GO:0030122

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Name AP-2 adaptor complex
Categary Component
Go Slim No
Go Link GO:0030122
Unique Molecular Interactions 118
Total Molecular Interactions 189
Total Single Events 2038
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for AP-2 adaptor complex. They are ordered first by their pain relevance and then by number of times they were reported for AP-2 adaptor complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT169218 Binding of EGFR and Coc 1 0.06 2.8 5.85
2 INT169297 TRPV1 Positive_regulation of EGFR 1 0.64 0.37 1.3
3 INT169289 CNR1 Positive_regulation of EGFR 1 0.62 0.36 1.28
4 INT118288 EGF Positive_regulation of Phosphorylation of EGFR 9 0.54 3.85 0.9
5 INT134454 EGF Positive_regulation of EGFR 3 0.56 1.32 0.88
6 INT134453 Negative_regulation of EGF Positive_regulation of EGFR 1 0.35 0.35 0.88
7 INT117341 ADAM17 Positive_regulation of EGFR 1 0.16 3.56 0.82
8 INT220738 EGF Regulation of Gene_expression of EGFR 1 0.09 0.6 0.67
9 INT169213 Binding of EGFR and CARTPT 1 0.00 0.22 0.67
10 INT55919 Binding of Sigmar1 and Ap2s1 1 0.02 0.84 0.6
11 INT169286 CNR1 Positive_regulation of Phosphorylation of EGFR 1 0.45 0.18 0.57
12 INT95059 Binding of Oprm1 and Slc18a3 1 0.04 0 0.52
13 INT220741 Binding of EGFR and SOAT1 1 0.02 0.37 0.49
14 INT272751 EGFR Regulation of Negative_regulation of Prkca 1 0.01 0 0.38
15 INT185799 Binding of EGFR and SPP1 1 0.19 0.64 0.29
16 INT166093 Negative_regulation of ROS1 Negative_regulation of Positive_regulation of EGFR 1 0.12 0.33 0.28
17 INT166094 Negative_regulation of CSK Negative_regulation of Positive_regulation of EGFR 1 0.02 0.33 0.28
18 INT258521 EGFR Positive_regulation of MMP2 1 0.39 0.91 0.24
19 INT202296 Binding of Slc18a3 and Gopc 1 0.02 0 0.23
20 INT258565 EGFR Positive_regulation of Meta 1 0.39 0.89 0.23
21 INT272753 Positive_regulation of Prkaca Positive_regulation of EGFR 1 0.01 0 0.23
22 INT352355 Binding of CNR1 and EGFR 1 0.19 0.76 0.2
23 INT145152 Binding of EGF and EGFR 4 0.15 2.45 0.19
24 INT298196 EGFR Positive_regulation of PIK3CD 1 0.04 0.65 0.18
25 INT298192 EGFR Positive_regulation of AKT1 1 0.10 0.65 0.18
26 INT352354 EGFR Regulation of Gene_expression of CNR1 1 0.23 1.16 0.17
27 INT160931 Slc18a3 Positive_regulation of Penk 1 0.30 1.18 0.15
28 INT147863 Binding of CHAT and SLC18A3 1 0.34 0.8 0.14
29 INT175401 Binding of EGFR and VEGFA 2 0.13 1.49 0.13
30 INT258016 AGTR1 Positive_regulation of EGFR 1 0.15 1.24 0.13
31 INT341828 Binding of BTC and EGFR 1 0.22 0.95 0.12
32 INT315829 Binding of EGFR and TKT 1 0.03 1.14 0.12
33 INT272750 Prkaca Positive_regulation of EGFR 1 0.02 0 0.11
34 INT272752 Regulation of Prkaca Positive_regulation of EGFR 1 0.01 0 0.11
35 INT191184 Binding of EGFR and GRB2 7 0.35 1.06 0.1
36 INT291353 IL8 Positive_regulation of Binding of EGFR 1 0.32 0.52 0.1
37 INT220743 Binding of AR and EGFR 1 0.01 0.46 0.1
38 INT291351 Binding of EGFR and SHC1 1 0.05 0.57 0.1
39 INT291350 IL8 Positive_regulation of Phosphorylation of EGFR 1 0.32 0.52 0.1
40 INT145153 JUN Positive_regulation of EGFR 1 0.24 0.94 0.09
