GO:0030162

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Name regulation of proteolysis
Categary Process
Go Slim No
Go Link GO:0030162
Unique Molecular Interactions 450
Total Molecular Interactions 606
Total Single Events 4524
Pain Genes Associated 43

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of proteolysis. They are ordered first by their pain relevance and then by number of times they were reported for regulation of proteolysis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT87891 Agt Regulation of Cck 1 0.28 0 1.97
2 INT66504 Binding of Agt and Agtr1a 8 0.39 3.78 1.78
3 INT10202 Agt Positive_regulation of Avp 3 0.70 0 1.69
4 INT24689 Binding of PLAT and Serpine1 1 0.00 3.77 1.64
5 INT162482 Binding of Agt and Vta1 1 0.23 0 1.27
6 INT46022 tp Positive_regulation of SERPINB1 1 0.04 0 1.26
7 INT123260 Binding of Gabrg2 and Serpini1 1 0.02 0.63 1.16
8 INT123261 Gabrg2 Regulation of Serpini1 1 0.01 0.63 1.16
9 INT108409 AGT Positive_regulation of AGTR2 2 0.31 1.49 1.11
10 INT2457 Agt Positive_regulation of Localization of Avp 5 0.59 0.2 1.09
11 INT63543 Binding of Adra2a and Serpini1 1 0.13 0 1
12 INT12050 Agt Positive_regulation of Localization of Oxt 1 0.29 0 0.91
13 INT34457 AGT Positive_regulation of POMC 1 0.01 0 0.91
14 INT61587 Agt Negative_regulation of REN 1 0.00 0.42 0.91
15 INT340437 Binding of SERPINH1 and HLA-DRB4 1 0.00 2.26 0.84
16 INT69424 Binding of Agt and Oprd1 1 0.14 0 0.84
17 INT34458 AGT Negative_regulation of PENK 1 0.00 0 0.81
18 INT47143 Negative_regulation of Agt Positive_regulation of Avp 1 0.22 0 0.79
19 INT16488 Binding of Serpinf2 and Crp 1 0.00 0.78 0.78
20 INT16491 Binding of ADRA1D and Serpinf2 1 0.02 0.78 0.78
21 INT16494 Binding of LPA and Serpinf2 1 0.00 0.78 0.78
22 INT16492 Positive_regulation of Binding of LPA and Serpinf2 1 0.00 0.78 0.78
23 INT16493 Positive_regulation of Binding of ADRA1D and Serpinf2 1 0.02 0.78 0.78
24 INT16489 Positive_regulation of Binding of Serpinf2 and Crp 1 0.00 0.78 0.78
25 INT39095 Negative_regulation of Agt Positive_regulation of Localization of Ren 1 0.38 0 0.73
26 INT113552 Binding of PLAU and PLAUR 4 0.31 3.09 0.72
27 INT117639 Serpini1 Negative_regulation of Cpox 1 0.00 0.64 0.72
28 INT177359 Serpinc1 Positive_regulation of CSRP1 1 0.00 0.97 0.72
29 INT224580 Gene_expression of IL18 Positive_regulation of SERPINH1 1 0.00 1.34 0.7
30 INT126779 Binding of Serpinc1 and F8 1 0.00 1.52 0.69
31 INT126781 Binding of F10 and Serpinc1 1 0.00 1.51 0.69
32 INT391 Binding of Agt and Ace 2 0.33 1.5 0.68
33 INT141063 Agt Regulation of Agtr1a 1 0.28 1.18 0.68
34 INT47145 Penk Negative_regulation of Agt 1 0.06 0 0.66
35 INT162878 Agt Regulation of Ang 1 0.21 1.15 0.66
36 INT329589 Serpina5 Positive_regulation of PTX3 1 0.03 1.52 0.66
37 INT92045 Binding of ALB and SERPINA1 1 0.30 1.37 0.64
38 INT113780 AGT Positive_regulation of Positive_regulation of Nfkb1 1 0.00 1.25 0.64
39 INT57421 Oprd1 Regulation of Agt 1 0.29 0 0.62
40 INT142993 Serpinc1 Positive_regulation of Phosphorylation of RHOA 1 0.05 0.05 0.59
41 INT142990 Serpinc1 Positive_regulation of Phosphorylation of S1pr1 1 0.03 0.05 0.59
42 INT56116 Agt Positive_regulation of Lhb 1 0.15 0 0.58
43 INT87294 SERPINA3 Negative_regulation of PTGS2 1 0.25 0.6 0.58
44 INT223924 Cux1 Regulation of Gene_expression of Serpina1 1 0.04 0.15 0.57
