GO:0030163

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Name protein catabolic process
Categary Process
Go Slim No
Go Link GO:0030163
Unique Molecular Interactions 683
Total Molecular Interactions 1006
Total Single Events 5898
Pain Genes Associated 35

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for protein catabolic process. They are ordered first by their pain relevance and then by number of times they were reported for protein catabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT132225 Negative_regulation of Binding of Akt1 and Sh2d6 1 0.10 3.92 7.2
2 INT132231 Negative_regulation of Binding of Akt1 and Pik3cg 1 0.34 1.96 3.6
3 INT317522 Akt1 Positive_regulation of Phosphorylation of Nos1 1 0.43 0.4 3.13
4 INT168758 Hist1h1t Positive_regulation of Phosphorylation of Akt1 2 0.02 0.44 2.79
5 INT317551 Binding of Akt1 and Oprm1 1 0.19 0.21 2.74
6 INT121726 Ngf Positive_regulation of Phosphorylation of Akt1 1 0.37 1.4 2.34
7 INT114432 Oprl1 Positive_regulation of Akt1 1 0.18 0.08 2.2
8 INT132229 Binding of Akt1 and Sh2d6 1 0.09 0.98 1.8
9 INT169464 Akt1 Positive_regulation of Egfr 1 0.28 1.63 1.7
10 INT30134 Binding of TPP1 and S100A9 1 0.13 0.74 1.69
11 INT322412 PPBP Negative_regulation of Phosphorylation of Akt1 1 0.01 0 1.65
12 INT214372 Ptprq Positive_regulation of Akt1 1 0.04 0.88 1.43
13 INT214369 Pik3cb Positive_regulation of Akt1 1 0.56 0.87 1.41
14 INT62019 CSF2 Regulation of ELANE 1 0.03 0.47 1.21
15 INT317548 Positive_regulation of Akt1 Positive_regulation of Prkca 1 0.15 0 1.11
16 INT317516 Binding of Oprm1 and Negative_regulation of Positive_regulation of Akt1 1 0.17 0.1 1.11
17 INT323175 PRKCA Positive_regulation of Akt1 1 0.02 0 1.1
18 INT312097 ELANE Regulation of ALOX5 1 0.08 1.75 1.05
19 INT151218 Negative_regulation of SIGMAR1 Negative_regulation of Positive_regulation of Akt1 1 0.00 0.26 1.03
20 INT317554 Akt1 Regulation of Negative_regulation of Oprm1 1 0.21 0.07 1
21 INT62017 ELANE Positive_regulation of Localization of ACOT1 1 0.05 0.35 0.98
22 INT4916 Binding of Pax3 and Wdyhv1 1 0.00 0 0.98
23 INT317567 Binding of Akt1 and Nos1 1 0.22 0 0.96
24 INT137923 VEGFA Positive_regulation of Phosphorylation of Akt1 1 0.05 0 0.93
25 INT13193 FPR1 Positive_regulation of ELANE 3 0.44 1.22 0.92
26 INT114883 Akt1 Regulation of Pik3r1 2 0.16 0.65 0.92
27 INT317541 Oprd1 Negative_regulation of Akt1 1 0.06 0 0.91
28 INT249012 Binding of Akt1 and Gabrg1 1 0.01 0 0.9
29 INT132226 Binding of Akt1 and Pik3cg 1 0.30 0.49 0.9
30 INT199109 Binding of Akt1 and Arhgdia 1 0.02 2.73 0.87
31 INT32441 POMC Positive_regulation of ELANE 1 0.13 0.09 0.83
32 INT317556 Phosphorylation of Gopc Positive_regulation of Akt1 1 0.10 0.08 0.82
33 INT317514 Akt1 Regulation of Localization of Oprm1 1 0.21 0.07 0.82
34 INT16438 Atp6v0d2 Regulation of Localization of Lnpep 1 0.01 0 0.81
35 INT296829 USE1 Regulation of CASP4 1 0.01 0.17 0.81
36 INT16435 Ubqln1 Regulation of Localization of Lnpep 1 0.01 0 0.81
37 INT228255 Binding of Akt1 and Pten 2 0.43 1.78 0.8
38 INT144286 ACP1 Negative_regulation of Phosphorylation of PSMC6 1 0.45 0.39 0.78
39 INT111888 Akt1 Regulation of Regulation of Oprm1 1 0.04 0 0.77
40 INT134043 Jak2 Positive_regulation of Akt1 1 0.31 0.22 0.76
41 INT335592 Ltp Positive_regulation of Positive_regulation of Akt1 1 0.01 0.19 0.74
42 INT106527 Akt1 Positive_regulation of Jun 1 0.05 0.53 0.74