41 INT145154 Positive_regulation of JUN Positive_regulation of EGFR 1 0.24 0.95 0.09
42 INT302167 PTGER2 Positive_regulation of EGFR 1 0.10 3.08 0.09
43 INT266952 Binding of Aspscr1 and Ap2s1 1 0.01 0.51 0.08
44 INT249332 GPNMB Positive_regulation of EGFR 1 0.17 2.63 0.08
45 INT242636 Ret Positive_regulation of Gene_expression of Slc18a3 1 0.20 0 0.06
46 INT221368 EGFR Regulation of Gene_expression of MUC1 1 0.05 3.82 0.06
47 INT210146 Binding of EGFR and TXN 1 0.15 0.09 0.06
48 INT339105 ERBB2 Positive_regulation of EGFR 1 0.37 0.68 0.06
49 INT251774 Negative_regulation of TXK Negative_regulation of EGFR 1 0.07 1.06 0.06
50 INT279290 EGFR Regulation of CDCP1 1 0.01 0.98 0.05
51 INT242618 Binding of Slc18a3 and Th 1 0.13 0.26 0.05
52 INT302165 PTGER2 Positive_regulation of Localization of EGFR 1 0.06 1.73 0.05
53 INT355583 Binding of EGFR and ANGPTL4 1 0.12 2.14 0.05
54 INT355589 Binding of EGFR and LTBP1 1 0.11 2.15 0.05
55 INT213903 Binding of EGFR and ERBB2 10 0.37 5.03 0.04
56 INT188737 Egfr Positive_regulation of EGFR 1 0.21 0.6 0.04
57 INT213901 EGFR Positive_regulation of ERBB2 1 0.52 0.41 0.04
58 INT302166 Positive_regulation of PTGER2 Positive_regulation of EGFR 1 0.07 1.49 0.04
59 INT186097 EGF Positive_regulation of Positive_regulation of EGFR 1 0.20 0.38 0.04
60 INT352356 Gene_expression of CNR1 Positive_regulation of Gene_expression of EGFR 1 0.24 0.95 0.04
61 INT302291 Positive_regulation of EGFR Positive_regulation of Myc 1 0.18 1.3 0.04
62 INT188735 EGFR Positive_regulation of Egfr 1 0.21 0.6 0.04
63 INT188732 EGFR Positive_regulation of Gene_expression of Egfr 1 0.21 0.6 0.04
64 INT213906 EGFR Positive_regulation of Gene_expression of ERBB2 1 0.52 0.42 0.04
65 INT188731 Egfr Regulation of EGFR 1 0.46 0.59 0.03
66 INT213902 ESR1 Positive_regulation of EGFR 1 0.48 0.31 0.03
67 INT187640 Binding of EGFR and KLF1 3 0.01 2.54 0
68 INT351090 Phosphorylation of TXK Positive_regulation of EGFR 1 0.04 0.33 0
69 INT250665 EGFR Positive_regulation of PIK3CB 1 0.21 1.39 0
70 INT145150 Positive_regulation of Binding of EGFR and JUN 1 0.24 0.11 0
71 INT266925 Regulation of Binding of EGFR and ERBB2 1 0.26 0.5 0
72 INT223577 TXK Negative_regulation of EGFR 1 0.08 0.18 0
73 INT206058 EGFR Negative_regulation of Gene_expression of IL6 1 0.07 0.62 0
74 INT341631 EGFR Positive_regulation of TXK 1 0.05 0.42 0
75 INT298197 EGFR Regulation of CDKN1A 1 0.04 1.14 0
76 INT297000 Binding of AP2A1 and AP1B1 1 0.00 0.21 0
77 INT334320 EGFR Positive_regulation of RASGRP1 1 0.05 0.76 0
78 INT213583 Binding of EGFR and NRG2 1 0.16 0.13 0
79 INT145148 Positive_regulation of Binding of EGFR and FOS 1 0.50 0.05 0
80 INT351604 TXK Positive_regulation of EGFR 1 0.02 1.78 0
81 INT339117 Binding of EGFR and GRB7 1 0.28 1.18 0
82 INT277664 Negative_regulation of Binding of EGF and EGFR 1 0.18 0.5 0
83 INT298191 EGFR Regulation of IFI27 1 0.05 1.14 0
84 INT334321 EGFR Positive_regulation of MAPK1 1 0.25 0.76 0
85 INT345506 Binding of EGFR and FNDC3A 1 0.00 0.08 0
86 INT286988 Twist1 Positive_regulation of EGFR 1 0.17 2.01 0
