GO:0030141

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Name secretory granule
Categary Component
Go Slim No
Go Link GO:0030141
Unique Molecular Interactions 5733
Total Molecular Interactions 8990
Total Single Events 95769
Pain Genes Associated 134

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for secretory granule. They are ordered first by their pain relevance and then by number of times they were reported for secretory granule. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69872 Binding of MC1R and POMC 52 0.54 8.87 18.3
2 INT6078 Pomc Positive_regulation of Localization of Penk 13 0.51 0 15.49
3 INT16531 Ghrh Positive_regulation of Localization of Gh1 31 0.64 2.12 14.2
4 INT10268 Binding of PDYN and POMC 11 0.39 0.08 10.36
5 INT6079 Pomc Positive_regulation of Penk 9 0.43 0 9.46
6 INT26468 Ghrh Positive_regulation of Localization of Gh 21 0.37 3.26 9.21
7 INT2714 Pomc Positive_regulation of Localization of Prl 17 0.79 0.5 8.18
8 INT140015 Avp Positive_regulation of Localization of Penk 3 0.63 3.48 6.63
9 INT31439 Penk Positive_regulation of Localization of Prl 8 0.55 0.23 6.24
10 INT91538 Pomc Positive_regulation of P9Ehs1 6 0.11 1.47 6.23
11 INT95068 Tlr4 Positive_regulation of IL1B 1 0.03 4.54 5.6
12 INT92466 Pomc Positive_regulation of Binding of Crygs 8 0.06 0 5.56
13 INT20133 Trh Positive_regulation of Localization of Prl 23 0.78 2.04 5.44
14 INT15842 Crh Positive_regulation of Localization of Pomc 15 0.73 5 5.05
15 INT1310 Pomc Regulation of Localization of Prl 9 0.40 0.61 4.96
16 INT10844 Ghrh Regulation of Gh 13 0.13 4.77 4.71
17 INT29206 Crh Regulation of Localization of POMC 4 0.64 0.96 4.68
18 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
19 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
20 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48
21 INT32444 Binding of Cpe and Pomc 2 0.22 0 4.47
22 INT38217 Penk Regulation of Localization of Avp 2 0.38 0.56 4.45
23 INT30423 Penk Regulation of Localization of Ins1 4 0.26 0.77 4.42
24 INT1390 Trh Positive_regulation of Prl 14 0.67 4.42 4.39
25 INT1392 Trh Regulation of Prl 15 0.29 2.47 4.29
26 INT113223 POMC Regulation of MC1R 6 0.68 0.39 4.24
27 INT1313 Pomc Positive_regulation of Prl 7 0.35 0 4.19
28 INT161109 Avp Positive_regulation of Chkb 1 0.12 0.18 4.19
29 INT11613 Cck Positive_regulation of Localization of Oxt 3 0.53 0 4.17
30 INT31440 Penk Positive_regulation of Prl 7 0.76 0 4.1
31 INT16221 Ghrh Positive_regulation of Gh 8 0.21 1.89 4.08
32 INT29240 Binding of POMC and YY1 5 0.40 0.17 4.06
33 INT34220 Binding of POMC and Oprl1 4 0.01 0.25 4.05
34 INT11248 Gh Positive_regulation of Ghrh 2 0.26 0.09 4.04
35 INT2169 Penk Regulation of Localization of Prl 6 0.48 0 4.03
36 INT20456 Binding of Pomc and Penk 9 0.41 0.26 3.93
37 INT107801 Ugt1a5 Positive_regulation of Localization of Prl 3 0.76 1 3.9
38 INT15984 Binding of Avp and Oxt 11 0.32 1.33 3.64
39 INT140011 Avp Positive_regulation of Dbi 2 0.07 0.93 3.61
40 INT57985 Il1b Positive_regulation of Il6 5 0.59 1.66 3.53
41 INT73071 Binding of Cpe and Insrr 3 0.01 0.33 3.38
42 INT24388 CRH Positive_regulation of Localization of POMC 8 0.51 5.67 3.35
43 INT7436 CFP Positive_regulation of Binding of POMC 1 0.02 0.18 3.35
44 INT146412 Tnf Positive_regulation of Gene_expression of Trpv1 2 0.66 5.22 3.22
