GO:0030212

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Name hyaluronan metabolic process
Categary Process
Go Slim No
Go Link GO:0030212
Unique Molecular Interactions 68
Total Molecular Interactions 106
Total Single Events 388
Pain Genes Associated 4

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for hyaluronan metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for hyaluronan metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT131257 ITIH4 Positive_regulation of Gene_expression of Nfkbia 1 0.23 1.41 2.3
2 INT275398 Binding of ITIH4 and Htatsf1 1 0.02 5.05 2.24
3 INT126400 ITIH4 Positive_regulation of Gene_expression of Il6 1 0.00 2.11 2.08
4 INT128654 ITIH4 Regulation of Gene_expression of CCL16 1 0.02 2.69 1.79
5 INT241750 Binding of CD4 and ITIH4 14 0.18 5.72 1.53
6 INT96796 ITIH4 Regulation of Gene_expression of OPRM1 2 0.20 0.89 1.41
7 INT95093 ITIH4 Positive_regulation of IL1B 1 0.43 1.04 1.32
8 INT95094 Negative_regulation of ITIH4 Positive_regulation of IL1B 1 0.36 1.04 1.32
9 INT194619 Il15 Positive_regulation of Gene_expression of TNF 1 0.24 2.23 1.2
10 INT137144 ITIH4 Regulation of OPRM1 1 0.20 1.13 1.16
11 INT126401 ITIH4 Positive_regulation of Gene_expression of Ptgs2 1 0.00 1.05 1.04
12 INT275406 Binding of ITIH4 and Ccr5 1 0.09 2.88 0.97
13 INT275409 Binding of ITIH4 and Cxcr4 1 0.09 2.87 0.97
14 INT128652 ITIH4 Regulation of Gene_expression of CCR5 1 0.36 1.46 0.93
15 INT128655 ITIH4 Regulation of Gene_expression of CCR3 1 0.36 1.45 0.92
16 INT128653 ITIH4 Regulation of Gene_expression of MIP 1 0.23 1.44 0.92
17 INT96795 ITIH4 Positive_regulation of Gene_expression of OPRM1 1 0.49 0.17 0.76
18 INT172134 Binding of IL6 and IL15 2 0.01 1.18 0.72
19 INT172147 Binding of IL15 and TNF 2 0.05 1.19 0.72
20 INT137139 ITIH4 Positive_regulation of OPRM1 1 0.37 0.67 0.72
21 INT120484 ITIH4 Positive_regulation of Il1 1 0.01 0.62 0.68
22 INT137142 Binding of ITIH4 and Positive_regulation of Localization of TNF 1 0.40 0.71 0.66
23 INT137138 ITIH4 Positive_regulation of Positive_regulation of OPRM1 1 0.42 0.55 0.59
24 INT137141 Binding of HIVEP1 and ITIH4 2 0.16 1.44 0.56
25 INT281152 Tcf21 Positive_regulation of Binding of ITIH4 1 0.03 1.21 0.54
26 INT4975 Binding of ITIH4 and MAG 1 0.44 2.24 0.39
27 INT281154 ITIH4 Positive_regulation of Cxcr4 1 0.09 0.71 0.37
28 INT281155 Binding of ITIH4 and Ddc 1 0.09 1.27 0.37
29 INT281153 Binding of ITIH4 and Cd4 1 0.10 0.91 0.37
30 INT264555 IL15 Positive_regulation of Gene_expression of BCL2 1 0.02 0.92 0.35
31 INT193784 ITIH4 Positive_regulation of YWHAZ 1 0.04 1.21 0.34
32 INT224691 Positive_regulation of Tlr4 Positive_regulation of Gene_expression of Il15 1 0.01 0.66 0.33
33 INT224681 Tlr2 Positive_regulation of Gene_expression of Il15 1 0.01 0.66 0.33
34 INT194614 Il15 Positive_regulation of Gene_expression of Klrk1 1 0.04 0.5 0.32
35 INT330182 Binding of ITIH2 and BRD4 1 0.05 0.37 0.32
36 INT284229 Binding of ITIH4 and Ccr5 1 0.10 0.27 0.31
37 INT64789 ITIH4 Positive_regulation of Positive_regulation of Pla2g1b 1 0.19 0.55 0.24
38 INT88310 ITIH4 Positive_regulation of CXCR4 2 0.27 1.98 0.23
39 INT275404 ITIH4 Regulation of Positive_regulation of Htatsf1 1 0.02 0.91 0.22
40 INT308533 ITIH4 Positive_regulation of Protein_catabolism of Tjp2 1 0.01 1.28 0.18
41 INT226380 Gene_expression of IL15 Negative_regulation of Positive_regulation of CD8A 1 0.02 1.59 0.18
42 INT284230 Positive_regulation of Binding of ITIH4 and Ccr5 1 0.10 0 0.17
43 INT88311 ITIH4 Positive_regulation of CCR5 1 0.49 1.57 0.16
44 INT193779 Positive_regulation of ITIH4 Positive_regulation of CXCR4 1 0.19 0.83 0.15
45 INT275375 Binding of ITIH4 and NDRG1 1 0.00 0.65 0.14
46 INT84050 IL6 Positive_regulation of ITIH4 1 0.49 0.18 0.13
47 INT275401 Binding of ITIH4 and Atf3 1 0.12 0.64 0.13
48 INT275408 Binding of ITIH4 and Gap43 1 0.03 0.64 0.13
49 INT275397 Binding of ITIH4 and Casp3 1 0.02 0.64 0.13
50 INT284228 Binding of ITIH4 and Eclc 1 0.02 0.29 0.12
51 INT251295 Binding of CD4 and Regulation of ITIH4 1 0.11 0.24 0.11
