GO:0030178

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Name negative regulation of Wnt receptor signaling pathway
Categary Process
Go Slim No
Go Link GO:0030178
Unique Molecular Interactions 308
Total Molecular Interactions 510
Total Single Events 2585
Pain Genes Associated 34

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of Wnt receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of Wnt receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT316673 Binding of CALR and LRP1 1 0.39 1.89 0.74
2 INT112870 Aap Positive_regulation of Gene_expression of Ccnd1 1 0.24 0.34 0.63
3 INT334013 Ccl25 Positive_regulation of Gene_expression of Lrp1 1 0.07 0.98 0.56
4 INT146113 Binding of Adra2a and Lrp1 1 0.01 1.07 0.48
5 INT114297 Apc Negative_regulation of Gene_expression of Fcer2a 1 0.03 0.96 0.48
6 INT197496 Binding of Apoe and Lrp1 4 0.22 2.32 0.46
7 INT163831 ERBB2 Positive_regulation of CCND1 1 0.03 0.82 0.38
8 INT291616 Cby1 Positive_regulation of Gene_expression of Smad7 1 0.00 0.79 0.38
9 INT316672 Binding of LRP1 and SFTPD 1 0.35 0.96 0.37
10 INT242162 Binding of Ccnd1 and Wnt2 1 0.10 0.23 0.34
11 INT134080 OPA1 Negative_regulation of Phosphorylation of Gnb2l1 1 0.03 0.22 0.34
12 INT242164 Wnt2 Positive_regulation of Localization of Apc 1 0.13 1.53 0.32
13 INT198566 Ddit4l Regulation of Axin1 1 0.03 1 0.31
14 INT146893 TNF Negative_regulation of Dkk1 1 0.01 1.27 0.3
15 INT299289 AKT1 Positive_regulation of Positive_regulation of TSC2 1 0.17 0 0.3
16 INT286042 Binding of Tp53 and Wwox 1 0.04 2.05 0.28
17 INT350813 Binding of Apc and Crp 1 0.18 1.12 0.27
18 INT220635 Binding of Lrp1 and Kat5 2 0.09 0.71 0.25
19 INT198926 Binding of Apbb1 and Lrp1 5 0.12 2.18 0.24
20 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19
21 INT72325 Binding of Sigmar1 and WWOX 1 0.26 0 0.18
22 INT217074 Binding of Acsm3 and Axin1 1 0.00 5.37 0.17
23 INT327310 Binding of Ccnd1 and Elavl1 1 0.04 0.38 0.16
24 INT327325 Binding of Hnrnpd and Ccnd1 1 0.03 0.38 0.16
25 INT201722 Myc Regulation of Gene_expression of Ccnd1 1 0.03 0.79 0.13
26 INT201762 JUP Regulation of Gene_expression of Ccnd1 1 0.03 0.8 0.13
27 INT242163 Wnt2 Positive_regulation of Regulation of Apc 1 0.13 0.71 0.13
28 INT18230 Binding of HP and WWOX 1 0.19 0.17 0.13
29 INT196433 Cdk4 Negative_regulation of Ccnd1 1 0.10 1.17 0.13
30 INT261690 Binding of GSC and TCF23 1 0.10 0 0.12
31 INT316190 Apc Negative_regulation of Positive_regulation of Mapk1 1 0.33 0.66 0.12
32 INT184522 Positive_regulation of Ptger2 Regulation of Localization of Ccnd1 1 0.01 0.95 0.11
33 INT184521 Ptger2 Regulation of Localization of Ccnd1 1 0.01 0.94 0.11
34 INT184520 Ptger2 Regulation of Ccnd1 1 0.00 0.94 0.11
35 INT273018 Binding of FGF9 and PDE1A 1 0.18 0.3 0.11
36 INT273020 Binding of FGF9 and PDE11A 1 0.22 0.3 0.11
37 INT286046 Binding of Wwox and Creb1 1 0.14 1.67 0.1
38 INT272006 Binding of YWHAQ and Tsc2 1 0.27 0.39 0.1
39 INT286045 Binding of Jun and Wwox 1 0.12 2.33 0.1
40 INT220511 Cav1 Negative_regulation of Transcription of Ccnd1 1 0.03 0.83 0.09
41 INT308666 Binding of Lrp1 and Chol1 1 0.10 0.69 0.09
42 INT185279 Binding of CCND1 and CDK4 4 0.13 2.05 0.08
43 INT185278 Binding of CCND1 and CDK6 3 0.13 1.62 0.08