45 INT3434 Vip Positive_regulation of Localization of Prl 6 0.76 0.16 3.21
46 INT270949 Binding of Slc6a3 and Cpe 1 0.28 0.25 3.19
47 INT17456 Binding of CSF2 and POMC 3 0.32 4.06 3.15
48 INT64719 IL1B Positive_regulation of IL6 7 0.41 6.84 3.14
49 INT6076 Negative_regulation of Pomc Positive_regulation of Penk 3 0.31 0 3.14
50 INT81708 POMC Regulation of Gene_expression of ITGAM 1 0.53 0.72 3.1
51 INT26677 Penk Regulation of Localization of Trh 5 0.50 0 3.05
52 INT40660 Pdyn Positive_regulation of Localization of Prl 1 0.27 0 3.01
53 INT150886 Il1a Regulation of Il1b 1 0.02 3.46 2.93
54 INT42728 Binding of PRLR and Cpe 1 0.00 0 2.91
55 INT150632 Ea1 Negative_regulation of Mpo 1 0.17 1.55 2.9
56 INT134212 CRH Regulation of Localization of POMC 1 0.47 2.89 2.9
57 INT140014 Avp Negative_regulation of Chkb 1 0.04 1.58 2.86
58 INT130721 Binding of IL1B and IL1RN 6 0.05 5.29 2.85
59 INT32656 Pomc Positive_regulation of Rbm39 1 0.08 0.42 2.84
60 INT107723 POMC Positive_regulation of MC1R 7 0.68 0.71 2.82
61 INT31513 Crh Regulation of POMC 3 0.29 5.06 2.78
62 INT137230 Trh Regulation of Gene_expression of Oprd1 1 0.01 1.62 2.75
63 INT147107 TGFB1 Positive_regulation of Gene_expression of NGF 1 0.49 0.67 2.69
64 INT7888 Oprl1 Regulation of Localization of Avp 4 0.49 0.25 2.63
65 INT30345 Pomc Regulation of Localization of Penk 3 0.31 0 2.61
66 INT140024 Tnf Positive_regulation of Gene_expression of Il1b 2 0.49 2.75 2.61
67 INT67663 Ins1 Positive_regulation of Ntrk2 1 0.00 0.19 2.59
68 INT29446 Crh Positive_regulation of Localization of POMC 8 0.38 1.87 2.58
69 INT57624 Calca Regulation of Positive_regulation of Trh 1 0.50 0 2.53
70 INT26892 OGG1 Negative_regulation of Gene_expression of Gh1 1 0.12 0 2.53
71 INT151826 Tnf Positive_regulation of TNF 1 0.04 3.38 2.51
72 INT20411 Ghrh Positive_regulation of Gh1 6 0.56 0.62 2.47
73 INT130284 Ins1 Negative_regulation of Gene_expression of Npy 1 0.32 0.1 2.47
74 INT21520 Crh Regulation of Pomc 3 0.22 0.4 2.45
75 INT56726 Cpe Negative_regulation of Pomc 1 0.07 0 2.41
76 INT214144 Cck Positive_regulation of Pomc 1 0.15 0.94 2.39
77 INT61733 Tlr4 Positive_regulation of Gene_expression of Tnf 3 0.26 1.99 2.36
78 INT7367 Ghrh Regulation of Localization of Gh1 5 0.49 1.55 2.25
79 INT51317 Binding of POMC and OR5D2P 1 0.00 0.6 2.23
80 INT34310 CRH Positive_regulation of POMC 3 0.42 0.62 2.21
81 INT94492 Il6 Positive_regulation of Gene_expression of Il1b 1 0.27 3.81 2.19
82 INT94491 Il1b Positive_regulation of Gene_expression of Tnf 1 0.25 3.81 2.19
83 INT94494 Il1b Positive_regulation of Gene_expression of Il6 1 0.27 3.81 2.19
84 INT32586 H2-Ab1 Regulation of Pomc 1 0.03 0.14 2.19
85 INT9180 Ghrh Regulation of Localization of Gh 3 0.24 0.25 2.18
86 INT209924 IL1B Negative_regulation of PPARA 1 0.20 4.38 2.17
87 INT1315 Pomc Positive_regulation of Localization of Gnrhr 3 0.38 0.16 2.16
88 INT49242 Binding of Mc1r and Pomc 10 0.38 3.79 2.15
89 INT66803 Oxt Regulation of Avp 7 0.16 0.19 2.15
90 INT3576 Sst Negative_regulation of Localization of Gh1 6 0.23 0 2.13
91 INT45376 Binding of Cpe and Mme 1 0.07 0.32 2.13
92 INT140019 Avp Positive_regulation of Localization of Kitl 1 0.00 1 2.13
93 INT28387 Pomc Positive_regulation of Localization of LH 2 0.40 0.28 2.07
94 INT140032 Tnf Positive_regulation of Gene_expression of Ifng 2 0.43 2.23 2