45 INT56117 Agt Positive_regulation of Positive_regulation of CGA 1 0.00 0 0.56
46 INT137897 Binding of SERPINH1 and IL36B 1 0.00 0.64 0.55
47 INT99736 Binding of PLG and Serpinf2 1 0.01 0.73 0.55
48 INT73367 Agt Negative_regulation of Localization of Calca 1 0.43 0.26 0.54
49 INT34459 AGT Negative_regulation of MBTPS1 1 0.01 0 0.54
50 INT129869 SERPINA6 Regulation of AVP 1 0.25 2.33 0.54
51 INT132438 Binding of AGT and OXTR 1 0.08 1.03 0.53
52 INT256019 Agt Negative_regulation of Lnpep 1 0.23 1.76 0.53
53 INT130561 NCKIPSD Regulation of SERPINF2 1 0.22 0 0.52
54 INT223925 Drd1a Positive_regulation of Gene_expression of Serpina1 1 0.01 0 0.51
55 INT19296 AGT Positive_regulation of Localization of AVP 1 0.38 0 0.5
56 INT21315 AGT Positive_regulation of Npy 1 0.03 0.15 0.5
57 INT55553 Avp Regulation of Serpina6 1 0.02 0 0.49
58 INT36143 Binding of SERPINH1 and HLA-B 1 0.00 0.66 0.49
59 INT175326 SERPINH1 Regulation of Pnlip 1 0.00 0.53 0.49
60 INT179237 Binding of SERPINA6 and POMC 1 0.03 1.15 0.49
61 INT39078 Binding of Agt and Penk 1 0.24 0.42 0.48
62 INT47144 Negative_regulation of Creg2-ps1 Positive_regulation of Agt 1 0.01 0 0.48
63 INT47146 Creg2-ps1 Positive_regulation of Agt 1 0.01 0 0.48
64 INT39077 Agt Negative_regulation of Prss12 1 0.05 0.44 0.46
65 INT342633 ACE Regulation of Gene_expression of AGT 1 0.01 0.14 0.46
66 INT106001 Binding of PLAUR and VTN 2 0.23 1.5 0.45
67 INT159538 SERPINB1 Regulation of Gene_expression of CALCA 1 0.01 0.8 0.45
68 INT262815 Gene_expression of Serpinf1 Negative_regulation of Gene_expression of Gfap 1 0.39 2.73 0.44
69 INT151958 Negative_regulation of Agt Positive_regulation of Agtrap 1 0.39 0 0.44
70 INT151959 Agt Positive_regulation of Agtrap 1 0.63 0 0.44
71 INT114341 Agt Positive_regulation of AGT 3 0.01 1.15 0.43
72 INT184543 Agt Positive_regulation of Ccl2 1 0.16 3.18 0.43
73 INT345288 AGT Positive_regulation of Localization of CCL2 1 0.01 1.5 0.43
74 INT36459 Binding of Agt and Positive_regulation of Localization of Avp 1 0.38 0.19 0.43
75 INT262819 Gene_expression of Serpinf1 Negative_regulation of Binding of 1190002H23Rik 1 0.05 2.66 0.43
76 INT345291 AGT Positive_regulation of CCL2 1 0.01 1.39 0.43
77 INT242992 Binding of Agt and Ppara 1 0.20 1.44 0.42
78 INT83915 Il1b Positive_regulation of SERPINA3 1 0.02 0.5 0.41
79 INT36460 Binding of Agt and Avp 1 0.28 0.16 0.4
80 INT275156 Agt Positive_regulation of Rac1 1 0.03 2.89 0.4
81 INT64384 Agt Negative_regulation of Son 1 0.26 0 0.39
82 INT185530 Binding of AGT and EDNRA 1 0.00 0.31 0.38
83 INT113560 Negative_regulation of Binding of FN1 and PLAUR 1 0.26 0.87 0.37
84 INT113556 Binding of FN1 and PLAUR 1 0.22 0.81 0.37
85 INT99738 Binding of F13A1 and Serpinf2 1 0.00 0.49 0.37
86 INT262824 Gene_expression of Serpinf1 Negative_regulation of Gene_expression of Il18 1 0.39 1.56 0.37
87 INT113553 Negative_regulation of Binding of PLAU and PLAUR 1 0.36 0.87 0.37
88 INT113547 Negative_regulation of Binding of PLAUR and VTN 1 0.26 0.87 0.37
89 INT39092 Agt Negative_regulation of Ren 1 0.39 0 0.37
90 INT21828 Binding of POMC and Serpinb1a 1 0.02 0 0.36
91 INT53257 CALCRL Negative_regulation of Binding of Agt 1 0.00 0 0.36
92 INT44112 Agt Regulation of Penk 1 0.08 0 0.35
93 INT230786 Binding of AGT and ACE 4 0.15 2.53 0.34
94 INT4638 Binding of Agt and Adarb1 3 0.01 0 0.34
95 INT330122 Agt Positive_regulation of Gene_expression of Agtr1a 1 0.03 0.69 0.34
