Binding of PCSK2 and POMC 1 0.30 0 0.15
101 INT270983 Binding of Cpe and GSTK1 1 0.01 0.12 0.07
102 INT270956 Slc6a3 Positive_regulation of Cpe 1 0.29 0 0.03
103 INT197784 Binding of Cpe and Ptgs1 1 0.20 0 0.03
104 INT270941 Slc6a3 Positive_regulation of Binding of Cpe 1 0.29 0 0.03
105 INT134563 Cpe Positive_regulation of Gene_expression of Ifng 1 0.39 0 0
106 INT197762 Binding of KRT5 and Cpe 1 0.19 1.14 0
107 INT197760 Binding of C4a and Cpe 1 0.01 1.14 0
108 INT74438 POMC Positive_regulation of Binding of Cpe 1 0.44 0 0
109 INT74432 Binding of POMC and Cpe 1 0.27 0 0
110 INT134560 Cpe Negative_regulation of Gene_expression of Il2 1 0.17 0 0
111 INT134562 Cpe Regulation of Gene_expression of Ifng 1 0.30 0 0
112 INT69257 Drd2 Regulation of Gene_expression of Cpe 1 0.06 0 0
113 INT114539 Binding of Pcsk2 and Penk 1 0.07 0 0
114 INT74435 Binding of PENK and Cpe 1 0.27 0 0
115 INT134561 Cpe Negative_regulation of Gene_expression of Il4 1 0.11 0 0
116 INT280483 Binding of Bdnf and Cpe 1 0.01 0.08 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for insulin processing. They are ordered first by their pain relevance and then by number of times they were reported in insulin processing. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT8962 Gene_expression of Cpe 110 0.71 39.67 71.67
2 INT1486 Negative_regulation of Cpe 85 0.59 28.78 54.08
3 INT1487 Regulation of Cpe 68 0.62 10.24 52.91
4 INT5957 Positive_regulation of Cpe 65 0.69 21.07 51.22
5 INT5214 Localization of Cpe 49 0.73 13.3 44.36
6 INT2699 Binding of Cpe 40 0.48 7.07 33.64
7 INT17938 Binding of Cpe 28 0.48 11.17 13.62
8 INT22003 Negative_regulation of Cpe 25 0.58 6.23 12.94
9 INT5959 Protein_catabolism of Cpe 17 0.90 0.98 12.43
10 INT12372 Negative_regulation of Localization of Cpe 12 0.53 1.85 11.39
11 INT11208 Gene_expression of Cpe 23 0.78 2.42 11.09
12 INT20425 Localization of Cpe 23 0.81 5.18 9.14
13 INT9387 Positive_regulation of Cpe 27 0.70 3.99 8.87
14 INT14033 Negative_regulation of Gene_expression of Cpe 10 0.33 3.47 8.2
15 INT9389 Regulation of Cpe 14 0.61 2.23 7.79
16 INT38466 Positive_regulation of Localization of Cpe 7 0.29 1.36 7.2
17 INT62691 Transcription of Cpe 11 0.40 3.5 6.66
18 INT25822 Negative_regulation of Positive_regulation of Cpe 7 0.29 2.43 6.02
19 INT20064 Regulation of Gene_expression of Cpe 9 0.47 2.05 5.16
20 INT15450 Positive_regulation of Gene_expression of Cpe 11 0.34 4.53 4.34
21 INT51986 Negative_regulation of Pcsk2 8 0.50 1.4 4.1
22 INT51985 Gene_expression of Pcsk2 10 0.76 1.34 3.44
23 INT54364 Negative_regulation of Protein_catabolism of Cpe 4 0.53 0.15 3.14
24 INT21343 Regulation of Localization of Cpe 3 0.21 1.38 2.83
25 INT68444 Gene_expression of CPE 9 0.76 4.6 2.59
26 INT1488 Negative_regulation of Negative_regulation of Cpe 3 0.42 0.86 2.42