52 INT251292 Binding of ITIH4 and ERVW-1 1 0.22 0.07 0.08
53 INT251293 Regulation of Binding of ITIH4 and ERVW-1 1 0.27 0.07 0.08
54 INT193783 ITIH4 Regulation of Gene_expression of CDKN1A 1 0.03 0.55 0.07
55 INT193790 ITIH4 Regulation of Gene_expression of MDM2 1 0.06 0.45 0.07
56 INT351012 IL2RB Positive_regulation of Gene_expression of IL15 1 0.10 0.42 0.05
57 INT193788 ITIH4 Regulation of Phosphorylation of TP53 1 0.07 0.45 0.05
58 INT343498 Binding of ITIH4 and TPPP 1 0.06 0.64 0.05
59 INT241751 Negative_regulation of Binding of CD4 and ITIH4 3 0.18 1.07 0.04
60 INT185756 Binding of ITIH4 and Cd4 2 0.05 1.22 0.04
61 INT241752 ITIH4 Negative_regulation of Binding of CXCR4 1 0.08 0.71 0.04
62 INT251296 Binding of CCR5 and ITIH4 1 0.16 0.08 0.04
63 INT241749 ITIH4 Negative_regulation of Binding of CCR5 1 0.16 0.71 0.04
64 INT193778 ITIH4 Positive_regulation of CASP3 1 0.03 0.98 0.03
65 INT230066 IL15 Positive_regulation of Gene_expression of KLRD1 1 0.01 0.37 0.03
66 INT319921 Binding of HLA-DOA and ITIH4 1 0.00 0.07 0
67 INT348934 Binding of ITIH4 and ERLEC1 1 0.03 0.47 0
68 INT286766 Tusc2 Positive_regulation of Gene_expression of Il15 1 0.28 1.73 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for hyaluronan metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in hyaluronan metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT53482 Gene_expression of ITIH4 75 0.77 58.87 26.05
2 INT4977 Binding of ITIH4 60 0.46 42.48 15.65
3 INT133549 Gene_expression of Il15 42 0.69 27.84 14.74
4 INT172171 Gene_expression of IL15 47 0.37 46.23 13.41
5 INT84057 Positive_regulation of Gene_expression of ITIH4 12 0.50 10.5 4.92
6 INT76099 Positive_regulation of ITIH4 8 0.69 5.71 2.66
7 INT120483 Localization of ITIH4 11 0.69 12.05 2.51
8 INT226453 Positive_regulation of Gene_expression of IL15 9 0.24 12.66 2.38
9 INT184234 Positive_regulation of Il15 5 0.19 4.99 2.31
10 INT194610 Positive_regulation of Gene_expression of Il15 5 0.33 3.45 2.19
11 INT171891 Regulation of Il15 3 0.18 3.78 2.02
12 INT194609 Regulation of Gene_expression of Il15 1 0.18 3.33 1.86
13 INT64787 Regulation of ITIH4 7 0.38 5.61 1.82
14 INT96797 Negative_regulation of ITIH4 5 0.42 3.21 1.8
15 INT181720 Regulation of IL15 9 0.20 3.65 1.79
16 INT193809 Regulation of Binding of ITIH4 2 0.31 1.82 1.59
17 INT133553 Negative_regulation of Gene_expression of Il15 5 0.52 2.01 1.16
18 INT103699 Negative_regulation of IL15 5 0.24 2.42 1.12
19 INT188398 Positive_regulation of IL15 8 0.19 4.64 1.06
20 INT133547 Transcription of Il15 3 0.48 1.3 0.97
21 INT133558 Binding of Il15 4 0.43 1.58 0.96
22 INT194612 Negative_regulation of Il15 2 0.28 1.37 0.87
23 INT231746 Negative_regulation of Regulation of Il15 1 0.13 1.99 0.79
24 INT193805 Negative_regulation of Gene_expression of ITIH4 3 0.42 3.98 0.76
25 INT88317 Negative_regulation of Binding of ITIH4 6 0.36 4.46 0.69
26 INT258630 Binding of IL15 3 0.24 2.2 0.65
27 INT137146 Positive_regulation of Binding of ITIH4 1 0.41 0.7 0.64
28 INT77443 Binding of ITIH2 1 0.00 0.2 0.6
29 INT275395 Regulation of Gene_expression of ITIH4 4 0.26 2.26 0.5
30 INT193812 Negative_regulation of Localization of ITIH4 1 0.30 1.15 0.44
31 INT64788 Negative_regulation of Regulation of ITIH4 1 0.34 0.71 0.41
32 INT285554 Regulation of Transcription of IL15 1 0.15 0.61 0.4
33 INT285546 Regulation of Gene_expression of IL15 1 0.15 0.61 0.4
34 INT285556 Transcription of IL15 1 0.23 0.6 0.4
35 INT235498 Localization of IL15 6 0.21 2.17 0.39
36 INT293351 Negative_regulation of Regulation of IL15 1 0.04 0.34 0.22
37 INT84056 Positive_regulation of Transcription of ITIH4 1 0.46 0.18 0.13
38 INT84054 Transcription of ITIH4 1 0.53 0.18 0.13
39 INT133548 Negative_regulation of Binding of Il15 1 0.38 0.13 0.11
40 INT274488 Positive_regulation of Localization of IL15 1 0.07 0.9 0.1
41 INT293348 Negative_regulation of Positive_regulation of IL15 1 0.04 0.12 0
42 INT348939 Positive_regulation of Localization of ITIH4 1 0.45 0.51 0
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