44 INT270464 Binding of Shh and Smo 1 0.07 1.3 0.08
45 INT270203 Binding of CD28 and Apc 1 0.04 0.58 0.08
46 INT290906 Shh Positive_regulation of Egfr 1 0.23 0 0.08
47 INT270197 Binding of Apc and Cd86 1 0.02 0.58 0.08
48 INT270198 Binding of Apc and Cd80 1 0.02 0.58 0.08
49 INT201173 Sox2 Positive_regulation of Localization of Ryr2 1 0.40 0.9 0.07
50 INT340567 Jun Positive_regulation of Gene_expression of Ccnd1 1 0.05 0.27 0.07
51 INT308655 Binding of Lrp1 and Gopc 1 0.01 0.49 0.07
52 INT335890 Binding of Dkk1 and Lrp4 1 0.37 0.64 0.07
53 INT335886 Binding of Sost and Lrp4 1 0.28 0.65 0.07
54 INT272003 Binding of Tsc2 and Tsc1 1 0.18 1.1 0.07
55 INT298349 HES3 Positive_regulation of Shh 1 0.12 0.14 0.07
56 INT215693 Trib3 Regulation of Gene_expression of Ccnd1 1 0.00 0.09 0.07
57 INT201172 Sox2 Positive_regulation of Localization of Ca2 1 0.47 0.9 0.07
58 INT290905 Gene_expression of Shh Positive_regulation of Gene_expression of Angpt1 1 0.14 0 0.06
59 INT312636 Negative_regulation of Binding of Musk and Lrp4 1 0.21 0.32 0.06
60 INT312639 Binding of Musk and Lrp4 1 0.23 0.91 0.06
61 INT312632 Binding of Agrn and Lrp4 1 0.17 0.32 0.06
62 INT176095 Binding of Apc and EC 1 0.04 0.51 0.05
63 INT213562 Ctnnd2 Regulation of Gene_expression of Sox2 1 0.35 0.07 0.05
64 INT286049 Binding of MAPK8 and Wwox 1 0.31 0.26 0.05
65 INT321891 Dkk1 Negative_regulation of Wnt2 1 0.12 0.94 0.05
66 INT120574 Binding of Apc and Egfr 1 0.27 1.02 0.05
67 INT242167 Binding of Dkk1 and Kremen2 1 0.01 0.06 0.04
68 INT316485 Stat3 Positive_regulation of Transcription of Ccnd1 1 0.23 1.27 0.04
69 INT246793 Binding of Tsc2 and Tsc1 1 0.04 0.71 0.04
70 INT311730 Binding of Plat and Lrp1 1 0.14 0.65 0.04
71 INT207702 CCND1 Regulation of MSMB 1 0.22 0.69 0.04
72 INT246786 Ogg1 Regulation of Phosphorylation of Tsc2 1 0.20 0.42 0.04
73 INT213563 Binding of Ctnnd2 and Shh 1 0.27 0.09 0.04
74 INT270459 Binding of Shh and Gli1 1 0.02 0.65 0.04
75 INT198919 Binding of Lrp1 and Lrpap1 1 0.07 0 0.04
76 INT321890 Slc3a2 Regulation of Dkk1 1 0.01 0.93 0.04
77 INT198921 Binding of App and Lrp1 3 0.32 2.7 0.03
78 INT254433 Binding of Lrp5 and Sost 2 0.39 1.51 0.03
79 INT190738 Adcyap1 Positive_regulation of Gene_expression of Gnb2l1 1 0.08 0 0.03
80 INT356102 Negative_regulation of Binding of App and Lrp1 1 0.32 0.71 0.03
81 INT352014 Shh Positive_regulation of Gene_expression of Pax1 1 0.29 0.07 0.03
82 INT272596 Binding of Dlg4 and Lrp1 1 0.16 0 0.03
83 INT246791 Tsc2 Regulation of Ogg1 1 0.27 0.56 0.03
84 INT277745 Trib3 Regulation of Ccnd1 1 0.00 0.41 0.03
85 INT311655 Shh Positive_regulation of Gene_expression of Fgf8 1 0.31 0.18 0.03
86 INT270462 Shh Positive_regulation of Ccnd1 1 0.10 0.6 0.03
87 INT213559 Binding of Egf and Shh 1 0.17 0.07 0.03
88 INT223067 IFI27 Negative_regulation of CCND1 1 0.05 0.65 0.03
89 INT223066 CDKN1A Negative_regulation of CCND1 1 0.04 0.66 0.03
90 INT272517 Binding of Ccnd1 and Celf1 3 0.08 0.07 0
91 INT144030 STAT3 Regulation of CCND1 2 0.09 1.05 0
92 INT220636 Binding of Lrp1 and Bace1 2 0.32 0.62 0
93 INT201771 CDKN1A Positive_regulation of Localization of Ccnd1 1 0.04 0 0
94 INT209984 Binding of LDLR and LRP1 1 0.08 0 0
95 INT218308 Binding of HPRT1 and Grb10 1 0.26 0.07 0