95 INT140030 Il1b Positive_regulation of Gene_expression of Ifng 2 0.48 2.23 2
96 INT140026 Il1b Positive_regulation of Gene_expression of Tnf 2 0.49 2.23 2
97 INT138962 Dbi Positive_regulation of Pomc 1 0.00 1.53 2
98 INT32585 H2-Ab1 Negative_regulation of Pomc 1 0.03 0.13 2
99 INT138960 Dbi Positive_regulation of Avp 1 0.02 1.53 2
100 INT138958 Dbi Positive_regulation of Positive_regulation of Avp 1 0.02 1.53 2
101 INT60626 Crh Positive_regulation of Localization of Pomc 7 0.54 2.3 1.99
102 INT26948 Pomc Positive_regulation of Localization of Gh1 2 0.22 0.15 1.99
103 INT45423 Avp Positive_regulation of Localization of Prl 4 0.67 1.37 1.98
104 INT264953 Binding of POMC and TLR4 1 0.03 0.89 1.96
105 INT129212 RYBP Positive_regulation of Tnf 2 0.03 1.9 1.95
106 INT69556 Slc7a11 Regulation of Cpe 2 0.06 0.46 1.95
107 INT264947 Binding of POMC and TLR2 1 0.03 0.89 1.95
108 INT73072 Negative_regulation of Binding of Cpe and Insrr 1 0.00 0 1.94
109 INT149470 Oxt Regulation of Gene_expression of Avp 1 0.46 1.2 1.92
110 INT14991 SFTPA1 Positive_regulation of Localization of MPO 1 0.11 1.65 1.92
111 INT149469 Oxt Regulation of Gene_expression of Crh 1 0.45 1.2 1.91
112 INT91607 Binding of EDN1 and POMC 1 0.12 0 1.9
113 INT31438 Penk Positive_regulation of Localization of Pomc 1 0.18 0 1.9
114 INT51051 IL1B Positive_regulation of Localization of IL6 7 0.57 3.79 1.87
115 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87
116 INT81920 Binding of IL1B and NFKB1 1 0.04 1.54 1.85
117 INT50993 Il1b Positive_regulation of Fos 2 0.40 0.43 1.84
118 INT40239 Penk Regulation of Avp 1 0.07 0 1.84
119 INT40238 Penk Regulation of Oxt 1 0.04 0 1.83
120 INT19496 Pomc Regulation of Localization of Ins1 1 0.55 0.33 1.82
121 INT117269 Binding of Avp and Prl 1 0.25 0.47 1.8
122 INT224432 TNF Positive_regulation of Gene_expression of VEGFA 1 0.13 5.83 1.8
123 INT31445 ENG Positive_regulation of Localization of Prl 4 0.01 0 1.77
124 INT167319 Binding of OPRM1 and PCSK2 1 0.22 0.63 1.77
125 INT23392 Gal Regulation of Trpv1 1 0.05 0.33 1.77
126 INT167320 Binding of CPE and OPRM1 1 0.14 0.63 1.77
127 INT302646 ARSA Positive_regulation of TGFB1 1 0.10 0.52 1.76
128 INT26676 Pomc Regulation of Localization of Trh 3 0.14 0 1.73
129 INT185143 Elane Positive_regulation of Pik3r1 1 0.01 0 1.72
130 INT24817 Binding of POMC and VTN 8 0.42 0.39 1.71
131 INT129717 TGFB1 Positive_regulation of Gene_expression of TNFRSF10D 3 0.38 4.29 1.71
132 INT167427 Mapk8 Regulation of Regulation of Tnf 1 0.26 2.83 1.7
133 INT10202 Agt Positive_regulation of Avp 3 0.70 0 1.69
134 INT56134 CALCA Positive_regulation of POMC 2 0.71 0.72 1.68
135 INT45306 Pomc Positive_regulation of ENG 2 0.07 1.11 1.68
136 INT18520 Adra2c Positive_regulation of Localization of Ins1 3 0.41 0.63 1.66
137 INT100274 IL1RN Negative_regulation of IL1B 5 0.53 1.79 1.65
138 INT83093 IL1B Positive_regulation of BDKRB1 1 0.51 0.44 1.65
139 INT140009 Avp Positive_regulation of Gene_expression of Penk 1 0.40 0.77 1.64
140 INT147108 TGFB1 Positive_regulation of Gene_expression of FN1 4 0.47 1.01 1.63
141 INT61134 IL10 Negative_regulation of Gene_expression of IL1B 3 0.46 2.13 1.63
142 INT32839 Binding of Trh and Penk 2 0.42 0 1.63
143 INT32482 Ghrh Positive_regulation of Prl 3 0.18 0.26 1.62