43 INT312101 ELANE Regulation of ALOX5AP 1 0.21 1.11 0.73
44 INT72229 Binding of NFKBIL1 and BTRC 1 0.00 0 0.73
45 INT276213 Pten Regulation of Phosphorylation of Akt1 1 0.51 0.61 0.72
46 INT298728 Akt1 Positive_regulation of Rela 1 0.01 1.03 0.67
47 INT293010 ELANE Regulation of Localization of LTF 1 0.00 0.54 0.67
48 INT289357 Ngfr Positive_regulation of Akt1 1 0.03 3.1 0.66
49 INT308668 Akt1 Positive_regulation of Nos3 3 0.05 4.61 0.65
50 INT296793 Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.75 0.65
51 INT296791 Positive_regulation of Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.8 0.65
52 INT312105 ELANE Positive_regulation of Localization of PTGER2 4 0.03 1.3 0.64
53 INT134047 Fitm1 Positive_regulation of Phosphorylation of Akt1 1 0.05 0.21 0.63
54 INT134044 Positive_regulation of Fitm1 Positive_regulation of Phosphorylation of Akt1 1 0.05 0.21 0.63
55 INT252772 ELANE Regulation of Gene_expression of CCL2 1 0.05 2.16 0.62
56 INT200808 Binding of Akt1 and Insrr 2 0.00 0.98 0.61
57 INT282286 Akt1 Positive_regulation of Pak1 1 0.15 0.24 0.61
58 INT139901 Ins1 Positive_regulation of Akt1 9 0.31 4.58 0.6
59 INT248994 Binding of Akt1 and Ptar1 1 0.00 0 0.58
60 INT323176 PRKCA Positive_regulation of Phosphorylation of Akt1 1 0.02 0 0.56
61 INT302832 Tnfsf10 Positive_regulation of Akt1 1 0.04 1.63 0.56
62 INT114064 Agtr2 Positive_regulation of Phosphorylation of Akt1 1 0.24 0.41 0.54
63 INT282284 Cpox Positive_regulation of Akt1 1 0.02 0.47 0.54
64 INT282282 Ptger2 Positive_regulation of Akt1 1 0.03 0.47 0.54
65 INT162994 Binding of Akt1 and Trib3 1 0.04 0.09 0.54
66 INT127320 Gpx3 Regulation of Akt1 2 0.00 3.11 0.53
67 INT317523 Oprm1 Positive_regulation of Gene_expression of Akt1 1 0.32 0.05 0.53
68 INT109307 Pik3r1 Positive_regulation of Phosphorylation of Akt1 1 0.29 0.4 0.53
69 INT256019 Agt Negative_regulation of Lnpep 1 0.23 1.76 0.53
70 INT317574 Oprm1 Positive_regulation of Akt1 1 0.22 0.05 0.52
71 INT57248 ELANE Regulation of Gene_expression of CGA 1 0.05 0 0.52
72 INT151221 Negative_regulation of SIGMAR1 Negative_regulation of Akt1 1 0.00 0.13 0.51
73 INT102844 Pdc Regulation of Akt1 1 0.03 0 0.49
74 INT312118 ELANE Regulation of PTGES 1 0.22 0.92 0.49
75 INT72230 Binding of BTRC and EMID1 1 0.00 0 0.49
76 INT72227 Binding of BTRC and AP1M2 1 0.00 0 0.49
77 INT114676 Mdm2 Negative_regulation of p53-ps 1 0.10 0.26 0.48
78 INT65006 DAK Negative_regulation of ELANE 1 0.05 0.35 0.47
79 INT134042 Jak2 Regulation of Akt1 1 0.18 0.13 0.47
80 INT309126 Edc4 Positive_regulation of Akt1 1 0.02 0.99 0.47
81 INT309144 Dlat Positive_regulation of Akt1 1 0.03 0.99 0.47
82 INT312112 ELANE Regulation of Transcription of ALOX5 1 0.09 0.82 0.47
83 INT276207 Binding of Akt1 and Myo1f 1 0.11 0.05 0.47
84 INT114065 Akt1 Regulation of Gene_expression of Insr 1 0.13 0.28 0.46
85 INT291018 Binding of NSF and USE1 1 0.03 0.98 0.46
86 INT276218 Binding of Akt1 and Pten 1 0.26 0.08 0.46
87 INT171123 TNF Positive_regulation of Localization of Spg7 1 0.01 1.35 0.46
88 INT221026 ELANE Positive_regulation of Gene_expression of CCL18 1 0.01 0.57 0.45
89 INT296827 Binding of BGN and USE1 1 0.01 0 0.44
90 INT56631 Negative_regulation of FPR1 Positive_regulation of ELANE 1 0.38 0.54 0.44
91 INT116610 Positive_regulation of Lnpep Regulation of Nos2 1 0.16 0.62 0.44
92 INT116608 Lnpep Regulation of Nos2 1 0.14 0.62 0.44
93 INT139900 Kcne2 Positive_regulation of Akt1 1 0.06 2.95 0.44