96 INT269943 Sox17 Regulation of Binding of Smad3 1 0.37 0.12 0
97 INT246784 Negative_regulation of Tsc2 Positive_regulation of Negative_regulation of Ogg1 1 0.20 0.43 0
98 INT290910 Pkm2 Negative_regulation of Shh 1 0.07 0.06 0
99 INT213034 Hdl1 Positive_regulation of Apc 1 0.08 1.21 0
100 INT269915 Binding of Smad2 and Sox17 1 0.21 0.07 0
101 INT246811 Ros1 Positive_regulation of Tsc2 1 0.02 0 0
102 INT356108 App Positive_regulation of Positive_regulation of Lrp1 1 0.43 0.52 0
103 INT314850 Shh Regulation of Atoh7 1 0.45 0.22 0
104 INT262938 Binding of PAX6 and SIX3 1 0.13 0.9 0
105 INT246808 Tsc2 Regulation of Regulation of Tsc1 1 0.02 0.05 0
106 INT246794 Ros1 Positive_regulation of Phosphorylation of Tsc2 1 0.03 0.66 0
107 INT341502 Negative_regulation of Binding of Apc and Pdcd1 1 0.00 0.53 0
108 INT290908 Regulation of Shh Positive_regulation of Ntn1 1 0.12 0 0
109 INT273106 Binding of Mtor and Cby1 1 0.01 0 0
110 INT293982 MYC Negative_regulation of SFRP1 1 0.21 0.62 0
111 INT302321 Negative_regulation of Binding of Lrp6 and SOST 1 0.16 0.26 0
112 INT269919 Sox17 Negative_regulation of Binding of Smad3 1 0.36 0 0
113 INT286044 Wwox Positive_regulation of Tp53 1 0.05 0.63 0
114 INT272518 Positive_regulation of Binding of Ccnd1 and Celf1 1 0.01 0 0
115 INT290911 Gene_expression of Shh Positive_regulation of Pkm2 1 0.07 0 0
116 INT271990 Tsc1 Positive_regulation of Tsc2 1 0.36 0.31 0
117 INT347124 Binding of FZD1 and Lrp1 1 0.11 0.24 0
118 INT272018 Binding of TSC1 and Tsc2 1 0.17 0.48 0
119 INT290904 Shh Positive_regulation of Prkcg 1 0.26 0.06 0
120 INT290900 Prkcg Regulation of Shh 1 0.23 0 0
121 INT269948 Sox17 Positive_regulation of Gene_expression of Ccnd1 1 0.61 0.19 0
122 INT269920 Positive_regulation of Binding of Ccnd1 and Qsox1 1 0.10 0 0
123 INT191096 Negative_regulation of Binding of Apc and Esr1 1 0.05 1.07 0
124 INT224291 Negative_regulation of ESR1 Positive_regulation of CCND1 1 0.16 0.07 0
125 INT246787 Akt2 Positive_regulation of Phosphorylation of Tsc2 1 0.10 0.16 0
126 INT269940 Binding of Sox17 and Scn4a 1 0.17 0.15 0
127 INT356095 Lrp1 Positive_regulation of App 1 0.37 0.53 0
128 INT356091 Lrp1 Positive_regulation of Positive_regulation of App 1 0.43 0.52 0
129 INT250658 FOS Positive_regulation of CCND1 1 0.03 0.6 0
130 INT246789 Pik3c3 Regulation of Tsc2 1 0.02 0.34 0
131 INT145338 Binding of PYGO1 and Positive_regulation of Transcription of CCND1 1 0.07 0 0
132 INT271991 Tsc1 Regulation of Tsc2 1 0.23 0.15 0
133 INT254432 Binding of Best1 and Sost 1 0.12 0.69 0
134 INT287885 Binding of DVL1 and AXIN1 1 0.02 0 0
135 INT286112 Binding of Apc and Afap1 1 0.05 0.71 0
136 INT290944 Shh Positive_regulation of VEGFA 1 0.04 0.05 0
137 INT269925 Binding of Ccnd1 and Qsox1 1 0.07 0 0
138 INT269955 Positive_regulation of Binding of Smad3 and Sox17 1 0.39 0.05 0
139 INT246809 Negative_regulation of Tsc2 Positive_regulation of Positive_regulation of Ogg1 1 0.20 0.45 0
140 INT269928 Binding of Sox17 and Mgst1 1 0.12 0 0
141 INT270461 Shh Regulation of Gene_expression of Ptch1 1 0.48 0.07 0
142 INT246801 Negative_regulation of Akt1 Negative_regulation of Phosphorylation of Tsc2 1 0.17 0 0
143 INT286043 Wwox Positive_regulation of Negative_regulation of Bcl2l1 1 0.04 0.7 0