144 INT32412 Penk Regulation of Pomc 3 0.21 0.36 1.62
145 INT140023 Avp Positive_regulation of Gene_expression of Kitl 1 0.00 0.76 1.62
146 INT86637 POMC Regulation of Gene_expression of KRT16 2 0.47 1.22 1.61
147 INT94270 Pomc Regulation of Transcription of Crh 1 0.17 0.67 1.6
148 INT141907 F2r Regulation of Plat 1 0.46 0 1.59
149 INT105112 Plat Positive_regulation of JUN 1 0.01 1.55 1.58
150 INT66408 Pomc Positive_regulation of Regulation of HRH1 1 0.01 0 1.58
151 INT40827 Sstr1 Negative_regulation of Localization of Gh1 1 0.13 0 1.58
152 INT41652 Binding of Pomc and Oprl1 3 0.16 0 1.57
153 INT42928 Penk Negative_regulation of Localization of Oxt 2 0.03 0 1.57
154 INT94271 Pomc Regulation of Avp 1 0.20 0.67 1.57
155 INT26985 Cpe Negative_regulation of Localization of Ins1 1 0.02 0 1.57
156 INT81710 POMC Regulation of Gene_expression of FCGR3B 1 0.50 0.34 1.57
157 INT81709 POMC Regulation of Gene_expression of ITGB2 1 0.40 0.34 1.57
158 INT81719 POMC Regulation of Gene_expression of ITGAL 1 0.35 0.34 1.57
159 INT81712 POMC Regulation of FCGR3B 1 0.16 0.34 1.56
160 INT76651 Cpe Positive_regulation of Gene_expression of Il6 1 0.08 0 1.56
161 INT74937 IL1B Positive_regulation of CPOX 5 0.18 1.13 1.55
162 INT6768 Oprl1 Regulation of Localization of Prl 2 0.12 0 1.55
163 INT81715 POMC Regulation of ITGB2 1 0.40 0.34 1.55
164 INT81721 POMC Regulation of ITGAM 1 0.39 0.34 1.55
165 INT41100 Mdk Positive_regulation of Localization of INS 1 0.01 0 1.55
166 INT81714 POMC Regulation of ITGAL 1 0.15 0.34 1.54
167 INT91456 IL1B Positive_regulation of Gene_expression of CPOX 6 0.17 3.36 1.53
168 INT32152 POMC Positive_regulation of Gene_expression of IFNA1 2 0.67 0 1.53
169 INT140013 Avp Positive_regulation of Gene_expression of Dbi 1 0.07 0.85 1.52
170 INT140016 Avp Positive_regulation of Gene_expression of Pdyn 1 0.21 0.85 1.52
171 INT23548 Negative_regulation of CNDP2 Negative_regulation of Localization of POMC 1 0.03 0 1.52
172 INT140017 Avp Positive_regulation of Gene_expression of Pomc 1 0.38 0.85 1.52
173 INT69709 NPL Positive_regulation of Localization of POMC 2 0.36 1.22 1.51
174 INT32657 Positive_regulation of Pomc Positive_regulation of Rbm39 1 0.08 0.22 1.51
175 INT76656 POMC Positive_regulation of Gene_expression of Il6 1 0.03 0 1.51
176 INT140008 Avp Positive_regulation of Pomc 1 0.38 0.84 1.51
177 INT10276 Il1b Regulation of Gene_expression of Penk 1 0.61 0.85 1.5
178 INT166360 Negative_regulation of Crhr1 Negative_regulation of Positive_regulation of Pomc 1 0.02 0.36 1.5
179 INT140029 Ifng Positive_regulation of Gene_expression of Tnf 1 0.43 1.69 1.5
180 INT140028 Ifng Positive_regulation of Gene_expression of Il1b 1 0.48 1.69 1.5
181 INT64628 Binding of Oxt and Gal 2 0.29 0.29 1.49
182 INT3573 Tf Negative_regulation of Localization of Gh1 1 0.36 0 1.49
183 INT14375 Gal Positive_regulation of Localization of Prl 1 0.77 0 1.48
184 INT44504 Mt1a Positive_regulation of Prl 1 0.37 0 1.48
185 INT59547 Avp Positive_regulation of Crh 2 0.14 1.13 1.47
186 INT165450 Gal Regulation of Ceacam3 1 0.41 0.06 1.47
187 INT40209 TNS3 Regulation of POMC 1 0.16 0.27 1.47
188 INT150887 Il1b Regulation of Il10 1 0.04 1.74 1.47
189 INT158776 Il1b Regulation of Ephb1 1 0.15 0.09 1.46
190 INT158711 Cdk5 Positive_regulation of Phosphorylation of Trh 1 0.02 0 1.46