96 INT330119 Agt Positive_regulation of Gene_expression of Bdkrb1 1 0.37 0.63 0.34
97 INT162157 Binding of SGCG and Agt 1 0.33 0.35 0.33
98 INT147436 Agt Positive_regulation of Gene_expression of Ros1 1 0.02 0.5 0.33
99 INT242995 Agt Positive_regulation of Spp1 1 0.36 1.82 0.33
100 INT229363 Negative_regulation of Binding of Agt and Agtr1a 2 0.22 0.9 0.32
101 INT44127 Agt Negative_regulation of DSPP 1 0.02 0 0.32
102 INT56115 Agt Regulation of Lhb 1 0.16 0 0.32
103 INT72445 Binding of AGT and REN 3 0.34 0.88 0.31
104 INT96096 Binding of Serpinc1 and Selp 1 0.00 0.69 0.3
105 INT250738 Binding of hs and Serpinc1 1 0.00 0.46 0.3
106 INT96101 Binding of SELP and Serpinc1 1 0.01 0.69 0.29
107 INT200631 AGT Positive_regulation of Gene_expression of TGFB1 1 0.06 1.36 0.29
108 INT96093 Binding of Serpinc1 and F2 1 0.00 0.68 0.29
109 INT288911 AGT Positive_regulation of CYBB 3 0.07 2.96 0.28
110 INT116853 Chdh Regulation of Positive_regulation of Agt 1 0.11 0.19 0.28
111 INT262826 Serpinf1 Negative_regulation of Gene_expression of TNF 1 0.29 1.83 0.28
112 INT45541 Agt Positive_regulation of Lnpep 1 0.03 0 0.27
113 INT45545 Agt Positive_regulation of Oxt 1 0.23 0 0.27
114 INT262820 Binding of Aif1 and Serpinf1 1 0.01 1.3 0.27
115 INT24222 Ifng Positive_regulation of Gene_expression of Serping1 1 0.00 0 0.26
116 INT126550 Agt Positive_regulation of Gene_expression of Nsfl1c 1 0.39 1.07 0.26
117 INT242991 Agt Positive_regulation of Gene_expression of Spp1 1 0.21 0.66 0.26
118 INT9528 Agt Positive_regulation of Localization of Pomc 2 0.50 0.14 0.25
119 INT342456 AGT Positive_regulation of Gene_expression of CCL2 1 0.07 0.63 0.25
120 INT351143 Binding of Cd3e and Ighg2a 1 0.00 1.56 0.25
121 INT126547 Agt Positive_regulation of Nfkb1 1 0.46 0.99 0.25
122 INT126548 Negative_regulation of Agt Positive_regulation of Nfkb1 1 0.29 0.99 0.25
123 INT297258 Binding of Agt and Agtr2 1 0.23 0.7 0.25
124 INT126553 Agt Positive_regulation of Nfkb1 1 0.06 0.99 0.25
125 INT191792 Binding of F2r and Serpinc1 1 0.00 3.74 0.24
126 INT256028 Binding of Agt and Lnpep 1 0.19 1.16 0.24
127 INT41588 Binding of AGT and Lhb 1 0.00 0 0.24
128 INT41589 Binding of AGT and Prl 1 0.00 0 0.24
129 INT126551 Agt Positive_regulation of Gene_expression of Ptgs1 1 0.25 0.92 0.24
130 INT126552 Agt Positive_regulation of Gene_expression of Ptgs2 1 0.32 0.92 0.24
131 INT191492 Binding of AGT and NLRP3 1 0.01 0.35 0.23
132 INT222178 SERPINB1 Regulation of ELANE 1 0.00 1.04 0.23
133 INT222184 SERPINB1 Regulation of PRTN3 1 0.00 1.04 0.23
134 INT126549 Agt Positive_regulation of Ptgs2 1 0.32 0.9 0.23
135 INT262817 Serpinf1 Regulation of Positive_regulation of 1190002H23Rik 1 0.06 1.3 0.22
136 INT202183 PLAU Regulation of Protein_catabolism of PLAUR 1 0.11 1.25 0.21
137 INT195705 Binding of SERPINC1 and SDC4 1 0.07 1.54 0.21
138 INT222566 Agt Positive_regulation of Localization of Prl 1 0.08 0.23 0.21
139 INT202184 SERPINE1 Regulation of Protein_catabolism of PLAUR 1 0.23 1.25 0.21
140 INT229360 Agt Positive_regulation of Agtr1a 2 0.48 1.26 0.2
141 INT115006 Binding of Serpine1 and Cpb2 1 0.09 1.53 0.2
142 INT275159 Agt Positive_regulation of Phosphorylation of Stat3 1 0.04 1.44 0.2
143 INT274094 EDN1 Positive_regulation of AGT 1 0.16 0.95 0.2
144 INT282864 Bpifa2 Positive_regulation of Gene_expression of Serpinf1 1 0.15 1.16 0.2