144 INT246792 Akt1 Positive_regulation of Phosphorylation of Tsc2 1 0.19 0.78 0
145 INT277928 WIF1 Negative_regulation of TLE1 1 0.26 0.37 0
146 INT312628 Agrn Positive_regulation of Lrp4 1 0.22 0.66 0
147 INT338197 CCND1 Negative_regulation of AR 1 0.24 0 0
148 INT272013 Binding of OGG1 and Tsc2 1 0.09 0.67 0
149 INT269949 Sox17 Positive_regulation of Ccnd1 1 0.61 0.96 0
150 INT269954 Sox17 Regulation of Gene_expression of Foxa2 1 0.43 0 0
151 INT302320 Binding of Lrp6 and SOST 1 0.18 0.26 0
152 INT272010 Tsc2 Negative_regulation of OGG1 1 0.17 0.6 0
153 INT271966 Phosphorylation of Rasa1 Positive_regulation of Tsc2 1 0.01 0.31 0
154 INT213007 Hdl1 Regulation of Regulation of Apc 1 0.08 1.24 0
155 INT236724 Binding of AXIN1 and Ctnnd2 1 0.39 1.03 0
156 INT302154 STAT3 Regulation of Transcription of CCND1 1 0.04 0.99 0
157 INT246798 Akt1 Regulation of Tsc2 1 0.16 0.34 0
158 INT315486 Slfn1 Negative_regulation of Ccnd1 1 0.07 0.28 0
159 INT335887 Akt1 Regulation of Lrp6 1 0.06 0.15 0
160 INT293979 Binding of CSNK1D and CSNK1E 1 0.21 0.18 0
161 INT269950 Sox17 Negative_regulation of Gene_expression of Cdkn2b 1 0.27 0.24 0
162 INT209985 Binding of LRP1 and LTF 1 0.01 0 0
163 INT276303 Negative_regulation of AKT1 Negative_regulation of CCND1 1 0.01 0.58 0
164 INT331224 Binding of Akt1 and Tsc2 1 0.03 0.33 0
165 INT269947 Sox17 Positive_regulation of Gene_expression of Atxn1 1 0.08 0 0
166 INT335883 Binding of Lrp6 and Wnt5a 1 0.27 0.08 0
167 INT269957 Sox17 Negative_regulation of Gene_expression of TGFB1 1 0.04 0 0
168 INT198927 Lrp1 Regulation of App 1 0.14 0.42 0
169 INT335891 Binding of Dkk1 and Lrp5 1 0.39 0.57 0
170 INT269941 Sox17 Regulation of Gene_expression of Foxa1 1 0.56 0 0
171 INT191095 Positive_regulation of Binding of Apc and Esr1 1 0.06 1.08 0
172 INT269942 Sox17 Regulation of Smad3 1 0.37 0.12 0
173 INT270471 Shh Regulation of VEGFA 1 0.39 0.08 0
174 INT269934 Sox17 Regulation of Gopc 1 0.12 0 0
175 INT290898 Shh Positive_regulation of Nos2 1 0.46 0.05 0
176 INT246797 Tgfb1i1 Positive_regulation of Phosphorylation of Tsc2 1 0.01 0.66 0
177 INT347123 Binding of Axin2 and Lrp1 1 0.08 0.2 0
178 INT342558 FGF9 Positive_regulation of MAPK3 1 0.03 1.21 0
179 INT269951 Binding of Sox17 and Gopc 1 0.11 0 0
180 INT285878 Negative_regulation of Binding of CCND1 and CDK4 1 0.00 0.44 0
181 INT268398 Binding of LRP1 and Wnt2 1 0.01 0.36 0
182 INT342555 FGF9 Positive_regulation of MAPK1 1 0.07 1.22 0
183 INT315194 Binding of SFRP1 and Slc10a1 1 0.02 8.85 0
184 INT269930 Binding of Smad3 and Sox17 1 0.40 1.16 0
185 INT335882 Dkk1 Negative_regulation of Wnt2 1 0.02 0.15 0
186 INT271984 Binding of Tsc2 and Skp2 1 0.06 0.34 0
187 INT269945 Sox17 Positive_regulation of Localization of Ccnd1 1 0.39 0 0
188 INT272011 Binding of RAB5A and Tsc2 1 0.02 0.16 0
189 INT186051 IFI27 Regulation of Gene_expression of CCND1 1 0.30 0.66 0
190 INT272004 Binding of Hspa1b and Tsc2 1 0.01 0.45 0
191 INT271983 Binding of Tsc2 and Rap1a 1 0.02 0.16 0
192 INT270466 Ptch1 Regulation of Gene_expression of Shh 1 0.48 0.07 0
193 INT246806 Gene_expression of Akt1 Positive_regulation of Phosphorylation of Tsc2 1 0.19 0.32 0
194 INT213009 Hdl1 Positive_regulation of Positive_regulation of Apc 1 0.09 1.14 0