27 INT5958 Positive_regulation of Positive_regulation of Cpe 3 0.38 0.58 2.39
28 INT9386 Transcription of Cpe 7 0.72 0.53 2.31
29 INT9354 Negative_regulation of Binding of Cpe 3 0.21 0.09 2.3
30 INT87315 Negative_regulation of Transcription of Cpe 3 0.13 1.76 1.81
31 INT64737 Regulation of Regulation of Cpe 1 0.05 0 1.8
32 INT91560 Positive_regulation of Negative_regulation of Cpe 2 0.40 0.62 1.67
33 INT51984 Localization of Pcsk2 3 0.66 0.37 1.62
34 INT165347 Localization of CPE 2 0.55 0.59 1.56
35 INT111755 Regulation of Positive_regulation of Cpe 1 0.03 0.27 1.37
36 INT11207 Positive_regulation of Gene_expression of Cpe 3 0.46 0.17 1.33
37 INT32039 Positive_regulation of CPE 3 0.37 1.92 1.32
38 INT20424 Protein_catabolism of Cpe 3 0.52 0 1.28
39 INT122783 Regulation of Transcription of Cpe 2 0.20 0.21 1.21
40 INT41628 Positive_regulation of PCSK2 2 0.31 0.58 1.21
41 INT12888 Positive_regulation of Protein_catabolism of Cpe 1 0.55 0.21 0.94
42 INT39226 Positive_regulation of Negative_regulation of Cpe 2 0.45 0.17 0.93
43 INT41480 Positive_regulation of Binding of Cpe 1 0.15 0.42 0.92
44 INT165346 Localization of PCSK2 1 0.48 0.16 0.84
45 INT106458 Negative_regulation of PCSK2 1 0.36 0.6 0.81
46 INT91561 Regulation of Pcsk2 2 0.52 0.15 0.76
47 INT212265 Positive_regulation of Gene_expression of CPE 1 0.44 1.26 0.7
48 INT135376 Negative_regulation of Regulation of Cpe 1 0.32 0.13 0.66
49 INT23039 Positive_regulation of Transcription of Cpe 1 0.46 0.06 0.6
50 INT33926 Negative_regulation of Gene_expression of Cpe 2 0.31 0 0.59
51 INT69252 Positive_regulation of Transcription of Cpe 2 0.09 0 0.58
52 INT270969 Regulation of Gene_expression of Cpe 1 0.27 0 0.55
53 INT30936 Regulation of Protein_catabolism of Cpe 1 0.35 0.16 0.48
54 INT23152 Regulation of Localization of Cpe 1 0.45 0.1 0.46
55 INT105987 Negative_regulation of Protein_catabolism of Cpe 1 0.04 0 0.45
56 INT90760 Positive_regulation of Pcsk2 1 0.49 0 0.44
57 INT53084 Gene_expression of PCSK2 13 0.78 3.98 0.43
58 INT40182 Regulation of Binding of Cpe 1 0.01 0 0.41
59 INT42846 Regulation of Binding of Cpe 1 0.01 0 0.38
60 INT23153 Positive_regulation of Positive_regulation of Cpe 1 0.50 0 0.36
61 INT270972 Phosphorylation of Cpe 1 0.33 0 0.33
62 INT33578 Regulation of Negative_regulation of Cpe 1 0.04 0 0.3
63 INT284110 Positive_regulation of Transcription of PCSK2 1 0.49 3.16 0.2
64 INT91559 Regulation of Gene_expression of Pcsk2 1 0.23 0.15 0.12
65 INT284101 Transcription of PCSK2 1 0.67 1.57 0.1
66 INT9388 Regulation of Transcription of Cpe 1 0.45 0.38 0.09
67 INT214097 Protein_catabolism of Pcsk2 1 0.12 0 0.07
68 INT57641 Positive_regulation of Gene_expression of PCSK2 1 0.40 0.34 0
69 INT209767 Negative_regulation of CPE 1 0.04 0.25 0
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