94 INT116613 Lnpep Negative_regulation of Gene_expression of BAX 1 0.42 0.62 0.43
95 INT116609 Lnpep Negative_regulation of Bcl2 1 0.05 0.62 0.43
96 INT116606 Lnpep Regulation of Gene_expression of Bcl2 1 0.07 0.62 0.43
97 INT296831 Binding of CASP4 and USE1 1 0.01 0 0.43
98 INT116607 Lnpep Negative_regulation of Gene_expression of Bcl2 1 0.10 0.62 0.43
99 INT20221 Binding of Grcc10 and Fbxo6 1 0.00 0 0.42
100 INT116612 Lnpep Negative_regulation of BAX 1 0.42 0.62 0.42
101 INT348785 Ins1 Positive_regulation of Phosphorylation of Akt1 1 0.17 3.5 0.42
102 INT322396 Hist1h1t Positive_regulation of Akt1 1 0.01 0 0.42
103 INT116611 Lnpep Positive_regulation of Binding of Nos2 1 0.16 0.62 0.42
104 INT293007 IRF6 Positive_regulation of ELANE 1 0.00 0 0.42
105 INT322395 Akt1 Regulation of Pik3cb 1 0.08 0 0.42
106 INT122749 Cyp3a23/3a1 Positive_regulation of Phosphorylation of Akt1 1 0.07 0.24 0.41
107 INT221027 ELANE Positive_regulation of IL8 2 0.14 1.3 0.4
108 INT276216 Binding of Akt1 and Ins1 2 0.03 2.61 0.4
109 INT231842 Pcdh8 Positive_regulation of Akt1 1 0.00 1.59 0.4
110 INT312123 ELANE Positive_regulation of ALOX5 1 0.09 0.74 0.4
111 INT322409 Positive_regulation of OPRM1 Positive_regulation of Phosphorylation of Akt1 1 0.04 0 0.4
112 INT312122 ELANE Positive_regulation of Protein_catabolism of COL2A1 1 0.05 0.65 0.39
113 INT166155 Ccr9 Positive_regulation of Akt1 1 0.58 2.14 0.39
114 INT312086 ELANE Positive_regulation of MMP13 1 0.13 0.64 0.39
115 INT146611 Ins1 Positive_regulation of Phosphorylation of Akt1 9 0.23 4.34 0.37
116 INT296828 USE1 Regulation of Gene_expression of BGN 1 0.01 0.17 0.37
117 INT296826 USE1 Regulation of Gene_expression of CASP4 1 0.02 0.17 0.37
118 INT296830 USE1 Regulation of BGN 1 0.00 0.17 0.37
119 INT148243 Binding of Akt1 and Kit 1 0.03 0.44 0.35
120 INT122758 Positive_regulation of Helt Positive_regulation of Akt1 1 0.00 0.2 0.35
121 INT288208 Binding of Mapk14 and Positive_regulation of Akt1 1 0.01 0.42 0.35
122 INT122756 Helt Positive_regulation of Akt1 1 0.00 0.2 0.35
123 INT309118 Dlat Positive_regulation of Positive_regulation of Akt1 1 0.03 0.32 0.34
124 INT249019 Gabrg1 Positive_regulation of Akt1 1 0.02 0 0.34
125 INT196820 Negative_regulation of Ppp1cc Positive_regulation of Akt1 1 0.00 0 0.34
126 INT214377 Akt1 Regulation of Amph 1 0.15 0 0.33
127 INT312119 ELANE Positive_regulation of Gene_expression of PTGES 1 0.18 0.74 0.33
128 INT312099 ELANE Positive_regulation of Gene_expression of PTGER2 1 0.02 0.64 0.32
129 INT346286 ELANE Positive_regulation of MAPK1 1 0.06 0.65 0.32
130 INT346281 Binding of ELANE and MAPK1 1 0.04 0.65 0.32
131 INT165580 Binding of Akt1 and Grin2b 1 0.02 0.2 0.32
132 INT312085 ELANE Regulation of Regulation of ALOX5 1 0.09 0.64 0.32
133 INT255740 Pik3r1 Positive_regulation of Akt1 5 0.24 2.42 0.31
134 INT198566 Ddit4l Regulation of Axin1 1 0.03 1 0.31
135 INT303063 Akt1 Negative_regulation of Gene_expression of Syn1 1 0.09 0.45 0.31
136 INT165921 Tlr4 Positive_regulation of Akt1 1 0.16 0.75 0.31
137 INT165920 Negative_regulation of Tlr4 Positive_regulation of Akt1 1 0.13 0.75 0.31
138 INT122575 Akt1 Positive_regulation of Phosphorylation of Nos3 4 0.37 3.89 0.29
139 INT190826 ELANE Positive_regulation of Localization of MUC1 1 0.07 0 0.29
140 INT116358 Binding of C3 and ELANE 1 0.12 0 0.29
141 INT116356 Positive_regulation of Binding of C3 and ELANE 1 0.16 0 0.29