195 INT218307 Grb10 Positive_regulation of Protein_catabolism of INSR 1 0.03 0 0
196 INT286569 Binding of Pkd1 and Tsc2 1 0.06 1.01 0
197 INT262940 Regulation of Binding of PAX6 and SIX3 1 0.16 0.91 0
198 INT246803 Binding of Akt1 and Tsc2 1 0.14 0.85 0
199 INT270460 Shh Positive_regulation of Gene_expression of Angpt1 1 0.04 0.08 0
200 INT269922 Sox17 Regulation of Ccnd1 1 0.47 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of Wnt receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of Wnt receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT129883 Gene_expression of Dkk1 56 0.77 45.42 12.52
2 INT102572 Gene_expression of Ccnd1 79 0.69 56.37 7.34
3 INT3819 Positive_regulation of Apc 36 0.69 27.03 6.02
4 INT75501 Gene_expression of CCND1 90 0.76 60.86 5.93
5 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22
6 INT111156 Negative_regulation of Dkk1 21 0.58 20.08 4.27
7 INT3817 Negative_regulation of Apc 29 0.58 22.12 3.91
8 INT93399 Gene_expression of Ccnd1 38 0.58 21 3.65
9 INT75500 Negative_regulation of Gene_expression of CCND1 21 0.57 11.59 3.24
10 INT90875 Negative_regulation of CCND1 31 0.42 26.22 2.66
11 INT111153 Positive_regulation of Dkk1 13 0.68 10.56 2.58
12 INT93396 Positive_regulation of Gene_expression of Ccnd1 13 0.52 8.59 2.26
13 INT93398 Negative_regulation of Gene_expression of Ccnd1 5 0.44 2.61 2.12
14 INT104402 Positive_regulation of CCND1 15 0.70 11.77 2.08
15 INT144973 Gene_expression of Shh 9 0.77 4.32 1.96
16 INT198885 Gene_expression of Lrp1 33 0.57 10.2 1.91
17 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77
18 INT112867 Positive_regulation of Gene_expression of Ccnd1 15 0.56 13.22 1.77
19 INT3818 Regulation of Apc 13 0.39 12.52 1.68
20 INT344978 Negative_regulation of Gene_expression of Dkk1 1 0.58 4.38 1.59
21 INT321889 Negative_regulation of Dkk1 2 0.38 5.7 1.42
22 INT220177 Binding of Apc 21 0.37 15.34 1.37
23 INT108327 Negative_regulation of Gene_expression of Ccnd1 18 0.38 14.36 1.31
24 INT110434 Positive_regulation of Gene_expression of Apc 20 0.50 11.37 1.3
25 INT108519 Binding of Lrp6 8 0.44 1.47 1.19
26 INT124008 Positive_regulation of Wwox 2 0.67 7.64 1.16
27 INT128987 Negative_regulation of Ccnd1 24 0.52 15.78 1.15
28 INT253191 Positive_regulation of Gene_expression of Shh 2 0.66 2.57 1.14
29 INT144427 Transcription of Ccnd1 10 0.41 7.89 1.07
30 INT165530 Positive_regulation of Shh 4 0.69 1.21 1.05
31 INT165338 Binding of Dkk1 4 0.37 3.64 1.04
32 INT198904 Localization of Lrp1 11 0.62 3.25 1.01
33 INT47039 Regulation of SFRP1 14 0.62 7.44 0.92
34 INT59198 Regulation of Ccnd1 11 0.47 6.54 0.9
35 INT198872 Binding of Lrp1 9 0.36 2.73 0.89
36 INT242134 Localization of Apc 8 0.74 4.83 0.88
37 INT163280 Negative_regulation of Phosphorylation of CCND1 6 0.19 3.92 0.87
38 INT109007 Positive_regulation of Ccnd1 23 0.53 9.5 0.86
39 INT229278 Positive_regulation of Cby1 5 0.67 8.07 0.85
40 INT165337 Regulation of Dkk1 3 0.44 2.16 0.83
41 INT163289 Phosphorylation of CCND1 7 0.36 4.81 0.81
42 INT242131 Localization of Dkk1 5 0.79 6 0.76
43 INT344975 Regulation of Gene_expression of Dkk1 1 0.44 3.44 0.73
44 INT129882 Positive_regulation of Gene_expression of Dkk1 4 0.69 4.62 0.72
