GO:0030148

From wiki-pain
Jump to: navigation, search
Name sphingolipid biosynthetic process
Categary Process
Go Slim No
Go Link GO:0030148
Unique Molecular Interactions 44
Total Molecular Interactions 55
Total Single Events 513
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for sphingolipid biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported for sphingolipid biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT110835 Binding of SPTLC2 and SPTLC1 2 0.42 1.36 0.68
2 INT36914 PPAP2A Regulation of Positive_regulation of CSF2 1 0.02 0.16 0.39
3 INT110834 Binding of AGXT and SPTLC2 2 0.27 0.71 0.36
4 INT329410 Binding of SPTLC1 and Spt 1 0.04 1 0.35
5 INT229785 Binding of RAB7A and SPTLC1 1 0.40 1.5 0.27
6 INT234831 Binding of SPTLC1 and Abo 1 0.00 1.61 0.23
7 INT329409 Binding of SPTLC1 and Dstn 1 0.05 1.3 0.23
8 INT332481 ANXA1 Regulation of SGPP2 1 0.45 1.01 0.22
9 INT29099 Binding of ADRB2 and PPAP2A 1 0.03 0.77 0.22
10 INT157212 Binding of SPTLC1 and WNK1 1 0.07 0.67 0.22
11 INT157216 Binding of SPTLC2 and WNK1 1 0.03 0.68 0.22
12 INT157214 Binding of SGCG and SPTLC2 1 0.14 0.68 0.22
13 INT157215 Binding of SGCG and SPTLC1 1 0.32 0.67 0.22
14 INT138323 Positive_regulation of CPOX Regulation of PPAP2A 1 0.09 0.18 0.18
15 INT332485 SGPP2 Regulation of ANXA1 1 0.27 0.69 0.13
16 INT350164 Binding of DURS1 and ELOVL1 1 0.00 1.47 0.11
17 INT350163 Regulation of Binding of DURS1 and ELOVL1 1 0.00 1.48 0.11
18 INT332480 OR2A5 Regulation of SGPP2 1 0.00 0.32 0.1
19 INT260070 Binding of PHF2 and SPTLC1 1 0.17 1.93 0.1
20 INT122927 Ntrk1 Positive_regulation of SPTLC1 1 0.00 0.65 0.09
21 INT336341 Binding of RTCA and ELOVL1 1 0.02 2.15 0.07
22 INT332489 Binding of JAM3 and SGPP2 1 0.27 0.24 0.04
23 INT332483 Binding of JAG1 and SGPP2 1 0.21 0.23 0.04
24 INT314266 SUPT4H1 Positive_regulation of SPTLC1 1 0.02 0.13 0.03
25 INT298858 Positive_regulation of Binding of VAPA and RILP 1 0.07 0.54 0
26 INT298863 Binding of VAPB and RILP 1 0.13 0.21 0
27 INT252020 Binding of HLA-A and ELOVL1 1 0.01 1.41 0
28 INT291329 Binding of NOTCH1 and CERS1 1 0.06 1.42 0
29 INT255167 Binding of SAE1 and CERS1 1 0.08 0.72 0
30 INT298845 VAPA Regulation of Negative_regulation of RAB7A 1 0.12 0.32 0
31 INT264683 Binding of VAPB and ALS2 1 0.29 1.1 0
32 INT181994 Binding of Mmp9 and ELOVL1 1 0.00 0.57 0
33 INT244690 FSHB Positive_regulation of KDSR 1 0.00 0 0
34 INT332487 ANXA1 Regulation of Gene_expression of SGPP2 1 0.45 0.08 0
35 INT335526 SPHK1 Regulation of Gene_expression of SGCB 1 0.27 0.86 0
36 INT327448 Binding of REN and PPAP2B 1 0.01 0.26 0
37 INT295617 UBXN11 Negative_regulation of SPTLC1 1 0.03 0.57 0
38 INT335525 Binding of SGCB and SPHK1 1 0.22 1.61 0
39 INT110836 Binding of AGXT and SPTLC1 1 0.30 0.11 0
40 INT298847 Binding of VAPA and RILP 1 0.05 0.54 0
41 INT298864 VAPB Regulation of Negative_regulation of RAB7A 1 0.32 0.32 0
42 INT352761 SGMS2 Regulation of Localization of Prkd1 1 0.20 0 0
43 INT264682 Binding of VAPB and SETX 1 0.28 1.09 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for sphingolipid biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported in sphingolipid biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT15722 Positive_regulation of PPAP2A 25 0.43 4.83 9.65
2 INT26707 Binding of PPAP2A 21 0.35 6.01 7.43
3 INT32903 Negative_regulation of PPAP2A 14 0.48 5.02 7.2
4 INT91100 Binding of SPTLC1 10 0.47 12.85 5.71
5 INT6601 Gene_expression of PPAP2A 21 0.27 3.13 5.52
6 INT66423 Binding of ELOVL1 52 0.40 61.63 5.16
7 INT23480 Regulation of PPAP2A 13 0.39 3.51 4.13
8 INT229788 Negative_regulation of SPTLC1 1 0.38 4.82 3.53
9 INT47949 Positive_regulation of ELOVL1 19 0.42 29.78 3.3