191 INT12691 SST Negative_regulation of Localization of POMC 3 0.24 1.24 1.45
192 INT1314 Pomc Regulation of Localization of Gnrhr 2 0.16 0.14 1.45
193 INT21425 Binding of Pomc and Gtpbp4 1 0.01 0.1 1.45
194 INT45307 ENG Positive_regulation of Localization of Avp 1 0.00 0 1.45
195 INT111760 Dio1 Positive_regulation of Binding of Cpe 1 0.04 0.34 1.44
196 INT150682 Pomc Regulation of Gene_expression of Eif2ak3 1 0.37 0.17 1.44
197 INT140012 Avp Negative_regulation of Dbi 1 0.06 0.8 1.44
198 INT5534 Binding of Oxt and Avp 7 0.04 0.6 1.43
199 INT111761 Positive_regulation of Binding of Cpe and Insrr 1 0.01 0.33 1.43
200 INT111756 Dio1 Positive_regulation of Cpe 1 0.04 0.34 1.42

Single Events

The table below shows the top 100 pain related interactions that have been reported for secretory granule. They are ordered first by their pain relevance and then by number of times they were reported in secretory granule. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT158 Localization of Prl 2431 0.81 378.96 952.2
2 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82
3 INT443 Localization of POMC 1020 0.81 284.52 443.17
4 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16
5 INT157 Positive_regulation of Localization of Prl 790 0.70 104.54 374.78
6 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83
7 INT876 Localization of Gh1 843 0.80 67.75 340.82
8 INT162 Regulation of Prl 794 0.62 165.01 322.24
9 INT477 Localization of Avp 813 0.81 131.58 300.4
10 INT161 Regulation of Localization of Prl 615 0.62 65.37 298.66
11 INT886 Gene_expression of Pomc 676 0.78 129.87 295.98
12 INT3579 Localization of Oxt 555 0.81 43.35 292.44
13 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97
14 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2
15 INT1893 Localization of Gh 1041 0.79 340.23 256.58
16 INT738 Regulation of POMC 459 0.62 111.19 243.74
17 INT1308 Localization of Pomc 457 0.81 66.83 217.5
18 INT2651 Positive_regulation of Pomc 403 0.70 95.72 206.24
19 INT156 Negative_regulation of Prl 542 0.59 131.97 192.24
20 INT528 Gene_expression of Prl 693 0.78 217.18 192.2
21 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58
22 INT1652 Regulation of Pomc 387 0.62 61.01 186.51
23 INT159 Negative_regulation of Localization of Prl 416 0.59 55.34 171.8
24 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77
25 INT1114 Localization of Ins1 748 0.80 192.95 165.48
26 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18
27 INT5513 Negative_regulation of Pomc 295 0.59 60.9 158.63
28 INT2640 Gene_expression of Pomc 424 0.78 120.72 155.37
29 INT880 Positive_regulation of Localization of Gh1 304 0.70 14.79 150.23
30 INT2451 Positive_regulation of Avp 355 0.70 102.66 147.69
31 INT812 Localization of INS 1026 0.81 515.6 145.31
32 INT1273 Gene_expression of Avp 356 0.78 90.56 138.7
33 INT695 Binding of POMC 304 0.48 56.66 126.85
34 INT6128 Positive_regulation of Localization of POMC 256 0.70 68.77 121.64
35 INT1438 Localization of Pomc 360 0.81 101.26 116.47
36 INT4207 Regulation of Avp 267 0.62 63.72 115.33
37 INT1530 Regulation of Gh 382 0.61 115.96 112.47
38 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01
39 INT10272 Gene_expression of Il1b 194 0.78 121.02 103.03
40 INT5940 Negative_regulation of Avp 236 0.59 67.86 101.2
41 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9