45 INT123443 Positive_regulation of WWOX 2 0.45 3.45 0.68
46 INT335876 Negative_regulation of Sost 11 0.51 6.77 0.67
47 INT252054 Phosphorylation of TSC2 4 0.80 0.63 0.67
48 INT122061 Negative_regulation of Lrp1 5 0.30 2.47 0.66
49 INT47038 Gene_expression of SFRP1 14 0.67 9.6 0.63
50 INT144432 Positive_regulation of Transcription of Ccnd1 4 0.36 2.36 0.63
51 INT185244 Gene_expression of Sox2 27 0.65 4.71 0.61
52 INT128498 Regulation of CCND1 17 0.39 12.51 0.58
53 INT145786 Binding of WWOX 2 0.35 0.59 0.55
54 INT164196 Binding of LRP1 5 0.47 2.59 0.53
55 INT146802 Positive_regulation of Ccnd1 4 0.38 1.37 0.53
56 INT75498 Positive_regulation of Gene_expression of CCND1 21 0.68 19.4 0.51
57 INT258835 Localization of Ccnd1 3 0.53 2.7 0.5
58 INT146522 Negative_regulation of Positive_regulation of CCND1 3 0.30 2.04 0.48
59 INT196424 Binding of Ccnd1 5 0.29 3.34 0.47
60 INT135366 Localization of SFRP1 4 0.75 1.82 0.47
61 INT93400 Negative_regulation of Ccnd1 4 0.33 0.77 0.47
62 INT286021 Gene_expression of Wwox 1 0.61 6.15 0.47
63 INT151720 Negative_regulation of Positive_regulation of Apc 3 0.37 2.15 0.46
64 INT206484 Localization of Shh 2 0.75 1.14 0.46
65 INT210125 Regulation of Axin1 1 0.02 2.45 0.46
66 INT198906 Positive_regulation of Localization of Lrp1 4 0.53 0.51 0.45
67 INT158643 Negative_regulation of Negative_regulation of CCND1 2 0.31 2.43 0.45
68 INT232798 Positive_regulation of Gene_expression of Shh 7 0.70 1.49 0.44
69 INT152151 Regulation of Gene_expression of Apc 4 0.44 3.87 0.42
70 INT185255 Positive_regulation of Sox2 3 0.26 1.22 0.42
71 INT294003 Gene_expression of CSNK1E 1 0.70 3.57 0.42
72 INT208559 Negative_regulation of Gene_expression of Shh 8 0.43 1.58 0.38
73 INT310250 Regulation of TLE1 1 0.00 0.68 0.37
74 INT220170 Regulation of Positive_regulation of Apc 1 0.10 0.46 0.35
75 INT146107 Positive_regulation of Lrp1 4 0.37 1.91 0.34
76 INT134072 Negative_regulation of Phosphorylation of Gnb2l1 1 0.11 0.22 0.34
77 INT221833 Positive_regulation of TSC2 2 0.23 0.39 0.33
78 INT242130 Positive_regulation of Positive_regulation of Dkk1 2 0.49 1.71 0.33
79 INT344976 Positive_regulation of Negative_regulation of Dkk1 1 0.49 1.13 0.33
80 INT198889 Protein_catabolism of Lrp1 5 0.68 1.6 0.32
81 INT225667 Transcription of Apc 3 0.52 3.73 0.32
82 INT229279 Negative_regulation of Cby1 15 0.42 9.4 0.31
83 INT342668 Regulation of LRP1 1 0.01 0.2 0.31
84 INT127984 Positive_regulation of LRP1 5 0.69 0.74 0.3
85 INT344977 Negative_regulation of Localization of Dkk1 2 0.42 2.57 0.3
86 INT134076 Phosphorylation of Gnb2l1 1 0.22 0.22 0.3
87 INT286024 Phosphorylation of Wwox 1 0.49 4.94 0.29
88 INT335875 Regulation of Lrp6 1 0.57 0.43 0.27
89 INT294013 Negative_regulation of CSNK1E 1 0.39 0.89 0.27
90 INT186057 Binding of CCND1 8 0.31 5.92 0.26
91 INT201143 Regulation of Sox2 6 0.44 2.71 0.26
92 INT97779 Negative_regulation of TSC2 3 0.41 3.45 0.26
93 INT232795 Positive_regulation of Shh 2 0.70 3.68 0.26
94 INT246762 Phosphorylation of Tsc2 60 0.67 15.71 0.25
95 INT113989 Regulation of Gene_expression of CCND1 11 0.44 7.57 0.24
96 INT198873 Regulation of Lrp1 3 0.35 1.45 0.24
97 INT335874 Regulation of Lrp4 1 0.18 0 0.23
98 INT335878 Localization of Sost 3 0.69 1.11 0.22