142 INT132367 Lgals1 Positive_regulation of Akt1 1 0.22 0.13 0.28
143 INT317533 Akt1 Positive_regulation of Nos1 1 0.43 0 0.28
144 INT45544 Ncapg2 Regulation of Localization of Lnpep 1 0.00 0 0.28
145 INT170719 Binding of Grm5 and Siah1a 1 0.01 1.1 0.28
146 INT45541 Agt Positive_regulation of Lnpep 1 0.03 0 0.27
147 INT149322 Amph Positive_regulation of Akt1 1 0.39 0 0.27
148 INT167881 Ctrb1 Regulation of Gene_expression of PRSS2 1 0.10 1.81 0.26
149 INT223930 Binding of Akt1 and Pik3cb 1 0.07 0.35 0.26
150 INT291019 Negative_regulation of Binding of NSF and USE1 1 0.03 0.59 0.26
151 INT223929 Negative_regulation of Binding of Akt1 and Pik3cb 1 0.08 0.36 0.26
152 INT303082 Akt1 Negative_regulation of Gene_expression of Mafk 1 0.20 0.37 0.26
153 INT114818 Try4 Positive_regulation of Afg3l2 1 0.04 0.39 0.25
154 INT308661 Akt1 Positive_regulation of Chuk 1 0.02 0.6 0.25
155 INT312115 ELANE Positive_regulation of Transcription of PTGES 1 0.25 0.53 0.25
156 INT314047 THL Negative_regulation of Phosphorylation of Akt1 1 0.14 0.71 0.25
157 INT312569 IL6 Positive_regulation of Localization of ELANE 1 0.11 1.05 0.24
158 INT114820 TPSG1 Positive_regulation of Afg3l2 1 0.06 0.39 0.24
159 INT256028 Binding of Agt and Lnpep 1 0.19 1.16 0.24
160 INT114819 Proc Positive_regulation of Afg3l2 1 0.07 0.39 0.24
161 INT326094 Akt1 Positive_regulation of Gene_expression of Gopc 1 0.03 0.49 0.24
162 INT15829 Ambp Regulation of Positive_regulation of ELANE 1 0.00 0 0.24
163 INT171124 Spg7 Positive_regulation of NOSTRIN 1 0.01 0.76 0.24
164 INT326092 Gene_expression of Akt1 Negative_regulation of Gopc 1 0.03 0.55 0.24
165 INT160464 Binding of Mme and Lnpep 1 0.31 0.37 0.24
166 INT72231 Negative_regulation of Binding of NFKBIL1 and BTRC 1 0.00 0 0.24
167 INT202422 IL8 Positive_regulation of Localization of ELANE 1 0.02 0.91 0.24
168 INT326093 Akt1 Positive_regulation of Gopc 1 0.03 0.43 0.23
169 INT222178 SERPINB1 Regulation of ELANE 1 0.00 1.04 0.23
170 INT323173 THRA Positive_regulation of Phosphorylation of Akt1 1 0.00 0 0.22
171 INT133166 ELANE Regulation of Tnf 1 0.01 0.98 0.22
172 INT224431 TNF Positive_regulation of Gene_expression of FBXO2 1 0.47 0.35 0.22
173 INT224452 Il1 Positive_regulation of Gene_expression of FBXO2 1 0.37 0.35 0.22
174 INT260844 NRP2 Positive_regulation of Akt1 1 0.00 0.73 0.22
175 INT60909 TPP1 Positive_regulation of Gh1 1 0.00 0 0.22
176 INT116467 Vegfa Positive_regulation of Akt1 1 0.33 1.41 0.21
177 INT323174 DBT Positive_regulation of Phosphorylation of Akt1 1 0.01 0 0.21
178 INT116468 VEGFA Positive_regulation of Akt1 1 0.04 1.39 0.21
179 INT289356 Binding of Akt1 and Fgf2 1 0.03 0.82 0.21
180 INT57250 ELANE Positive_regulation of Localization of CGA 1 0.08 0 0.21
181 INT309661 C5 Positive_regulation of Phosphorylation of Akt1 1 0.51 0.45 0.21
182 INT221237 Prkca Regulation of Phosphorylation of Akt1 1 0.01 0.28 0.2
183 INT310939 Binding of ELANE and COPD 1 0.08 1.51 0.2
184 INT252814 ELANE Positive_regulation of Positive_regulation of CCL2 1 0.05 0.8 0.2
185 INT310938 Binding of ELANE and HRCT1 1 0.02 1.5 0.2
186 INT168828 Binding of DDB1 and UBR1 1 0.00 0.67 0.19
187 INT224688 Pten Regulation of Akt1 1 0.04 1.12 0.19
188 INT170721 Siah1a Regulation of Negative_regulation of Grm2 1 0.22 0 0.18
189 INT334631 Igf1r Positive_regulation of Phosphorylation of Akt1 1 0.19 0.5 0.18
190 INT42467 PTGER1 Negative_regulation of LNPEP 1 0.02 0 0.18