87 INT298195 Negative_regulation of EGFR Regulation of IFI27 1 0.08 0.58 0
88 INT294090 Negative_regulation of Binding of EGFR and ERBB2 1 0.14 0.6 0
89 INT334323 IL8 Positive_regulation of EGFR 1 0.50 1.29 0
90 INT145149 Binding of EGFR and JUN 1 0.16 0.11 0
91 INT279282 Binding of EGFR and ESR2 1 0.45 1.39 0
92 INT341856 Binding of EGFR and IgG1 1 0.27 1.12 0
93 INT296999 Binding of EPS15 and TFAP2A 1 0.06 0.2 0
94 INT278446 Binding of EGFR and EMR1 1 0.00 0.75 0
95 INT323506 ROS1 Positive_regulation of Phosphorylation of EGFR 1 0.32 0.69 0
96 INT277663 Binding of EGFR and TTPA 1 0.05 0.41 0
97 INT344405 Binding of EGFR and Spp1 1 0.09 1.34 0
98 INT319319 Binding of EGFR and KRAS 1 0.22 0.27 0
99 INT191181 Binding of EGFR and H3F3B 1 0.32 0.17 0
100 INT307586 Binding of EGFR and CDCP1 1 0.01 0.51 0
101 INT191186 Binding of EGFR and RECQL5 1 0.35 0.34 0
102 INT194362 PDGFA Regulation of EGFR 1 0.23 1.56 0
103 INT188734 Egfr Positive_regulation of Gene_expression of EGFR 1 0.52 0.61 0
104 INT277836 EGFR Positive_regulation of VEGFA 1 0.24 0.47 0
105 INT307585 Binding of EGFR and MET 1 0.11 0.52 0
106 INT220461 Binding of VCAN and EGFR 1 0.00 0.86 0
107 INT277766 EGFR Regulation of Gene_expression of VEGFA 1 0.54 0.14 0
108 INT242301 Binding of EGFR and ACCS 1 0.11 1.31 0
109 INT236615 Binding of RERE and EGFR 1 0.04 0.35 0
110 INT307584 Binding of EGFR and IGF1R 1 0.03 0.52 0
111 INT339100 Binding of ASIP and EGFR 1 0.00 0.58 0
112 INT194361 VEGFA Regulation of EGFR 1 0.22 1.58 0
113 INT145151 Binding of EGFR and FOS 1 0.48 0.05 0
114 INT351085 Binding of EGFR and Positive_regulation of Phosphorylation of TXK 1 0.04 0.35 0
115 INT277772 Binding of EGFR and fc 1 0.01 0.57 0
116 INT341632 Binding of EGFR and FOXM1 1 0.02 0.56 0
117 INT242619 Ret Negative_regulation of Transcription of Slc18a3 1 0.18 0 0
118 INT297004 Binding of EPS15 and FABP4 1 0.11 0.17 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for AP-2 adaptor complex. They are ordered first by their pain relevance and then by number of times they were reported in AP-2 adaptor complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69
2 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32
3 INT19795 Positive_regulation of EGFR 161 0.70 103.69 11.55
4 INT96994 Phosphorylation of EGFR 99 0.82 52.75 7.33
5 INT11154 Binding of EGFR 149 0.48 96.23 6.29
6 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93
7 INT136904 Gene_expression of SLC18A3 4 0.68 3.71 4.4
8 INT119731 Gene_expression of Slc18a3 19 0.41 3.93 4.32
9 INT163832 Negative_regulation of Gene_expression of EGFR 50 0.59 39.71 3.45
10 INT117348 Regulation of EGFR 75 0.61 47.73 3.09
11 INT88638 Gene_expression of Slc18a3 8 0.57 3.17 2.77
12 INT95058 Localization of Slc18a3 2 0.76 0 2.17
13 INT65545 Localization of EGFR 35 0.79 20.8 1.88
14 INT118292 Negative_regulation of Phosphorylation of EGFR 27 0.59 13.62 1.54
15 INT96993 Positive_regulation of Phosphorylation of EGFR 15 0.59 5.44 1.37
16 INT127725 Negative_regulation of Positive_regulation of EGFR 6 0.57 2.69 1.3