99 INT154360 Localization of Tsc2 1 0.56 0.16 0.22
100 INT225666 Regulation of Transcription of Apc 1 0.29 0.33 0.22
101 INT286040 Gene_expression of Wwox 1 0.47 0.08 0.22
102 INT254040 Regulation of FGF9 2 0.57 1.04 0.21
103 INT312604 Gene_expression of Lrp4 2 0.71 1.48 0.21
104 INT335864 Gene_expression of Sost 4 0.77 2.36 0.2
105 INT146801 Regulation of Ccnd1 5 0.34 2.4 0.19
106 INT218284 Gene_expression of Grb10 15 0.72 1.85 0.18
107 INT335869 Binding of Sost 6 0.32 1.79 0.18
108 INT157172 Gene_expression of WWOX 2 0.65 1.99 0.18
109 INT294009 Negative_regulation of Gene_expression of CSNK1E 1 0.39 0.19 0.18
110 INT139662 Gene_expression of FGF9 7 0.65 2.26 0.17
111 INT198877 Regulation of Gene_expression of Lrp1 2 0.32 0.62 0.17
112 INT335861 Localization of Lrp6 1 0.69 0.54 0.17
113 INT242127 Positive_regulation of Localization of Dkk1 1 0.05 0.35 0.17
114 INT228603 Positive_regulation of Positive_regulation of Apc 1 0.24 0.24 0.17
115 INT210123 Localization of Axin1 1 0.04 0.84 0.17
116 INT66933 Binding of AXIN1 6 0.32 1.8 0.16
117 INT232799 Regulation of Gene_expression of Shh 3 0.27 1.04 0.16
118 INT253177 Negative_regulation of Gene_expression of Shh 2 0.55 0.63 0.16
119 INT127985 Localization of LRP1 1 0.80 0.21 0.16
120 INT286023 Binding of Wwox 1 0.38 3.18 0.15
121 INT263410 Negative_regulation of Axin1 1 0.01 0 0.14
122 INT271943 Phosphorylation of Tsc2 9 0.52 3.35 0.13
123 INT119228 Gene_expression of TSC2 3 0.75 4.43 0.13
124 INT253190 Localization of Shh 2 0.77 1.06 0.13
125 INT145248 Negative_regulation of Negative_regulation of Ccnd1 1 0.23 0.47 0.13
126 INT196428 Negative_regulation of Binding of Ccnd1 1 0.14 1.17 0.13
127 INT246776 Negative_regulation of Tsc2 18 0.48 6.82 0.12
128 INT246749 Negative_regulation of Phosphorylation of Tsc2 11 0.35 3.4 0.12
129 INT253183 Negative_regulation of Shh 8 0.55 2.13 0.12
130 INT196427 Negative_regulation of Transcription of Ccnd1 1 0.14 1.17 0.12
131 INT271941 Binding of Tsc2 12 0.24 2.96 0.11
132 INT169908 Localization of Ccnd1 7 0.57 2.68 0.11
133 INT254428 Binding of Lrp4 4 0.44 1.52 0.11
134 INT201144 Regulation of Gene_expression of Sox2 3 0.44 0.82 0.11
135 INT286015 Positive_regulation of Gene_expression of Wwox 1 0.54 2.39 0.11
136 INT242140 Regulation of Localization of Apc 1 0.12 0.12 0.11
137 INT261711 Binding of GSC 1 0.32 0 0.11
138 INT184473 Regulation of Gene_expression of Ccnd1 5 0.40 2.73 0.1
139 INT242819 Negative_regulation of Gene_expression of Apc 4 0.37 5.6 0.1
140 INT201140 Transcription of Sox2 4 0.67 1.31 0.1
141 INT286012 Positive_regulation of Localization of Wwox 1 0.39 1.34 0.1
142 INT215750 Transcription of Ccnd1 2 0.14 2.23 0.09
143 INT270442 Transcription of Shh 1 0.53 0.25 0.09
144 INT246772 Regulation of Phosphorylation of Tsc2 1 0.26 1.37 0.09
145 INT262957 Localization of SIX3 1 0.23 0.67 0.09
146 INT213515 Binding of Shh 8 0.37 1.92 0.08
147 INT294014 Regulation of AXIN1 3 0.24 1.04 0.08
148 INT145364 Negative_regulation of AXIN1 2 0.33 0.52 0.08
149 INT235892 Gene_expression of Cby1 1 0.65 0 0.08
150 INT270453 Regulation of Shh 1 0.27 0.83 0.08
151 INT341574 Localization of WWOX 1 0.42 0.66 0.08
152 INT286014 Negative_regulation of Gene_expression of Wwox 1 0.34 0.66 0.08