191 INT175073 Fig4 Regulation of Psmc1 1 0.05 0.07 0.18
192 INT303058 Akt1 Negative_regulation of Gene_expression of Syt1 1 0.21 0.43 0.18
193 INT221231 Pdpk1 Positive_regulation of Akt1 1 0.09 0.13 0.18
194 INT221244 Pdpk1 Positive_regulation of Phosphorylation of Akt1 1 0.09 0.13 0.18
195 INT253129 Ins1 Regulation of Phosphorylation of Akt1 3 0.11 1.66 0.17
196 INT179841 Il11 Regulation of Positive_regulation of Akt1 1 0.08 0.07 0.17
197 INT221025 TNF Positive_regulation of ELANE 1 0.01 0.13 0.17
198 INT217074 Binding of Acsm3 and Axin1 1 0.00 5.37 0.17
199 INT282858 Bpifa2 Negative_regulation of Akt1 1 0.05 0.91 0.17
200 INT346305 Binding of ELANE and Col2a1 1 0.00 0.98 0.17

Single Events

The table below shows the top 100 pain related interactions that have been reported for protein catabolic process. They are ordered first by their pain relevance and then by number of times they were reported in protein catabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34
2 INT117713 Phosphorylation of Akt1 275 0.82 95.82 54.34
3 INT40777 Positive_regulation of Akt1 163 0.69 59.41 49.43
4 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82
5 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81
6 INT5653 Positive_regulation of ELANE 136 0.70 72.78 27.94
7 INT112707 Negative_regulation of Akt1 89 0.59 28.85 27.76
8 INT2609 Localization of ELANE 111 0.81 50.22 26.63
9 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53
10 INT40776 Gene_expression of Akt1 99 0.77 34.91 24.39
11 INT117718 Positive_regulation of Phosphorylation of Akt1 112 0.69 39.26 24.09
12 INT16431 Localization of Lnpep 62 0.70 6.28 23.94
13 INT5905 Negative_regulation of ELANE 113 0.59 47.43 22.09
14 INT8580 Gene_expression of ELANE 132 0.75 62.98 21.79
15 INT109304 Positive_regulation of Phosphorylation of Akt1 113 0.69 40.92 13.49
16 INT26534 Regulation of Akt1 34 0.61 14.47 11.86
17 INT114674 Gene_expression of Mdm2 15 0.78 3.51 11.85
18 INT75137 Regulation of Akt1 74 0.48 37.89 9.7
19 INT120967 Negative_regulation of Phosphorylation of Akt1 47 0.57 23.67 8.98
20 INT104396 Positive_regulation of Positive_regulation of Akt1 44 0.55 14.78 8.69
21 INT114675 Positive_regulation of Gene_expression of Mdm2 1 0.70 1.98 7.9
22 INT10627 Positive_regulation of Lnpep 24 0.69 3.36 7.85
23 INT106522 Negative_regulation of Phosphorylation of Akt1 65 0.58 34.44 7.83
24 INT103925 Negative_regulation of Positive_regulation of Akt1 32 0.58 15.19 7.39
25 INT2605 Regulation of ELANE 39 0.61 18.22 7.11
26 INT126748 Positive_regulation of Positive_regulation of Akt1 26 0.55 11.15 7.08
27 INT117721 Positive_regulation of Gene_expression of Akt1 22 0.69 6.26 6.08
28 INT114882 Positive_regulation of Gene_expression of Akt1 45 0.69 21.29 6.06
29 INT10624 Regulation of Lnpep 13 0.61 3.27 5.6
30 INT118124 Binding of USE1 24 0.16 16.64 5.44
31 INT10100 Binding of ELANE 22 0.47 15.32 5.19
32 INT16432 Positive_regulation of Localization of Lnpep 12 0.32 1.15 5.05
33 INT17582 Negative_regulation of Localization of ELANE 17 0.53 6.11 4.89
34 INT134657 Localization of Akt1 37 0.68 11.58 4.62
35 INT122569 Negative_regulation of Gene_expression of Akt1 34 0.54 17.15 4.44
36 INT75136 Binding of Akt1 27 0.27 8.81 4.15
37 INT139898 Negative_regulation of Positive_regulation of Akt1 15 0.42 4.66 4.06
38 INT183207 Negative_regulation of USE1 14 0.18 10.97 4
39 INT132223 Negative_regulation of Negative_regulation of Akt1 6 0.42 2.75 3.66