17 INT55916 Binding of Ap2s1 4 0.14 6.56 1.27
18 INT118293 Regulation of Phosphorylation of EGFR 2 0.61 1.01 1.1
19 INT86384 Negative_regulation of Localization of EGFR 4 0.43 2.5 0.97
20 INT11160 Regulation of Gene_expression of EGFR 27 0.62 22.05 0.96
21 INT104160 Negative_regulation of Slc18a3 1 0.36 0 0.96
22 INT356228 Positive_regulation of Slc18a3 1 0.35 0.9 0.94
23 INT117347 Positive_regulation of Positive_regulation of EGFR 15 0.69 11.17 0.84
24 INT270060 Negative_regulation of Gene_expression of SLC18A3 1 0.21 0.51 0.79
25 INT270062 Negative_regulation of SLC18A3 1 0.21 0.51 0.79
26 INT138955 Transcription of EGFR 18 0.71 11.39 0.78
27 INT186119 Protein_catabolism of EGFR 6 0.98 3.68 0.76
28 INT114246 Positive_regulation of Negative_regulation of EGFR 13 0.49 8.67 0.7
29 INT186117 Negative_regulation of Protein_catabolism of EGFR 1 0.42 0.67 0.68
30 INT186118 Positive_regulation of Protein_catabolism of EGFR 1 0.68 0.66 0.68
31 INT135870 Binding of Slc18a3 3 0.32 0 0.67
32 INT126807 Regulation of Slc18a3 2 0.11 1.32 0.42
33 INT74979 Regulation of Ap2s1 2 0.13 0.59 0.42
34 INT120690 Regulation of Slc18a3 1 0.22 0 0.42
35 INT80895 Localization of Slc18a3 1 0.04 0 0.42
36 INT138954 Regulation of Transcription of EGFR 2 0.27 0.82 0.35
37 INT145155 Regulation of Positive_regulation of EGFR 6 0.38 4.54 0.33
38 INT186115 Negative_regulation of Negative_regulation of EGFR 5 0.57 3.42 0.33
39 INT223597 Negative_regulation of Binding of EGFR 12 0.43 7.97 0.23
40 INT313392 Regulation of Gene_expression of Slc18a3 1 0.10 0.18 0.19
41 INT242578 Negative_regulation of Gene_expression of Slc18a3 1 0.23 0.35 0.15
42 INT175416 Regulation of Negative_regulation of EGFR 4 0.60 3.94 0.14
43 INT147864 Regulation of SLC18A3 1 0.39 0.87 0.14
44 INT147865 Positive_regulation of SLC18A3 1 0.43 0.8 0.14
45 INT211343 Gene_expression of Ap2s1 2 0.22 2.84 0.13
46 INT242540 Positive_regulation of Gene_expression of Slc18a3 3 0.37 0.38 0.12
47 INT266950 Positive_regulation of Binding of Ap2s1 1 0.14 0.47 0.1
48 INT266947 Negative_regulation of Binding of Ap2s1 1 0.12 0.47 0.1
49 INT248803 Transcription of Slc18a3 1 0.45 0 0.08
50 INT229184 Regulation of Protein_catabolism of EGFR 1 0.25 1.11 0.08
51 INT266934 Regulation of Binding of EGFR 3 0.45 1.16 0.07
52 INT242521 Regulation of Gene_expression of Slc18a3 1 0.24 0.18 0.05
53 INT242538 Negative_regulation of Transcription of Slc18a3 1 0.23 0.55 0.05
54 INT183275 Positive_regulation of Regulation of EGFR 1 0.36 0.21 0.05
55 INT297034 Gene_expression of EPS15 1 0.54 1.03 0.03
56 INT145156 Regulation of Regulation of EGFR 1 0.24 1.31 0.03
57 INT242565 Transcription of Slc18a3 1 0.28 0.28 0.03
58 INT242547 Negative_regulation of Slc18a3 1 0.31 0.23 0.03
59 INT266931 Positive_regulation of Binding of EGFR 6 0.50 5.44 0
60 INT315831 Positive_regulation of Localization of EGFR 2 0.49 0.6 0
61 INT319331 Regulation of Localization of EGFR 2 0.32 1.85 0
62 INT297044 Positive_regulation of EPS15 1 0.35 0.2 0
63 INT297027 Binding of EPS15 1 0.26 0.37 0
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