153 INT145375 Transcription of CCND1 7 0.52 3.86 0.07
154 INT251976 Positive_regulation of TLE1 3 0.52 0.95 0.07
155 INT124004 Regulation of Wwox 2 0.35 1.16 0.07
156 INT229283 Negative_regulation of Positive_regulation of Cby1 1 0.42 0.18 0.07
157 INT124009 Negative_regulation of Wwox 1 0.57 0.19 0.07
158 INT256862 Regulation of Shh 1 0.25 0 0.07
159 INT286011 Localization of Wwox 1 0.59 2.37 0.07
160 INT341546 Negative_regulation of Positive_regulation of WWOX 1 0.26 0.75 0.06
161 INT215731 Positive_regulation of Transcription of Ccnd1 1 0.13 0.1 0.06
162 INT206866 Positive_regulation of SFRP1 7 0.51 3.97 0.05
163 INT235057 Positive_regulation of Negative_regulation of Apc 2 0.30 0.66 0.05
164 INT287913 Positive_regulation of Gene_expression of SFRP1 2 0.25 2.12 0.05
165 INT176590 Positive_regulation of Transcription of CCND1 1 0.17 0.27 0.05
166 INT335865 Positive_regulation of Phosphorylation of Lrp6 1 0.64 0.46 0.05
167 INT335862 Phosphorylation of Lrp6 1 0.76 0.37 0.05
168 INT270445 Positive_regulation of Localization of Shh 1 0.44 0.13 0.05
169 INT246770 Positive_regulation of Negative_regulation of Tsc2 1 0.20 1.91 0.05
170 INT286036 Positive_regulation of Transcription of Wwox 1 0.37 0.2 0.05
171 INT244699 Positive_regulation of AXIN1 1 0.02 0 0.05
172 INT185260 Positive_regulation of Positive_regulation of Sox2 1 0.15 0 0.05
173 INT271916 Positive_regulation of Phosphorylation of Tsc2 4 0.32 0.52 0.04
174 INT213537 Positive_regulation of Gene_expression of Sox2 3 0.48 1.34 0.04
175 INT335868 Negative_regulation of Gene_expression of Sost 2 0.58 1.12 0.04
176 INT242338 Binding of TSC2 2 0.22 1.56 0.04
177 INT208560 Negative_regulation of Shh 2 0.59 2.22 0.04
178 INT213528 Negative_regulation of Gene_expression of Sox2 1 0.30 0.07 0.04
179 INT341576 Regulation of WWOX 1 0.42 0.76 0.04
180 INT286019 Positive_regulation of Positive_regulation of Wwox 1 0.36 0 0.04
181 INT321885 Localization of Dkk1 1 0.56 0.87 0.04
182 INT271937 Positive_regulation of Binding of Tsc2 1 0.25 0 0.04
183 INT119227 Gene_expression of Tsc2 8 0.68 10.67 0.03
184 INT221830 Negative_regulation of Transcription of CCND1 3 0.18 2.15 0.03
185 INT294011 Protein_catabolism of CSNK1E 1 0.80 0.17 0.03
186 INT190723 Gene_expression of Gnb2l1 1 0.17 0 0.03
187 INT351638 Gene_expression of Cby1 1 0.00 0.68 0.03
188 INT242139 Protein_catabolism of Apc 1 0.17 0.27 0.03
189 INT286032 Transcription of Wwox 1 0.42 0.25 0.03
190 INT225226 Positive_regulation of Negative_regulation of Ccnd1 1 0.14 1.18 0.03
191 INT258832 Regulation of Transcription of Ccnd1 1 0.16 1.57 0.03
192 INT261706 Regulation of Binding of GSC 1 0.34 0 0.03
193 INT253187 Negative_regulation of Transcription of Shh 1 0.41 0.55 0.03
194 INT286020 Protein_catabolism of Wwox 1 0.51 0.67 0.03
195 INT253181 Transcription of Shh 1 0.68 0.54 0.03
196 INT294010 Positive_regulation of Protein_catabolism of CSNK1E 1 0.45 0.17 0.03
197 INT198907 Positive_regulation of Gene_expression of Lrp1 7 0.49 3.2 0
198 INT226288 Negative_regulation of SFRP1 6 0.43 4.45 0
199 INT246774 Positive_regulation of Tsc2 6 0.41 2.4 0
200 INT271919 Gene_expression of Tsc2 6 0.39 2.23 0
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