40 INT136692 Localization of Akt1 12 0.78 2.14 3.65
41 INT39786 Transcription of Lnpep 3 0.69 0.52 3.61
42 INT22891 Positive_regulation of Localization of ELANE 16 0.69 11.52 3.42
43 INT42581 Regulation of Gene_expression of ELANE 11 0.38 9.25 3.38
44 INT22823 Positive_regulation of Positive_regulation of ELANE 12 0.45 6.89 3.35
45 INT157687 Regulation of Gene_expression of Akt1 9 0.62 4.96 3.27
46 INT32340 Negative_regulation of Lnpep 14 0.49 2.63 3.26
47 INT25674 Positive_regulation of Gene_expression of ELANE 16 0.60 7.46 3.12
48 INT17673 Negative_regulation of Localization of Lnpep 8 0.09 2.63 3.12
49 INT117720 Negative_regulation of Gene_expression of Akt1 11 0.37 2.33 3.08
50 INT54749 Binding of BTRC 7 0.09 0.88 2.9
51 INT41721 Negative_regulation of MTOR 40 0.58 32.49 2.83
52 INT117715 Regulation of Phosphorylation of Akt1 15 0.51 3.23 2.78
53 INT12903 Gene_expression of Lnpep 14 0.71 1.3 2.78
54 INT181267 Gene_expression of USE1 12 0.32 7.6 2.7
55 INT214355 Binding of Akt1 13 0.36 3.72 2.59
56 INT16433 Regulation of Localization of Lnpep 6 0.11 0.32 2.45
57 INT170712 Gene_expression of Siah1a 1 0.77 2.33 2.33
58 INT10626 Regulation of Positive_regulation of Lnpep 2 0.11 0.1 2.31
59 INT138286 Regulation of Positive_regulation of Akt1 13 0.45 4.93 2.22
60 INT60279 Gene_expression of VHL 70 0.78 75.21 2.21
61 INT30137 Negative_regulation of TPP1 5 0.37 0.96 2.2
62 INT12061 Negative_regulation of LNPEP 19 0.58 5.52 2.14
63 INT42583 Protein_catabolism of ELANE 8 0.89 4.33 2.11
64 INT130754 Gene_expression of Cast 21 0.78 11.6 2.08
65 INT36245 Negative_regulation of Gene_expression of ELANE 11 0.40 5.32 1.88
66 INT142236 Regulation of Phosphorylation of Akt1 13 0.61 5.02 1.75
67 INT165332 Negative_regulation of Negative_regulation of Akt1 5 0.42 3.27 1.7
68 INT100375 Gene_expression of Vhl 14 0.15 22.3 1.69
69 INT30138 Binding of TPP1 1 0.16 0.74 1.69
70 INT117714 Regulation of Positive_regulation of Akt1 3 0.61 0.44 1.61
71 INT211136 Localization of USE1 3 0.11 2.67 1.57
72 INT54750 Gene_expression of BTRC 4 0.14 0.99 1.55
73 INT100376 Positive_regulation of Gene_expression of Vhl 4 0.10 6.47 1.47
74 INT41719 Gene_expression of MTOR 27 0.77 19.43 1.44
75 INT96137 Gene_expression of LNPEP 8 0.68 5.27 1.43
76 INT114671 Positive_regulation of Mdm2 1 0.61 0.5 1.38
77 INT36643 Negative_regulation of Ctrb1 2 0.16 0.08 1.33
78 INT224447 Gene_expression of FBXO2 7 0.75 7.33 1.31
79 INT79660 Phosphorylation of PSMC6 3 0.80 0.45 1.28
80 INT190067 Binding of Traf2 5 0.20 3.28 1.27
81 INT45959 Gene_expression of Psmc1 10 0.29 0.71 1.22
82 INT5652 Negative_regulation of Positive_regulation of ELANE 7 0.37 2.46 1.21
83 INT130755 Positive_regulation of Gene_expression of Cast 4 0.70 4.3 1.18
84 INT181269 Positive_regulation of Gene_expression of USE1 3 0.24 1.43 1.18
85 INT39785 Positive_regulation of Transcription of Lnpep 2 0.50 0.47 1.18
86 INT211134 Positive_regulation of Localization of USE1 1 0.06 1.23 1.18
87 INT207203 Transcription of Akt1 6 0.67 3.73 1.1
88 INT17805 Regulation of Localization of ELANE 7 0.59 1.88 1.08
89 INT96138 Positive_regulation of LNPEP 6 0.45 3.81 1.07
90 INT191050 Positive_regulation of Negative_regulation of Akt1 6 0.31 1.82 1.03
91 INT114673 Regulation of Gene_expression of Mdm2 1 0.62 0.23 1.02
92 INT4914 Binding of Wdyhv1 1 0.01 0 0.98
93 INT171118 Localization of Spg7 1 0.26 2.59 0.95