42 INT874 Positive_regulation of Gh1 244 0.70 27.17 97.98
43 INT5865 Positive_regulation of Localization of Gh 282 0.69 84.86 93.5
44 INT203 Positive_regulation of Pomc 257 0.70 90.56 92.84
45 INT214 Localization of AVP 370 0.81 208.51 91.09
46 INT7885 Positive_regulation of Localization of Oxt 160 0.70 14.36 87.7
47 INT1472 Positive_regulation of Ins1 349 0.69 146.2 86.36
48 INT2149 Positive_regulation of Oxt 181 0.70 24.8 85.43
49 INT875 Regulation of Localization of Gh1 166 0.62 12.87 84.97
50 INT339 Regulation of Trh 156 0.62 39.27 83.55
51 INT8650 Gene_expression of Gal 152 0.78 61.97 81.72
52 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65
53 INT403 Localization of Trh 241 0.81 28.55 81.45
54 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16
55 INT2893 Localization of Oxt 219 0.80 28.96 79.43
56 INT3214 Localization of Ins1 527 0.80 196.9 79.26
57 INT2431 Positive_regulation of Mpo 275 0.70 211.99 78.47
58 INT4358 Positive_regulation of Localization of Avp 195 0.70 30.79 77.58
59 INT3657 Gene_expression of Ins1 514 0.78 321.69 75.76
60 INT15769 Gene_expression of Il1b 146 0.78 114.51 75.35
61 INT881 Negative_regulation of Localization of Gh1 164 0.58 15.1 75.28
62 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71
63 INT10274 Positive_regulation of Il1b 123 0.70 79.76 73.56
64 INT7886 Regulation of Localization of Avp 146 0.62 14.53 72.99
65 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35
66 INT8962 Gene_expression of Cpe 110 0.71 39.67 71.67
67 INT1376 Binding of Trh 121 0.48 20 69.86
68 INT1377 Positive_regulation of Trh 172 0.70 40.55 69.83
69 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73
70 INT6849 Localization of IL1B 229 0.81 112.56 69.63
71 INT451 Regulation of Oxt 142 0.62 22.07 69.42
72 INT1988 Positive_regulation of Localization of Ins1 254 0.69 59.25 68.37
73 INT6489 Positive_regulation of Gene_expression of Tnf 140 0.70 92.31 67.85
74 INT462 Regulation of Pomc 157 0.62 41.67 67.27
75 INT7468 Negative_regulation of Localization of Oxt 109 0.59 9.46 66.79
76 INT6486 Positive_regulation of Tnf 168 0.70 123.47 66.05
77 INT5941 Gene_expression of Oxt 164 0.76 22.63 65.47
78 INT480 Negative_regulation of Localization of Avp 151 0.59 27.64 63.72
79 INT7884 Regulation of Localization of Oxt 102 0.62 7.95 61.71
80 INT1437 Negative_regulation of Pomc 132 0.59 35.22 60.97
81 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18
82 INT3161 Regulation of Localization of Gh 163 0.61 35.43 59.45
83 INT1307 Positive_regulation of Localization of Pomc 120 0.70 24.58 58.48
84 INT2148 Negative_regulation of Oxt 105 0.59 11.42 57
85 INT5453 Regulation of Localization of POMC 114 0.62 20.56 56.34
86 INT1463 Binding of Pomc 129 0.48 15.89 56.27
87 INT1200 Negative_regulation of Ins1 274 0.58 155.17 56.14
88 INT1782 Regulation of Gh1 125 0.62 22 55.74
89 INT251 Regulation of INS 398 0.62 232.47 55.04
90 INT5506 Positive_regulation of Gene_expression of Pomc 132 0.70 26.78 54.3
91 INT1486 Negative_regulation of Cpe 85 0.59 28.78 54.08
92 INT2276 Regulation of Ins1 234 0.61 103.78 54.05
93 INT3213 Gene_expression of Ins1 511 0.76 357.59 53.32
94 INT1487 Regulation of Cpe 68 0.62 10.24 52.91
95 INT1781 Negative_regulation of Gh1 127 0.59 16.94 51.77
96 INT5957 Positive_regulation of Cpe 65 0.69 21.07 51.22