145 INT249993 Binding of Agt and Igkv4-55 1 0.02 0.49 0.2
146 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19
147 INT258017 Binding of AGT and ANGPT2 3 0.11 2.35 0.19
148 INT99731 Binding of Serpinf2 and Ppp1r1a 1 0.00 0.24 0.19
149 INT99734 Binding of SERPINE1 and Serpinf2 1 0.00 0.25 0.19
150 INT46308 Asrgl1 Positive_regulation of Gene_expression of Serpinc1 1 0.01 1.07 0.19
151 INT46307 Asrgl1 Positive_regulation of Negative_regulation of Serpinc1 1 0.01 1.07 0.19
152 INT279507 Serping1 Negative_regulation of Gene_expression of C3 1 0.03 1.12 0.19
153 INT279500 Serping1 Negative_regulation of Transcription of C3 1 0.03 1.12 0.19
154 INT184540 Agt Regulation of Gene_expression of Ccl2 1 0.08 1.66 0.18
155 INT41978 Binding of Agt and Htr1a 1 0.41 0.54 0.18
156 INT262818 Serpinf1 Negative_regulation of Gene_expression of Gfap 1 0.45 0.71 0.18
157 INT262822 Serpinf1 Negative_regulation of Negative_regulation of 1190002H23Rik 1 0.07 1.27 0.18
158 INT261579 Serpinc1 Negative_regulation of Gene_expression of CYBB 1 0.00 1.69 0.18
159 INT271451 TGFB1 Regulation of Serpine1 1 0.00 0.68 0.18
160 INT310302 Tlr4 Regulation of Positive_regulation of Serpina10 1 0.01 0.53 0.18
161 INT229223 Binding of AGT and FAS 1 0.08 0.91 0.17
162 INT310932 Binding of Tgm2 and Serpinb1a 1 0.04 0.87 0.17
163 INT36568 AGT Positive_regulation of FBF1 1 0.39 0.5 0.17
164 INT142332 Binding of SERPINH1 and TNNI3 1 0.03 1.05 0.17
165 INT226759 Serpinf1 Negative_regulation of Cxcr4 1 0.01 0.58 0.17
166 INT233904 NLRP3 Positive_regulation of AGT 1 0.06 0.81 0.17
167 INT229224 Positive_regulation of Binding of AGT and FAS 1 0.09 0.92 0.17
168 INT97820 Serpine1 Negative_regulation of TIMP1 1 0.00 0.29 0.17
169 INT36567 Negative_regulation of AGT Positive_regulation of FBF1 1 0.36 0.5 0.17
170 INT83514 SERPINC1 Negative_regulation of F2 2 0.16 0.62 0.16
171 INT111863 Negative_regulation of Binding of AGT and LNPEP 1 0.09 0 0.16
172 INT83513 Negative_regulation of SERPINC1 Negative_regulation of F2 1 0.16 0.64 0.16
173 INT111861 Binding of AGT and LNPEP 1 0.07 0 0.16
174 INT310303 Serpina10 Positive_regulation of Hspa1a 1 0.02 0.53 0.16
175 INT21509 Agt Regulation of Edn1 1 0.53 0 0.15
176 INT195708 SERPINC1 Negative_regulation of TNF 1 0.17 0.66 0.15
177 INT106008 Binding of PLAUR and Plaur 1 0.15 1.36 0.15
178 INT131304 Binding of Serping1 and Sele 1 0.01 1.07 0.15
179 INT109886 F2 Negative_regulation of Serpinc1 1 0.00 1.18 0.15
180 INT2230 SERPINB1 Positive_regulation of Localization of CDON 1 0.00 0 0.14
181 INT72817 Agt Negative_regulation of Avp 1 0.07 0.34 0.14
182 INT347071 Negative_regulation of REN Negative_regulation of Positive_regulation of AGT 1 0.35 0.44 0.14
183 INT34430 AGT Positive_regulation of Localization of POMC 1 0.30 0.31 0.14
184 INT43496 SERPINB1 Negative_regulation of Ifng 1 0.00 0 0.14
185 INT170817 CMA1 Positive_regulation of Gene_expression of AGT 1 0.19 1.41 0.14
186 INT180671 Binding of Plat and Regulation of Serpine1 1 0.16 0.06 0.14
187 INT344946 AGT Regulation of Negative_regulation of ACE 1 0.21 0.61 0.14
188 INT293115 Agt Regulation of Positive_regulation of Crh 1 0.16 0.37 0.14
189 INT293117 Agt Regulation of Gene_expression of Aqp2 1 0.23 0.36 0.14
190 INT293123 Agtr1a Regulation of Negative_regulation of Agt 1 0.14 0.25 0.14