94 INT257453 Positive_regulation of USE1 12 0.20 6.7 0.94
95 INT134660 Positive_regulation of Localization of Akt1 10 0.32 6.33 0.94
96 INT163508 Regulation of Gene_expression of Akt1 3 0.45 1.65 0.92
97 INT144289 Negative_regulation of Positive_regulation of PSMC6 1 0.41 0.56 0.92
98 INT144287 Positive_regulation of PSMC6 1 0.49 0.56 0.92
99 INT256006 Negative_regulation of Lnpep 1 0.48 2.61 0.9
100 INT32443 Negative_regulation of Binding of ELANE 2 0.11 0.54 0.89
101 INT201252 Negative_regulation of Binding of USE1 1 0.01 0 0.86
102 INT42469 Regulation of LNPEP 9 0.60 0.46 0.83
103 INT68665 Binding of Vhl 9 0.48 10.3 0.82
104 INT171112 Negative_regulation of Spg7 2 0.15 1.37 0.79
105 INT142422 Regulation of Positive_regulation of ELANE 1 0.02 0.65 0.78
106 INT46295 Regulation of Negative_regulation of ELANE 4 0.39 2.34 0.76
107 INT141115 Negative_regulation of Transcription of Lnpep 1 0.31 0 0.76
108 INT105483 Protein_catabolism of LNPEP 3 0.42 3.26 0.74
109 INT151170 Regulation of Regulation of Akt1 2 0.45 3.28 0.73
110 INT213923 Positive_regulation of MTOR 16 0.65 9.28 0.7
111 INT11551 Localization of VHL 12 0.65 22.76 0.68
112 INT200219 Positive_regulation of VHL 18 0.50 15.38 0.67
113 INT34493 Negative_regulation of Psmc1 2 0.04 0 0.67
114 INT207204 Regulation of Transcription of Akt1 3 0.35 1.41 0.66
115 INT281466 Negative_regulation of Regulation of Akt1 1 0.33 0.31 0.63
116 INT100370 Negative_regulation of Gene_expression of Vhl 1 0.06 0.9 0.62
117 INT48697 Gene_expression of Ctrb1 3 0.22 0.34 0.6
118 INT154745 Protein_catabolism of Traf2 1 0.86 1.04 0.59
119 INT170695 Binding of Siah1a 1 0.48 1.19 0.59
120 INT154750 Positive_regulation of Protein_catabolism of Traf2 1 0.60 1.05 0.59
121 INT294555 Negative_regulation of Traf2 1 0.06 1.24 0.58
122 INT175062 Localization of Psmc1 4 0.27 0.18 0.56
123 INT43158 Regulation of TPP1 1 0.23 0 0.55
124 INT74016 Binding of VHL 20 0.48 15.49 0.54
125 INT16681 Positive_regulation of PSMC2 1 0.07 0 0.54
126 INT30783 Positive_regulation of Gene_expression of Lnpep 3 0.64 0.66 0.53
127 INT218900 Regulation of Negative_regulation of Akt1 3 0.15 1.73 0.53
128 INT137412 Negative_regulation of Cast 6 0.49 4.03 0.52
129 INT142911 Binding of Lnpep 5 0.31 0.36 0.52
130 INT190074 Positive_regulation of Traf2 1 0.19 0.37 0.52
131 INT141117 Regulation of Transcription of Lnpep 1 0.14 0 0.51
132 INT57943 Protein_catabolism of Lnpep 2 0.89 0.09 0.5
133 INT276189 Regulation of Localization of Akt1 1 0.43 0.2 0.5
134 INT223599 Regulation of MTOR 14 0.42 8.52 0.49
135 INT85659 Gene_expression of TPP1 2 0.53 1.84 0.48
136 INT114815 Positive_regulation of Afg3l2 1 0.45 0.68 0.47
137 INT235200 Positive_regulation of Negative_regulation of ELANE 3 0.38 1.68 0.46
138 INT48696 Regulation of Gene_expression of Ctrb1 1 0.11 0.34 0.46
139 INT48703 Localization of Ctrb1 1 0.17 0.34 0.46
140 INT48698 Regulation of Ctrb1 1 0.05 0.34 0.46
141 INT210125 Regulation of Axin1 1 0.02 2.45 0.46
142 INT171110 Gene_expression of Spg7 1 0.21 1.05 0.4
143 INT188687 Negative_regulation of Negative_regulation of Spg7 1 0.05 0.31 0.4
144 INT171116 Negative_regulation of Gene_expression of Spg7 1 0.15 1.06 0.4
145 INT171111 Regulation of Spg7 1 0.09 0.94 0.4
146 INT137410 Positive_regulation of Cast 4 0.70 4.37 0.39
147 INT252736 Transcription of ELANE 2 0.25 0.94 0.39
148 INT256014 Binding of Lnpep 1 0.31 0.64 0.39