10 INT81955 Positive_regulation of SPTLC1 12 0.70 10.25 3.12
11 INT129358 Gene_expression of ELOVL1 23 0.66 29.39 2.83
12 INT66192 Regulation of Positive_regulation of PPAP2A 6 0.01 0.65 1.79
13 INT99388 Positive_regulation of Negative_regulation of PPAP2A 1 0.30 0.54 1.74
14 INT72870 Negative_regulation of SPTLC2 7 0.57 1.82 1.73
15 INT47950 Negative_regulation of ELOVL1 15 0.41 20.33 1.41
16 INT57067 Positive_regulation of Gene_expression of PPAP2A 6 0.10 0.25 1.39
17 INT229793 Negative_regulation of Positive_regulation of SPTLC1 1 0.43 1.49 1.17
18 INT80338 Gene_expression of SPTLC1 10 0.78 4.06 1.09
19 INT66043 Regulation of SPTLC2 3 0.44 1.62 1.09
20 INT280495 Regulation of PPAP2B 1 0.06 1.64 1
21 INT229786 Transcription of SPTLC1 1 0.60 0.78 0.71
22 INT201257 Positive_regulation of VAPA 1 0.01 0 0.71
23 INT66042 Positive_regulation of SPTLC2 2 0.68 0.97 0.66
24 INT80335 Localization of SPTLC1 4 0.75 0.61 0.65
25 INT332498 Positive_regulation of SGPP2 1 0.44 1.21 0.55
26 INT26704 Transcription of PPAP2A 2 0.23 1.49 0.53
27 INT198613 Localization of ELOVL1 2 0.56 1.84 0.52
28 INT181991 Positive_regulation of Positive_regulation of ELOVL1 1 0.01 1.7 0.51
29 INT136074 Regulation of ELOVL1 5 0.23 3.6 0.49
30 INT34498 Localization of PPAP2A 1 0.15 0.19 0.48
31 INT332520 Gene_expression of SGPP2 1 0.74 0.79 0.37
32 INT332502 Positive_regulation of Gene_expression of SGPP2 1 0.48 0.55 0.37
33 INT94146 Regulation of SPTLC1 2 0.51 2.39 0.36
34 INT110837 Binding of SPTLC2 1 0.36 0.7 0.35
35 INT43326 Positive_regulation of Binding of PPAP2A 1 0.27 0.34 0.29
36 INT198614 Phosphorylation of ELOVL1 2 0.11 1.79 0.25
37 INT79719 Negative_regulation of VAPA 6 0.43 2.94 0.21
38 INT280593 Negative_regulation of Gene_expression of SPHK1 2 0.43 3.92 0.19
39 INT280594 Gene_expression of SPHK1 2 0.78 71.47 0.19
40 INT181993 Regulation of Gene_expression of ELOVL1 1 0.00 1.23 0.19
41 INT332500 Regulation of SGPP2 1 0.43 0.8 0.18
42 INT76278 Binding of VAPA 4 0.48 3.32 0.16
43 INT181990 Positive_regulation of Gene_expression of ELOVL1 1 0.01 1.06 0.14
44 INT280581 Regulation of SPHK1 2 0.45 1.33 0.13
45 INT280589 Localization of SPHK1 2 0.75 2.61 0.13
46 INT352739 Negative_regulation of SGMS2 1 0.35 0.94 0.13
47 INT56469 Negative_regulation of Binding of PPAP2A 1 0.03 0 0.13
48 INT172101 Negative_regulation of Binding of ELOVL1 1 0.36 0.78 0.12
49 INT199419 Negative_regulation of Gene_expression of PPAP2A 1 0.03 0.21 0.11
50 INT110410 Negative_regulation of CERS1 1 0.01 0.09 0.08
51 INT242691 Transcription of SPTLC2 1 0.01 0 0.05
52 INT179728 Gene_expression of CERS1 2 0.15 1.04 0
53 INT255168 Binding of CERS1 2 0.07 1.85 0
54 INT332499 Negative_regulation of Gene_expression of SGPP2 1 0.56 0 0
55 INT284584 Localization of CERS1 1 0.01 0.32 0
56 INT352736 Regulation of Gene_expression of SGMS2 1 0.27 0.07 0
57 INT335530 Positive_regulation of Gene_expression of SPHK1 1 0.69 21.31 0
58 INT335533 Negative_regulation of SPHK1 1 0.59 2.38 0
59 INT352741 Gene_expression of SGMS2 1 0.47 0.16 0
60 INT335531 Phosphorylation of SPHK1 1 0.81 1 0
61 INT335529 Transcription of SPHK1 1 0.53 0.74 0
62 INT352746 Negative_regulation of Regulation of SGMS2 1 0.26 0.06 0
63 INT352743 Regulation of SGMS2 1 0.37 0.22 0
64 INT335539 Regulation of Gene_expression of SPHK1 1 0.62 4.55 0
65 INT335535 Positive_regulation of SPHK1 1 0.69 12.71 0
66 INT81956 Positive_regulation of Protein_catabolism of SPTLC1 1 0.06 0.16 0
67 INT81957 Protein_catabolism of SPTLC1 1 0.10 0.15 0
68 INT352745 Positive_regulation of Gene_expression of SGMS2 1 0.42 0.09 0
69 INT352744 Regulation of Negative_regulation of SGMS2 1 0.27 0 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox