GO:0030159

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Name receptor signaling complex scaffold activity
Categary Function
Go Slim No
Go Link GO:0030159
Unique Molecular Interactions 53
Total Molecular Interactions 86
Total Single Events 242
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for receptor signaling complex scaffold activity. They are ordered first by their pain relevance and then by number of times they were reported for receptor signaling complex scaffold activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT296484 Binding of Gria2 and GRIP1 1 0.04 4.52 4.59
2 INT146352 Binding of Rgs14 and Mors1 1 0.23 0.27 1.17
3 INT238091 Binding of GRIP1 and Mmp24 1 0.00 0 0.98
4 INT232622 Magi2 Regulation of Cysltr1 1 0.01 0.58 0.67
5 INT296486 Binding of Pick1 and GRIP1 1 0.03 0.32 0.59
6 INT296483 Prkca Positive_regulation of Localization of GRIP1 1 0.02 0.31 0.55
7 INT296485 Negative_regulation of Binding of Gria2 and GRIP1 1 0.05 0.3 0.54
8 INT353392 Binding of DRD4 and NCK1 1 0.37 0.62 0.37
9 INT296482 Binding of GRIP1 and Myo18a 1 0.00 0.35 0.32
10 INT317034 Binding of GRIP1 and Tmub1 1 0.02 0.11 0.23
11 INT175196 Binding of NCOR1 and NUP62 1 0.02 0.84 0.12
12 INT48211 Binding of SELL and DEDD2 1 0.03 0.18 0.12
13 INT303179 Binding of Dlgap1 and Shank1 1 0.22 0.31 0.1
14 INT217476 Nup62 Positive_regulation of Ngf 1 0.37 0.52 0.1
15 INT217477 Traf6 Positive_regulation of Binding of Nup62 1 0.32 0.47 0.09
16 INT303180 Trim3 Negative_regulation of Shank1 1 0.40 0 0.09
17 INT337888 Ins1 Positive_regulation of Gene_expression of Ldlrap1 1 0.06 0 0.08
18 INT337889 Binding of Ins1 and Ldlrap1 1 0.06 0.27 0.08
19 INT175195 Binding of SH2B2 and NUP62 1 0.01 0 0.07
20 INT303176 Gene_expression of Trim3 Positive_regulation of Protein_catabolism of Shank1 1 0.44 0 0.07
21 INT333247 Gene_expression of Cxcl12 Negative_regulation of Pxn 1 0.09 1 0.07
22 INT217472 Binding of Nup62 and Mul1 1 0.12 0 0.05
23 INT217471 Binding of Nup62 and Traf6 1 0.26 0 0.05
24 INT217468 Positive_regulation of Binding of Nup62 and Mul1 1 0.16 0 0.05
25 INT217467 Binding of Nup62 and Tnfrsf11a 1 0.31 0 0.05
26 INT354963 Binding of Cttn and Shank1 1 0.12 0 0.04
27 INT354971 Binding of HOMER1 and Shank1 1 0.01 0 0.04
28 INT290312 Binding of CASP1 and NCK1 1 0.00 0.29 0.04
29 INT303170 Gene_expression of Trim3 Negative_regulation of Shank1 1 0.40 0.12 0.04
30 INT238212 Binding of STAT3 and Pxn 1 0.02 0 0.03
31 INT272594 Binding of Dlg4 and Shank1 1 0.20 0 0.03
32 INT303159 Trim3 Negative_regulation of Gene_expression of Shank1 1 0.40 0 0
33 INT303185 Binding of Shank1 and Trim3 1 0.35 0 0
34 INT217473 Nup62 Regulation of Tnfrsf11a 1 0.38 0.66 0
35 INT284914 Binding of HDAC1 and NCK1 1 0.00 0.13 0
36 INT232893 Binding of ABR and Nup62 1 0.03 0.13 0
37 INT303161 Gene_expression of Trim3 Positive_regulation of Shank1 1 0.44 0 0
38 INT175192 Binding of NUP62 and GOPC 1 0.03 0 0
39 INT188436 Negative_regulation of NUP62 Positive_regulation of TNFRSF11A 1 0.39 1.6 0
40 INT303169 Trim3 Regulation of Gene_expression of Shank1 1 0.42 0 0
41 INT175194 Binding of UBC and NUP62 1 0.01 0.05 0
42 INT175193 NUP62 Regulation of Binding of TRAF6 1 0.07 0.06 0
43 INT303163 Shank1 Positive_regulation of Trim3 1 0.47 0 0
44 INT303173 Negative_regulation of Trim3 Negative_regulation of Shank1 1 0.40 0 0
45 INT175191 Binding of TRAF6 and NUP62 1 0.06 0.06 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for receptor signaling complex scaffold activity. They are ordered first by their pain relevance and then by number of times they were reported in receptor signaling complex scaffold activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT146350 Phosphorylation of Rgs14 1 0.80 0.79 3.77