191 INT129868 Regulation of SERPINA6 Regulation of AVP 1 0.25 0.59 0.14
192 INT11641 Binding of SERPINE1 and Serpinc1 1 0.00 0.78 0.13
193 INT254855 Agt Positive_regulation of Tgfb1 1 0.03 0.18 0.13
194 INT33749 Crh Positive_regulation of Localization of Agt 1 0.31 0 0.13
195 INT310313 Serpina10 Regulation of Gene_expression of Tlr4 1 0.00 0.25 0.13
196 INT59808 Binding of AGT and PLCB1 1 0.02 0 0.13
197 INT241167 Binding of TNXA and Serpinc1 1 0.00 0.43 0.13
198 INT59809 AGT Positive_regulation of PLCB1 1 0.03 0 0.13
199 INT244338 Slc12a7 Positive_regulation of SERPINH1 1 0.00 0.26 0.13
200 INT59810 ADRA1D Positive_regulation of AGT 1 0.01 0 0.13

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of proteolysis. They are ordered first by their pain relevance and then by number of times they were reported in regulation of proteolysis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT385 Gene_expression of Agt 182 0.78 63.62 37.91
2 INT390 Positive_regulation of Agt 170 0.70 61.47 36.08
3 INT1159 Negative_regulation of Agt 133 0.59 40.14 31.67
4 INT1158 Regulation of Agt 106 0.61 29.4 30.29
5 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73
6 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91
7 INT1533 Negative_regulation of AGT 105 0.42 46.54 16.92
8 INT2066 Localization of Agt 56 0.80 9.95 16.25
9 INT15921 Positive_regulation of Serpine1 85 0.68 81.24 13.4
10 INT3962 Regulation of AGT 50 0.62 20.96 13.01
11 INT4199 Binding of Agt 76 0.48 21.06 12.66
12 INT398 Localization of AGT 45 0.78 16.97 11.54
13 INT8065 Binding of AGT 54 0.48 20.54 10.85
14 INT10049 Negative_regulation of SERPINA1 56 0.59 44.52 9.93
15 INT4391 Gene_expression of SERPINA1 47 0.78 41.43 9.7
16 INT27551 Gene_expression of SERPINH1 45 0.62 42.87 9.04
17 INT591 Negative_regulation of Serpinc1 44 0.57 31.73 8.82
18 INT386 Positive_regulation of Gene_expression of Agt 37 0.70 15.92 8.73
19 INT621 Positive_regulation of SERPINH1 19 0.57 21.52 8.44
20 INT6133 Negative_regulation of Serpinc1 56 0.58 42.8 8.35
21 INT10065 Positive_regulation of Serpina6 12 0.70 1.48 8.22
22 INT44816 Regulation of Serpina6 16 0.62 3.63 8.02
23 INT15918 Gene_expression of Serpine1 60 0.62 41.73 7.72
24 INT67822 Binding of SERPINH1 17 0.36 19.05 7.24
25 INT16068 Gene_expression of SERPINB1 27 0.60 20.51 6.56
26 INT10131 Gene_expression of Serpinf1 53 0.76 35.57 6.42
27 INT16359 Positive_regulation of Gene_expression of AGT 30 0.49 28.27 6.14
28 INT4587 Negative_regulation of Serping1 32 0.47 19.11 5.92
29 INT5762 Negative_regulation of Gene_expression of Agt 18 0.57 6.09 5.84
30 INT10147 Gene_expression of Serpinc1 28 0.76 17.73 5.77
31 INT29821 Gene_expression of Serpina1 18 0.60 2.98 5.75
32 INT187295 Gene_expression of Serpinb1a 6 0.58 13.73 5.05
33 INT20200 Positive_regulation of Serpinc1 25 0.68 17.08 4.98
34 INT15920 Regulation of Serpine1 34 0.42 17.36 4.89
35 INT37661 Negative_regulation of SERPINC1 48 0.59 38.6 4.77
36 INT3880 Negative_regulation of Serping1 54 0.58 37.19 4.75
37 INT6005 Gene_expression of Serpini1 5 0.58 1.62 4.74
38 INT35254 Negative_regulation of SERPINB1 22 0.48 11.42 4.7
39 INT15474 Gene_expression of PLAUR 36 0.75 22.32 4.63
40 INT46121 Negative_regulation of SERPINH1 14 0.38 10.84 4.41
41 INT3332 Protein_catabolism of AGT 23 0.87 3.17 4.39
42 INT17548 Negative_regulation of Serpine1 30 0.57 24.69 3.93