149 INT136180 Binding of MTOR 9 0.35 5.01 0.38
150 INT156201 Negative_regulation of Gene_expression of MTOR 6 0.58 7.7 0.36
151 INT52071 Negative_regulation of Negative_regulation of ELANE 2 0.13 0.78 0.36
152 INT84798 Gene_expression of Vhl 2 0.48 2.28 0.35
153 INT21451 Regulation of Regulation of ELANE 2 0.07 0.06 0.35
154 INT175065 Positive_regulation of Psmc1 1 0.21 0 0.35
155 INT321348 Positive_regulation of Localization of Akt1 1 0.30 0.08 0.32
156 INT172957 Negative_regulation of Mdm2 4 0.14 4.28 0.3
157 INT137409 Negative_regulation of Positive_regulation of Cast 1 0.38 0.95 0.3
158 INT173086 Negative_regulation of VHL 14 0.59 12.54 0.29
159 INT41720 Positive_regulation of Gene_expression of MTOR 2 0.49 1.54 0.28
160 INT41722 Positive_regulation of Negative_regulation of MTOR 1 0.45 0.73 0.28
161 INT167873 Transcription of Ctrb1 1 0.23 1.92 0.28
162 INT336997 Negative_regulation of Gene_expression of LNPEP 2 0.16 0.93 0.27
163 INT291024 Negative_regulation of Positive_regulation of USE1 1 0.03 0.59 0.26
164 INT97755 Regulation of Gene_expression of LNPEP 1 0.54 0.52 0.26
165 INT156207 Negative_regulation of Phosphorylation of MTOR 5 0.58 2.33 0.25
166 INT239464 Regulation of Negative_regulation of Akt1 3 0.31 0.37 0.25
167 INT351659 Positive_regulation of Gene_expression of LNPEP 1 0.18 1.27 0.25
168 INT170714 Regulation of Gene_expression of Siah1a 1 0.61 0.71 0.25
169 INT224449 Positive_regulation of Gene_expression of FBXO2 3 0.49 1.72 0.24
170 INT72235 Negative_regulation of BTRC 3 0.02 0 0.24
171 INT114817 Protein_catabolism of Afg3l2 1 0.64 0.39 0.24
172 INT102851 Binding of LNPEP 4 0.48 1.53 0.23
173 INT26381 Positive_regulation of Fbxo6 1 0.04 0 0.22
174 INT156204 Phosphorylation of MTOR 15 0.82 3.99 0.21
175 INT188686 Positive_regulation of Spg7 2 0.06 0.81 0.21
176 INT256005 Localization of Lnpep 1 0.66 0.97 0.21
177 INT230483 Protein_catabolism of Akt1 2 0.10 1.11 0.2
178 INT172958 Positive_regulation of Mdm2 4 0.56 2.43 0.19
179 INT122598 Positive_regulation of Vhl 1 0.60 0.67 0.19
180 INT336998 Negative_regulation of Positive_regulation of LNPEP 1 0.02 0.09 0.19
181 INT224448 Positive_regulation of FBXO2 1 0.49 0.72 0.19
182 INT256009 Positive_regulation of Lnpep 1 0.41 0.15 0.19
183 INT332297 Negative_regulation of Binding of MTOR 2 0.40 1.6 0.18
184 INT276192 Transcription of Akt1 1 0.66 0.47 0.18
185 INT142910 Negative_regulation of Negative_regulation of Lnpep 1 0.15 0 0.18
186 INT137411 Negative_regulation of Gene_expression of Cast 4 0.49 2.38 0.17
187 INT20209 Binding of Fbxo6 2 0.00 2.05 0.17
188 INT210123 Localization of Axin1 1 0.04 0.84 0.17
189 INT74017 Regulation of VHL 4 0.43 7.59 0.16
190 INT245655 Regulation of Gene_expression of Cast 2 0.38 0.44 0.16
191 INT154744 Regulation of Protein_catabolism of Traf2 1 0.39 0.18 0.16
192 INT111871 Negative_regulation of Regulation of LNPEP 1 0.42 0 0.16
193 INT154710 Gene_expression of UBR1 3 0.47 1.64 0.15
194 INT266010 Localization of Mdm2 2 0.75 2.64 0.15
195 INT204054 Negative_regulation of Negative_regulation of Mdm2 2 0.14 2.23 0.15
196 INT139331 Localization of Vhl 2 0.65 2.34 0.15
197 INT286764 Regulation of Localization of Mdm2 1 0.14 1.38 0.15
198 INT286748 Regulation of Mdm2 1 0.14 1.37 0.15
199 INT256007 Negative_regulation of Localization of Lnpep 1 0.35 0.88 0.15
200 INT226185 Protein_catabolism of Akt1 7 0.53 2.43 0.14
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