97 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86
98 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43
99 INT2323 Gene_expression of Trh 146 0.78 29.92 49.5
100 INT937 Positive_regulation of Oxt 195 0.70 37.82 49.3
101 INT51163 Gene_expression of Gal 119 0.78 67.48 49.23
102 INT66029 Negative_regulation of Tnf 100 0.59 84.28 48.16
103 INT1197 Negative_regulation of Localization of POMC 109 0.59 28.29 48.02
104 INT1977 Negative_regulation of Positive_regulation of Prl 98 0.59 17.06 47.88
105 INT873 Gene_expression of Gh1 130 0.76 26.15 46.75
106 INT683 Positive_regulation of AVP 173 0.70 74.55 46.41
107 INT55670 Negative_regulation of Gene_expression of Tnf 83 0.59 57.16 46.33
108 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98
109 INT619 Positive_regulation of Positive_regulation of Prl 116 0.70 22.69 45.06
110 INT2275 Negative_regulation of Localization of Ins1 183 0.59 51.02 44.94
111 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53
112 INT5214 Localization of Cpe 49 0.73 13.3 44.36
113 INT989 Negative_regulation of Trh 90 0.59 15.45 43.63
114 INT1894 Negative_regulation of Localization of Gh 168 0.58 64.12 43.56
115 INT1474 Regulation of Localization of Ins1 132 0.61 25.96 43.07
116 INT1295 Binding of Pomc 85 0.48 12.92 42.8
117 INT9233 Negative_regulation of Gene_expression of IL1B 114 0.59 56.99 41.82
118 INT48075 Positive_regulation of Il1b 71 0.67 48.63 40.48
119 INT685 Regulation of AVP 124 0.62 34.9 39.91
120 INT5973 Regulation of IL1B 109 0.62 66.6 39.88
121 INT2429 Negative_regulation of Mpo 128 0.59 93.76 39.57
122 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52
123 INT2782 Regulation of Gene_expression of Pomc 75 0.62 15.04 38.97
124 INT1931 Positive_regulation of Gene_expression of POMC 116 0.70 37.26 38.67
125 INT5039 Positive_regulation of Gal 67 0.68 27.97 37.36
126 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61
127 INT101992 Localization of VEGFA 413 0.81 258.23 36.15
128 INT1976 Regulation of Gene_expression of Prl 80 0.62 20.19 36
129 INT927 Gene_expression of Oxt 184 0.78 44.71 35.79
130 INT3216 Positive_regulation of Localization of Ins1 170 0.69 56.78 35.63
131 INT2296 Positive_regulation of Gene_expression of Prl 137 0.70 36.96 35.39
132 INT3679 Gene_expression of AVP 171 0.78 72.9 35.23
133 INT8747 Positive_regulation of Ins1 221 0.69 154.28 35.15
134 INT6484 Binding of IL1B 122 0.47 75.84 35.07
135 INT2274 Regulation of Localization of INS 101 0.62 41.55 34.79
136 INT2699 Binding of Cpe 40 0.48 7.07 33.64
137 INT3117 Regulation of Oxt 103 0.61 17.93 32.28
138 INT35406 Localization of Tnf 94 0.81 64.63 31.65
139 INT9347 Localization of Il1b 58 0.81 26.13 31.53
140 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52
141 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1
142 INT6277 Positive_regulation of Gene_expression of Pomc 76 0.70 21.45 31.09
143 INT15347 Positive_regulation of Localization of Pomc 81 0.70 28.1 31.01
144 INT5505 Regulation of Localization of Pomc 54 0.61 6.96 30.77
145 INT894 Binding of Avp 84 0.48 29.16 29.63
146 INT4868 Gene_expression of GAL 75 0.78 22.23 29.02
147 INT1196 Positive_regulation of Positive_regulation of POMC 51 0.70 15.99 28.58
148 INT57692 Positive_regulation of Gene_expression of Il1b 50 0.67 43.54 28.29
149 INT5653 Positive_regulation of ELANE 136 0.70 72.78 27.94
150 INT48202 Gene_expression of Tgfb1 146 0.78 89.93 27.76
151 INT6174 Regulation of Gene_expression of POMC 49 0.61 9.75 27.69
152 INT7565 Transcription of Pomc 69 0.72 14.46 27.41
153 INT3217 Regulation of Ins1 154 0.62 87.11 27.29
154 INT2609 Localization of ELANE 111 0.81 50.22 26.63
155 INT5650 Gene_expression of Mpo 117 0.77 80.27 26.42
156 INT10273 Positive_regulation of Gene_expression of Il1b 47 0.68 31.15 26.21
157 INT5948 Regulation of Il1b 44 0.60 22.8 25.4
158 INT17625 Localization of GCG 210 0.80 55.69 24.97
159 INT3028 Negative_regulation of Oxt 76 0.58 18.52 24.4
160 INT10349 Negative_regulation of Il1b 48 0.58 25.53 24.24
161 INT58301 Positive_regulation of Mpo 87 0.70 80.19 23.99
162 INT682 Negative_regulation of AVP 97 0.59 50.67 23.91
163 INT61665 Phosphorylation of Trh 53 0.79 2.26 23.9
164 INT11303 Gene_expression of Avp 116 0.78 39.23 23.88
165 INT51029 Negative_regulation of Il1b 34 0.57 29.34 23.62
166 INT2290 Protein_catabolism of POMC 41 0.99 4.86 23.36
167 INT9526 Negative_regulation of Localization of Pomc 41 0.58 6.93 23.3
168 INT18323 Negative_regulation of Localization of Ins1 122 0.58 45.74 23.04
169 INT5511 Negative_regulation of Gene_expression of Pomc 47 0.59 12.08 23.02
170 INT18322 Negative_regulation of Ins1 132 0.58 88.49 22.59
171 INT48081 Localization of Il1b 46 0.80 21.59 22.4
172 INT14731 Positive_regulation of TGFB1 78 0.67 52.57 22.23
173 INT14733 Positive_regulation of Gene_expression of TGFB1 71 0.69 49.89 22.2
174 INT5905 Negative_regulation of ELANE 113 0.59 47.43 22.09
175 INT1327 Regulation of Localization of Trh 45 0.62 6.05 22.09
176 INT8580 Gene_expression of ELANE 132 0.75 62.98 21.79
177 INT48692 Binding of VEGFA 345 0.48 210.3 21.31
178 INT5040 Regulation of Gal 42 0.60 12.72 21.18
179 INT2894 Negative_regulation of Localization of Oxt 43 0.58 4.59 20.85
180 INT6127 Regulation of Localization of AVP 60 0.62 15.12 20.84
181 INT1512 Binding of Prl 73 0.48 26.22 20.63
182 INT53575 Regulation of Gene_expression of Tnf 46 0.62 34.35 20.63
183 INT9237 Regulation of Gene_expression of IL1B 49 0.62 30.69 20.34
184 INT68683 Regulation of Gene_expression of VEGFA 143 0.62 104.19 20.14
185 INT160 Regulation of Positive_regulation of Prl 37 0.62 7.56 20.09
186 INT7470 Positive_regulation of Gene_expression of Avp 37 0.70 19.55 19.96
187 INT5499 Transcription of Avp 52 0.72 7.98 19.87
188 INT53574 Regulation of Tnf 45 0.62 40.68 19.71
189 INT6993 Negative_regulation of Mpo 72 0.59 61.83 19.51
190 INT5099 Localization of Gal 46 0.81 10.66 18.93
191 INT11628 Regulation of Localization of Pomc 44 0.61 10.46 18.66
192 INT1975 Regulation of Regulation of Prl 32 0.59 5.78 18.53
193 INT14306 Positive_regulation of Gal 36 0.70 21.66 18.51
194 INT13454 Positive_regulation of Positive_regulation of Gh 49 0.68 14.53 18.49
195 INT5533 Binding of Oxt 43 0.48 8.69 18.35
196 INT61519 Gene_expression of Mpo 112 0.78 89.29 18.22
197 INT1060 Negative_regulation of Pla2g1b 50 0.57 22.91 18.12
198 INT3118 Negative_regulation of Positive_regulation of POMC 33 0.59 9.42 18.07
199 INT82531 Positive_regulation of Gene_expression of Gal 41 0.69 28.67 18.04
200 INT871 Negative_regulation of Gene_expression of Prl 53 0.58 18.89 17.79
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