43 INT51312 Positive_regulation of Gene_expression of SERPINA1 4 0.46 9.41 3.84
44 INT179261 Gene_expression of SERPINA6 12 0.14 3.53 3.82
45 INT24231 Localization of SERPINB1 13 0.61 3.1 3.61
46 INT3889 Regulation of Serpinc1 13 0.61 8.6 3.46
47 INT76399 Binding of Serpina6 4 0.34 3.81 3.46
48 INT8539 Negative_regulation of Serpina1a 21 0.58 12.65 3.39
49 INT14397 Gene_expression of Serpinc1 27 0.46 14.54 3.32
50 INT7773 Localization of SERPINF1 18 0.55 8.54 3.25
51 INT22092 Gene_expression of SERPINA3 17 0.75 11.57 3.16
52 INT37811 Negative_regulation of SERPINB6 8 0.47 4.65 3.15
53 INT10132 Negative_regulation of Serpinf1 14 0.58 11.72 3.14
54 INT14086 Binding of SERPINB1 18 0.34 4.32 3.13
55 INT14960 Positive_regulation of Serpinc1 17 0.68 12.71 3.02
56 INT45673 Gene_expression of Serpina6 10 0.53 3.47 3
57 INT64843 Gene_expression of Serping1 19 0.67 8.88 2.72
58 INT71794 Binding of SERPINC1 17 0.39 10.5 2.64
59 INT29818 Regulation of Serpina1 8 0.27 0.08 2.64
60 INT100427 Binding of SERPINA1 9 0.36 9.63 2.51
61 INT5180 Binding of Serpinc1 27 0.36 13.39 2.47
62 INT60142 Negative_regulation of Serpinb1a 2 0.42 0.59 2.46
63 INT17857 Negative_regulation of Gene_expression of AGT 25 0.46 21.16 2.45
64 INT10044 Positive_regulation of Serpina1 5 0.69 0.99 2.45
65 INT148071 Gene_expression of Agt 42 0.74 44.9 2.43
66 INT10048 Positive_regulation of SERPINA1 11 0.68 8.59 2.43
67 INT4270 Negative_regulation of Negative_regulation of Agt 10 0.43 1.08 2.43
68 INT4585 Gene_expression of Serping1 19 0.46 12.4 2.35
69 INT27988 Negative_regulation of Positive_regulation of AGT 11 0.42 5.71 2.27
70 INT71490 Positive_regulation of Positive_regulation of Serpina6 3 0.70 0.16 2.27
71 INT43612 Regulation of SERPINB1 12 0.11 3.26 2.21
72 INT10201 Positive_regulation of Localization of Agt 8 0.50 0.97 2.21
73 INT35058 Positive_regulation of PLAUR 11 0.61 7.21 2.16
74 INT15922 Positive_regulation of Positive_regulation of Serpine1 6 0.31 8.34 2.16
75 INT37809 Gene_expression of SERPINB6 7 0.77 6.58 2.12
76 INT45672 Negative_regulation of Serpina6 5 0.43 1.66 2.08
77 INT10045 Negative_regulation of Serpina1 7 0.43 1.01 2.07
78 INT83911 Negative_regulation of Gene_expression of SERPINA1 3 0.43 5.2 2.07
79 INT12005 Negative_regulation of Localization of Agt 6 0.57 1.49 2.06
80 INT46109 Binding of SERPINF2 6 0.37 1.08 2.06
81 INT63542 Positive_regulation of Serpini1 3 0.20 0.51 1.98
82 INT79915 Positive_regulation of Agt 27 0.56 12.97 1.96
83 INT144973 Gene_expression of Shh 9 0.77 4.32 1.96
84 INT12801 Negative_regulation of Regulation of Agt 4 0.43 1.2 1.96
85 INT130560 Negative_regulation of Gene_expression of Serpinf1 17 0.58 13.39 1.94
86 INT43944 Negative_regulation of Positive_regulation of Agt 4 0.42 1.44 1.93
87 INT40954 Regulation of Serping1 5 0.32 3.71 1.88
88 INT16391 Regulation of Serpinf2 5 0.03 4.22 1.82
89 INT6006 Positive_regulation of Gene_expression of Serpini1 1 0.00 0 1.82
90 INT37810 Positive_regulation of Negative_regulation of SERPINB6 2 0.41 1.84 1.78
91 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77
92 INT67183 Binding of Serpinb1a 4 0.37 4 1.77
93 INT15980 Positive_regulation of Positive_regulation of Agt 6 0.50 2.99 1.76
94 INT211200 Regulation of SERPINH1 2 0.03 3.8 1.75
95 INT67604 Gene_expression of SERPINC1 14 0.67 11.47 1.72
96 INT3152 Transcription of Agt 7 0.72 5.09 1.68