2 INT238088 Binding of GRIP1 6 0.04 2.35 2.75
3 INT126276 Regulation of Rgs14 1 0.39 0.71 1.63
4 INT146351 Positive_regulation of Phosphorylation of Rgs14 1 0.45 0.27 1.23
5 INT296479 Negative_regulation of Binding of GRIP1 1 0.05 1.55 1.18
6 INT128413 Positive_regulation of Shank1 2 0.70 0.61 1.16
7 INT126279 Gene_expression of Rgs14 1 0.67 0.34 0.98
8 INT128411 Regulation of Shank1 2 0.45 0.81 0.95
9 INT127432 Gene_expression of Nup62 20 0.71 11.01 0.71
10 INT285478 Negative_regulation of Rgs14 1 0.27 1.25 0.6
11 INT296480 Localization of GRIP1 1 0.08 0.3 0.54
12 INT175219 Binding of NUP62 31 0.27 4.51 0.53
13 INT217452 Binding of Nup62 1 0.38 2.7 0.44
14 INT303211 Gene_expression of Shank1 1 0.64 0.48 0.4
15 INT243089 Gene_expression of Ldlrap1 2 0.65 0.14 0.35
16 INT303286 Localization of Nup62 1 0.08 0 0.35
17 INT134738 Gene_expression of NCK1 2 0.01 0.14 0.34
18 INT217446 Negative_regulation of Binding of Nup62 1 0.33 1.54 0.25
19 INT321550 Gene_expression of Pxn 5 0.18 2.08 0.21
20 INT217463 Positive_regulation of Nup62 5 0.39 1.79 0.17
21 INT232830 Positive_regulation of Protein_catabolism of Nup62 3 0.39 0.75 0.15
22 INT48213 Binding of DEDD2 1 0.05 0.25 0.15
23 INT303216 Protein_catabolism of Shank1 1 0.83 0 0.15
24 INT243075 Regulation of Gene_expression of Ldlrap1 2 0.44 0.15 0.13
25 INT337866 Binding of Ldlrap1 1 0.18 0.56 0.12
26 INT321546 Negative_regulation of Pxn 3 0.10 0.72 0.11
27 INT217454 Positive_regulation of Gene_expression of Nup62 2 0.39 1.56 0.11
28 INT303217 Binding of Shank1 1 0.36 0 0.11
29 INT333240 Negative_regulation of Gene_expression of Pxn 1 0.08 0.27 0.11
30 INT303233 Negative_regulation of Gene_expression of Shank1 1 0.49 0.07 0.1
31 INT127433 Negative_regulation of Gene_expression of Nup62 2 0.53 2.36 0.08
32 INT181030 Regulation of Pxn 1 0.09 1.11 0.08
33 INT303212 Positive_regulation of Protein_catabolism of Shank1 1 0.42 0 0.08
34 INT232834 Protein_catabolism of Nup62 3 0.56 0.8 0.07
35 INT217461 Negative_regulation of Positive_regulation of Nup62 1 0.33 0.41 0.07
36 INT272574 Gene_expression of Shank1 2 0.61 0.22 0.06
37 INT303195 Positive_regulation of Gene_expression of Shank1 1 0.42 0.08 0.06
38 INT333229 Negative_regulation of Phosphorylation of Pxn 1 0.08 0.96 0.06
39 INT333237 Phosphorylation of Pxn 1 0.12 0.95 0.06
40 INT175226 Gene_expression of NUP62 4 0.52 1.26 0.05
41 INT217443 Regulation of Nup62 1 0.48 1.47 0.05
42 INT188456 Negative_regulation of Gene_expression of NUP62 1 0.33 0.99 0.05
43 INT352009 Positive_regulation of Gene_expression of Pxn 1 0.07 0.1 0.04
44 INT303204 Negative_regulation of Shank1 1 0.42 0.11 0.04
45 INT198711 Binding of NCK1 1 0.05 1.08 0.03
46 INT217457 Negative_regulation of Nup62 2 0.33 0.94 0
47 INT303227 Regulation of Negative_regulation of Shank1 1 0.26 0 0
48 INT286551 Binding of Pxn 1 0.08 0.94 0
49 INT188443 Negative_regulation of NUP62 1 0.33 1.53 0
50 INT309323 Positive_regulation of NCK1 1 0.01 0.06 0
51 INT175215 Negative_regulation of Binding of NUP62 1 0.19 0.13 0
52 INT303202 Negative_regulation of Protein_catabolism of Shank1 1 0.49 0 0
53 INT303209 Positive_regulation of Positive_regulation of Shank1 1 0.34 0 0
54 INT188454 Positive_regulation of NUP62 1 0.36 0.92 0
55 INT303193 Localization of Shank1 1 0.62 0.19 0
56 INT217459 Regulation of Gene_expression of Nup62 1 0.35 0.35 0
57 INT303199 Regulation of Gene_expression of Shank1 1 0.23 0 0
58 INT354939 Positive_regulation of Gene_expression of Shank1 1 0.45 0.14 0
59 INT353775 Negative_regulation of Ldlrap1 1 0.02 1 0
60 INT243095 Positive_regulation of Ldlrap1 1 0.49 0.18 0
61 INT303232 Regulation of Protein_catabolism of Shank1 1 0.38 0 0
62 INT243072 Transcription of Ldlrap1 1 0.67 0 0
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