97 INT223923 Positive_regulation of Gene_expression of Serpina1 1 0.08 0.27 1.67
98 INT14405 Gene_expression of SERPINF2 14 0.65 3 1.64
99 INT20982 Positive_regulation of SERPINB1 7 0.28 7.27 1.61
100 INT73330 Positive_regulation of SERPINB2 6 0.47 5.33 1.57
101 INT223920 Regulation of Gene_expression of Serpina1 1 0.05 0.4 1.57
102 INT202935 Gene_expression of SERPINF1 12 0.50 7.53 1.54
103 INT14404 Negative_regulation of SERPINF2 11 0.47 3.15 1.47
104 INT11710 Positive_regulation of SERPINC1 6 0.59 6.15 1.47
105 INT34768 Negative_regulation of Negative_regulation of AGT 10 0.25 2.79 1.42
106 INT8067 Negative_regulation of Binding of AGT 12 0.25 10.33 1.39
107 INT72359 Binding of Serpini1 3 0.32 1.02 1.39
108 INT239215 Binding of Agt 9 0.38 6.75 1.35
109 INT24685 Localization of Serpine1 12 0.59 7.76 1.32
110 INT56944 Positive_regulation of SERPINA3 8 0.67 6.56 1.32
111 INT17052 Binding of SERPINB2 4 0.43 4.89 1.32
112 INT11306 Regulation of Gene_expression of Agt 7 0.45 3.29 1.31
113 INT69723 Gene_expression of SERPINB2 7 0.60 4.54 1.28
114 INT11241 Transcription of AGT 4 0.52 1.83 1.27
115 INT200463 Regulation of SERPINB6 9 0.25 3.46 1.25
116 INT211198 Localization of SERPINH1 2 0.66 4.33 1.25
117 INT306702 Transcription of SERPINB6 1 0.01 0.24 1.25
118 INT19319 Negative_regulation of Binding of Agt 9 0.42 3.42 1.24
119 INT179257 Binding of SERPINA6 5 0.10 2.09 1.24
120 INT169525 Positive_regulation of Serpinb1a 4 0.44 6.48 1.24
121 INT79916 Negative_regulation of Agt 14 0.47 6 1.22
122 INT177629 Negative_regulation of SERPINA6 5 0.57 2.1 1.22
123 INT96845 Positive_regulation of Regulation of Serpinc1 1 0.18 1.78 1.22
124 INT135218 Positive_regulation of Gene_expression of Serpini1 1 0.67 1.02 1.21
125 INT23767 Positive_regulation of SERPINA7 6 0.67 1.96 1.2
126 INT47644 Positive_regulation of Localization of AGT 4 0.45 1.24 1.2
127 INT135217 Gene_expression of Serpini1 1 0.75 1.02 1.2
128 INT57494 Positive_regulation of Positive_regulation of Serpinc1 3 0.26 1.67 1.19
129 INT20100 Binding of Serpine1 16 0.29 6.78 1.18
130 INT14396 Regulation of Serpinc1 5 0.19 3.16 1.16
131 INT15919 Positive_regulation of Gene_expression of Serpine1 6 0.41 4.5 1.15
132 INT28594 Positive_regulation of Transcription of Agt 2 0.47 1.3 1.15
133 INT115621 Positive_regulation of Binding of AGT 1 0.02 0 1.15
134 INT45674 Regulation of Gene_expression of Serpina6 3 0.14 0.86 1.14
135 INT253191 Positive_regulation of Gene_expression of Shh 2 0.66 2.57 1.14
136 INT11109 Positive_regulation of Serpina1a 5 0.68 4.97 1.12
137 INT179262 Localization of SERPINA6 4 0.16 1.29 1.1
138 INT16393 Gene_expression of Serpinf2 4 0.08 3.39 1.09
139 INT5643 Positive_regulation of SERPINF2 3 0.35 0.94 1.09
140 INT165530 Positive_regulation of Shh 4 0.69 1.21 1.05
141 INT71491 Negative_regulation of Positive_regulation of Serpina6 2 0.59 0.3 1.04
142 INT37687 Binding of PLAUR 8 0.29 3.61 1.03
143 INT96327 Transcription of Serpina6 1 0.29 0 1.03
144 INT76398 Regulation of Binding of Serpina6 1 0.18 0.24 1.02
145 INT67283 Binding of Serpinc1 8 0.47 5.02 1.01
146 INT101841 Localization of SERPINF2 4 0.68 1.27 1.01
147 INT26508 Regulation of Serpini1 2 0.19 0.84 1.01
148 INT305307 Gene_expression of Serpina5 88 0.78 10.09 1
149 INT294191 Localization of Serpini1 3 0.67 1.21 0.99
150 INT20156 Positive_regulation of Negative_regulation of Serpine1 4 0.49 2.89 0.97
151 INT76757 Positive_regulation of SERPINA6 3 0.59 1.19 0.97
152 INT77093 Positive_regulation of Serpina3c 1 0.67 1.31 0.95
153 INT97174 Positive_regulation of SERPINB6 5 0.50 3.74 0.91
154 INT24410 Negative_regulation of Gene_expression of Serpinc1 4 0.28 1.98 0.91
155 INT16479 Positive_regulation of Serpinf2 2 0.05 1.2 0.9
156 INT131719 Negative_regulation of Serpini1 2 0.42 0.63 0.89
157 INT353148 Positive_regulation of Binding of SERPINA1 1 0.13 1.87 0.89
158 INT13359 Negative_regulation of SERPINF1 6 0.33 0.6 0.86
159 INT36199 Regulation of SERPINA7 1 0.12 0 0.86
160 INT230806 Positive_regulation of Gene_expression of Agt 11 0.55 16.08 0.83
161 INT10047 Positive_regulation of Negative_regulation of SERPINA1 4 0.47 2.27 0.83
162 INT89360 Negative_regulation of Serpina3k 2 0.57 11.06 0.81
163 INT73030 Regulation of SERPINF2 10 0.39 5.69 0.8
164 INT74260 Positive_regulation of Serping1 5 0.64 6.05 0.8
165 INT21943 Positive_regulation of Positive_regulation of AGT 6 0.46 3.29 0.75
166 INT34715 Regulation of Regulation of AGT 2 0.37 0.96 0.75
167 INT103672 Localization of Serpinf1 4 0.69 2.45 0.74
168 INT17051 Regulation of SERPINB2 2 0.41 2.41 0.74
169 INT316727 Positive_regulation of Localization of Serpini1 1 0.08 0.76 0.73
170 INT328725 Localization of Serpina6 1 0.50 1.51 0.71
171 INT10130 Positive_regulation of Serpinf1 10 0.53 5.62 0.7
172 INT148074 Regulation of Agt 9 0.49 5.42 0.7
173 INT38735 Protein_catabolism of Agt 7 0.99 2.79 0.7
174 INT160461 Phosphorylation of Agt 1 0.31 0.4 0.7
175 INT160463 Positive_regulation of Phosphorylation of Agt 1 0.19 0.41 0.7
176 INT73977 Gene_expression of Serpinh1 14 0.54 8.14 0.69
177 INT46392 Regulation of SERPINA1 4 0.44 2.23 0.68
178 INT146109 Positive_regulation of Serping1 4 0.59 2.73 0.68
179 INT52901 Localization of PLAUR 2 0.49 1.92 0.68
180 INT103623 Negative_regulation of Serpini1 2 0.02 0.15 0.68
181 INT34769 Regulation of Gene_expression of AGT 3 0.19 1.39 0.67
182 INT310292 Gene_expression of Serpina10 1 0.03 4.13 0.67
183 INT23348 Negative_regulation of Serpinf2 8 0.38 3.02 0.65
184 INT103673 Positive_regulation of Gene_expression of Serpinf1 13 0.60 4.94 0.64
185 INT16392 Protein_catabolism of Serpinf2 1 0.03 1.38 0.64
186 INT96321 Negative_regulation of Gene_expression of Serpina6 1 0.23 0 0.62
187 INT96325 Negative_regulation of Transcription of Serpina6 1 0.24 0 0.62
188 INT158193 Regulation of Negative_regulation of Serpina1 1 0.18 0 0.62
189 INT35059 Protein_catabolism of PLAUR 5 0.88 4.61 0.61
190 INT96844 Regulation of Positive_regulation of Serpinc1 1 0.10 0.89 0.61
191 INT22784 Positive_regulation of Serpina1c 3 0.20 1.11 0.6
192 INT146108 Regulation of Positive_regulation of Serping1 1 0.05 1.04 0.6
193 INT142625 Negative_regulation of Localization of SERPINF2 1 0.31 0.16 0.59
194 INT224608 Positive_regulation of Gene_expression of SERPINH1 4 0.55 3.34 0.58
195 INT142988 Regulation of Gene_expression of Serpinc1 1 0.04 0.56 0.58
196 INT106004 Positive_regulation of Gene_expression of PLAUR 9 0.67 5.96 0.56
197 INT83909 Positive_regulation of Gene_expression of SERPINA3 4 0.67 3.04 0.56
198 INT79839 Positive_regulation of Serpina5 3 0.44 1.2 0.56
199 INT81371 Binding of Serping1 3 0.37 2.67 0.55
200 INT40021 Regulation of Binding of Agt 4 0.59 1.53 0.53
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